The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Agilent Technologies Inc Common Stock 00846U101 BBG000C2V3D6 261,176 1,759 SH   SOLE   1,759 0 0
Apple Inc Common Stock 037833100 BBG000B9XRY4 83,728,084 359,348 SH   DFND   359,348 0 0
AbbVie Inc Common Stock 00287Y109 BBG0025Y4RY4 3,621,980 18,341 SH   SOLE   18,341 0 0
Airbnb Inc Common Stock 009066101 BBG001Y2XS07 1,201,017 9,471 SH   DFND   9,471 0 0
Abbott Laboratories Common Stock 002824100 BBG000B9ZXB4 1,506,870 13,217 SH   SOLE   13,217 0 0
ACADIA Pharmaceuticals Inc Common Stock 004225108 BBG000BHG9K0 281,946 18,332 SH   SOLE   18,332 0 0
Arcellx Inc Common Stock 03940C100 BBG00QHJM4S9 299,132 3,582 SH   SOLE   3,582 0 0
Accenture PLC Common Stock G1151C101 BBG000D9D830 4,388,100 12,414 SH   SOLE   12,414 0 0
Adobe Inc Common Stock 00724F101 BBG000BB5006 6,640,528 12,825 SH   DFND   12,825 0 0
Analog Devices Inc Common Stock 032654105 BBG000BB6G37 2,714,625 11,794 SH   DFND   11,794 0 0
ADMA Biologics Inc Common Stock 000899104 BBG002NCK5M5 502,108 25,118 SH   SOLE   25,118 0 0
Automatic Data Processing Inc Common Stock 053015103 BBG000JG0547 1,222,316 4,417 SH   DFND   4,417 0 0
Autodesk Inc Common Stock 052769106 BBG000BM7HL0 1,423,404 5,167 SH   DFND   5,167 0 0
American Electric Power Co In Common Stock 025537101 BBG000BB9KF2 589,334 5,744 SH   DFND   5,744 0 0
Agios Pharmaceuticals Inc Common Stock 00847X104 BBG000QY4ZD0 255,516 5,751 SH   SOLE   5,751 0 0
Akamai Technologies Inc Common Stock 00971T101 BBG000BJQWD2 217,850 2,158 SH   SOLE   2,158 0 0
Align Technology Inc Common Stock 016255101 BBG000BRNLL2 217,443 855 SH   SOLE   855 0 0
Alkermes PLC Common Stock G01767105 BBG000C9F2F9 459,399 16,413 SH   SOLE   16,413 0 0
Allogene Therapeutics Inc Common Stock 019770106 BBG00KHRRDX3 57,016 20,363 SH   SOLE   20,363 0 0
Alnylam Pharmaceuticals Inc Common Stock 02043Q107 BBG000BFGNJ5 3,475,554 12,637 SH   SOLE   12,637 0 0
Altimmune Inc Common Stock 02155H200 BBG000FXML90 61,461 10,010 SH   SOLE   10,010 0 0
Applied Materials Inc Common Stock 038222105 BBG000BBPFB9 27,258,363 134,909 SH   SOLE   134,909 0 0
Advanced Micro Devices Inc Common Stock 007903107 BBG000BBQCY0 7,699,289 46,924 SH   DFND   46,924 0 0
Amgen Inc Common Stock 031162100 BBG000BBS2Y0 3,104,171 9,634 SH   SOLE   9,634 0 0
American Tower Corp REIT 03027X100 BBG000B9XYV2 238,141 1,024 SH   SOLE   1,024 0 0
Amazon.com Inc Common Stock 023135106 BBG000BVPV84 21,631,235 116,091 SH   DFND   116,091 0 0
Arista Networks Inc Common Stock 040413106 BBG000N2HDY5 4,365,952 11,375 SH   DFND   11,375 0 0
Annexon Inc Common Stock 03589W102 BBG007QVDFG2 67,257 11,361 SH   SOLE   11,361 0 0
ANSYS Inc Common Stock 03662Q105 BBG000GXZ4W7 670,079 2,103 SH   DFND   2,103 0 0
Apogee Therapeutics Inc Common Stock 03770N101 BBG01H51WYQ5 205,942 3,506 SH   SOLE   3,506 0 0
Amphenol Corp Common Stock 032095101 BBG000B9YJ35 1,134,109 17,405 SH   SOLE   17,405 0 0
Apellis Pharmaceuticals Inc Common Stock 03753U106 BBG007KGRPY4 378,265 13,116 SH   SOLE   13,116 0 0
Applied Therapeutics Inc Common Stock 03828A101 BBG000DD0489 86,971 10,232 SH   SOLE   10,232 0 0
Ardelyx Inc Common Stock 039697107 BBG001WH4DQ3 263,149 38,193 SH   SOLE   38,193 0 0
Argenx SE ADR 04016X101 BBG00GHB88X9 3,144,063 5,800 SH   SOLE   5,800 0 0
Arcutis Biotherapeutics Inc Common Stock 03969K108 BBG00QN8K4M4 165,400 17,785 SH   SOLE   17,785 0 0
Arrowhead Pharmaceuticals Inc Common Stock 04280A100 BBG000BRVKH0 221,554 11,438 SH   SOLE   11,438 0 0
ASML Holding NV NY Reg Shrs N07059210 BBG000K6MRN4 30,014,497 36,021 SH   DFND   36,021 0 0
Autohome Inc ADR 05278C107 BBG005JYTDQ5 13,575,041 416,157 SH   DFND   416,157 0 0
Broadcom Inc Common Stock 11135F101 BBG00KHY5S69 27,154,087 157,415 SH   DFND   157,415 0 0
Axon Enterprise Inc Common Stock 05464C101 BBG000BHJWG1 349,250 874 SH   DFND   874 0 0
American Express Co Common Stock 025816109 BBG000BCQZS4 226,451 835 SH   SOLE   835 0 0
AstraZeneca PLC ADR 046353108 BBG000BZ0DK8 423,207 5,432 SH   DFND   5,432 0 0
