The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   5,090,621 242,526 SH   DFND 1,2 242,526 0 0
89BIO INC COM 282559103   4,217,641 526,547 SH   DFND 1,2 526,547 0 0
ABBVIE INC COM 00287Y109   6,517,760 38,000 SH   DFND 1,2 38,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   5,322,509 327,539 SH   DFND 1,2 327,539 0 0
ADC THERAPEUTICS SA SHS H0036K147   2,166,329 685,547 SH   DFND 1,2 685,547 0 0
AKERO THERAPEUTICS INC COM 00973Y108   3,322,405 141,620 SH   DFND 1,2 141,620 0 0
ALECTOR INC COM 014442107   2,769,400 610,000 SH   DFND 1,2 610,000 0 0
ALUMIS INC COM 022307102   1,662,500 125,000 SH   DFND 1,2 125,000 0 0
AMAZON COM INC COM 023135106   19,601,734 101,432 SH   DFND   101,432 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   68,495 36,050 SH   DFND 1,2 36,050 0 0
ANALOG DEVICES INC COM 032654105   2,967,380 13,000 SH   DFND   13,000 0 0
APPLE INC COM 037833100   12,953,130 61,500 SH   DFND   61,500 0 0
APPLIED MATLS INC COM 038222105   5,806,298 24,604 SH   DFND   24,604 0 0
APPLIED THERAPEUTICS INC COM 03828A101   3,148,832 674,268 SH   DFND 1,2 674,268 0 0
APREA THERAPEUTICS INC COM NEW 03836J201   1,098,900 270,000 SH   DFND 1,2 270,000 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100   82,445 43,165 SH   DFND   43,165 0 0
ARGENX SE SPONSORED ADR 04016X101   669,142 1,556 SH   DFND 1,2 1,556 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   1,252,068 48,175 SH   DFND 1,2 48,175 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210   10,126,050 9,901 SH   DFND   9,901 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   14,822,779 190,060 SH   DFND 1,2 190,060 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   1,481,862 162,842 SH   DFND 1,2 162,842 0 0
BIOGEN INC COM 09062X103   10,991,050 47,412 SH   DFND 1,2 47,412 0 0
BRIDGEBIO PHARMA INC COM 10806X102   23,052,073 910,070 SH   DFND 1,2 910,070 0 0
BRIDGEBIO PHARMA INC COM 10806X102   5,182,518 204,600 SH Call DFND 1,2 0 0 0
BROADCOM INC COM 11135F101   3,108,306 19,360 SH   DFND   19,360 0 0
CAMTEK LTD ORD M20791105   242,966 1,940 SH   DFND   1,940 0 0
CARGO THERAPEUTICS INC COM 14179K101   2,553,409 155,506 SH   DFND 1,2 155,506 0 0
CARTESIAN THERAPEUTICS INC COM NEW 816212302   677,141 25,070 SH   DFND 1,2 25,070 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101   4,461,120 288,000 SH   DFND 1,2 288,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   11,445,898 309,265 SH   DFND 1,2 309,265 0 0
COMPUGEN LTD ORD M25722105   1,241,922 739,239 SH   DFND 1,2 739,239 0 0
CYBIN INC COM 23256X100   6,932,558 25,581,395 SH   DFND 1,2 25,581,395 0 0
CYTOKINETICS INC COM NEW 23282W605   20,855,182 384,924 SH   DFND 1,2 384,924 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   4,790,300 347,627 SH   DFND 1,2 347,627 0 0
DISC MEDICINE INC COM 254604101   2,616,043 58,044 SH   DFND 1,2 58,044 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101   3,424,135 1,297,021 SH   DFND 1,2 1,297,021 0 0
ELEVATION ONCOLOGY INC COM 28623U101   891,000 330,000 SH   DFND 1,2 330,000 0 0
ELI LILLY & CO COM 532457108   11,941,962 13,190 SH   DFND 1,2 13,190 0 0
ELIEM THERAPEUTICS INC COM 28658R106   1,529,923 215,179 SH   DFND 1,2 215,179 0 0
ENLIGHT RENEWABLE ENERGY LTD SHS M4056D110   2,735,565 169,280 SH   DFND   169,280 0 0
