The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Alibaba Group Holding Ltd ADR 01609W102 1,321,955 12,150,324 SH   SOLE   12,150,324 0 0
JD.com Inc ADR 47215P106 301,823 5,215,567 SH   DFND   5,215,567 0 0
Baidu Inc ADR 056752108 279,420 2,111,104 SH   DFND   2,111,104 0 0
NetEase Inc ADR 64110W102 201,849 2,250,523 SH   SOLE   2,250,523 0 0
Pinduoduo Inc ADR 722304102 162,698 4,042,764 SH   DFND   4,042,764 0 0
Trip.com Group Ltd ADR 89677Q107 88,151 3,833,855 SH   DFND   3,833,855 0 0
Kanzhun Ltd ADR 48553T106 57,587 2,314,161 SH   DFND   2,314,161 0 0
Apple Inc Common Stock 037833100 45,170 258,693 SH   SOLE   258,693 0 0
KE Holdings Inc ADR 482497104 43,783 3,508,522 SH   DFND   3,508,522 0 0
Full Truck Alliance Co Ltd ADR 35969L108 40,138 6,017,723 SH   SOLE   6,017,723 0 0
Microsoft Corp Common Stock 594918104 37,853 122,775 SH   SOLE   122,775 0 0
Bilibili Inc ADR 090040106 30,331 1,176,925 SH   DFND   1,176,925 0 0
Vipshop Holdings Ltd ADR 92763W103 25,803 2,893,317 SH   DFND   2,893,317 0 0
Lufax Holding Ltd ADR 54975P102 24,589 4,412,063 SH   DFND   4,412,063 0 0
Tencent Music Entertainment Gr ADR 88034P109 20,210 4,142,692 SH   DFND   4,142,692 0 0
Autohome Inc ADR 05278C107 14,149 466,775 SH   DFND   466,775 0 0
NVIDIA Corp Common Stock 67066G104 12,763 46,776 SH   SOLE   46,776 0 0
Amazon.com Inc Common Stock 023135106 12,287 3,769 SH   SOLE   3,769 0 0
JOYY Inc ADR 46591M109 12,283 332,517 SH   DFND   332,517 0 0
51job Inc ADR 316827104 11,784 200,602 SH   DFND   200,602 0 0
Tesla Inc Common Stock 88160R101 11,031 10,237 SH   SOLE   10,237 0 0
STAAR Surgical Co Common Stock 852312305 10,572 132,296 SH   SOLE   132,296 0 0
iQIYI Inc ADR 46267X108 10,367 2,287,631 SH   DFND   2,287,631 0 0
Weibo Corp ADR 948596101 10,246 418,822 SH   DFND   418,822 0 0
360 DigiTech Inc ADR 88557W101 9,163 599,954 SH   DFND   599,954 0 0
I-Mab ADR 44975P103 7,011 434,823 SH   DFND   434,823 0 0
TAL Education Group ADR 874080104 6,799 2,244,990 SH   DFND   2,244,990 0 0
Alphabet Inc Common Stock 02079K107 6,580 2,356 SH   SOLE   2,356 0 0
Alphabet Inc Common Stock 02079K305 6,428 2,311 SH   SOLE   2,311 0 0
Invesco DB Oil Fund ETP 46140H403 5,889 340,000 SH   SOLE   340,000 0 0
United States Oil Fund LP ETP 91232N207 5,559 75,000 SH   SOLE   75,000 0 0
United States Brent Oil Fund L ETP 91167Q100 5,537 185,000 SH   SOLE   185,000 0 0
Meta Platforms Inc Common Stock 30303M102 5,420 24,375 SH   SOLE   24,375 0 0
Broadcom Inc Common Stock 11135F101 5,219 8,288 SH   SOLE   8,288 0 0
iShares MSCI Global Gold Miner ETP 46434G855 5,112 164,624 SH   SOLE   164,624 0 0
iShares Gold Trust ETP 464285204 4,961 134,710 SH   SOLE   134,710 0 0
SPDR Gold MiniShares Trust ETP 98149E303 4,955 128,809 SH   SOLE   128,809 0 0
Zhihu Inc ADR 98955N108 4,840 2,000,000 SH   SOLE   2,000,000 0 0
Cisco Systems Inc Common Stock 17275R102 4,710 84,461 SH   SOLE   84,461 0 0
Adobe Inc Common Stock 00724F101 4,338 9,522 SH   SOLE   9,522 0 0
Intel Corp Common Stock 458140100 4,067 82,056 SH   SOLE   82,056 0 0