Bank of America Corp Common Stock 060505104 BBG000BCTLF6 1,925,471 48,525 SH   SOLE   48,525 0 0
Bridgebio Pharma Inc Common Stock 10806X102 BBG00P9KDZK6 398,041 15,634 SH   SOLE   15,634 0 0
BioCryst Pharmaceuticals Inc Common Stock 09058V103 BBG000BLYWX6 181,168 23,838 SH   SOLE   23,838 0 0
Becton Dickinson & Co Common Stock 075887109 BBG000BCZYD3 290,284 1,204 SH   SOLE   1,204 0 0
Beam Therapeutics Inc Common Stock 07373V105 BBG00KXC8646 294,490 12,020 SH   SOLE   12,020 0 0
KE Holdings Inc ADR 482497104 BBG00W9L9LX1 82,367,730 4,137,003 SH   DFND   4,137,003 0 0
Biohaven Ltd Common Stock G1110E107 BBG017BXV3Q9 441,634 8,838 SH   SOLE   8,838 0 0
Biogen Inc Common Stock 09062X103 BBG000C17X76 1,562,544 8,061 SH   DFND   8,061 0 0
Booking Holdings Inc Common Stock 09857L108 BBG000BLBVN4 1,528,999 363 SH   SOLE   363 0 0
Baker Hughes Co Common Stock 05722G100 BBG00GBVBK51 389,769 10,782 SH   DFND   10,782 0 0
BioMarin Pharmaceutical Inc Common Stock 09061G101 BBG000CZWZ05 899,430 12,796 SH   SOLE   12,796 0 0
Bristol-Myers Squibb Co Common Stock 110122108 BBG000DQLV23 347,227 6,711 SH   SOLE   6,711 0 0
Blueprint Medicines Corp Common Stock 09627Y109 BBG001MC8YF7 694,490 7,508 SH   SOLE   7,508 0 0
Berkshire Hathaway Inc Common Stock 084670702 BBG000DWG505 4,411,592 9,585 SH   SOLE   9,585 0 0
Boston Scientific Corp Common Stock 101137107 BBG000C0LW92 4,489,501 53,574 SH   DFND   53,574 0 0
Kanzhun Ltd ADR 48553T106 BBG01163M5L4 41,727,519 2,403,659 SH   DFND   2,403,659 0 0
Cabaletta Bio Inc Common Stock 12674W109 BBG00MJ3BKW2 1,322,227 280,133 SH   SOLE   280,133 0 0
Cardinal Health Inc Common Stock 14149Y108 BBG000D898T9 214,629 1,942 SH   SOLE   1,942 0 0
Caterpillar Inc Common Stock 149123101 BBG000BF0K17 1,351,710 3,456 SH   SOLE   3,456 0 0
Coca-Cola Europacific Partners Common Stock G25839104 BBG00B6BFWH9 337,128 4,281 SH   SOLE   4,281 0 0
Carnival Corp Common Stock 143658300 BBG000BF6LY3 999,324 54,076 SH   SOLE   54,076 0 0
Cadence Design Systems Inc Common Stock 127387108 BBG000C13CD9 1,751,124 6,461 SH   DFND   6,461 0 0
CDW Corp/DE Common Stock 12514G108 BBG001P63B80 729,590 3,224 SH   DFND   3,224 0 0
Constellation Energy Corp Common Stock 21037T109 BBG014KFRNP7 881,207 3,389 SH   DFND   3,389 0 0
Cullinan Therapeutics Inc Common Stock 230031106 BBG00HW2DGQ4 1,269,544 75,839 SH   SOLE   75,839 0 0
Charter Communications Inc Common Stock 16119P108 BBG000VPGNR2 475,749 1,468 SH   DFND   1,468 0 0
Cigna Group/The Common Stock 125523100 BBG00KXRCDP0 312,488 902 SH   SOLE   902 0 0
Comcast Corp Common Stock 20030N101 BBG000BFT2L4 1,743,438 41,739 SH   DFND   41,739 0 0
Chipotle Mexican Grill Inc Common Stock 169656105 BBG000QX74T1 739,783 12,839 SH   DFND   12,839 0 0
Centene Corp Common Stock 15135B101 BBG000BDXCJ5 242,702 3,224 SH   SOLE   3,224 0 0
Coinbase Global Inc Common Stock 19260Q107 BBG00ZGF7771 328,189 1,842 SH   SOLE   1,842 0 0
Cooper Cos Inc/The Common Stock 216648501 BBG000BG3445 211,080 1,913 SH   SOLE   1,913 0 0
ConocoPhillips Common Stock 20825C104 BBG000BQQH30 234,668 2,229 SH   DFND   2,229 0 0
Cencora Inc Common Stock 03073E105 BBG000MDCQC2 225,980 1,004 SH   SOLE   1,004 0 0
Costco Wholesale Corp Common Stock 22160K105 BBG000F6H8W8 6,589,502 7,433 SH   DFND   7,433 0 0
Copart Inc Common Stock 217204106 BBG000BM9RH1 625,446 11,936 SH   DFND   11,936 0 0
Salesforce Inc Common Stock 79466L302 BBG000BN2DC2 5,494,454 20,074 SH   DFND   20,074 0 0
Crinetics Pharmaceuticals Inc Common Stock 22663K107 BBG00BC59224 319,988 6,262 SH   SOLE   6,262 0 0
CRISPR Therapeutics AG Common Stock H17182108 BBG00DBBGRX1 645,317 13,736 SH   SOLE   13,736 0 0
Crowdstrike Holdings Inc Common Stock 22788C105 BBG00BLYKS03 1,534,731 5,472 SH   DFND   5,472 0 0
Cisco Systems Inc Common Stock 17275R102 BBG000C3J3C9 6,205,824 116,607 SH   SOLE   116,607 0 0
CoStar Group Inc Common Stock 22160N109 BBG000D7JKW9 333,897 4,426 SH   DFND   4,426 0 0
CSX Corp Common Stock 126408103 BBG000BGJRC8 725,302 21,005 SH   DFND   21,005 0 0
Cintas Corp Common Stock 172908105 BBG000H3YXF8 881,578 4,282 SH   DFND   4,282 0 0
