Simplex Trading, LLC Biotechnology

Simplex Trading, LLC

$156 Billion
Q1 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
SEER Seer, Inc.	$117M	$1,000 0.0% of portfolio	712	Q1 2025 Reduced 71.26%
YMAB Y M Abs Therapeutics, Inc.	$202M	$1,000 0.0% of portfolio	437	Q1 2025 Reduced 75.49%
ACIU Ac Immune Sa	$140M	$0 0.0% of portfolio	284	Q1 2025 New
ACXP Acurx Pharmaceuticals, Inc.	$4.51M	$0 0.0% of portfolio	1,400	Q1 2025 New
ALXO Alx Oncology Holdings Inc	$18.3M	$0 0.0% of portfolio	391	Q1 2025 Reduced 97.32%
ATHA Athira Pharma, Inc.	$10.6M	$0 0.0% of portfolio	324	Q1 2025 Reduced 85.16%
ATXS Astria Therapeutics, Inc.	$62.1M	$0 0.0% of portfolio	69	Q1 2025 Reduced 90.55%
AURA Aura Biosciences, Inc.	$176M	$0 0.0% of portfolio	54	Q1 2025 New
COGT Cogent Biosciences, Inc.	$321M	$0 0.0% of portfolio	12	Q1 2025 Reduced 99.97%
EQ Equillium, Inc.	$13.7M	$0 0.0% of portfolio	1,495	Q1 2025 Reduced 28.47%
ERAS Erasca, Inc.	$134M	$0 0.0% of portfolio	258	Q1 2025 Reduced 94.21%
GALT Galectin Therapeutics Inc	$74.3M	$0 0.0% of portfolio	779	Q1 2025 Reduced 95.67%
GHRS Gh Research PLC	$654M	$0 0.0% of portfolio	17	Q1 2025 New
IMMP Immutep LTD	$172M	$0 0.0% of portfolio	51	Q1 2025 Reduced 99.5%
INVA Innoviva, Inc.	$1.33B	$0 0.0% of portfolio	30	Q1 2025 New
IPA Immuno Precise Antibodies Ltd.	$14.2M	$0 0.0% of portfolio	755	Q1 2025 Added 328.98%
LRMR Larimar Therapeutics, Inc.	$79.2M	$0 0.0% of portfolio	264	Q1 2025 New
LYEL Lyell Immunopharma, Inc.	$102M	$0 0.0% of portfolio	990	Q1 2025 Added 60.45%
LYRA Lyra Therapeutics, Inc.	$153M	$0 0.0% of portfolio	1,317	Q1 2025 Added 262.81%
MNOV Medicinova Inc	$68.2M	$0 0.0% of portfolio	16	Q1 2025 Reduced 95.47%
ORIC Oric Pharmaceuticals, Inc.	$295M	$0 0.0% of portfolio	146	Q1 2025 New
RAPT Rapt Therapeutics, Inc.	$28.8M	$0 0.0% of portfolio	255	Q1 2025 New
ENOB Enochian Biosciences Inc	$244M	$0 0.0% of portfolio	730	Q1 2025 Reduced 88.04%
RZLT Rezolute, Inc.	$149M	$0 0.0% of portfolio	32	Q1 2025 Reduced 98.05%
SLGL Sol Gel Technologies Ltd.	$169M	$0 0.0% of portfolio	256	Q1 2025 Added 848.15%
SLN Silence Therapeutics PLC	$186M	$0 0.0% of portfolio	251	Q1 2025 Added 392.16%
TBPH Theravance Biopharma, Inc.	$611M	$0 0.0% of portfolio	106	Q1 2025 New
VIRX Viracta Therapeutics, Inc.	$751K	$0 0.0% of portfolio	400	Q1 2025 New
VRCA Verrica Pharmaceuticals Inc.	$327M	$0 0.0% of portfolio	1,563	Q1 2025 Reduced 78.64%
XNCR Xencor Inc	$451M	$0 0.0% of portfolio	5	Q1 2025 New

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