Visa Inc Common Stock 92826C839 3,921 17,681 SH   SOLE   17,681 0 0
Advanced Micro Devices Inc Common Stock 007903107 3,592 32,853 SH   SOLE   32,853 0 0
QUALCOMM Inc Common Stock 747525103 3,469 22,698 SH   SOLE   22,698 0 0
Texas Instruments Inc Common Stock 882508104 3,412 18,594 SH   SOLE   18,594 0 0
VanEck Gold Miners ETF/USA ETP 92189F106 3,394 88,508 SH   SOLE   88,508 0 0
Mastercard Inc Common Stock 57636Q104 3,285 9,192 SH   SOLE   9,192 0 0
Lululemon Athletica Inc Common Stock 550021109 2,995 8,200 SH   SOLE   8,200 0 0
Costco Wholesale Corp Common Stock 22160K105 2,926 5,081 SH   SOLE   5,081 0 0
Intuit Inc Common Stock 461202103 2,745 5,708 SH   SOLE   5,708 0 0
PayPal Holdings Inc Common Stock 70450Y103 2,712 23,454 SH   SOLE   23,454 0 0
PepsiCo Inc Common Stock 713448108 2,654 15,859 SH   SOLE   15,859 0 0
Estee Lauder Cos Inc/The Common Stock 518439104 2,512 9,224 SH   SOLE   9,224 0 0
Comcast Corp Common Stock 20030N101 2,431 51,922 SH   SOLE   51,922 0 0
Marriott International Inc/MD Common Stock 571903202 2,407 13,693 SH   SOLE   13,693 0 0
Applied Materials Inc Common Stock 038222105 2,357 17,884 SH   SOLE   17,884 0 0
NIKE Inc Common Stock 654106103 2,297 17,074 SH   SOLE   17,074 0 0
Accenture PLC Common Stock G1151C101 2,268 6,725 SH   SOLE   6,725 0 0
Salesforce Inc Common Stock 79466L302 2,229 10,500 SH   SOLE   10,500 0 0
Amgen Inc Common Stock 031162100 1,946 8,048 SH   SOLE   8,048 0 0
Automatic Data Processing Inc Common Stock 053015103 1,910 8,392 SH   SOLE   8,392 0 0
Netflix Inc Common Stock 64110L106 1,906 5,088 SH   SOLE   5,088 0 0
United States 12 Month Oil Fun ETP 91288V103 1,858 50,000 SH   SOLE   50,000 0 0
Micron Technology Inc Common Stock 595112103 1,764 22,651 SH   SOLE   22,651 0 0
Analog Devices Inc Common Stock 032654105 1,756 10,632 SH   SOLE   10,632 0 0
T-Mobile US Inc Common Stock 872590104 1,673 13,032 SH   SOLE   13,032 0 0
Honeywell International Inc Common Stock 438516106 1,521 7,817 SH   SOLE   7,817 0 0
Lam Research Corp Common Stock 512807108 1,510 2,808 SH   SOLE   2,808 0 0
Oracle Corp Common Stock 68389X105 1,393 16,836 SH   SOLE   16,836 0 0
Intuitive Surgical Inc Common Stock 46120E602 1,355 4,493 SH   SOLE   4,493 0 0
Fiserv Inc Common Stock 337738108 1,263 12,458 SH   SOLE   12,458 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 1,263 1,808 SH   SOLE   1,808 0 0
Berkshire Hathaway Inc Common Stock 084670702 1,261 3,573 SH   SOLE   3,573 0 0
International Business Machine Common Stock 459200101 1,251 9,619 SH   SOLE   9,619 0 0
Gilead Sciences Inc Common Stock 375558103 1,240 20,856 SH   SOLE   20,856 0 0
Moderna Inc Common Stock 60770K107 1,240 7,200 SH   SOLE   7,200 0 0
Starbucks Corp Common Stock 855244109 1,205 13,247 SH   SOLE   13,247 0 0
ServiceNow Inc Common Stock 81762P102 1,189 2,135 SH   SOLE   2,135 0 0
ProShares Ultra Gold ETP 74347W601 1,184 17,903 SH   SOLE   17,903 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100 1,179 4,517 SH   SOLE   4,517 0 0
SPDR Gold Shares ETP 78463V107 1,118 6,191 SH   SOLE   6,191 0 0