Catalent Inc Common Stock 148806102 BBG005XR47P5 201,031 3,319 SH   SOLE   3,319 0 0
Cognizant Technology Solution Common Stock 192446102 BBG000BBDV81 921,838 11,944 SH   DFND   11,944 0 0
CVS Health Corp Common Stock 126650100 BBG000BGRY34 314,274 4,998 SH   SOLE   4,998 0 0
Chevron Corp Common Stock 166764100 BBG000K4ND22 1,705,975 11,584 SH   SOLE   11,584 0 0
Cytokinetics Inc Common Stock 23282W605 BBG000F0R4N9 725,313 13,737 SH   SOLE   13,737 0 0
DoorDash Inc Common Stock 25809K105 BBG005D7QCJ3 512,257 3,589 SH   DFND   3,589 0 0
Datadog Inc Common Stock 23804L103 BBG003NJHZT9 334,019 2,903 SH   DFND   2,903 0 0
Deckers Outdoor Corp Common Stock 243537107 BBG000BKXYX5 1,030,046 6,460 SH   SOLE   6,460 0 0
Dell Technologies Inc Common Stock 24703L202 BBG00DW3SZS1 492,296 4,153 SH   SOLE   4,153 0 0
Quest Diagnostics Inc Common Stock 74834L100 BBG000BN84F3 210,984 1,359 SH   SOLE   1,359 0 0
Danaher Corp Common Stock 235851102 BBG000BH3JF8 3,115,214 11,205 SH   DFND   11,205 0 0
Walt Disney Co/The Common Stock 254687106 BBG000BH4R78 262,791 2,732 SH   SOLE   2,732 0 0
Denali Therapeutics Inc Common Stock 24823R105 BBG008P7F869 220,251 7,561 SH   SOLE   7,561 0 0
Duolingo Inc Common Stock 26603R106 BBG003D4V951 795,860 2,822 SH   SOLE   2,822 0 0
Dynavax Technologies Corp Common Stock 268158201 BBG000BFX694 187,775 16,856 SH   SOLE   16,856 0 0
Dexcom Inc Common Stock 252131107 BBG000QTF8K1 464,318 6,926 SH   DFND   6,926 0 0
Dyne Therapeutics Inc Common Stock 26818M108 BBG00NSGPJD0 380,716 10,599 SH   SOLE   10,599 0 0
Electronic Arts Inc Common Stock 285512109 BBG000BP0KQ8 406,365 2,833 SH   DFND   2,833 0 0
Vanguard Extended Duration Tr ETP 921910709 BBG000RRTPG6 2,381,396 29,887 SH   SOLE   29,887 0 0
Estee Lauder Cos Inc/The Common Stock 518439104 BBG000FKJRC5 683,075 6,852 SH   SOLE   6,852 0 0
Elevance Health Inc Common Stock 036752103 BBG000BCG930 345,800 665 SH   SOLE   665 0 0
Enphase Energy Inc Common Stock 29355A107 BBG001R3MNY9 220,275 1,949 SH   SOLE   1,949 0 0
Equinix Inc REIT 29444U700 BBG000MBDGM6 255,636 288 SH   DFND   288 0 0
Erasca Inc Common Stock 29479A108 BBG00MTSR883 40,723 14,917 SH   SOLE   14,917 0 0
Eaton Corp PLC Common Stock G29183103 BBG000BJ3PD2 432,197 1,304 SH   SOLE   1,304 0 0
Edwards Lifesciences Corp Common Stock 28176E108 BBG000BRXP69 235,782 3,573 SH   SOLE   3,573 0 0
iShares MSCI Japan ETF ETP 46434G822 BBG000BK38F5 430,742 6,021 SH   SOLE   6,021 0 0
Exact Sciences Corp Common Stock 30063P105 BBG000CWL0F5 1,129,157 16,576 SH   SOLE   16,576 0 0
Exelon Corp Common Stock 30161N101 BBG000J6XT05 438,102 10,804 SH   DFND   10,804 0 0
Exelixis Inc Common Stock 30161Q104 BBG000BQ4WF8 368,775 14,211 SH   SOLE   14,211 0 0
Diamondback Energy Inc Common Stock 25278X109 BBG002PHSYX9 878,377 5,095 SH   DFND   5,095 0 0
Fastenal Co Common Stock 311900104 BBG000BJ8YN7 441,947 6,188 SH   DFND   6,188 0 0
Fate Therapeutics Inc Common Stock 31189P102 BBG000QP35H2 1,238,198 353,771 SH   SOLE   353,771 0 0
Fair Isaac Corp Common Stock 303250104 BBG000DW76Y6 1,519,832 782 SH   SOLE   782 0 0
Amicus Therapeutics Inc Common Stock 03152W109 BBG000PLF6N0 279,463 26,167 SH   SOLE   26,167 0 0
First Solar Inc Common Stock 336433107 BBG000BFL116 380,894 1,527 SH   SOLE   1,527 0 0
Fortinet Inc Common Stock 34959E109 BBG000BCMBG4 1,254,216 16,173 SH   DFND   16,173 0 0
Futu Holdings Ltd ADR 36118L106 BBG00MYXW4R8 48,191,435 503,831 SH   DFND   503,831 0 0
GoDaddy Inc Common Stock 380237107 BBG006MDLY05 325,788 2,078 SH   SOLE   2,078 0 0
VanEck Gold Miners ETF/USA ETP 92189F106 BBG000PLNQN7 2,045,951 51,380 SH   SOLE   51,380 0 0
General Electric Co Common Stock 369604301 BBG000BK6MB5 2,307,087 12,234 SH   DFND   12,234 0 0
GE HealthCare Technologies In Common Stock 36266G107 BBG01BFR8YV1 655,167 6,981 SH   DFND   6,981 0 0
Gen Digital Inc Common Stock 668771108 BBG000BH2JM1 224,103 8,170 SH   SOLE   8,170 0 0
Geron Corp Common Stock 374163103 BBG000GX1891 415,355 91,488 SH   SOLE   91,488 0 0
GE Vernova Inc Common Stock 36828A101 BBG013G17W31 953,370 3,739 SH   DFND   3,739 0 0
