The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U INC Common Stock 90214J101 16,076 286,867 SH   OTR   167,299 6,189 113,379
3D SYSTEMS CORP Common Stock 88554D205 1,446 107,960 SH   SOLE   107,960 0 0
5N PLUS INC Common Stock 33833X101 55 21,253 SH   SOLE   21,253 0 0
ADOBE SYSTEMS INC Common Stock 00724F101 1,047 7,020 SH   SOLE   7,020 0 0
AEROVIRONMENT INC Common Stock 008073108 7,530 139,142 SH   OTR   40,050 0 99,092
AGIOS PHARMACEUTICALS INC Common Stock 00847X104 894 13,399 SH   SOLE   13,399 0 0
AKAMAI TECHNOLOGIES INC Common Stock 00971T101 7,528 154,510 SH   OTR   70,450 5,443 78,617
ALBEMARLE CORP Common Stock 012653101 811 5,953 SH   SOLE   5,953 0 0
ALIBABA GROUP HOLDING-SP ADR ADR 01609W102 10,633 61,568 SH   OTR   24,758 1,738 35,072
ALIGN TECHNOLOGY INC Common Stock 016255101 2,644 14,197 SH   SOLE   14,197 0 0
ALLEGHENY TECHNOLOGIES INC Common Stock 01741R102 69 2,888 SH   SOLE   2,888 0 0
ALLIED MOTION TECHNOLOGIES Common Stock 019330109 742 29,275 SH   SOLE   29,275 0 0
ALNYLAM PHARMACEUTICALS INC Common Stock 02043Q107 1,066 9,074 SH   SOLE   9,074 0 0
ALPHABET INC-CL C Common Stock 02079K107 17,673 18,426 SH   OTR   9,709 596 8,121
AMAZON.COM INC Common Stock 023135106 35,016 36,424 SH   OTR   19,204 1,304 15,916
AMETEK INC Common Stock 031100100 511 7,741 SH   SOLE   7,741 0 0
ANSYS INC Common Stock 03662Q105 1,987 16,193 SH   SOLE   16,193 0 0
APPLE INC Common Stock 037833100 8,748 56,764 SH   OTR   33,246 1,923 21,595
ARCONIC INC Common Stock 03965L100 616 24,767 SH   SOLE   24,767 0 0
ARKEMA SA Common Stock F0392W125 54 443 SH   SOLE   443 0 0
ARRK CORP Common Stock J0198N101 579 603,748 SH   SOLE   603,748 0 0
ATHENAHEALTH INC Common Stock 04685W103 30,351 244,056 SH   OTR   104,652 9,558 129,846
AUTODESK INC Common Stock 052769106 3,221 28,688 SH   SOLE   28,688 0 0
BAIDU INC - SPON ADR ADR 056752108 23,695 95,664 SH   OTR   32,816 1,795 61,053
BAYER AG REG Common Stock D0712D163 53 390 SH   OTR   0 390 0
BAYER AG-SPONSORED ADR ADR 072730302 366 10,684 SH   SOLE   10,684 0 0
BERTRANDT AG Common Stock D1014N107 593 5,899 SH   SOLE   5,899 0 0
BIOGEN INC Common Stock 09062X103 1,336 4,268 SH   SOLE   4,268 0 0
BITCOIN INVESTMENT TRUST Open-End Fund 09173T108 27,801 39,603 SH   OTR   23,552 2,594 13,457
BLACKBERRY LTD Common Stock 09228F103 5,840 522,359 SH   OTR   166,564 25,763 330,032
BLUEBIRD BIO INC Common Stock 09609G100 18,478 134,531 SH   OTR   49,510 6,321 78,700
BOX INC - CLASS A Common Stock 10316T104 994 51,438 SH   SOLE   51,438 0 0
BYD CO LTD-UNSPONSORED ADR ADR 05606L100 1,128 59,583 SH   SOLE   59,583 0 0
CARPENTER TECHNOLOGY Common Stock 144285103 65 1,343 SH   SOLE   1,343 0 0
CELGENE CORP Common Stock 151020104 361 2,479 SH   SOLE   2,479 0 0
CELLECTIS - ADR ADR 15117K103 465 16,334 SH   SOLE   16,334 0 0
