The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101   3,339,687 25,871 SH   SOLE   25,871 0 0
ABBOTT LABS COM 002824100   2,497,356 22,079 SH   SOLE   22,079 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206   2,275,813 408,584 SH   SOLE   408,584 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500   766,814 217,845 SH   SOLE   217,845 0 0
ADMA BIOLOGICS INC COM 000899104   6,605,974 385,188 SH   SOLE   385,188 0 0
AGILON HEALTH INC COM 00857U107   209,988 110,520 SH   SOLE   110,520 0 0
AGNC INVT CORP COM 00123Q104   1,322,096 143,550 SH   SOLE   143,550 0 0
AKERO THERAPEUTICS INC COM 00973Y108   7,363,314 264,677 SH   SOLE   264,677 0 0
ALIGNMENT HEALTHCARE INC COM 01625V104   1,493,708 132,774 SH   SOLE   132,774 0 0
ANNALY CAPITAL MANAGEMENT IN COM NEW 035710839   1,469,014 80,274 SH   SOLE   80,274 0 0
APPLIED THERAPEUTICS INC COM 03828A101   2,412,348 2,817,505 SH   SOLE   2,817,505 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   10,340,225 742,299 SH   SOLE   742,299 0 0
ARDELYX INC COM 039697107   3,495,075 689,364 SH   SOLE   689,364 0 0
ARGENX SE SPONSORED ADR 04016X101   990,765 1,611 SH   SOLE   1,611 0 0
ARMOUR RESIDENTIAL REIT INC COM SHS 042315705   518,650 27,500 SH   SOLE   27,500 0 0
ATHIRA PHARMA INC COM 04746L104   875,821 1,492,792 SH   SOLE   1,492,792 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   3,635,000 125,000 SH   SOLE   125,000 0 0
BENITEC BIOPHARMA INC COM NEW 08205P209   964,136 76,337 SH   SOLE   76,337 0 0
CARDINAL HEALTH INC COM 14149Y108   718,481 6,101 SH   SOLE   6,101 0 0
CENTRAL & EASTERN EUROPE FD COM 153436100   264,646 24,235 SH   SOLE   24,235 0 0
CHEWY INC CL A 16679L109   2,458,534 73,411 SH   SOLE   73,411 0 0
CHIMERA INVT CORP COM SHS 16934Q802   359,800 25,700 SH   SOLE   25,700 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   53,857 14,248 SH   SOLE   14,248 0 0
COOPER COS INC COM 216648501   1,451,850 15,793 SH   SOLE   15,793 0 0
CVS HEALTH CORP COM 126650100   409,127 9,114 SH   SOLE   9,114 0 0
DANAHER CORPORATION COM 235851102   313,336 1,365 SH   SOLE   1,365 0 0
DELCATH SYS INC COM NEW 24661P807   204,680 17,000 SH   SOLE   17,000 0 0
DEXCOM INC COM 252131107   8,197,347 105,405 SH   SOLE   105,405 0 0
DIREXION SHS ETF TR DAILY TSLA 2X SH 25460G286   5,013,819 182,122 SH   SOLE   182,122 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108   5,978,515 80,758 SH   SOLE   80,758 0 0
ELI LILLY & CO COM 532457108   6,646,148 8,609 SH   SOLE   8,609 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   2,962,301 64,300 SH   SOLE   64,300 0 0
FULCRUM THERAPEUTICS INC COM 359616109   379,356 80,714 SH   SOLE   80,714 0 0
GILEAD SCIENCES INC COM 375558103   4,264,446 46,167 SH   SOLE   46,167 0 0
GRANITESHARES ETF TR 2X LONG TSLA DAI 38747R777   817,814 18,909 SH   SOLE   18,909 0 0
GRAYSCALE BITCOIN MINI TR ET SHS NEW 389930207   4,159,743 99,349 SH   SOLE   99,349 0 0
INSMED INC COM PAR $.01 457669307   1,416,701 20,520 SH   SOLE   20,520 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   1,692,783 20,268 SH   SOLE   20,268 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   7,039,675 13,487 SH   SOLE   13,487 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101   41,527,500 750,000 SH Call SOLE   750,000 0 0
ISHARES TR CORE US AGGBD ET 464287226   224,772,922 2,319,638 SH   SOLE   2,319,638 0 0
ISHARES TR CORE S&P500 ETF 464287200   581,179,039 987,258 SH   SOLE   987,258 0 0
ISHARES TR CORE S&P SCP ETF 464287804   2,221,442 19,280 SH   SOLE   19,280 0 0
JASPER THERAPEUTICS INC COM NEW 471871202   427,600 20,000 SH   SOLE   20,000 0 0
JOHNSON & JOHNSON COM 478160104   6,220,540 43,013 SH   SOLE   43,013 0 0
KURA ONCOLOGY INC COM 50127T109   696,800 80,000 SH   SOLE   80,000 0 0
KYMERA THERAPEUTICS INC COM 501575104   1,227,618 30,515 SH   SOLE   30,515 0 0
LEAP THERAPEUTICS INC COM NEW 52187K200   2,719,882 946,046 SH   SOLE   946,046 0 0