GLOBALFOUNDRIES Inc Common Stock G39387108 BBG000C2L5G9 207,126 5,146 SH   DFND   5,146 0 0
Gilead Sciences Inc Common Stock 375558103 BBG000CKGBP2 2,412,412 28,774 SH   DFND   28,774 0 0
SPDR Gold Shares ETP 78463V107 BBG000CRF6Q8 2,631,124 10,825 SH   SOLE   10,825 0 0
SPDR Gold MiniShares Trust ETP 98149E303 BBG00L8YYP89 3,754,715 72,026 SH   SOLE   72,026 0 0
Corning Inc Common Stock 219350105 BBG000BKFZM4 512,091 11,342 SH   SOLE   11,342 0 0
Alphabet Inc Common Stock 02079K107 BBG009S3NB30 10,551,528 63,111 SH   DFND   63,111 0 0
Alphabet Inc Common Stock 02079K305 BBG009S39JX6 10,598,146 63,902 SH   DFND   63,902 0 0
Goldman Sachs Group Inc/The Common Stock 38141G104 BBG000C6CFJ5 224,779 454 SH   SOLE   454 0 0
Halozyme Therapeutics Inc Common Stock 40637H109 BBG000CZ8W54 681,671 11,909 SH   SOLE   11,909 0 0
HCA Healthcare Inc Common Stock 40412C101 BBG000QW7VC1 300,351 739 SH   SOLE   739 0 0
Home Depot Inc/The Common Stock 437076102 BBG000BKZB36 3,540,637 8,738 SH   DFND   8,738 0 0
Hilton Worldwide Holdings Inc Common Stock 43300A203 BBG0058KMH30 1,971,466 8,553 SH   SOLE   8,553 0 0
Hologic Inc Common Stock 436440101 BBG000C3NTN5 208,374 2,558 SH   SOLE   2,558 0 0
Honeywell International Inc Common Stock 438516106 BBG000H556T9 1,456,065 7,044 SH   DFND   7,044 0 0
Hewlett Packard Enterprise Co Common Stock 42824C109 BBG0078W3NQ3 392,402 19,179 SH   SOLE   19,179 0 0
HP Inc Common Stock 40434L105 BBG000KHWT55 457,234 12,747 SH   SOLE   12,747 0 0
Henry Schein Inc Common Stock 806407102 BBG000BNMMJ3 203,318 2,789 SH   SOLE   2,789 0 0
H World Group Ltd ADR 44332N106 BBG000QFPM65 5,600,646 150,555 SH   SOLE   150,555 0 0
Humana Inc Common Stock 444859102 BBG000BLKK03 236,604 747 SH   SOLE   747 0 0
Humacyte Inc Common Stock 44486Q103 BBG00XPPT7S7 86,327 15,869 SH   SOLE   15,869 0 0
Howmet Aerospace Inc Common Stock 443201108 BBG00DYNJGH9 623,956 6,224 SH   DFND   6,224 0 0
iShares Gold Trust ETP 464285204 BBG000QLKDR4 3,810,747 76,675 SH   SOLE   76,675 0 0
International Business Machine Common Stock 459200101 BBG000BLNNH6 3,996,242 18,076 SH   SOLE   18,076 0 0
ImmunityBio Inc Common Stock 45256X103 BBG007T9DYW9 108,914 29,278 SH   SOLE   29,278 0 0
IDEXX Laboratories Inc Common Stock 45168D104 BBG000BLRT07 1,229,705 2,434 SH   DFND   2,434 0 0
Ideaya Biosciences Inc Common Stock 45166A102 BBG00CTZ4D83 256,512 8,097 SH   SOLE   8,097 0 0
Immunovant Inc Common Stock 45258J102 BBG00P5MC0Q8 279,084 9,789 SH   SOLE   9,789 0 0
Incyte Corp Common Stock 45337C102 BBG000BNPSQ9 1,338,194 20,245 SH   SOLE   20,245 0 0
Insmed Inc Common Stock 457669307 BBG000BWM5P3 1,062,222 14,551 SH   SOLE   14,551 0 0
Intel Corp Common Stock 458140100 BBG000C0G1D1 2,381,096 101,496 SH   SOLE   101,496 0 0
Intuit Inc Common Stock 461202103 BBG000BH5DV1 5,022,647 8,088 SH   DFND   8,088 0 0
Ionis Pharmaceuticals Inc Common Stock 462222100 BBG000JH6683 510,845 12,752 SH   SOLE   12,752 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 BBG000FTLBV7 393,929 41,952 SH   SOLE   41,952 0 0
iQIYI Inc ADR 46267X108 BBG00K6DZBD3 5,466,049 1,911,206 SH   DFND   1,911,206 0 0
IQVIA Holdings Inc Common Stock 46266C105 BBG00333FYS2 993,615 4,193 SH   DFND   4,193 0 0
Ironwood Pharmaceuticals Inc Common Stock 46333X108 BBG000GBZ3J2 104,998 25,485 SH   SOLE   25,485 0 0
Intuitive Surgical Inc Common Stock 46120E602 BBG000BJPDZ1 2,074,632 4,223 SH   DFND   4,223 0 0
Gartner Inc Common Stock 366651107 BBG000BB65D0 1,197,980 2,364 SH   DFND   2,364 0 0
iShares Core S&P 500 ETF ETP 464287200 BBG000BVZ4F5 13,899,055 24,096 SH   SOLE   24,096 0 0
Janux Therapeutics Inc Common Stock 47103J105 BBG00ZHSKH11 2,957,402 65,098 SH   SOLE   65,098 0 0
Johnson & Johnson Common Stock 478160104 BBG000BMHYD1 2,786,621 17,195 SH   SOLE   17,195 0 0
JPMorgan Chase & Co Common Stock 46625H100 BBG000DMBXR2 4,588,524 21,761 SH   SOLE   21,761 0 0
Keurig Dr Pepper Inc Common Stock 49271V100 BBG000TJM7F0 531,803 14,189 SH   DFND   14,189 0 0
Keysight Technologies Inc Common Stock 49338L103 BBG0059FN811 394,464 2,482 SH   SOLE   2,482 0 0