CERUS CORP Common Stock 157085101 7,325 2,683,202 SH   OTR   1,097,799 132,818 1,452,585
COMPUGEN LTD Common Stock M25722105 4,370 1,150,032 SH   OTR   915,313 91,590 143,129
CONFORMIS INC Common Stock 20717E101 955 271,209 SH   SOLE   271,209 0 0
CORNERSTONE ONDEMAND INC Common Stock 21925Y103 1,289 31,733 SH   SOLE   31,733 0 0
CRISPR THERAPEUTICS AG Common Stock H17182108 457 25,555 SH   SOLE   25,555 0 0
CTRIP.COM INTERNATIONAL-ADR ADR 22943F100 8,365 158,601 SH   OTR   67,024 5,906 85,671
DASSAULT SYSTEMES SE Common Stock F2457H472 1,400 13,859 SH   SOLE   13,859 0 0
DEERE & CO Common Stock 244199105 1,338 10,653 SH   SOLE   10,653 0 0
DELPHI AUTOMOTIVE PLC Common Stock G27823106 1,520 15,452 SH   SOLE   15,452 0 0
DOWDUPONT INC Common Stock 26078J100 146 2,105 SH   SOLE   2,105 0 0
EASTMAN CHEMICAL CO Common Stock 277432100 54 600 SH   SOLE   600 0 0
EASTMAN KODAK CO Common Stock 277461406 40 5,496 SH   SOLE   5,496 0 0
EDITAS MEDICINE INC Common Stock 28106W103 16,516 687,870 SH   OTR   227,024 25,109 435,737
ELBIT SYSTEMS LTD Common Stock M3760D101 1,098 7,462 SH   SOLE   7,462 0 0
EVOGENE LTD Common Stock M4119S104 91 20,542 SH   SOLE   20,542 0 0
EXA CORP Common Stock 300614500 2,249 92,997 SH   SOLE   92,997 0 0
EXONE CO/THE Common Stock 302104104 10,722 943,830 SH   OTR   534,908 28,103 380,819
FACEBOOK INC-A Common Stock 30303M102 14,828 86,781 SH   OTR   35,917 3,079 47,785
FANUC CORP Common Stock J13440102 45 220 SH   OTR   0 220 0
FANUC CORP-UNSP ADR ADR 307305102 4,409 217,425 SH   OTR   162,394 5,075 49,956
FARO TECHNOLOGIES INC Common Stock 311642102 460 12,035 SH   SOLE   12,035 0 0
FENNER PLC Common Stock G33656102 50 11,128 SH   SOLE   11,128 0 0
FIVE PRIME THERAPEUTICS INC Common Stock 33830X104 900 22,004 SH   SOLE   22,004 0 0
FLEX LTD Common Stock Y2573F102 911 54,954 SH   SOLE   54,954 0 0
FOUNDATION MEDICINE INC Common Stock 350465100 12,537 311,868 SH   OTR   97,596 9,757 204,515
GEELY AUTOMOBILE-UNSPON ADR ADR 36847Q103 587 10,268 SH   SOLE   10,268 0 0
GENERAL ELECTRIC CO Common Stock 369604103 437 18,081 SH   SOLE   18,081 0 0
GENERAL MOTORS CO Common Stock 37045V100 828 20,517 SH   SOLE   20,517 0 0
GILEAD SCIENCES INC Common Stock 375558103 511 6,305 SH   SOLE   6,305 0 0
GROUPE GORGE Common Stock F4606F100 1,167 46,857 SH   SOLE   46,857 0 0
HEXAGON AB Common Stock W40063104 480 9,714 SH   SOLE   9,714 0 0
HEXCEL CORP Common Stock 428291108 54 942 SH   SOLE   942 0 0
HORTONWORKS INC Common Stock 440894103 15,130 892,638 SH   OTR   321,973 24,047 546,618
HP INC Common Stock 40434L105 1,998 100,077 SH   SOLE   100,077 0 0
HUBSPOT INC Common Stock 443573100 2,357 28,037 SH   SOLE   28,037 0 0
ILLUMINA INC Common Stock 452327109 25,159 126,299 SH   OTR   46,467 5,661 74,171
IMPINJ INC Common Stock 453204109 1,413 33,965 SH   SOLE   33,965 0 0
INCYTE CORP Common Stock 45337C102 838 7,179 SH   SOLE   7,179 0 0