KLA Corp Common Stock 482480100 1,108 3,027 SH   SOLE   3,027 0 0
Booking Holdings Inc Common Stock 09857L108 1,104 470 SH   SOLE   470 0 0
UnitedHealth Group Inc Common Stock 91324P102 1,051 2,061 SH   SOLE   2,061 0 0
Charter Communications Inc Common Stock 16119P108 1,029 1,886 SH   SOLE   1,886 0 0
Johnson & Johnson Common Stock 478160104 1,023 5,770 SH   SOLE   5,770 0 0
Synopsys Inc Common Stock 871607107 1,021 3,065 SH   SOLE   3,065 0 0
Fortinet Inc Common Stock 34959E109 1,018 2,978 SH   SOLE   2,978 0 0
Mondelez International Inc Common Stock 609207105 990 15,777 SH   SOLE   15,777 0 0
NXP Semiconductors NV Common Stock N6596X109 981 5,298 SH   SOLE   5,298 0 0
AbbVie Inc Common Stock 00287Y109 968 5,971 SH   SOLE   5,971 0 0
CSX Corp Common Stock 126408103 943 25,183 SH   SOLE   25,183 0 0
Cognizant Technology Solutions Common Stock 192446102 943 10,517 SH   SOLE   10,517 0 0
Autodesk Inc Common Stock 052769106 939 4,380 SH   SOLE   4,380 0 0
Paychex Inc Common Stock 704326107 929 6,808 SH   SOLE   6,808 0 0
Cadence Design Systems Inc Common Stock 127387108 918 5,581 SH   SOLE   5,581 0 0
Microchip Technology Inc Common Stock 595017104 840 11,182 SH   SOLE   11,182 0 0
JPMorgan Chase & Co Common Stock 46625H100 786 5,765 SH   SOLE   5,765 0 0
Biogen Inc Common Stock 09062X103 752 3,571 SH   SOLE   3,571 0 0
Illumina Inc Common Stock 452327109 742 2,124 SH   SOLE   2,124 0 0
Procter & Gamble Co/The Common Stock 742718109 721 4,721 SH   SOLE   4,721 0 0
Activision Blizzard Inc Common Stock 00507V109 707 8,829 SH   SOLE   8,829 0 0
Dexcom Inc Common Stock 252131107 705 1,378 SH   SOLE   1,378 0 0
Exxon Mobil Corp Common Stock 30231G102 682 8,258 SH   SOLE   8,258 0 0
Pfizer Inc Common Stock 717081103 678 13,087 SH   SOLE   13,087 0 0
IDEXX Laboratories Inc Common Stock 45168D104 651 1,190 SH   SOLE   1,190 0 0
Fidelity National Information Common Stock 31620M106 643 6,404 SH   SOLE   6,404 0 0
Hilton Worldwide Holdings Inc Common Stock 43300A203 642 4,233 SH   SOLE   4,233 0 0
Home Depot Inc/The Common Stock 437076102 616 2,059 SH   SOLE   2,059 0 0
Chevron Corp Common Stock 166764100 612 3,760 SH   SOLE   3,760 0 0
Airbnb Inc Common Stock 009066101 606 3,531 SH   SOLE   3,531 0 0
Bank of America Corp Common Stock 060505104 579 14,048 SH   SOLE   14,048 0 0
Palo Alto Networks Inc Common Stock 697435105 577 927 SH   SOLE   927 0 0
Marvell Technology Inc Common Stock 573874104 576 8,028 SH   SOLE   8,028 0 0
Thermo Fisher Scientific Inc Common Stock 883556102 574 972 SH   SOLE   972 0 0
MercadoLibre Inc Common Stock 58733R102 570 479 SH   SOLE   479 0 0
American Electric Power Co Inc Common Stock 025537101 569 5,708 SH   SOLE   5,708 0 0
Eli Lilly & Co Common Stock 532457108 559 1,953 SH   SOLE   1,953 0 0
ANSYS Inc Common Stock 03662Q105 558 1,756 SH   SOLE   1,756 0 0
Exelon Corp Common Stock 30161N101 532 11,166 SH   SOLE   11,166 0 0
Seagen Inc Common Stock 81181C104 530 3,679 SH   SOLE   3,679 0 0
ASML Holding NV NY Reg Shrs N07059210 526 788 SH   SOLE   788 0 0