Kraft Heinz Co/The Common Stock 500754106 BBG005CPNTQ2 438,348 12,485 SH   DFND   12,485 0 0
KLA Corp Common Stock 482480100 BBG000BMTFR4 29,579,364 38,196 SH   DFND   38,196 0 0
Coca-Cola Co/The Common Stock 191216100 BBG000BMX289 1,979,958 27,553 SH   DFND   27,553 0 0
Krystal Biotech Inc Common Stock 501147102 BBG00HDGRHH7 535,350 2,941 SH   SOLE   2,941 0 0
Kymera Therapeutics Inc Common Stock 501575104 BBG00SDHC8D1 2,569,640 54,292 SH   SOLE   54,292 0 0
Kyverna Therapeutics Inc Common Stock 501976104 BBG00RCYMHR1 926,322 189,432 SH   SOLE   189,432 0 0
Legend Biotech Corp ADR 52490G102 BBG00TTGH5W4 5,688,983 116,745 SH   DFND   116,745 0 0
Labcorp Holdings Inc Common Stock 504922105 BBG01MMT6PL7 209,847 939 SH   SOLE   939 0 0
Linde PLC Common Stock G54950103 BBG01FND0CC1 3,659,423 7,674 SH   DFND   7,674 0 0
Eli Lilly & Co Common Stock 532457108 BBG000BNBDC2 4,927,598 5,562 SH   SOLE   5,562 0 0
Lowe's Cos Inc Common Stock 548661107 BBG000BNDN65 224,805 830 SH   SOLE   830 0 0
Lam Research Corp Common Stock 512807306 BBG000BNFLM9 6,034,911 7,395 SH   DFND   7,395 0 0
Lufax Holding Ltd ADR 54975P201 BBG00XS6QZN2 3,903,481 1,118,476 SH   SOLE   1,118,476 0 0
Lululemon Athletica Inc Common Stock 550021109 BBG000R8ZVD1 1,470,716 5,420 SH   DFND   5,420 0 0
Las Vegas Sands Corp Common Stock 517834107 BBG000JWD753 269,067 5,345 SH   SOLE   5,345 0 0
Mastercard Inc Common Stock 57636Q104 BBG000F1ZSQ2 3,858,553 7,814 SH   DFND   7,814 0 0
Marriott International Inc/MD Common Stock 571903202 BBG000BGD7W6 3,353,116 13,488 SH   DFND   13,488 0 0
McDonald's Corp Common Stock 580135101 BBG000BNSZP1 1,467,738 4,820 SH   SOLE   4,820 0 0
Microchip Technology Inc Common Stock 595017104 BBG000BHCP19 1,012,777 12,614 SH   DFND   12,614 0 0
McKesson Corp Common Stock 58155Q103 BBG000DYGNW7 269,458 545 SH   SOLE   545 0 0
Moody's Corp Common Stock 615369105 BBG000F86GP6 619,339 1,305 SH   DFND   1,305 0 0
Madrigal Pharmaceuticals Inc Common Stock 558868105 BBG000QS6NV8 607,585 2,863 SH   SOLE   2,863 0 0
Mondelez International Inc Common Stock 609207105 BBG000D4LWF6 1,065,783 14,467 SH   DFND   14,467 0 0
Medtronic PLC Common Stock G5960L103 BBG000BNWG87 353,817 3,930 SH   SOLE   3,930 0 0
MercadoLibre Inc Common Stock 58733R102 BBG000GQPB11 1,389,176 677 SH   DFND   677 0 0
Meta Platforms Inc Common Stock 30303M102 BBG000MM2P62 17,829,216 31,146 SH   DFND   31,146 0 0
Mirum Pharmaceuticals Inc Common Stock 604749101 BBG00MH7T2M7 214,148 5,491 SH   SOLE   5,491 0 0
MannKind Corp Common Stock 56400P706 BBG000PPL3G9 127,127 20,211 SH   SOLE   20,211 0 0
Monster Beverage Corp Common Stock 61174X109 BBG008NVB1C0 1,041,313 19,960 SH   DFND   19,960 0 0
Molina Healthcare Inc Common Stock 60855R100 BBG000MBHNC8 205,702 597 SH   SOLE   597 0 0
Hello Group Inc ADR 423403104 BBG007HTCQT0 322,360 42,360 SH   SOLE   42,360 0 0
Monolithic Power Systems Inc Common Stock 609839105 BBG000C30L48 638,829 691 SH   SOLE   691 0 0
Merck & Co Inc Common Stock 58933Y105 BBG000BPD168 2,101,995 18,510 SH   SOLE   18,510 0 0
Moderna Inc Common Stock 60770K107 BBG003PHHZT1 1,513,899 22,653 SH   DFND   22,653 0 0
Marvell Technology Inc Common Stock 573874104 BBG00ZXBJ153 611,866 8,484 SH   DFND   8,484 0 0
MSCI Inc Common Stock 55354G100 BBG000RTDY25 1,837,978 3,153 SH   DFND   3,153 0 0
Microsoft Corp Common Stock 594918104 BBG000BPH459 104,377,440 242,569 SH   SOLE   242,569 0 0
Motorola Solutions Inc Common Stock 620076307 BBG000BP8Z50 1,274,700 2,835 SH   DFND   2,835 0 0
Mettler-Toledo International I Common Stock 592688105 BBG000BZCKH3 245,950 164 SH   SOLE   164 0 0
Micron Technology Inc Common Stock 595112103 BBG000C5Z1S3 2,862,188 27,598 SH   DFND   27,598 0 0
Neurocrine Biosciences Inc Common Stock 64125C109 BBG000GJS7C1 1,023,960 8,887 SH   SOLE   8,887 0 0
NextEra Energy Inc Common Stock 65339F101 BBG000BJSBJ0 333,978 3,951 SH   SOLE   3,951 0 0
Netflix Inc Common Stock 64110L106 BBG000CL9VN6 5,017,376 7,074 SH   DFND   7,074 0 0
NIKE Inc Common Stock 654106103 BBG000C5HS04 745,212 8,430 SH   SOLE   8,430 0 0