INOVIO PHARMACEUTICALS INC Common Stock 45773H201 909 143,383 SH   SOLE   143,383 0 0
INTELLIA THERAPEUTICS INC Common Stock 45826J105 9,256 372,478 SH   OTR   338,790 33,688 0
INTREXON CORP Common Stock 46122T102 169 8,908 SH   SOLE   8,908 0 0
INTUIT INC Common Stock 461202103 1,909 13,428 SH   OTR   1,536 232 11,660
INVITAE CORP Common Stock 46185L103 13,689 1,460,938 SH   OTR   623,574 62,574 774,790
IONIS PHARMACEUTICALS INC Common Stock 462222100 12,546 247,463 SH   OTR   94,084 8,644 144,735
JD.COM INC-ADR ADR 47215P106 851 22,272 SH   SOLE   22,272 0 0
JOUNCE THERAPEUTICS INC Common Stock 481116101 445 28,532 SH   SOLE   28,532 0 0
JUNO THERAPEUTICS INC Common Stock 48205A109 23,377 521,115 SH   OTR   185,823 24,381 310,911
K2M GROUP HOLDINGS INC Common Stock 48273J107 1,612 76,006 SH   SOLE   76,006 0 0
KITE PHARMA INC Common Stock 49803L109 100 557 SH   OTR   55 502 0
KONINKLIJKE DSM NV Common Stock N5017D122 57 693 SH   SOLE   693 0 0
LENDINGCLUB CORP Common Stock 52603A109 13,169 2,162,425 SH   OTR   939,634 95,045 1,127,746
LENDINGTREE INC Common Stock 52603B107 9,389 38,408 SH   OTR   11,872 1,263 25,273
MATERIALISE NV-ADR ADR 57667T100 7,101 487,676 SH   OTR   456,343 18,716 12,617
MAZOR ROBOTICS LTD-SPON ADR ADR 57886P103 1,389 28,135 SH   SOLE   28,135 0 0
MEDIDATA SOLUTIONS INC Common Stock 58471A105 8,140 104,280 SH   OTR   54,104 3,213 46,963
MELLANOX TECHNOLOGIES LTD Common Stock M51363113 992 21,045 SH   SOLE   21,045 0 0
MERCADOLIBRE INC Common Stock 58733R102 5,233 20,209 SH   OTR   8,268 0 11,941
MGI DIGITAL GRAPHIC TECHNOLO Common Stock F4090S113 2,050 32,651 SH   SOLE   32,651 0 0
MICROSOFT CORP Common Stock 594918104 1,273 17,083 SH   SOLE   17,083 0 0
NANO DIMENSION LTD - ADR ADR 63008G104 171 33,309 SH   SOLE   33,309 0 0
NANOSTRING TECHNOLOGIES INC Common Stock 63009R109 4,587 283,858 SH   OTR   255,179 28,679 0
NETFLIX INC Common Stock 64110L106 17,173 94,696 SH   OTR   43,840 3,681 47,175
NINTENDO CO LTD Common Stock J51699106 63 171 SH   OTR   0 171 0
NINTENDO CO LTD-UNSPONS ADR ADR 654445303 9,644 209,891 SH   OTR   62,991 5,654 141,246
NVIDIA CORP Common Stock 67066G104 28,931 161,834 SH   OTR   88,256 5,112 68,466
ORGANOVO HOLDINGS INC Common Stock 68620A104 5,831 2,626,704 SH   OTR   2,488,396 138,308 0
PACIFIC BIOSCIENCES OF CALIF Common Stock 69404D108 182 34,725 SH   SOLE   34,725 0 0
PAYPAL HOLDINGS INC Common Stock 70450Y103 8,698 135,847 SH   OTR   56,294 5,704 73,849
PLUG POWER INC Common Stock 72919P202 881 337,457 SH   SOLE   337,457 0 0
PLURISTEM THERAPEUTICS INC Common Stock 72940R102 95 62,773 SH   SOLE   62,773 0 0
POLYONE CORPORATION Common Stock 73179P106 53 1,330 SH   SOLE   1,330 0 0
PRAXAIR INC Common Stock 74005P104 53 381 SH   SOLE   381 0 0
PRODWAYS GROUP SA Common Stock F7329W102 659 95,211 SH   SOLE   95,211 0 0