O'Reilly Automotive Inc Common Stock 67103H107 525 766 SH   SOLE   766 0 0
Abbott Laboratories Common Stock 002824100 520 4,393 SH   SOLE   4,393 0 0
Merck & Co Inc Common Stock 58933Y105 517 6,301 SH   SOLE   6,301 0 0
Kraft Heinz Co/The Common Stock 500754106 515 13,064 SH   SOLE   13,064 0 0
Align Technology Inc Common Stock 016255101 511 1,171 SH   SOLE   1,171 0 0
Keurig Dr Pepper Inc Common Stock 49271V100 501 13,229 SH   SOLE   13,229 0 0
Cintas Corp Common Stock 172908105 488 1,147 SH   SOLE   1,147 0 0
Walt Disney Co/The Common Stock 254687106 486 3,545 SH   SOLE   3,545 0 0
Danaher Corp Common Stock 235851102 484 1,651 SH   SOLE   1,651 0 0
Amphenol Corp Common Stock 032095101 478 6,350 SH   SOLE   6,350 0 0
Coca-Cola Co/The Common Stock 191216100 470 7,583 SH   SOLE   7,583 0 0
VeriSign Inc Common Stock 92343E102 461 2,073 SH   SOLE   2,073 0 0
Monster Beverage Corp Common Stock 61174X109 459 5,749 SH   SOLE   5,749 0 0
TE Connectivity Ltd Common Stock H84989104 454 3,465 SH   SOLE   3,465 0 0
Crowdstrike Holdings Inc Common Stock 22788C105 450 1,981 SH   SOLE   1,981 0 0
Xcel Energy Inc Common Stock 98389B100 442 6,120 SH   SOLE   6,120 0 0
Workday Inc Common Stock 98138H101 438 1,828 SH   SOLE   1,828 0 0
Skyworks Solutions Inc Common Stock 83088M102 436 3,273 SH   SOLE   3,273 0 0
Motorola Solutions Inc Common Stock 620076307 435 1,797 SH   SOLE   1,797 0 0
Incyte Corp Common Stock 45337C102 433 5,449 SH   SOLE   5,449 0 0
Bristol-Myers Squibb Co Common Stock 110122108 430 5,891 SH   SOLE   5,891 0 0
Walgreens Boots Alliance Inc Common Stock 931427108 426 9,522 SH   SOLE   9,522 0 0
HP Inc Common Stock 40434L105 423 11,656 SH   SOLE   11,656 0 0
Global Payments Inc Common Stock 37940X102 422 3,081 SH   SOLE   3,081 0 0
Electronic Arts Inc Common Stock 285512109 415 3,279 SH   SOLE   3,279 0 0
Walmart Inc Common Stock 931142103 413 2,774 SH   SOLE   2,774 0 0
Verizon Communications Inc Common Stock 92343V104 411 8,076 SH   SOLE   8,076 0 0
Dollar Tree Inc Common Stock 256746108 411 2,565 SH   SOLE   2,565 0 0
Medtronic PLC Common Stock G5960L103 406 3,661 SH   SOLE   3,661 0 0
Verisk Analytics Inc Common Stock 92345Y106 401 1,869 SH   SOLE   1,869 0 0
Lucid Group Inc Common Stock 549498103 393 15,480 SH   SOLE   15,480 0 0
eBay Inc Common Stock 278642103 390 6,813 SH   SOLE   6,813 0 0
Atlassian Corp PLC Common Stock G06242104 388 1,320 SH   SOLE   1,320 0 0
Fastenal Co Common Stock 311900104 388 6,531 SH   SOLE   6,531 0 0
Datadog Inc Common Stock 23804L103 381 2,514 SH   SOLE   2,514 0 0
Old Dominion Freight Line Inc Common Stock 679580100 381 1,274 SH   SOLE   1,274 0 0
Wells Fargo & Co Common Stock 949746101 377 7,778 SH   SOLE   7,778 0 0
CVS Health Corp Common Stock 126650100 366 3,614 SH   SOLE   3,614 0 0
Ross Stores Inc Common Stock 778296103 362 3,998 SH   SOLE   3,998 0 0
McDonald's Corp Common Stock 580135101 361 1,458 SH   SOLE   1,458 0 0
Ocugen Inc Common Stock 67577C105 361 109,488 SH   SOLE   109,488 0 0
AstraZeneca PLC ADR 046353108 360 5,427 SH   SOLE   5,427 0 0