LIVANOVA PLC SHS G5509L101   435,175 9,397 SH   SOLE   9,397 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   7,190,298 23,302 SH   SOLE   23,302 0 0
MICROSTRATEGY INC CL A NEW 594972408   95,343,178 317,800 SH Put SOLE   317,800 0 0
PACIRA BIOSCIENCES INC COM 695127100   711,059 37,742 SH   SOLE   37,742 0 0
PENNYMAC MTG INVT TR COM 70931T103   725,184 57,600 SH   SOLE   57,600 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   4,725,312 581,935 SH   SOLE   581,935 0 0
PIMCO ETF TR ENHAN SHRT MA AC 72201R833   25,265,612 251,800 SH   SOLE   251,800 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207   23,385,977 1,272,360 SH   SOLE   1,272,360 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   3,315,822 43,085 SH   SOLE   43,085 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103   11,902,382 1,161,208 SH   SOLE   1,161,208 0 0
QURATE RETAIL INC COM SER A 74915M100   198,000 600,000 SH   SOLE   600,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107   4,457,761 6,258 SH   SOLE   6,258 0 0
RESMED INC COM 761152107   6,892,945 30,141 SH   SOLE   30,141 0 0
REVVITY INC COM 714046109   1,776,831 15,920 SH   SOLE   15,920 0 0
RITHM CAPITAL CORP COM NEW 64828T201   1,903,697 175,780 SH   SOLE   175,780 0 0
SANOFI SPONSORED ADR 80105N105   1,947,865 40,387 SH   SOLE   40,387 0 0
SAREPTA THERAPEUTICS INC COM 803607100   3,985,599 32,779 SH   SOLE   32,779 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND E 82889N723   107,136,830 5,193,254 SH   SOLE   5,193,254 0 0
SIMPLIFY EXCHANGE TRADED FUN TREASURY OPT INC 82889N640   109,168,129 4,448,579 SH   SOLE   4,448,579 0 0
SIMPLIFY EXCHANGE TRADED FUN MANAGED FUTURES 82889N699   3,915,142 140,378 SH   SOLE   140,378 0 0
SIMPLIFY EXCHANGE TRADED FUN MULTI QIS ALTERN 82889N533   3,975,692 162,293 SH   SOLE   162,293 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQUITY PLUS 82889N517   913,293 33,592 SH   SOLE   33,592 0 0
SIMPLIFY EXCHANGE TRADED FUN SHORT TERM TREA 82889N657   3,615,527 170,383 SH   SOLE   170,383 0 0
SIMPLIFY EXCHANGE TRADED FUN WOLFE US EQUITY 82889N434   1,561,940 59,800 SH   SOLE   59,800 0 0
SIMPLIFY EXCHANGE TRADED FUN INTMD TERM TRSRY 82889N798   47,172,753 3,843,182 SH   SOLE   3,843,182 0 0
SIMPLIFY EXCHANGE TRADED FUN NEXT INTANGIBLE 82889N467   680,604 26,999 SH   SOLE   26,999 0 0
SIMPLIFY EXCHANGE TRADED FUN HIGH YIELD PLUS 82889N830   28,339,761 1,299,393 SH   SOLE   1,299,393 0 0
SIMPLIFY EXCHANGE TRADED FUN NATL MUNI BD ETF 82889N442   75,811,461 3,126,710 SH   SOLE   3,126,710 0 0
SIMPLIFY EXCHANGE TRADED FUN NEXT INTANGIBLE 82889N475   757,160 26,999 SH   SOLE   26,999 0 0
SPDR GOLD TR GOLD SHS 78463V107   449,094,058 1,829,900 SH Put SOLE   1,829,900 0 0
STRYKER CORPORATION COM 863667101   434,220 1,206 SH   SOLE   1,206 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   1,951,814 147,641 SH   SOLE   147,641 0 0
TELEFLEX INCORPORATED COM 879369106   2,267,821 12,742 SH   SOLE   12,742 0 0
TESLA INC COM 88160R101   5,060,519 12,531 SH   SOLE   12,531 0 0
TG THERAPEUTICS INC COM 88322Q108   338,234 11,237 SH   SOLE   11,237 0 0
THE CIGNA GROUP COM 125523100   3,465,833 12,551 SH   SOLE   12,551 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   4,694,035 9,023 SH   SOLE   9,023 0 0
TSCAN THERAPEUTICS INC COM 89854M101   3,182,625 1,046,916 SH   SOLE   1,046,916 0 0
TWO HBRS INVT CORP COM 90187B804   130,130 11,000 SH   SOLE   11,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   707,197 16,810 SH   SOLE   16,810 0 0
UNITEDHEALTH GROUP INC COM 91324P102   6,099,154 12,057 SH   SOLE   12,057 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   1,888,260 4,689 SH   SOLE   4,689 0 0
ZEVRA THERAPEUTICS INC COM NEW 488445206   1,000,800 120,000 SH   SOLE   120,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   243,688 2,307 SH   SOLE   2,307 0 0