PROTO LABS INC Common Stock 743713109 15,812 196,914 SH   OTR   80,785 4,628 111,501
PTC INC Common Stock 69370C100 1,311 23,286 SH   SOLE   23,286 0 0
QUALCOMM INC Common Stock 747525103 777 14,982 SH   SOLE   14,982 0 0
RED HAT INC Common Stock 756577102 9,591 86,514 SH   OTR   38,594 3,194 44,726
REDFIN CORP Common Stock 75737F108 6,681 266,290 SH   OTR   116,173 10,452 139,665
REGENERON PHARMACEUTICALS Common Stock 75886F107 998 2,231 SH   SOLE   2,231 0 0
RENISHAW PLC Common Stock G75006117 2,357 36,940 SH   SOLE   36,940 0 0
ROCKWELL AUTOMATION INC Common Stock 773903109 836 4,690 SH   SOLE   4,690 0 0
SALESFORCE.COM INC Common Stock 79466L302 14,901 159,510 SH   OTR   65,450 5,758 88,302
SANDVIK AB Common Stock W74857165 55 3,192 SH   SOLE   3,192 0 0
SERES THERAPEUTICS INC Common Stock 81750R102 14,322 892,922 SH   OTR   306,870 34,879 551,173
SERVICENOW INC Common Stock 81762P102 1,360 11,568 SH   SOLE   11,568 0 0
SHOPIFY INC - CLASS A Common Stock 82509L107 1,147 9,847 SH   SOLE   9,847 0 0
SIEMENS AG Common Stock D69671218 634 4,505 SH   SOLE   4,505 0 0
SIGMA LABS INC Common Stock 826598302 84 44,462 SH   SOLE   44,462 0 0
SLM SOLUTIONS GROUP AG Common Stock D6T690109 1,818 43,261 SH   SOLE   43,261 0 0
SOFTBANK GROUP CORP Common Stock J75963108 45 555 SH   OTR   0 555 0
SOFTBANK GROUP CORP-UNSP ADR ADR 83404D109 10,289 253,041 SH   OTR   126,391 6,994 119,656
SPLUNK INC Common Stock 848637104 16,781 252,610 SH   OTR   127,309 8,875 116,426
SQUARE INC - A Common Stock 852234103 9,413 326,714 SH   OTR   142,833 10,757 173,124
STRATASYS LTD Common Stock M85548101 36,027 1,558,269 SH   OTR   693,118 49,160 815,991
SYROS PHARMACEUTICALS INC Common Stock 87184Q107 1,983 134,699 SH   OTR   123,133 11,566 0
TELADOC INC Common Stock 87918A105 333 10,047 SH   SOLE   10,047 0 0
TENCENT HOLDINGS LTD-UNS ADR ADR 88032Q109 13,065 297,497 SH   OTR   153,622 8,001 135,874
TERADYNE INC Common Stock 880770102 8,881 238,149 SH   OTR   117,638 8,046 112,465
TESLA INC Common Stock 88160R101 21,636 63,429 SH   OTR   58,737 4,692 0
THERMO FISHER SCIENTIFIC INC Common Stock 883556102 3,575 18,893 SH   OTR   1,996 0 16,897
TORAY INDUSTRIES INC Common Stock J89494116 56 5,792 SH   SOLE   5,792 0 0
TOYOTA MOTOR CORP -SPON ADR ADR 892331307 1,247 10,466 SH   SOLE   10,466 0 0
TRIMBLE INC Common Stock 896239100 2,077 52,928 SH   SOLE   52,928 0 0
TWILIO INC - A Common Stock 90138F102 8,579 287,416 SH   OTR   145,058 9,393 132,965
TWITTER INC Common Stock 90184L102 27,591 1,635,499 SH   OTR   677,818 71,062 886,619
ULTRA CLEAN HOLDINGS INC Common Stock 90385V107 784 25,611 SH   SOLE   25,611 0 0
UNITED PARCEL SERVICE-CL B Common Stock 911312106 657 5,468 SH   SOLE   5,468 0 0
VERACYTE INC Common Stock 92337F107 4,283 488,338 SH   OTR   455,777 32,561 0
XILINX INC Common Stock 983919101 15,137 213,702 SH   OTR   112,330 7,304 94,068