Carnival Corp Common Stock 143658300 356 17,609 SH   SOLE   17,609 0 0
Match Group Inc Common Stock 57667L107 350 3,223 SH   SOLE   3,223 0 0
Anthem Inc Common Stock 036752103 347 706 SH   SOLE   706 0 0
PACCAR Inc Common Stock 693718108 347 3,943 SH   SOLE   3,943 0 0
Union Pacific Corp Common Stock 907818108 343 1,254 SH   SOLE   1,254 0 0
Editas Medicine Inc Common Stock 28106W103 339 17,812 SH   SOLE   17,812 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 339 20,353 SH   SOLE   20,353 0 0
Global Blood Therapeutics Inc Common Stock 37890U108 334 9,646 SH   SOLE   9,646 0 0
Karuna Therapeutics Inc Common Stock 48576A100 331 2,607 SH   SOLE   2,607 0 0
AT&T Inc Common Stock 00206R102 329 13,929 SH   SOLE   13,929 0 0
Arista Networks Inc Common Stock 040413106 328 2,359 SH   SOLE   2,359 0 0
Copart Inc Common Stock 217204106 328 2,616 SH   SOLE   2,616 0 0
NextEra Energy Inc Common Stock 65339F101 324 3,828 SH   SOLE   3,828 0 0
CareDx Inc Common Stock 14167L103 322 8,715 SH   SOLE   8,715 0 0
Arcturus Therapeutics Holdings Common Stock 03969T109 321 11,910 SH   SOLE   11,910 0 0
Linde PLC Common Stock G5494J103 319 1,000 SH   SOLE   1,000 0 0
Intellia Therapeutics Inc Common Stock 45826J105 318 4,377 SH   SOLE   4,377 0 0
Zscaler Inc Common Stock 98980G102 318 1,316 SH   SOLE   1,316 0 0
Bridgebio Pharma Inc Common Stock 10806X102 317 31,264 SH   SOLE   31,264 0 0
Vir Biotechnology Inc Common Stock 92764N102 316 12,283 SH   SOLE   12,283 0 0
Apellis Pharmaceuticals Inc Common Stock 03753U106 315 6,196 SH   SOLE   6,196 0 0
Veracyte Inc Common Stock 92337F107 311 11,276 SH   SOLE   11,276 0 0
Fate Therapeutics Inc Common Stock 31189P102 310 7,996 SH   SOLE   7,996 0 0
Ionis Pharmaceuticals Inc Common Stock 462222100 309 8,334 SH   SOLE   8,334 0 0
Halozyme Therapeutics Inc Common Stock 40637H109 308 7,726 SH   SOLE   7,726 0 0
United Parcel Service Inc Common Stock 911312106 305 1,423 SH   SOLE   1,423 0 0
Twist Bioscience Corp Common Stock 90184D100 303 6,126 SH   SOLE   6,126 0 0
Emergent BioSolutions Inc Common Stock 29089Q105 302 7,354 SH   SOLE   7,354 0 0
Blueprint Medicines Corp Common Stock 09627Y109 300 4,698 SH   SOLE   4,698 0 0
Keysight Technologies Inc Common Stock 49338L103 300 1,901 SH   SOLE   1,901 0 0
Exact Sciences Corp Common Stock 30063P105 299 4,275 SH   SOLE   4,275 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 299 83,306 SH   SOLE   83,306 0 0
Karyopharm Therapeutics Inc Common Stock 48576U106 299 40,582 SH   SOLE   40,582 0 0
Dynavax Technologies Corp Common Stock 268158201 298 27,513 SH   SOLE   27,513 0 0
Ultragenyx Pharmaceutical Inc Common Stock 90400D108 298 4,101 SH   SOLE   4,101 0 0
Arrowhead Pharmaceuticals Inc Common Stock 04280A100 295 6,421 SH   SOLE   6,421 0 0
Corning Inc Common Stock 219350105 293 7,925 SH   SOLE   7,925 0 0
PTC Therapeutics Inc Common Stock 69366J200 292 7,830 SH   SOLE   7,830 0 0
Stryker Corp Common Stock 863667101 291 1,089 SH   SOLE   1,089 0 0
Exelixis Inc Common Stock 30161Q104 290 12,780 SH   SOLE   12,780 0 0