ServiceNow Inc Common Stock 81762P102 BBG000M1R011 4,440,645 4,965 SH   DFND   4,965 0 0
Norfolk Southern Corp Common Stock 655844108 BBG000BQ5DS5 315,097 1,268 SH   SOLE   1,268 0 0
NetApp Inc Common Stock 64110D104 BBG000FP1N32 375,717 3,042 SH   SOLE   3,042 0 0
Intellia Therapeutics Inc Common Stock 45826J105 BBG007KC7PB0 337,410 16,419 SH   SOLE   16,419 0 0
Natera Inc Common Stock 632307104 BBG001J1BQ86 1,090,119 8,587 SH   SOLE   8,587 0 0
Nuvalent Inc Common Stock 670703107 BBG00Z1SLMK5 281,631 2,753 SH   SOLE   2,753 0 0
Novavax Inc Common Stock 670002401 BBG000NVSBL7 304,648 24,121 SH   SOLE   24,121 0 0
NVIDIA Corp Common Stock 67066G104 BBG000BBJQV0 74,062,127 609,866 SH   DFND   609,866 0 0
NXP Semiconductors NV Common Stock N6596X109 BBG000BND699 1,455,660 6,065 SH   DFND   6,065 0 0
Ocugen Inc Common Stock 67577C105 BBG00194VJB1 50,827 51,227 SH   SOLE   51,227 0 0
Old Dominion Freight Line Inc Common Stock 679580100 BBG000CHSS88 449,324 2,262 SH   DFND   2,262 0 0
ON Semiconductor Corp Common Stock 682189105 BBG000DV7MX4 750,714 10,339 SH   DFND   10,339 0 0
On Holding AG Common Stock H5919C104 BBG00LQK89F6 752,150 14,998 SH   DFND   14,998 0 0
Oracle Corp Common Stock 68389X105 BBG000BQLTW7 5,449,391 31,980 SH   DFND   31,980 0 0
O'Reilly Automotive Inc Common Stock 67103H107 BBG000BGYWY6 1,438,348 1,249 SH   DFND   1,249 0 0
Palo Alto Networks Inc Common Stock 697435105 BBG0014GJCT9 2,631,860 7,700 SH   DFND   7,700 0 0
Paychex Inc Common Stock 704326107 BBG000BQSQ38 513,678 3,828 SH   DFND   3,828 0 0
PACCAR Inc Common Stock 693718108 BBG000BQVTF5 560,700 5,682 SH   DFND   5,682 0 0
Vaxcyte Inc Common Stock 92243G108 BBG009PHHPL8 473,534 4,144 SH   SOLE   4,144 0 0
PDD Holdings Inc ADR 722304102 BBG00LBLDDR2 628,750,065 4,663,972 SH   DFND   4,663,972 0 0
PepsiCo Inc Common Stock 713448108 BBG000DH7JK6 3,738,209 21,983 SH   DFND   21,983 0 0
Pfizer Inc Common Stock 717081103 BBG000BR2B91 1,278,106 44,164 SH   SOLE   44,164 0 0
Procter & Gamble Co/The Common Stock 742718109 BBG000BR2TH3 2,727,380 15,747 SH   SOLE   15,747 0 0
Progressive Corp/The Common Stock 743315103 BBG000BR37X2 224,577 885 SH   SOLE   885 0 0
Palantir Technologies Inc Common Stock 69608A108 BBG000N7QR55 1,081,143 29,063 SH   SOLE   29,063 0 0
Philip Morris International In Common Stock 718172109 BBG000J2XL74 1,264,381 10,415 SH   SOLE   10,415 0 0
Insulet Corp Common Stock 45784P101 BBG000R7XX87 206,682 888 SH   SOLE   888 0 0
PTC Inc Common Stock 69370C100 BBG000C2VBB0 309,831 1,715 SH   SOLE   1,715 0 0
PTC Therapeutics Inc Common Stock 69366J200 BBG000QT15P7 241,372 6,506 SH   SOLE   6,506 0 0
Protagonist Therapeutics Inc Common Stock 74366E102 BBG002B63KM7 3,224,970 71,666 SH   SOLE   71,666 0 0
PayPal Holdings Inc Common Stock 70450Y103 BBG0077VNXV6 867,771 11,121 SH   DFND   11,121 0 0
QUALCOMM Inc Common Stock 747525103 BBG000CGC1X8 5,482,922 32,243 SH   DFND   32,243 0 0
Qifu Technology Inc ADR 88557W101 BBG00MDY4KL0 26,048,216 873,808 SH   DFND   873,808 0 0
Ultragenyx Pharmaceutical Inc Common Stock 90400D108 BBG001RWPDW6 351,242 6,323 SH   SOLE   6,323 0 0
Royal Caribbean Cruises Ltd Common Stock V7780T103 BBG000BB5792 1,365,672 7,700 SH   SOLE   7,700 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 BBG000C734W3 2,385,263 2,269 SH   DFND   2,269 0 0
RH Common Stock 74967X103 BBG002293PJ4 994,594 2,974 SH   SOLE   2,974 0 0
iShares MSCI Global Gold Miner ETP 46434G855 BBG002GKR6T9 4,132,620 125,193 SH   SOLE   125,193 0 0
Relay Therapeutics Inc Common Stock 75943R102 BBG00DSS08K9 81,774 11,550 SH   SOLE   11,550 0 0
ResMed Inc Common Stock 761152107 BBG000L4M7F1 232,890 954 SH   SOLE   954 0 0
Avidity Biosciences Inc Common Stock 05370A108 BBG00FQ7LXW1 587,490 12,791 SH   SOLE   12,791 0 0
Roivant Sciences Ltd Common Stock G76279101 BBG007STW2B8 485,972 42,112 SH   SOLE   42,112 0 0
Roper Technologies Inc Common Stock 776696106 BBG000F1ZSN5 1,408,349 2,531 SH   DFND   2,531 0 0
Ross Stores Inc Common Stock 778296103 BBG000BSBZH7 544,996 3,621 SH   DFND   3,621 0 0
