The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adobe Inc Common Stock 00724F101 7,911 23,986 SH   SOLE   23,986 0 0
Aerojet Rocketdyne Holdings In Common Stock 007800105 288 6,308 SH   SOLE   6,308 0 0
Advanced Micro Devices Inc Common Stock 007903107 8,715 190,039 SH   SOLE   190,039 0 0
AeroVironment Inc Common Stock 008073108 11,288 182,832 SH   SOLE   101,984 0 80,848
Alibaba Group Holding Ltd ADR 01609W102 32,259 152,094 SH   SOLE   112,503 10,741 28,850
Align Technology Inc Common Stock 016255101 533 1,911 SH   SOLE   1,911 0 0
Allegheny Technologies Inc Common Stock 01741R102 41 1,995 SH   SOLE   1,995 0 0
Alphabet Inc Common Stock 02079K305 2,760 2,061 SH   SOLE   2,061 0 0
Altair Engineering Inc Common Stock 021369103 997 27,758 SH   SOLE   27,758 0 0
Amazon.com Inc Common Stock 023135106 20,796 11,254 SH   SOLE   9,508 0 1,746
AMETEK Inc Common Stock 031100100 461 4,621 SH   SOLE   4,621 0 0
ANSYS Inc Common Stock 03662Q105 3,586 13,930 SH   SOLE   13,930 0 0
Apple Inc Common Stock 037833100 21,030 71,615 SH   SOLE   51,317 0 20,298
AquaBounty Technologies Inc Common Stock 03842K200 882 406,682 SH   SOLE   406,682 0 0
Arconic Inc Common Stock 03965L100 337 10,954 SH   SOLE   10,954 0 0
Arcturus Therapeutics Holdings Common Stock 03969T109 15,041 1,383,756 SH   SOLE   1,383,756 0 0
Autodesk Inc Common Stock 052769106 37,673 205,347 SH   SOLE   158,036 15,282 32,029
Baidu Inc ADR 056752108 12,878 101,885 SH   SOLE   101,885 0 0
Renishaw PLC Common Stock G75006117 2,397 47,956 SH   SOLE   47,956 0 0
Bellicum Pharmaceuticals Inc Common Stock 079481107 538 417,433 SH   SOLE   417,433 0 0
Bristol-Myers Squibb Co Common Stock 110122108 3,406 53,054 SH   SOLE   7,037 42,499 3,518
CareDx Inc Common Stock 14167L103 12,196 565,438 SH   SOLE   565,438 0 0
Carpenter Technology Corp Common Stock 144285103 39 785 SH   SOLE   785 0 0
Castle Biosciences Inc Common Stock 14843C105 7,081 206,014 SH   SOLE   206,014 0 0
Cellectis SA ADR 15117K103 22,975 1,342,001 SH   SOLE   1,197,781 134,034 10,186
Cellular Biomedicine Group Inc Common Stock 15117P102 6,689 411,880 SH   SOLE   411,880 0 0
Cerus Corp Common Stock 157085101 39,737 9,416,460 SH   SOLE   7,558,293 165,930 1,692,237
Cloudera Inc Common Stock 18914U100 16,144 1,388,111 SH   SOLE   909,618 0 478,493
Codexis Inc Common Stock 192005106 10,935 683,855 SH   SOLE   675,727 8,128 0
Cognex Corp Common Stock 192422103 2,614 46,649 SH   SOLE   46,649 0 0
Conformis Inc Common Stock 20717E101 638 425,240 SH   SOLE   425,240 0 0
Deere & Co Common Stock 244199105 1,885 10,880 SH   SOLE   10,880 0 0
DuPont de Nemours Inc Common Stock 26614N102 40 617 SH   SOLE   617 0 0
Eastman Chemical Co Common Stock 277432100 45 563 SH   SOLE   563 0 0
Eastman Kodak Co Common Stock 277461406 79 17,072 SH   SOLE   17,072 0 0
Editas Medicine Inc Common Stock 28106W103 131,684 4,447,277 SH   SOLE   3,397,873 322,639 726,765
Eventbrite Inc Common Stock 29975E109 37,638 1,866,050 SH   SOLE   1,498,299 126,554 241,197
ExOne Co/The Common Stock 302104104 17,686 2,370,763 SH   SOLE   1,989,944 0 380,819
FLIR Systems Inc Common Stock 302445101 2,408 46,253 SH   SOLE   46,253 0 0
Facebook Inc Common Stock 30303M102 1,028 5,010 SH   SOLE   5,010 0 0
