Two Sigma Securities, LLC Biotechnology

Two Sigma Securities, LLC

$769 Million
Q2 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
HRTX Heron Therapeutics, Inc.	$154M	$29,000 0.0% of portfolio	14,376	Q2 2025 New
RNXT Renovo Rx, Inc.	$10.2M	$28,000 0.0% of portfolio	21,835	Q2 2025 New
SILO Silo Pharma, Inc.	$1.91M	$27,000 0.0% of portfolio	43,219	Q2 2025 New
TLSA Tiziana Life Sciences LTD	$186M	$27,000 0.0% of portfolio	17,458	Q2 2025 Reduced 14.39%
ALLO Allogene Therapeutics, Inc.	$164M	$26,000 0.0% of portfolio	23,039	Q2 2025 New
CABA Cabaletta Bio, Inc.	$48.2M	$25,000 0.0% of portfolio	16,491	Q2 2025 New
EDIT Editas Medicine, Inc.	$192M	$25,000 0.0% of portfolio	11,402	Q2 2025 New
ARMP Armata Pharmaceuticals, Inc.	$103M	$24,000 0.0% of portfolio	13,104	Q2 2025 New
HOWL Werewolf Therapeutics, Inc.	$38.7M	$24,000 0.0% of portfolio	22,409	Q2 2025 New
ABOS Acumen Pharmaceuticals, Inc.	$57.1M	$23,000 0.0% of portfolio	20,066	Q2 2025 Added 68.92%
AUTL Autolus Therapeutics PLC	$130M	$22,000 0.0% of portfolio	10,001	Q2 2025 New
ACIU Ac Immune Sa	$184M	$20,000 0.0% of portfolio	10,085	Q2 2025 New
ATOS Atossa Therapeutics, Inc.	$100M	$18,000 0.0% of portfolio	22,220	Q2 2025 New
LVTX Lava Therapeutics Nv	$40.2M	$18,000 0.0% of portfolio	14,236	Q2 2025 New
AADI Aadi Bioscience, Inc.	$35.9M	$18,000 0.0% of portfolio	11,103	Q2 2025 New
LCTX Lineage Cell Therapeutics, Inc.	$210M	$16,000 0.0% of portfolio	18,028	Q2 2025 New
CCCC C4 Therapeutics, Inc.	$133M	$15,000 0.0% of portfolio	10,589	Q2 2025 New
CRTX Cortexyme, Inc.	$70.5M	$15,000 0.0% of portfolio	12,004	Q2 2025 New
CLGN Coll Plant Biotechnologies LTD	$29.2M	$14,000 0.0% of portfolio	10,349	Q2 2025 New
IOBT Io Biotech, Inc.	$50.7M	$14,000 0.0% of portfolio	10,385	Q2 2025 New
PGEN Precigen, Inc.	$866M	$14,000 0.0% of portfolio	10,313	Q2 2025 New
IGMS Igm Biosciences, Inc.	$36.8M	$13,000 0.0% of portfolio	11,950	Q2 2025 Reduced 11.39%
PLRX Pliant Therapeutics, Inc.	$84.2M	$13,000 0.0% of portfolio	12,042	Q2 2025 New
GBIO Generation Bio Co.	$344M	$10,000 0.0% of portfolio	32,669	Q2 2025 New
VERU Veru Inc.	$270M	$9,000 0.0% of portfolio	16,228	Q2 2025 Added 11.2%
IPSC Century Therapeutics, Inc.	$30M	$6,000 0.0% of portfolio	11,767	Q2 2025 New
MRSN Mersana Therapeutics, Inc.	$684M	$5,000 0.0% of portfolio	17,566	Q2 2025 New
RLYB Rallybio Corp	$19M	$5,000 0.0% of portfolio	15,153	Q2 2025 New
ELEV Elevation Oncology, Inc.	$8.39M	$4,000 0.0% of portfolio	12,717	Q2 2025 Reduced 32.61%
PASG Passage Bio, Inc.	$378M	$4,000 0.0% of portfolio	11,724	Q2 2025 New
ATHA Athira Pharma, Inc.	$14.7M	$3,000 0.0% of portfolio	11,680	Q2 2025 New
CELUW Celularity Inc Wt Exp 05/24/20	$0	$0 0.0% of portfolio	17,768	Q2 2025 Added 1.32%
DRMAW Dermata Therapeutics Inc Wt Ex	$0	$0 0.0% of portfolio	13,115	Q2 2025 Reduced 0.76%

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