|  |  |                   
      $40.76 - $45.86
      $197K - $222K
     |                   
              4.83K
              $301K
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              1.75M
              $2.01M
             |  | 
          
        
          |  |  |                   
      $27.03 - $31.93
      $255K - $301K
     |                   
              9.43K
              $291K
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              2M
              $2.35M
             |  | 
          
        
          |  |  |                   
      $167.51 - $223.5
      $186K - $248K
     |                   
              4.84K
              $1.04M
             |  | 
          
        
          |  |  |                   
      $236.44 - $328.0
      $205K - $284K
     |                   
              866
              $284K
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              1.75M
              $2.61M
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              702K
              $50M
             |  | 
          
        
          |  |  |                   
      $10.65 - $12.9
      $202K - $245K
     |                   
              51.7K
              $667K
             |  | 
          
        
          |  |  |                   
      $106.53 - $122.8
      $330K - $381K
     |                   
              11.3K
              $1.27M
             |  | 
          
        
          |  |  |                   
      $483.48 - $539.8
      $3.98M - $4.44M
     |                   
              88.2K
              $42.8M
             |  | 
          
        
          |  |  |                   
      $145.28 - $176.09
      $217K - $263K
     |                   
              1.5K
              $250K
             |  | 
          
        
          |  |  |                   
      $13.62 - $19.06
      $252K - $353K
     |                   
              81.4K
              $1.45M
             |  | 
          
        
          |  |  |                   
      $255.31 - $313.93
      $68.2K - $83.8K
     |                   
              11.5K
              $3.61M
             |  | 
          
        
          |  |  |                   
      $97.32 - $136.25
      $35.4K - $49.6K
     |                   
              7.48K
              $952K
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              5.85M
              $5.32M
             |  | 
          
        
          |  |  |                   
      $23.18 - $30.7
      $190K - $251K
     |                   
              8.19K
              $233K
             |  | 
          
        
          |  |  |                   
      $23.18 - $35.33
      $93K - $142K
     |                   
              20.1K
              $701K
             |  | 
          
        
          |  |  |                   
      $66.85 - $79.33
      $553K - $656K
     |                   
              102K
              $7.51M
             |  | 
          
        
          |  |  |                   
      $33.98 - $44.06
      $182K - $236K
     |                   
              5.37K
              $221K
             |  | 
          
        
          |  |  |                   
      $415.82 - $510.91
      $176K - $216K
     |                   
              423
              $216K
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              3.3M
              $3.05M
             |  | 
          
        
          |  |  |                   
      $29.11 - $31.44
      $239K - $259K
     |                   
              64.9K
              $1.96M
             |  | 
          
        
          |  |  |                   
      $69.3 - $105.57
      $147K - $223K
     |                   
              2.12K
              $209K
             |  | 
          
        
          |  |  |                   
      $14.03 - $21.24
      $151K - $228K
     |                   
              10.8K
              $197K
             |  | 
          
        
          |  |  |                   
      $8.26 - $10.1
      $459K - $561K
     |                   
              530K
              $5.02M
             |  | 
          
        
          |  |  |                   
      $12.29 - $15.47
      $198K - $249K
     |                   
              92.4K
              $1.39M
             |  | 
          
        
          |  |  |                   
      $296.51 - $536.21
      $107K - $194K
     |                   
              361
              $194K
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              1.06K
              $193K
             |  | 
          
        
          | 
                  
    
      
     
      Ionis Pharmaceuticals Inc
     |  | 
      N/A
     |                   
              2.5M
              $2.62M
             |  | 
          
        
          |  |  |                   
      $26.68 - $50.09
      $103K - $193K
     |                   
              3.84K
              $192K
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              7.31K
              $190K
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              18.9K
              $5.36M
             |  | 
          
        
          |  |  |                   
      $12.94 - $16.96
      $132K - $174K
     |                   
              35.1K
              $577K
             |  | 
          
        
          |  |  |                   
      $35.75 - $69.14
      $90.7K - $175K
     |                   
              2.54K
              $175K
             |  | 
          
        
          |  |  |                   
      $87.23 - $109.91
      $137K - $173K
     |                   
              1.57K
              $173K
             |  | 
          
        
          |  |  |                   
      $16.31 - $21.47
      $168K - $221K
     |                   
              10.3K
              $171K
             |  | 
          
        
          |  |  |                   
      $30.82 - $37.95
      $274K - $337K
     |                   
              52.6K
              $1.79M
             |  | 
          
        
          |  |  |                   
      $43.53 - $59.11
      $123K - $168K
     |                   
              2.84K
              $165K
             |  | 
          
        
          |  |  |                   
      $61.46 - $68.02
      $194K - $214K
     |                   
              9.42K
              $581K
             |  | 
          
        
          |  |  |                   
      $59.63 - $70.52
      $138K - $163K
     |                   
              59.1K
              $3.87M
             |  | 
          
        
          |  |  |                   
      $53.93 - $61.5
      $55.3K - $63K
     |                   
              74K
              $4.55M
             |  | 
          
        
          |  |  | 
      N/A
     |                   
              9.25K
              $162K
             |  | 
          
        
          |  |  |                   
      $86.65 - $120.54
      $129K - $180K
     |                   
              1.49K
              $159K
             |  | 
          
        
          |  |  |                   
      $183.31 - $241.46
      $120K - $158K
     |                   
              655
              $158K
             |  | 
          
        
          |  |  |                   
      $70.48 - $82.91
      $138K - $162K
     |                   
              1.96K
              $158K
             |  | 
          
        
          |  |  |                   
      $91.46 - $128.1
      $113K - $158K
     |                   
              1.23K
              $156K
             |  | 
          
        
          |  |  |                   
      $43.07 - $54.05
      $138K - $174K
     |                   
              3.22K
              $155K
             |  | 
          
        
          |  |  |                   
      $107.83 - $119.94
      $155K - $172K
     |                   
              1.43K
              $155K
             |  | 
          
        
          |  |  |                   
      $183.37 - $234.7
      $54.8K - $70.2K
     |                   
              5.24K
              $1.17M
             |  |