FARO Technologies Inc Common Stock 311642102 435 8,640 SH   SOLE   8,640 0 0
Fate Therapeutics Inc Common Stock 31189P102 8,437 431,128 SH   SOLE   431,128 0 0
General Electric Co Common Stock 369604103 372 33,337 SH   SOLE   33,337 0 0
General Motors Co Common Stock 37045V100 1,517 41,437 SH   SOLE   41,437 0 0
Grayscale Bitcoin Trust BTC Open-End Fund 389637109 19,241 2,349,322 SH   SOLE   1,064,987 472,999 811,336
Guardant Health Inc Common Stock 40131M109 11,862 151,807 SH   SOLE   151,807 0 0
Guidewire Software Inc Common Stock 40171V100 1,825 16,630 SH   SOLE   16,630 0 0
HDFC Bank Ltd ADR 40415F101 2,059 32,498 SH   SOLE   32,498 0 0
HP Inc Common Stock 40434L105 2,443 118,859 SH   SOLE   118,859 0 0
Hexcel Corp Common Stock 428291108 39 534 SH   SOLE   534 0 0
HubSpot Inc Common Stock 443573100 9,443 59,580 SH   SOLE   59,580 0 0
Illumina Inc Common Stock 452327109 241,420 727,740 SH   SOLE   559,556 51,573 116,611
Incyte Corp Common Stock 45337C102 11,778 134,882 SH   SOLE   134,882 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 15,130 4,584,966 SH   SOLE   4,584,966 0 0
Intellia Therapeutics Inc Common Stock 45826J105 128,237 8,741,432 SH   SOLE   7,186,050 616,716 938,666
Interactive Brokers Group Inc Common Stock 45841N107 831 17,821 SH   SOLE   17,821 0 0
Intercontinental Exchange Inc Common Stock 45866F104 2,554 27,593 SH   SOLE   27,593 0 0
Intuit Inc Common Stock 461202103 1,843 7,037 SH   SOLE   7,037 0 0
Intuitive Surgical Inc Common Stock 46120E602 2,155 3,646 SH   SOLE   3,646 0 0
Intrexon Corp Common Stock 46122T102 1,780 324,891 SH   SOLE   324,891 0 0
OC Oerlikon Corp AG Common Stock H59187106 351 29,881 SH   SOLE   29,881 0 0
Invitae Corp Common Stock 46185L103 169,512 10,509,132 SH   SOLE   8,091,047 578,129 1,839,956
Ionis Pharmaceuticals Inc Common Stock 462222100 13,050 216,025 SH   SOLE   216,025 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 22,790 823,344 SH   SOLE   823,344 0 0
Iridium Communications Inc Common Stock 46269C102 3,425 138,992 SH   SOLE   138,992 0 0
JD.com Inc ADR 47215P106 5,199 147,581 SH   SOLE   147,581 0 0
SGL Carbon SE Common Stock D6949M108 43 8,041 SH   SOLE   8,041 0 0
Kaiser Aluminum Corp Common Stock 483007704 341 3,079 SH   SOLE   3,079 0 0
Komatsu Ltd ADR 500458401 2,480 103,154 SH   SOLE   103,154 0 0
Kratos Defense & Security Solu Common Stock 50077B207 2,590 143,836 SH   SOLE   143,836 0 0
Henkel AG & Co KGaA Preference D3207M110 41 392 SH   SOLE   392 0 0
Bertrandt AG Common Stock D1014N107 399 6,323 SH   SOLE   6,323 0 0
LendingClub Corp Common Stock 52603A208 53,738 4,258,140 SH   SOLE   3,560,231 62,797 635,112
LendingTree Inc Common Stock 52603B107 86,374 284,649 SH   SOLE   205,074 22,643 56,932
Dassault Systemes SE Common Stock F2457H472 1,053 6,401 SH   SOLE   6,401 0 0
Lincoln Electric Holdings Inc Common Stock 533900106 335 3,462 SH   SOLE   3,462 0 0
Siemens AG Common Stock D69671218 361 2,764 SH   SOLE   2,764 0 0
Materialise NV ADR 57667T100 51,898 2,834,406 SH   SOLE   2,545,931 55,558 232,917
MercadoLibre Inc Common Stock 58733R102 58,584 102,431 SH   SOLE   81,409 7,474 13,548
Microsoft Corp Common Stock 594918104 1,107 7,019 SH   SOLE   7,019 0 0
Bezeq The Israeli Telecommunic Common Stock M2012Q100 437 544,272 SH   SOLE   544,272 0 0