ENPHASE ENERGY INC COM 29355A107   5,662,730 56,792 SH   DFND   56,792 0 0
FULCRUM THERAPEUTICS INC COM 359616109   365,800 59,000 SH Put DFND 1,2 59,000 0 0
GLOBAL E ONLINE LTD SHS M5216V106   2,425,883 66,884 SH   DFND   66,884 0 0
GOSSAMER BIO INC COM 38341P102   200,121 222,134 SH   DFND 1,2 222,134 0 0
GSK PLC SPONSORED ADR 37733W204   3,850,000 100,000 SH   DFND 1,2 100,000 0 0
ICL GROUP LTD SHS M53213100   458,979 107,238 SH   DFND   107,238 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117   277,000 100,000 SH   DFND 1,2 100,000 0 0
IMMATICS N.V SHS N44445109   8,495,510 731,111 SH   DFND 1,2 731,111 0 0
INOZYME PHARMA INC COM 45790W108   6,523,749 1,462,724 SH   DFND 1,2 1,462,724 0 0
INSMED INC COM PAR $.01 457669307   1,111,463 16,589 SH   DFND 1,2 16,589 0 0
INTELLIA THERAPEUTICS INC COM 45826J105   3,120,197 139,419 SH   DFND 1,2 139,419 0 0
INVESCO QQQ TR UNIT SER 1 46090E103   10,971,619 22,900 SH Call DFND   0 0 0
IONIS PHARMACEUTICALS INC COM 462222100   6,683,743 140,238 SH   DFND 1,2 140,238 0 0
JASPER THERAPEUTICS INC COM NEW 471871202   10,310,953 454,227 SH   DFND 1,2 454,227 0 0
JFROG LTD ORD SHS M6191J100   4,426,432 117,881 SH   DFND   117,881 0 0
JOHNSON & JOHNSON COM 478160104   10,206,499 69,831 SH   DFND 1,2 69,831 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   1,231,006 2,051,676 SH   DFND 1,2 2,051,676 0 0
KLA CORP COM NEW 482480100   2,720,883 3,300 SH   DFND   3,300 0 0
KURA ONCOLOGY INC COM 50127T109   12,576,907 610,826 SH   DFND 1,2 610,826 0 0
KYVERNA THERAPEUTICS INC COM 501976104   1,770,218 236,029 SH   DFND 1,2 236,029 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109   2,245,800 10,000 SH   DFND   10,000 0 0
LAM RESEARCH CORP COM 512807108   3,939,945 3,700 SH   DFND   3,700 0 0
LARIMAR THERAPEUTICS INC COM 517125100   2,265,400 312,469 SH   DFND 1,2 312,469 0 0
LAVA THERAPEUTICS NV SHS N51517105   661,648 367,582 SH   DFND 1,2 367,582 0 0
MARVELL TECHNOLOGY INC COM 573874104   1,398,000 20,000 SH   DFND   20,000 0 0
MERCK & CO INC COM 58933Y105   7,378,480 59,600 SH   DFND 1,2 59,600 0 0
MERUS N V COM N5749R100   8,735,445 147,633 SH   DFND 1,2 147,633 0 0
META PLATFORMS INC CL A 30303M102   16,860,613 33,439 SH   DFND   33,439 0 0
MICRON TECHNOLOGY INC COM 595112103   4,866,610 37,000 SH   DFND   37,000 0 0
MICROSOFT CORP COM 594918104   14,716,723 32,927 SH   DFND   32,927 0 0
MINERALYS THERAPEUTICS INC COM 603170101   5,180,198 442,752 SH   DFND 1,2 442,752 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   1,402,500 375,000 SH   DFND 1,2 375,000 0 0
NICE LTD SPONSORED ADR 653656108   14,008,848 81,461 SH   DFND   81,461 0 0
NICE LTD SPONSORED ADR 653656108   5,520,237 32,100 SH Call DFND   0 0 0
NOVARTIS AG SPONSORED ADR 66987V109   5,323,000 50,000 SH   DFND 1,2 50,000 0 0
NOVO-NORDISK A S ADR 670100205   11,145,139 78,080 SH   DFND 1,2 78,080 0 0
NUTRIEN LTD COM 67077M108   2,073,564 40,730 SH   DFND   40,730 0 0
NVIDIA CORPORATION COM 67066G104   2,470,800 20,000 SH   DFND   20,000 0 0
OUTLOOK THERAPEUTICS INC COM 69012T305   4,217,139 571,428 SH   DFND 1,2 571,428 0 0
PALO ALTO NETWORKS INC COM 697435105   6,102,180 18,000 SH   DFND   18,000 0 0
PERION NETWORK LTD SHS NEW M78673114   1,958,985 234,609 SH   DFND   234,609 0 0