RTX Corp Common Stock 75513E101 BBG000BW8S60 243,168 2,007 SH   SOLE   2,007 0 0
REVOLUTION Medicines Inc Common Stock 76155X100 BBG00829F4P8 489,054 10,784 SH   SOLE   10,784 0 0
Revvity Inc Common Stock 714046109 BBG000FXW512 210,148 1,645 SH   SOLE   1,645 0 0
Recursion Pharmaceuticals Inc Common Stock 75629V104 BBG00PQ4XJ45 286,124 43,418 SH   SOLE   43,418 0 0
Rhythm Pharmaceuticals Inc Common Stock 76243J105 BBG007DLZ601 217,366 4,149 SH   SOLE   4,149 0 0
Sana Biotechnology Inc Common Stock 799566104 BBG00N5BMH61 85,654 20,590 SH   SOLE   20,590 0 0
Starbucks Corp Common Stock 855244109 BBG000CTQBF3 1,192,887 12,236 SH   SOLE   12,236 0 0
Scilex Holding Co Common Stock 80880W106 BBG00YJTT4L8 29,061 31,431 SH   SOLE   31,431 0 0
Sherwin-Williams Co/The Common Stock 824348106 BBG000BSXQV7 243,886 639 SH   DFND   639 0 0
Schlumberger NV Common Stock 806857108 BBG000BT41Q8 495,303 11,807 SH   DFND   11,807 0 0
Super Micro Computer Inc Common Stock 86800U302 BBG000MYZDJ3 535,906 1,287 SH   SOLE   1,287 0 0
Summit Therapeutics Inc Common Stock 86627T108 BBG00X3GQL76 6,156,199 281,105 SH   SOLE   281,105 0 0
Syndax Pharmaceuticals Inc Common Stock 87164F105 BBG000R33JY1 212,135 11,020 SH   SOLE   11,020 0 0
Synopsys Inc Common Stock 871607107 BBG000BSFRF3 2,749,697 5,430 SH   DFND   5,430 0 0
Sohu.com Ltd ADR 83410S108 BBG00L2DB535 312,449 19,838 SH   SOLE   19,838 0 0
S&P Global Inc Common Stock 78409V104 BBG000BP1Q11 1,028,590 1,991 SH   DFND   1,991 0 0
SPDR Portfolio Long Term Trea ETP 78464A664 BBG000RFRG83 2,228,245 76,651 SH   SOLE   76,651 0 0
SPDR S&P 500 ETF Trust ETP 78462F103 BBG000BDTBL9 9,110,735 15,879 SH   SOLE   15,879 0 0
Sarepta Therapeutics Inc Common Stock 803607100 BBG000BCJ161 1,088,541 8,716 SH   SOLE   8,716 0 0
STAAR Surgical Co Common Stock 852312305 BBG000C4QB95 2,579,361 69,431 SH   SOLE   69,431 0 0
STERIS PLC Common Stock G8473T100 BBG00MRHG523 216,588 893 SH   SOLE   893 0 0
Seagate Technology Holdings PL Common Stock G7997R103 BBG0113JGQF0 314,789 2,874 SH   SOLE   2,874 0 0
Savara Inc Common Stock 805111101 BBG000MS0823 45,800 10,802 SH   SOLE   10,802 0 0
Skyworks Solutions Inc Common Stock 83088M102 BBG000KLB4Q1 226,973 2,298 SH   SOLE   2,298 0 0
SpringWorks Therapeutics Inc Common Stock 85205L107 BBG00Q011TW9 284,290 8,873 SH   SOLE   8,873 0 0
Stryker Corp Common Stock 863667101 BBG000DN7P92 361,260 1,000 SH   SOLE   1,000 0 0
AT&T Inc Common Stock 00206R102 BBG000BSJK37 237,929 10,815 SH   SOLE   10,815 0 0
TAL Education Group ADR 874080104 BBG0016XJ8S0 33,114,396 2,796,824 SH   DFND   2,796,824 0 0
Trip.com Group Ltd ADR 89677Q107 BBG000CWKYS8 2,010,636 33,832 SH   DFND   33,832 0 0
Teledyne Technologies Inc Common Stock 879360105 BBG000BMT9T6 305,486 698 SH   SOLE   698 0 0
Atlassian Corp Common Stock 049468101 BBG01BGWHFR5 237,103 1,493 SH   DFND   1,493 0 0
Bio-Techne Corp Common Stock 09073M104 BBG000C15114 210,056 2,628 SH   SOLE   2,628 0 0
TE Connectivity PLC Common Stock G87052109 BBG01Q08MMR1 652,578 4,322 SH   SOLE   4,322 0 0
Teradyne Inc Common Stock 880770102 BBG000BV4DR6 299,869 2,239 SH   SOLE   2,239 0 0
Teleflex Inc Common Stock 879369106 BBG000BV59Y6 201,071 813 SH   SOLE   813 0 0
TG Therapeutics Inc Common Stock 88322Q108 BBG000FVZQY1 510,907 21,843 SH   SOLE   21,843 0 0
TJX Cos Inc/The Common Stock 872540109 BBG000BV8DN6 750,375 6,384 SH   DFND   6,384 0 0
iShares TR ETP 464287432 BBG000BJKYW3 5,164,082 52,641 SH   SOLE   52,641 0 0
Tencent Music Entertainment G ADR 88034P109 BBG00LDC5RK5 47,837,547 3,969,921 SH   DFND   3,969,921 0 0
Thermo Fisher Scientific Inc Common Stock 883556102 BBG000BVDLH9 3,489,972 5,642 SH   DFND   5,642 0 0
T-Mobile US Inc Common Stock 872590104 BBG000NDV1D4 2,398,521 11,623 SH   DFND   11,623 0 0
Toll Brothers Inc Common Stock 889478103 BBG000BVHBM1 735,063 4,758 SH   SOLE   4,758 0 0
Tapestry Inc Common Stock 876030107 BBG000BY29C7 589,317 12,544 SH   SOLE   12,544 0 0
Thomson Reuters Corp Common Stock 884903808 BBG000BBS9F6 451,919 2,649 SH   SOLE   2,649 0 0
Trimble Inc Common Stock 896239100 BBG000BNPS52 223,586 3,601 SH   SOLE   3,601 0 0
