Two Sigma Investments, LP Puma Biotechnology, Inc. Transaction History

Two Sigma Investments, LP

$59 Billion
Q3 2025

A detailed history of Two Sigma Investments, LP transactions in Puma Biotechnology, Inc. stock. As of the latest transaction made, Two Sigma Investments, LP holds 56,126 shares of PBYI stock, worth $277,823. This represents 0.0% of its overall portfolio holdings.

Number of Shares

56,126

Previous 190,621 70.56%

Holding current value

$277,823

Previous $653,000 56.05%

% of portfolio

0.0%

Previous 0.0%

24 transactions

Quarter	Operation	Price Per share	shares change	shares Held
Q3 2025 Nov 14, 2025	SELL	$3.07 - $5.73 $412,899 - $770,656	-134,495 Reduced 70.56%	56,126 $287,000
Q2 2025 Aug 14, 2025	SELL	$2.74 - $3.72 $5,970 - $8,105	-2,179 Reduced 1.13%	190,621 $653,000
Q1 2025 May 15, 2025	BUY	$2.76 - $3.88 $31,268 - $43,956	11,329 Added 6.24%	192,800 $570,000
Q4 2024 Feb 14, 2025	BUY	$2.42 - $3.39 $319,236 - $447,195	131,916 Added 266.2%	181,471 $553,000
Q3 2024 Nov 14, 2024	BUY	$2.25 - $4.03 $34,328 - $61,485	15,257 Added 44.48%	49,555 $126,000

Q2 2024 Aug 14, 2024	SELL	$2.92 - $5.83 $138,396 - $276,318	-47,396 Reduced 58.02%	34,298 $111,000
Q1 2024 May 15, 2024	SELL	$4.29 - $7.4 $572,620 - $987,737	-133,478 Reduced 62.03%	81,694 $432,000
Q4 2023 Feb 14, 2024	BUY	$2.23 - $4.49 $239,577 - $482,378	107,434 Added 99.72%	215,172 $931,000
Q3 2023 Nov 14, 2023	BUY	$2.63 - $4.09 $4,378 - $6,809	1,665 Added 1.57%	107,738 $283,000
Q2 2023 Aug 14, 2023	SELL	$2.6 - $3.58 $265,397 - $365,432	-102,076 Reduced 49.04%	106,073 $374,000
Q1 2023 May 15, 2023	SELL	$2.21 - $4.82 $167,520 - $365,360	-75,801 Reduced 26.7%	208,149 $643,000
Q4 2022 Feb 14, 2023	BUY	$2.12 - $5.08 $424,727 - $1.02 Million	200,343 Added 239.62%	283,950 $1.2 Million
Q3 2022 Nov 14, 2022	SELL	$2.27 - $3.84 $160,255 - $271,092	-70,597 Reduced 45.78%	83,607 $198,000
Q2 2022 Aug 15, 2022	SELL	$1.64 - $3.3 $20,085 - $40,415	-12,247 Reduced 7.36%	154,204 $439,000
Q1 2022 May 16, 2022	BUY	$2.13 - $3.24 $354,540 - $539,301	166,451 New	166,451 $479,000
Q4 2021 Feb 14, 2022	SELL	$2.85 - $6.58 $45,372 - $104,753	-15,920 Closed	0 $0
Q3 2021 Nov 15, 2021	SELL	$6.63 - $9.39 $262,799 - $372,200	-39,638 Reduced 71.35%	15,920 $112,000
Q2 2021 Aug 16, 2021	BUY	$8.98 - $11.6 $498,910 - $644,472	55,558 New	55,558 $510,000
Q3 2019 Nov 14, 2019	SELL	$8.75 - $12.85 $2.04 Million - $2.99 Million	-232,772 Closed	0 $0
Q2 2019 Aug 14, 2019	BUY	$12.3 - $35.76 $1.29 Million - $3.76 Million	105,115 Added 82.34%	232,772 $2.96 Million
Q1 2019 May 15, 2019	BUY	$20.77 - $42.37 $67,398 - $137,490	3,245 Added 2.61%	127,657 $4.95 Million
Q4 2018 Feb 14, 2019	BUY	$20.07 - $46.7 $2.5 Million - $5.81 Million	124,412 New	124,412 $2.53 Million
Q4 2017 Feb 14, 2018	SELL	$93.85 - $132.45 $167,616 - $236,555	-1,786 Closed	0 $0
Q3 2017 Nov 14, 2017	BUY	$72.0 - $119.75 $128,592 - $213,873	1,786	1,786 $214,000

Others Institutions Holding PBYI

# of Institutions

135

Shares Held

35.2M

Call Options Held

264K

Put Options Held

View Full List

About PUMA BIOTECHNOLOGY, INC.

Ticker PBYI
Exchange NASDAQ
Sector Healthcare
Industry Biotechnology
Shares Outstandng 45,556,000
Market Cap $226M
Description
Puma Biotechnology, Inc., a biopharmaceutical company, focuses on the development and commercialization of products to enhance cancer care in the United States and internationally. The company's drug candidates include PB272 neratinib (oral) for the patients with early stage HER2-overexpressed/amplified breast cancer; PB272 (neratinib, oral) for...

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Two Sigma Investments, LP Puma Biotechnology, Inc. Transaction History