PERSPECTIVE THERAPEUTICS INC COM NEW 46489V302   7,845,483 786,909 SH   DFND 1,2 786,909 0 0
PFIZER INC COM 717081103   2,518,200 90,000 SH   DFND 1,2 90,000 0 0
PHARVARIS N V COM N69605108   7,581,382 403,265 SH   DFND 1,2 403,265 0 0
PLIANT THERAPEUTICS INC COM 729139105   2,779,456 258,554 SH   DFND 1,2 258,554 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   11,722,417 283,424 SH   DFND 1,2 283,424 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   3,102,000 75,000 SH Call DFND 1,2 0 0 0
PRIME MEDICINE INC COM 74168J101   654,959 127,424 SH   DFND 1,2 127,424 0 0
PROMIS NEUROSCIENCES INC COM NEW 74346M406   2,721,320 1,814,213 SH   DFND 1,2 1,814,213 0 0
PTC THERAPEUTICS INC COM 69366J200   2,884,244 94,318 SH   DFND 1,2 94,318 0 0
QUALCOMM INC COM 747525103   3,749,564 18,825 SH   DFND   18,825 0 0
REZOLUTE INC COM NEW 76200L309   7,344,396 1,707,999 SH   DFND 1,2 1,707,999 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   4,455,267 206,933 SH   DFND 1,2 206,933 0 0
SALESFORCE INC COM 79466L302   8,638,560 33,600 SH   DFND   33,600 0 0
SANOFI SPONSORED ADR 80105N105   21,810,468 449,515 SH   DFND 1,2 449,515 0 0
SAREPTA THERAPEUTICS INC COM 803607100   13,218,122 83,659 SH   DFND 1,2 83,659 0 0
SAREPTA THERAPEUTICS INC COM 803607100   2,370,000 15,000 SH Call DFND 1,2 0 0 0
SAVARA INC COM 805111101   3,879,629 962,687 SH   DFND 1,2 962,687 0 0
SENTINELONE INC CL A 81730H109   5,974,074 283,804 SH   DFND   283,804 0 0
SHL TELEMEDICINE LTD SPONSORED ADS 78423T200   3,223,438 632,456 SH   DFND   632,456 0 0
SKYE BIOSCIENCE INC COM NEW 83086J200   10,399,479 1,298,312 SH   DFND 1,2 1,298,312 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   2,647,033 70,269 SH   DFND 1,2 70,269 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   16,876,625 822,047 SH   DFND 1,2 822,047 0 0
TABOOLA.COM LTD ORD SHS M8744T106   2,295,801 667,384 SH   DFND   667,384 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   982,027 5,650 SH   DFND   5,650 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   6,093,750 375,000 SH   DFND 1,2 375,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   6,734,260 414,416 SH   DFND   414,416 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   53,119,625 3,268,900 SH Call DFND   0 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274   5,880,776 149,600 SH   DFND   149,600 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   12,076,495 293,832 SH   DFND 1,2 293,832 0 0
UPWORK INC COM 91688F104   1,257,750 117,000 SH   DFND   117,000 0 0
VANECK ETF TRUST SEMICONDUCTR ETF 92189F676   39,052,862 149,800 SH Put DFND   149,800 0 0
VARONIS SYS INC COM 922280102   767,520 16,000 SH   DFND   16,000 0 0
VENTYX BIOSCIENCES INC COM 92332V107   2,339,450 1,012,749 SH   DFND 1,2 1,012,749 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   6,768,664 1,692,166 SH   DFND 1,2 1,692,166 0 0
VIR BIOTECHNOLOGY INC COM 92764N102   1,442,254 162,051 SH   DFND 1,2 162,051 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400   2,813,754 808,550 SH   DFND 1,2 808,550 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107   1,529,416 626,810 SH   DFND 1,2 626,810 0 0
WIX COM LTD SHS M98068105   4,004,905 25,177 SH   DFND   25,177 0 0