Tesla Inc Common Stock 88160R101 BBG000N9MNX3 13,328,478 50,944 SH   DFND   50,944 0 0
TSMC ADR 874039100 BBG000BD8ZK0 62,070,179 357,403 SH   DFND   357,403 0 0
Trane Technologies PLC Common Stock G8994E103 BBG000BM6788 521,286 1,341 SH   SOLE   1,341 0 0
Trade Desk Inc/The Common Stock 88339J105 BBG00629NGT2 457,898 4,176 SH   DFND   4,176 0 0
Take-Two Interactive Software Common Stock 874054109 BBG000BS1YV5 284,210 1,849 SH   DFND   1,849 0 0
Twist Bioscience Corp Common Stock 90184D100 BBG006KDCHJ4 403,818 8,938 SH   SOLE   8,938 0 0
Texas Instruments Inc Common Stock 882508104 BBG000BVV7G1 5,500,339 26,627 SH   DFND   26,627 0 0
Tyler Technologies Inc Common Stock 902252105 BBG000BVWZF9 361,322 619 SH   SOLE   619 0 0
Uber Technologies Inc Common Stock 90353T100 BBG002B04MT8 308,156 4,100 SH   DFND   4,100 0 0
Universal Health Services Inc Common Stock 913903100 BBG000CB8Q50 201,528 880 SH   SOLE   880 0 0
UnitedHealth Group Inc Common Stock 91324P102 BBG000CH5208 3,970,562 6,791 SH   DFND   6,791 0 0
Union Pacific Corp Common Stock 907818108 BBG000BW3299 317,712 1,289 SH   SOLE   1,289 0 0
United Rentals Inc Common Stock 911363109 BBG000BXMFC3 212,149 262 SH   DFND   262 0 0
United Therapeutics Corp Common Stock 91307C102 BBG000BV4XJ1 1,148,153 3,204 SH   SOLE   3,204 0 0
Visa Inc Common Stock 92826C839 BBG000PSKYX7 3,010,702 10,950 SH   SOLE   10,950 0 0
Vera Therapeutics Inc Common Stock 92337R101 BBG00Q72WYG3 224,226 5,073 SH   SOLE   5,073 0 0
Verve Therapeutics Inc Common Stock 92539P101 BBG00P33TCZ8 65,601 13,554 SH   SOLE   13,554 0 0
Vanguard Long-Term Treasury E ETP 92206C847 BBG000PX0M82 2,400,122 39,001 SH   SOLE   39,001 0 0
Vipshop Holdings Ltd ADR 92763W103 BBG002NLDLV8 33,508,423 2,130,224 SH   DFND   2,130,224 0 0
Vir Biotechnology Inc Common Stock 92764N102 BBG00H2QQ8T5 83,663 11,170 SH   SOLE   11,170 0 0
Viking Therapeutics Inc Common Stock 92686J106 BBG006LGV869 1,030,686 16,280 SH   SOLE   16,280 0 0
Verisk Analytics Inc Common Stock 92345Y106 BBG000BCZL41 413,462 1,543 SH   DFND   1,543 0 0
VeriSign Inc Common Stock 92343E102 BBG000BGKHZ3 236,690 1,246 SH   SOLE   1,246 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100 BBG000C1S2X2 2,513,757 5,405 SH   DFND   5,405 0 0
Viatris Inc Common Stock 92556V106 BBG00Y4RQNH4 202,315 17,426 SH   SOLE   17,426 0 0
Verizon Communications Inc Common Stock 92343V104 BBG000HS77T5 1,266,506 28,201 SH   SOLE   28,201 0 0
Waters Corp Common Stock 941848103 BBG000FQRVM3 229,609 638 SH   SOLE   638 0 0
Weibo Corp ADR 948596101 BBG0065XPGX9 418,481 41,516 SH   SOLE   41,516 0 0
Warner Bros Discovery Inc Common Stock 934423104 BBG011386VF4 213,418 25,869 SH   DFND   25,869 0 0
Workday Inc Common Stock 98138H101 BBG000VC0T95 485,397 1,986 SH   DFND   1,986 0 0
Western Digital Corp Common Stock 958102105 BBG000BWNFZ9 328,679 4,813 SH   SOLE   4,813 0 0
Wells Fargo & Co Common Stock 949746101 BBG000BWQFY7 1,345,591 23,820 SH   SOLE   23,820 0 0
Walmart Inc Common Stock 931142103 BBG000BWXBC2 2,370,577 29,357 SH   SOLE   29,357 0 0
Williams-Sonoma Inc Common Stock 969904101 BBG000FSMWC3 789,782 5,098 SH   SOLE   5,098 0 0
West Pharmaceutical Services I Common Stock 955306105 BBG000BX24N8 215,214 717 SH   SOLE   717 0 0
Xcel Energy Inc Common Stock 98389B100 BBG000BCTQ65 394,150 6,036 SH   DFND   6,036 0 0
Exxon Mobil Corp Common Stock 30231G102 BBG000GZQ728 3,502,768 29,882 SH   SOLE   29,882 0 0
Full Truck Alliance Co Ltd ADR 35969L108 BBG01186DLS3 47,058,130 5,222,878 SH   SOLE   5,222,878 0 0
JOYY Inc ADR 46591M109 BBG003H0XV18 3,772,511 104,098 SH   DFND   104,098 0 0
Zimmer Biomet Holdings Inc Common Stock 98956P102 BBG000BKPL53 218,274 2,022 SH   SOLE   2,022 0 0
Zebra Technologies Corp Common Stock 989207105 BBG000CC7LQ7 271,814 734 SH   SOLE   734 0 0
Zhihu Inc ADR 98955N207 BBG00ZKGL1K6 317,202 82,390 SH   SOLE   82,390 0 0
Zscaler Inc Common Stock 98980G102 BBG003338H34 241,025 1,410 SH   DFND   1,410 0 0
Zoetis Inc Common Stock 98978V103 BBG0039320N9 318,664 1,631 SH   SOLE   1,631 0 0