The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 41,686 | 1,900,000 | SH | SOLE | 1,900,000 | 0 | 0 | ||
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 23,340 | 1,000,000 | SH | Call | SOLE | 1,000,000 | 0 | 0 | |
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 | 13,067 | 1,933,040 | SH | SOLE | 1,933,040 | 0 | 0 | ||
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 1,984 | 11,700 | SH | Put | SOLE | 11,700 | 0 | 0 | |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 10,762 | 80,000 | SH | SOLE | 80,000 | 0 | 0 | ||
| ASSEMBLY BIOSCIENCES INC | COM | 045396108 | 6,990 | 3,000,000 | SH | SOLE | 3,000,000 | 0 | 0 | ||
| ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 11,820 | 750,000 | SH | SOLE | 750,000 | 0 | 0 | ||
| ATYR PHARMA INC | COM NEW | 002120202 | 8,217 | 1,100,000 | SH | SOLE | 1,100,000 | 0 | 0 | ||
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 23,770 | 1,000,000 | SH | SOLE | 1,000,000 | 0 | 0 | ||
| AVROBIO INC | COM | 05455M100 | 4,043 | 1,050,132 | SH | SOLE | 1,050,132 | 0 | 0 | ||
| BEAM THERAPEUTICS INC | COM | 07373V105 | 55,783 | 700,000 | SH | SOLE | 700,000 | 0 | 0 | ||
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 66,957 | 1,100,000 | SH | SOLE | 1,100,000 | 0 | 0 | ||
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 6,672 | 400,000 | SH | Call | SOLE | 400,000 | 0 | 0 | |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 4,504 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| CENTURY THERAPEUTICS INC | COM | 15673T100 | 3,965 | 250,000 | SH | SOLE | 250,000 | 0 | 0 | ||
| CHINOOK THERAPEUTICS INC | COM | 16961L106 | 39,478 | 2,420,502 | SH | SOLE | 2,420,502 | 0 | 0 | ||
| CONNECT BIOPHARMA HLDGS LTD | ADS | 207523101 | 3,332 | 647,057 | SH | SOLE | 647,057 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 53,979 | 1,900,000 | SH | SOLE | 1,900,000 | 0 | 0 | ||
| DICE THERAPEUTICS INC | COM | 23345J104 | 33,941 | 1,341,004 | SH | SOLE | 1,341,004 | 0 | 0 | ||
| DYNE THERAPEUTICS INC | COM | 26818M108 | 27,255 | 2,292,250 | SH | SOLE | 2,292,250 | 0 | 0 | ||
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 28,208 | 5,641,668 | SH | SOLE | 5,641,668 | 0 | 0 | ||
| FATE THERAPEUTICS INC | COM | 31189P102 | 24,459 | 418,037 | SH | SOLE | 418,037 | 0 | 0 | ||
| FULCRUM THERAPEUTICS INC | COM | 359616109 | 13,268 | 750,000 | SH | SOLE | 750,000 | 0 | 0 | ||
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 11,651 | 499,400 | SH | SOLE | 499,400 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 58,540 | 2,000,000 | SH | SOLE | 2,000,000 | 0 | 0 | ||
| GRITSTONE BIO INC | COM | 39868T105 | 22,785 | 1,771,801 | SH | SOLE | 1,771,801 | 0 | 0 | ||
| IMMUNOVANT INC | COM | 45258J102 | 40,683 | 4,775,000 | SH | SOLE | 4,775,000 | 0 | 0 | ||
| IVERIC BIO INC | COM | 46583P102 | 66,880 | 4,000,000 | SH | SOLE | 4,000,000 | 0 | 0 | ||
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 63,700 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| JOUNCE THERAPEUTICS INC | COM | 481116101 | 33,400 | 4,000,000 | SH | SOLE | 4,000,000 | 0 | 0 | ||
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 19,845 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 17,056 | 130,200 | SH | SOLE | 130,200 | 0 | 0 | ||
| KEROS THERAPEUTICS INC | COM | 492327101 | 76,063 | 1,300,000 | SH | SOLE | 1,300,000 | 0 | 0 | ||
| KURA ONCOLOGY INC | COM | 50127T109 | 35,700 | 2,550,000 | SH | SOLE | 2,550,000 | 0 | 0 | ||
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 42,370 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| MAGENTA THERAPEUTICS INC | COM | 55910K108 | 21,574 | 4,870,000 | SH | SOLE | 4,870,000 | 0 | 0 | ||
| NEKTAR THERAPEUTICS | COM | 640268108 | 6,755 | 500,000 | SH | Put | SOLE | 500,000 | 0 | 0 | |
| NKARTA INC | COM | 65487U108 | 19,409 | 1,264,426 | SH | SOLE | 1,264,426 | 0 | 0 | ||
| NOVOCURE LTD | ORD SHS | G6674U108 | 41,294 | 550,000 | SH | SOLE | 550,000 | 0 | 0 | ||
| ONCORUS INC | COM | 68236R103 | 3,162 | 600,000 | SH | SOLE | 600,000 | 0 | 0 | ||
| PASSAGE BIO INC | COM | 702712100 | 20,428 | 3,216,997 | SH | SOLE | 3,216,997 | 0 | 0 | ||
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 14,421 | 421,660 | SH | SOLE | 421,660 | 0 | 0 | ||
| RAFAEL HLDGS INC | COM CL B | 75062E106 | 1,457 | 285,714 | SH | SOLE | 285,714 | 0 | 0 | ||
| REPARE THERAPEUTICS INC | COM | 760273102 | 44,289 | 2,100,000 | SH | SOLE | 2,100,000 | 0 | 0 | ||
| SAGE THERAPEUTICS INC | COM | 78667J108 | 17,016 | 400,000 | SH | Call | SOLE | 400,000 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 21,270 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM NEW | 82640U404 | 13,209 | 607,600 | SH | SOLE | 607,600 | 0 | 0 | ||
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 22,715 | 950,798 | SH | SOLE | 950,798 | 0 | 0 | ||
| TENAYA THERAPEUTICS INC | COM | 87990A106 | 14,446 | 762,317 | SH | SOLE | 762,317 | 0 | 0 | ||
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | 76,048 | 2,450,000 | SH | SOLE | 2,450,000 | 0 | 0 | ||
| TRICIDA INC | COM | 89610F101 | 22,324 | 2,335,143 | SH | SOLE | 2,335,143 | 0 | 0 | ||
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 7,845 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 7,845 | 500,000 | SH | Call | SOLE | 500,000 | 0 | 0 | |
| VERVE THERAPEUTICS INC | COM | 92539P101 | 18,435 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 26,426 | 1,336,690 | SH | SOLE | 1,336,690 | 0 | 0 | ||