The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALECTOR INC COM 014442107   68,539 14,708 SH   SOLE   14,708 0 0
ALTIMMUNE INC COM NEW 02155H200   144,290 23,500 SH Put SOLE   23,500 0 0
ALTIMMUNE INC COM NEW 02155H200   160,868 26,200 SH Call SOLE   26,200 0 0
AMGEN INC COM 031162100   644,420 2,000 SH Put SOLE   2,000 0 0
AMGEN INC COM 031162100   644,420 2,000 SH Call SOLE   2,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   377,804 13,100 SH Call SOLE   13,100 0 0
APOGEE THERAPEUTICS INC COM 03770N101   307,798 5,240 SH   SOLE   5,240 0 0
APPLIED THERAPEUTICS INC COM 03828A101   172,550 20,300 SH Call SOLE   20,300 0 0
ARGENX SE SPONSORED ADR 04016X101   516,602 953 SH   SOLE   953 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   684,586 4,585 SH   SOLE   4,585 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   4,986,240 64,000 SH Call SOLE   64,000 0 0
AVADEL PHARMACEUTICALS PLC COM SHS G29687103   343,613 26,200 SH Call SOLE   26,200 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   99,560 13,100 SH Call SOLE   13,100 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   242,165 2,618 SH   SOLE   2,618 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108   920,196 17,785 SH   SOLE   17,785 0 0
C4 THERAPEUTICS INC COM STK 12529R107   59,850 10,500 SH Call SOLE   10,500 0 0
CASSAVA SCIENCES INC COM 14817C107   414,963 14,100 SH Put SOLE   14,100 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   220,935 6,500 SH Put SOLE   6,500 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   341,552 6,684 SH   SOLE   6,684 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   615,438 13,100 SH Call SOLE   13,100 0 0
ELI LILLY & CO COM 532457108   560,800 633 SH   SOLE   633 0 0
ELIEM THERAPEUTICS INC COM 28658R106   61,309 12,045 SH   SOLE   12,045 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106   206,568 19,939 SH   SOLE   19,939 0 0
ERASCA INC COM 29479A108   128,100 46,923 SH   SOLE   46,923 0 0
GOSSAMER BIO INC COM 38341P102   20,418 20,700 SH Call SOLE   20,700 0 0
INDIVIOR PLC ORD G4766E116   564,186 57,293 SH   SOLE   57,293 0 0
INSMED INC COM PAR $.01 457669307   481,800 6,600 SH Call SOLE   6,600 0 0
INSMED INC COM PAR $.01 457669307   574,145 7,865 SH   SOLE   7,865 0 0
INTELLIA THERAPEUTICS INC COM 45826J105   267,561 13,020 SH   SOLE   13,020 0 0
INVESCO QQQ TR UNIT SER 1 46090E103   43,022,882 88,149 SH   SOLE   88,149 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   123,009 13,100 SH Call SOLE   13,100 0 0
ISHARES INC MSCI JPN ETF NEW 46434G822   7,771,676 108,634 SH   SOLE   108,634 0 0
ISHARES TR EAFE VALUE ETF 464288877   22,965,171 399,186 SH   SOLE   399,186 0 0
ISHARES TR MSCI UK ETF NEW 46435G334   7,831,559 209,344 SH   SOLE   209,344 0 0
ISHARES TR MSCI INTL QUALTY 46434V456   42,580,772 1,026,290 SH   SOLE   1,026,290 0 0
ISHARES TR MSCI USA QLT FCT 46432F339   60,508,730 337,472 SH   SOLE   337,472 0 0
JANUX THERAPEUTICS INC COM 47103J105   104,489 2,300 SH Put SOLE   2,300 0 0
JANUX THERAPEUTICS INC COM 47103J105   356,944 7,857 SH   SOLE   7,857 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   999,236 8,969 SH   SOLE   8,969 0 0
KEROS THERAPEUTICS INC COM 492327101   466,012 8,025 SH   SOLE   8,025 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   16,342 21,136 SH   SOLE   21,136 0 0
LEAP THERAPEUTICS INC COM NEW 52187K200   47,573 18,511 SH   SOLE   18,511 0 0
MODERNA INC COM 60770K107   274,003 4,100 SH Call SOLE   4,100 0 0
NEKTAR THERAPEUTICS COM 640268108   33,939 26,107 SH   SOLE   26,107 0 0
NOVO-NORDISK A S ADR 670100205   464,373 3,900 SH Call SOLE   3,900 0 0
NUVALENT INC COM 670703107   420,965 4,115 SH   SOLE   4,115 0 0
RELAY THERAPEUTICS INC COM 75943R102   185,496 26,200 SH   SOLE   26,200 0 0
SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y308   13,717,161 165,267 SH   SOLE   165,267 0 0
SELECT SECTOR SPDR TR SBI INT-UTILS 81369Y886   4,195,713 51,940 SH   SOLE   51,940 0 0
SOLENO THERAPEUTICS INC COM 834203309   490,056 9,706 SH   SOLE   9,706 0 0
SOLENO THERAPEUTICS INC COM 834203309   631,125 12,500 SH Call SOLE   12,500 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   109,624 15,728 SH   SOLE   15,728 0 0
TYRA BIOSCIENCES INC COM 90240B106   310,050 13,188 SH   SOLE   13,188 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   383,295 6,900 SH Call SOLE   6,900 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   235,588 4,241 SH   SOLE   4,241 0 0
VANGUARD INDEX FDS VALUE ETF 922908744   16,868,699 96,630 SH   SOLE   96,630 0 0
VAXCYTE INC COM 92243G108   282,018 2,468 SH   SOLE   2,468 0 0
VIR BIOTECHNOLOGY INC COM 92764N102   252,039 33,650 SH   SOLE   33,650 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   298,025 13,100 SH Call SOLE   13,100 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400   103,472 34,376 SH   SOLE   34,376 0 0
ZEVRA THERAPEUTICS INC COM NEW 488445206   149,876 21,596 SH   SOLE   21,596 0 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101   71,030 17,495 SH   SOLE   17,495 0 0