TG Therapeutics Inc Common Stock 88322Q108 290 30,483 SH   SOLE   30,483 0 0
Raytheon Technologies Corp Common Stock 75513E101 289 2,920 SH   SOLE   2,920 0 0
Alkermes PLC Common Stock G01767105 289 11,003 SH   SOLE   11,003 0 0
Ironwood Pharmaceuticals Inc Common Stock 46333X108 289 22,986 SH   SOLE   22,986 0 0
Enphase Energy Inc Common Stock 29355A107 288 1,427 SH   SOLE   1,427 0 0
Sorrento Therapeutics Inc Common Stock 83587F202 287 123,048 SH   SOLE   123,048 0 0
Sage Therapeutics Inc Common Stock 78667J108 286 8,634 SH   SOLE   8,634 0 0
Philip Morris International In Common Stock 718172109 285 3,037 SH   SOLE   3,037 0 0
Insmed Inc Common Stock 457669307 285 12,116 SH   SOLE   12,116 0 0
ChemoCentryx Inc Common Stock 16383L106 284 11,309 SH   SOLE   11,309 0 0
Denali Therapeutics Inc Common Stock 24823R105 284 8,827 SH   SOLE   8,827 0 0
Royal Caribbean Cruises Ltd Common Stock V7780T103 284 3,388 SH   SOLE   3,388 0 0
Zoetis Inc Common Stock 98978V103 284 1,504 SH   SOLE   1,504 0 0
S&P Global Inc Common Stock 78409V104 283 691 SH   SOLE   691 0 0
Alnylam Pharmaceuticals Inc Common Stock 02043Q107 283 1,732 SH   SOLE   1,732 0 0
Neurocrine Biosciences Inc Common Stock 64125C109 282 3,005 SH   SOLE   3,005 0 0
ACADIA Pharmaceuticals Inc Common Stock 004225108 280 11,573 SH   SOLE   11,573 0 0
Natera Inc Common Stock 632307104 280 6,882 SH   SOLE   6,882 0 0
OPKO Health Inc Common Stock 68375N103 280 81,338 SH   SOLE   81,338 0 0
Horizon Therapeutics Plc Common Stock G46188101 280 2,663 SH   SOLE   2,663 0 0
Zentalis Pharmaceuticals Inc Common Stock 98943L107 280 6,079 SH   SOLE   6,079 0 0
United Therapeutics Corp Common Stock 91307C102 278 1,551 SH   SOLE   1,551 0 0
IVERIC bio Inc Common Stock 46583P102 276 16,370 SH   SOLE   16,370 0 0
Lowe's Cos Inc Common Stock 548661107 273 1,351 SH   SOLE   1,351 0 0
Amicus Therapeutics Inc Common Stock 03152W109 273 28,875 SH   SOLE   28,875 0 0
Heron Therapeutics Inc Common Stock 427746102 273 47,763 SH   SOLE   47,763 0 0
Mirati Therapeutics Inc Common Stock 60468T105 273 3,321 SH   SOLE   3,321 0 0
BioMarin Pharmaceutical Inc Common Stock 09061G101 272 3,531 SH   SOLE   3,531 0 0
BioCryst Pharmaceuticals Inc Common Stock 09058V103 271 16,641 SH   SOLE   16,641 0 0
Novavax Inc Common Stock 670002401 271 3,676 SH   SOLE   3,676 0 0
Ligand Pharmaceuticals Inc Common Stock 53220K504 270 2,399 SH   SOLE   2,399 0 0
Sarepta Therapeutics Inc Common Stock 803607100 269 3,446 SH   SOLE   3,446 0 0
Zoom Video Communications Inc Common Stock 98980L101 269 2,298 SH   SOLE   2,298 0 0
Cigna Corp Common Stock 125523100 269 1,121 SH   SOLE   1,121 0 0
Biohaven Pharmaceutical Holdin Common Stock G11196105 268 2,259 SH   SOLE   2,259 0 0
Celldex Therapeutics Inc Common Stock 15117B202 267 7,838 SH   SOLE   7,838 0 0
Edwards Lifesciences Corp Common Stock 28176E108 266 2,258 SH   SOLE   2,258 0 0
Kymera Therapeutics Inc Common Stock 501575104 264 6,228 SH   SOLE   6,228 0 0
Cytokinetics Inc Common Stock 23282W605 263 7,154 SH   SOLE   7,154 0 0