Bet Shemesh Engines Holdings 1 Common Stock M20119109 363 9,254 SH   SOLE   9,254 0 0
Moog Inc Common Stock 615394202 304 3,560 SH   SOLE   3,560 0 0
Rakuten Inc Common Stock J64264104 2,292 266,905 SH   SOLE   266,905 0 0
Danel Adir Yeoshua Ltd Common Stock M27013107 442 4,754 SH   SOLE   4,754 0 0
Hilan Ltd Common Stock M5299H123 346 8,605 SH   SOLE   8,605 0 0
Nano Dimension Ltd ADR 63008G203 184 72,612 SH   SOLE   72,612 0 0
NanoString Technologies Inc Common Stock 63009R109 84,999 3,055,316 SH   SOLE   2,839,195 204,603 11,518
Elbit Systems Ltd Common Stock M3760D101 2,542 16,394 SH   SOLE   16,394 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 2,432 114,400 SH   SOLE   114,400 0 0
Nasdaq Inc Common Stock 631103108 800 7,474 SH   SOLE   7,474 0 0
FMS Enterprises Migun Ltd Common Stock M42619102 355 9,571 SH   SOLE   9,571 0 0
Partner Communications Co Ltd Common Stock M78465107 354 79,452 SH   SOLE   79,452 0 0
Netflix Inc Common Stock 64110L106 53,826 166,350 SH   SOLE   126,415 12,074 27,861
Nice Ltd ADR 653656108 370 2,382 SH   SOLE   2,382 0 0
FirstRand Ltd Common Stock S5202Z131 149 34,982 SH   SOLE   34,982 0 0
NVIDIA Corp Common Stock 67066G104 55,233 234,736 SH   SOLE   186,483 14,511 33,742
NuVasive Inc Common Stock 670704105 360 4,660 SH   SOLE   4,660 0 0
Matrix IT Ltd Common Stock M6859E153 414 20,581 SH   SOLE   20,581 0 0
Organovo Holdings Inc Common Stock 68620A104 6,936 19,499,439 SH   SOLE   19,428,870 70,569 0
Toray Industries Inc Common Stock J89494116 37 5,508 SH   SOLE   5,508 0 0
PTC Inc Common Stock 69370C100 1,136 15,174 SH   SOLE   15,174 0 0
Pacific Biosciences of Califor Common Stock 69404D108 7,758 1,509,414 SH   SOLE   1,509,414 0 0
One Software Technologies Ltd Common Stock M9866H102 404 5,288 SH   SOLE   5,288 0 0
PayPal Holdings Inc Common Stock 70450Y103 10,155 93,880 SH   SOLE   93,880 0 0
Personalis Inc Common Stock 71535D106 6,822 625,856 SH   SOLE   625,856 0 0
Straumann Holding AG Common Stock H8300N119 2,249 2,291 SH   SOLE   2,291 0 0
Pinduoduo Inc ADR 722304102 13,495 356,811 SH   SOLE   356,811 0 0
Pinterest Inc Common Stock 72352L106 30,892 1,657,274 SH   SOLE   1,424,575 111,317 121,382
Pluristem Therapeutics Inc Common Stock 72940R300 2,308 585,694 SH   SOLE   585,694 0 0
PolyOne Corp Common Stock 73179P106 47 1,288 SH   SOLE   1,288 0 0
Proto Labs Inc Common Stock 743713109 81,740 804,925 SH   SOLE   595,320 68,392 141,213
Wirecard AG Common Stock D22359133 1,120 9,291 SH   SOLE   9,291 0 0
Rakuten Inc ADR 75102W108 2,629 309,129 SH   SOLE   309,129 0 0
Redhill Biopharma Ltd ADR 757468103 354 58,373 SH   SOLE   58,373 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 33 89 SH   SOLE   89 0 0
Roku Inc Common Stock 77543R102 98,762 737,580 SH   SOLE   582,686 51,000 103,894
Rubius Therapeutics Inc Common Stock 78116T103 6,467 680,764 SH   SOLE   533,293 135,102 12,369
salesforce.com Inc Common Stock 79466L302 76,529 470,544 SH   SOLE   337,929 41,579 91,036
Charles Schwab Corp/The Common Stock 808513105 1,037 21,800 SH   SOLE   21,800 0 0
Seres Therapeutics Inc Common Stock 81750R102 25,095 7,273,840 SH   SOLE   5,983,163 445,694 844,983
Shopify Inc Common Stock 82509L107 9,766 24,563 SH   SOLE   24,563 0 0
Snap Inc Common Stock 83304A106 8,221 503,430 SH   SOLE   503,430 0 0
