The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 31,417 3,776,121 SH   SOLE   3,776,121 0 0
AGENUS INC COM NEW 00847G705 25,496 9,373,582 SH   SOLE   9,373,582 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 12,947 2,084,839 SH   SOLE   2,084,839 0 0
ANTARES PHARMA INC COM 036642106 7,809 1,900,000 SH   SOLE   1,900,000 0 0
ASPIRA WOMENS HEALTH INC COM 04537Y109 58,368 8,647,094 SH   SOLE   8,647,094 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 24,079 2,367,670 SH   SOLE   2,367,670 0 0
BIODESIX INC COM 09075X108 4,783 235,511 SH   SOLE   235,511 0 0
BIOGEN INC COM 09062X103 675 2,412 SH   SOLE   2,412 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 145,126 2,123,271 SH   SOLE   2,123,271 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 17 33,600 SH Put SOLE   33,600 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 9,357 1,999,464 SH   SOLE   1,999,464 0 0
CODIAK BIOSCIENCES INC COM 192010106 8,224 545,360 SH   SOLE   545,360 0 0
CONTRAFECT CORP COM NEW 212326300 7,452 1,552,423 SH   SOLE   1,552,423 0 0
DERMTECH INC COM 24984K105 36,243 713,577 SH   SOLE   713,577 0 0
DERMTECH INC COM 24984K105 356 46,900 SH Put SOLE   46,900 0 0
FORIAN INC COM 34630N106 1,571 155,440 SH   SOLE   155,440 0 0
MOTUS GI HLDGS INC COM 62014P108 4,535 3,747,551 SH   SOLE   3,747,551 0 0
OPKO HEALTH INC COM 68375N103 55,003 12,821,273 SH   SOLE   12,821,273 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 48,182 1,446,459 SH   SOLE   1,446,459 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 505 100,000 SH Put SOLE   100,000 0 0
QUIDEL CORP COM 74838J101 139,483 1,090,309 SH   SOLE   1,090,309 0 0
QUIDEL CORP COM 74838J101 363 50,000 SH Put SOLE   50,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 7,673 225,000 SH   SOLE   225,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 585 100,000 SH Put SOLE   100,000 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 2,686 2,132,000 SH   SOLE   2,132,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 23,088 450,331 SH   SOLE   450,331 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 221 19,000 SH Put SOLE   19,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 11,511 380,642 SH   SOLE   380,642 0 0