Prothena Corp PLC Common Stock G72800108 263 7,202 SH   SOLE   7,202 0 0
Becton Dickinson and Co Common Stock 075887109 262 984 SH   SOLE   984 0 0
Agios Pharmaceuticals Inc Common Stock 00847X104 260 8,923 SH   SOLE   8,923 0 0
Gartner Inc Common Stock 366651107 260 875 SH   SOLE   875 0 0
Allogene Therapeutics Inc Common Stock 019770106 258 28,315 SH   SOLE   28,315 0 0
Direxion Daily Gold Miners Ind ETP 25460G781 258 3,646 SH   SOLE   3,646 0 0
CDW Corp/DE Common Stock 12514G108 258 1,441 SH   SOLE   1,441 0 0
ConocoPhillips Common Stock 20825C104 257 2,573 SH   SOLE   2,573 0 0
SpringWorks Therapeutics Inc Common Stock 85205L107 257 4,557 SH   SOLE   4,557 0 0
Turning Point Therapeutics Inc Common Stock 90041T108 257 9,584 SH   SOLE   9,584 0 0
Arcus Biosciences Inc Common Stock 03969F109 256 8,105 SH   SOLE   8,105 0 0
Beam Therapeutics Inc Common Stock 07373V105 252 4,404 SH   SOLE   4,404 0 0
Vaxart Inc Common Stock 92243A200 252 49,989 SH   SOLE   49,989 0 0
Relay Therapeutics Inc Common Stock 75943R102 250 8,365 SH   SOLE   8,365 0 0
Sirius XM Holdings Inc Common Stock 82968B103 249 37,608 SH   SOLE   37,608 0 0
Charles Schwab Corp/The Common Stock 808513105 247 2,933 SH   SOLE   2,933 0 0
Protagonist Therapeutics Inc Common Stock 74366E102 247 10,440 SH   SOLE   10,440 0 0
Morgan Stanley Common Stock 617446448 245 2,800 SH   SOLE   2,800 0 0
Vericel Corp Common Stock 92346J108 240 6,269 SH   SOLE   6,269 0 0
Bluebird Bio Inc Common Stock 09609G100 238 49,119 SH   SOLE   49,119 0 0
Boston Scientific Corp Common Stock 101137107 237 5,359 SH   SOLE   5,359 0 0
Caterpillar Inc Common Stock 149123101 235 1,056 SH   SOLE   1,056 0 0
Zebra Technologies Corp Common Stock 989207105 234 566 SH   SOLE   566 0 0
Prologis Inc REIT 74340W103 233 1,443 SH   SOLE   1,443 0 0
Hewlett Packard Enterprise Co Common Stock 42824C109 230 13,790 SH   SOLE   13,790 0 0
American Express Co Common Stock 025816109 229 1,224 SH   SOLE   1,224 0 0
Deere & Co Common Stock 244199105 229 551 SH   SOLE   551 0 0
Madrigal Pharmaceuticals Inc Common Stock 558868105 228 2,322 SH   SOLE   2,322 0 0
Anavex Life Sciences Corp Common Stock 032797300 227 18,467 SH   SOLE   18,467 0 0
Splunk Inc Common Stock 848637104 226 1,520 SH   SOLE   1,520 0 0
Teledyne Technologies Inc Common Stock 879360105 225 477 SH   SOLE   477 0 0
American Tower Corp REIT 03027X100 223 889 SH   SOLE   889 0 0
Avid Bioservices Inc Common Stock 05368M106 221 10,835 SH   SOLE   10,835 0 0
Goldman Sachs Group Inc/The Common Stock 38141G104 219 663 SH   SOLE   663 0 0
Humana Inc Common Stock 444859102 219 504 SH   SOLE   504 0 0
HCA Healthcare Inc Common Stock 40412C101 218 871 SH   SOLE   871 0 0
Monolithic Power Systems Inc Common Stock 609839105 215 442 SH   SOLE   442 0 0
BlackRock Inc Common Stock 09247X101 213 279 SH   SOLE   279 0 0
Cerner Corp Common Stock 156782104 213 2,279 SH   SOLE   2,279 0 0
Verve Therapeutics Inc Common Stock 92539P101 212 9,282 SH   SOLE   9,282 0 0
Lockheed Martin Corp Common Stock 539830109 211 479 SH   SOLE   479 0 0