SolarEdge Technologies Inc Common Stock 83417M104 404 4,251 SH   SOLE   4,251 0 0
Splunk Inc Common Stock 848637104 94,739 632,564 SH   SOLE   471,313 47,708 113,543
Square Inc Common Stock 852234103 234,474 3,747,978 SH   SOLE   2,843,124 261,711 643,143
Stryker Corp Common Stock 863667101 296 1,411 SH   SOLE   1,411 0 0
Syros Pharmaceuticals Inc Common Stock 87184Q107 35,088 5,077,807 SH   SOLE   4,348,862 65,652 663,293
Taiwan Semiconductor Manufactu ADR 874039100 3,476 59,833 SH   SOLE   59,833 0 0
Teladoc Health Inc Common Stock 87918A105 62,845 750,655 SH   SOLE   626,449 53,343 70,863
Tencent Holdings Ltd ADR 88032Q109 56,419 1,175,156 SH   SOLE   892,780 81,519 200,857
Teradyne Inc Common Stock 880770102 44,665 655,002 SH   SOLE   448,780 53,252 152,970
Tesla Inc Common Stock 88160R101 302,029 721,988 SH   SOLE   658,002 59,836 4,150
Teva Pharmaceutical Industries ADR 881624209 452 46,129 SH   SOLE   46,129 0 0
Trade Desk Inc/The Common Stock 88339J105 70,424 271,092 SH   SOLE   212,762 18,827 39,503
3D Systems Corp Common Stock 88554D205 2,118 242,026 SH   SOLE   242,026 0 0
3M Co Common Stock 88579Y101 45 253 SH   SOLE   253 0 0
TransUnion Common Stock 89400J107 1,141 13,325 SH   SOLE   13,325 0 0
Trimble Inc Common Stock 896239100 5,339 128,075 SH   SOLE   128,075 0 0
Twilio Inc Common Stock 90138F102 14,661 149,177 SH   SOLE   149,177 0 0
Twist Bioscience Corp Common Stock 90184D100 8,371 398,613 SH   SOLE   398,613 0 0
Twitter Inc Common Stock 90184L102 94,480 2,947,892 SH   SOLE   2,167,134 242,472 538,286
2U Inc Common Stock 90214J101 125,234 5,220,253 SH   SOLE   4,017,808 334,322 868,123
Ultra Clean Holdings Inc Common Stock 90385V107 446 18,986 SH   SOLE   18,986 0 0
United Parcel Service Inc Common Stock 911312106 301 2,568 SH   SOLE   2,568 0 0
Veracyte Inc Common Stock 92337F107 77,853 2,788,436 SH   SOLE   2,746,983 41,453 0
Verisk Analytics Inc Common Stock 92345Y106 1,040 6,964 SH   SOLE   6,964 0 0
Workday Inc Common Stock 98138H101 6,154 37,421 SH   SOLE   37,421 0 0
Xilinx Inc Common Stock 983919101 104,276 1,066,539 SH   SOLE   831,548 69,840 165,151
Xerox Holdings Corp Common Stock 98421M106 51 1,384 SH   SOLE   1,384 0 0
Zillow Group Inc Common Stock 98954M101 110,098 2,407,049 SH   SOLE   1,795,179 185,438 426,432
Gilat Satellite Networks Ltd Common Stock M51474118 344 43,487 SH   SOLE   43,487 0 0
Koninklijke DSM NV Common Stock N5017D122 44 338 SH   SOLE   338 0 0
Kamada Ltd Common Stock M6240T109 478 69,617 SH   SOLE   69,617 0 0
Arkema SA Common Stock F0392W125 43 409 SH   SOLE   409 0 0
MGI Digital Graphic Technology Common Stock F4090S113 2,277 37,140 SH   SOLE   37,140 0 0
Sandvik AB Common Stock W74857165 49 2,505 SH   SOLE   2,505 0 0
Hexagon AB Common Stock W40063104 486 8,634 SH   SOLE   8,634 0 0
Intercure Ltd Common Stock M549GJ103 311 288,825 SH   SOLE   288,825 0 0
Cellcom Israel Ltd Common Stock M2196U109 430 135,055 SH   SOLE   135,055 0 0
Evonik Industries AG Common Stock D2R90Y117 48 1,571 SH   SOLE   1,571 0 0
Fattal Holdings 1998 Ltd Common Stock M4148G105 382 2,345 SH   SOLE   2,345 0 0
Meituan Dianping Common Stock G59669104 2,564 196,027 SH   SOLE   196,027 0 0
SLM Solutions Group AG Common Stock D6T690109 2,479 125,343 SH   SOLE   125,343 0 0