Okta Inc Common Stock 679295105 211 1,395 SH   SOLE   1,395 0 0
Constellation Energy Corp Common Stock 21037T109 209 3,722 SH   SOLE   3,722 0 0
McKesson Corp Common Stock 58155Q103 208 681 SH   SOLE   681 0 0
Citigroup Inc Common Stock 172967424 207 3,871 SH   SOLE   3,871 0 0
Boeing Co/The Common Stock 097023105 206 1,078 SH   SOLE   1,078 0 0
Enanta Pharmaceuticals Inc Common Stock 29251M106 206 2,890 SH   SOLE   2,890 0 0
FleetCor Technologies Inc Common Stock 339041105 206 829 SH   SOLE   829 0 0
Travere Therapeutics Inc Common Stock 89422G107 205 7,951 SH   SOLE   7,951 0 0
ImmunoGen Inc Common Stock 45253H101 204 42,786 SH   SOLE   42,786 0 0
Centene Corp Common Stock 15135B101 204 2,428 SH   SOLE   2,428 0 0
IQVIA Holdings Inc Common Stock 46266C105 203 877 SH   SOLE   877 0 0
Target Corp Common Stock 87612E106 202 952 SH   SOLE   952 0 0
Sana Biotechnology Inc Common Stock 799566104 201 24,328 SH   SOLE   24,328 0 0
Krystal Biotech Inc Common Stock 501147102 200 3,011 SH   SOLE   3,011 0 0
Deciphera Pharmaceuticals Inc Common Stock 24344T101 196 21,190 SH   SOLE   21,190 0 0
2seventy bio Inc Common Stock 901384107 188 11,035 SH   SOLE   11,035 0 0
Intercept Pharmaceuticals Inc Common Stock 45845P108 186 11,431 SH   SOLE   11,431 0 0
Myovant Sciences Ltd Common Stock G637AM102 181 13,601 SH   SOLE   13,601 0 0
Atara Biotherapeutics Inc Common Stock 046513107 180 19,420 SH   SOLE   19,420 0 0
Coherus Biosciences Inc Common Stock 19249H103 174 13,486 SH   SOLE   13,486 0 0
FibroGen Inc Common Stock 31572Q808 167 13,904 SH   SOLE   13,904 0 0
DermTech Inc Common Stock 24984K105 164 11,153 SH   SOLE   11,153 0 0
Alector Inc Common Stock 014442107 163 11,434 SH   SOLE   11,434 0 0
MannKind Corp Common Stock 56400P706 160 43,489 SH   SOLE   43,489 0 0
Agenus Inc Common Stock 00847G705 144 58,558 SH   SOLE   58,558 0 0
Viatris Inc Common Stock 92556V106 142 13,088 SH   SOLE   13,088 0 0
Sangamo Therapeutics Inc Common Stock 800677106 134 23,101 SH   SOLE   23,101 0 0
ImmunityBio Inc Common Stock 45256X103 128 22,816 SH   SOLE   22,816 0 0
Radius Health Inc Common Stock 750469207 112 12,738 SH   SOLE   12,738 0 0
Seres Therapeutics Inc Common Stock 81750R102 106 14,871 SH   SOLE   14,871 0 0
G1 Therapeutics Inc Common Stock 3621LQ109 98 12,869 SH   SOLE   12,869 0 0
Catalyst Pharmaceuticals Inc Common Stock 14888U101 96 11,614 SH   SOLE   11,614 0 0
MacroGenics Inc Common Stock 556099109 92 10,417 SH   SOLE   10,417 0 0
Organogenesis Holdings Inc Common Stock 68621F102 90 11,780 SH   SOLE   11,780 0 0
VBI Vaccines Inc Common Stock 91822J103 88 53,148 SH   SOLE   53,148 0 0
Adagene Inc ADR 005329107 69 19,310 SH   SOLE   19,310 0 0
Chimerix Inc Common Stock 16934W106 59 12,868 SH   SOLE   12,868 0 0
Rigel Pharmaceuticals Inc Common Stock 766559603 52 17,470 SH   SOLE   17,470 0 0
MiMedx Group Inc Common Stock 602496101 50 10,673 SH   SOLE   10,673 0 0
Geron Corp Common Stock 374163103 43 31,687 SH   SOLE   31,687 0 0
Akebia Therapeutics Inc Common Stock 00972D105 25 35,250 SH   SOLE   35,250 0 0