ZhongAn Online P&C Insurance C Common Stock Y989DF109 1,846 511,700 SH   SOLE   511,700 0 0
Adyen NV Common Stock N3501V104 1,901 2,316 SH   SOLE   2,316 0 0
Atlassian Corp PLC Common Stock G06242104 5,344 44,410 SH   SOLE   44,410 0 0
Medtronic PLC Common Stock G5960L103 318 2,802 SH   SOLE   2,802 0 0
Aptiv PLC Common Stock G6095L109 8,347 87,890 SH   SOLE   72,581 1,424 13,885
Sapiens International Corp NV Common Stock G7T16G103 415 18,064 SH   SOLE   18,064 0 0
CRISPR Therapeutics AG Common Stock H17182108 180,074 2,956,635 SH   SOLE   2,259,481 193,127 504,027
Spotify Technology SA Common Stock L8681T102 8,918 59,630 SH   SOLE   45,773 12,860 997
Allot Ltd Common Stock M0854Q105 399 46,919 SH   SOLE   46,919 0 0
AudioCodes Ltd Common Stock M15342104 496 19,300 SH   SOLE   19,300 0 0
Camtek Ltd/Israel Common Stock M20791105 382 35,243 SH   SOLE   35,243 0 0
Ceragon Networks Ltd Common Stock M22013102 273 129,788 SH   SOLE   129,788 0 0
Check Point Software Technolog Common Stock M22465104 367 3,303 SH   SOLE   3,303 0 0
Compugen Ltd Common Stock M25722105 53,493 8,975,310 SH   SOLE   8,740,866 91,315 143,129
CyberArk Software Ltd Common Stock M2682V108 408 3,499 SH   SOLE   3,499 0 0
Evogene Ltd Common Stock M4119S104 345 227,211 SH   SOLE   227,211 0 0
Foamix Pharmaceuticals Ltd Common Stock M46135105 367 110,343 SH   SOLE   110,343 0 0
Galmed Pharmaceuticals Ltd Common Stock M47238106 525 90,748 SH   SOLE   90,748 0 0
Fiverr International Ltd Common Stock M4R82T106 391 16,635 SH   SOLE   16,635 0 0
Mellanox Technologies Ltd Common Stock M51363113 377 3,214 SH   SOLE   3,214 0 0
Ituran Location and Control Lt Common Stock M6158M104 364 14,474 SH   SOLE   14,474 0 0
Nova Measuring Instruments Ltd Common Stock M7516K103 412 10,879 SH   SOLE   10,879 0 0
Radware Ltd Common Stock M81873107 396 15,376 SH   SOLE   15,376 0 0
Silicom Ltd Common Stock M84116108 368 11,057 SH   SOLE   11,057 0 0
Stratasys Ltd Common Stock M85548101 171,183 8,463,934 SH   SOLE   6,314,061 606,361 1,543,512
Taro Pharmaceutical Industries Common Stock M8737E108 414 4,707 SH   SOLE   4,707 0 0
Tower Semiconductor Ltd Common Stock M87915274 386 16,035 SH   SOLE   16,035 0 0
UroGen Pharma Ltd Common Stock M96088105 535 16,025 SH   SOLE   16,025 0 0
Wix.com Ltd Common Stock M98068105 353 2,884 SH   SOLE   2,884 0 0
NXP Semiconductors NV Common Stock N6596X109 3,497 27,476 SH   SOLE   27,476 0 0
Bayer AG Common Stock D0712D163 32 390 SH   SOLE   0 390 0
FANUC Corp Common Stock J13440102 41 220 SH   SOLE   0 220 0
Nintendo Co Ltd Common Stock J51699106 69 171 SH   SOLE   0 171 0
SoftBank Group Corp Common Stock J75963108 48 1,110 SH   SOLE   0 1,110 0
DocuSign Inc Common Stock 256163106 947 12,772 SH   SOLE   12,772 0 0
Zscaler Inc Common Stock 98980G102 5,875 126,339 SH   SOLE   126,339 0 0
LINE Corp ADR 53567X101 64 1,314 SH   SOLE   1,314 0 0
Wirecard AG ADR 97654L108 201 3,360 SH   SOLE   3,360 0 0
GMO internet Inc Common Stock J1822R104 51 2,700 SH   SOLE   2,700 0 0
Discovery Ltd Common Stock S2192Y109 906 104,920 SH   SOLE   104,920 0 0
Magic Software Enterprises Ltd Common Stock 559166103 381 39,134 SH   SOLE   39,134 0 0
Malam - Team Ltd Common Stock M87437105 417 2,199 SH   SOLE   2,199 0 0
BATM Advanced Communications Common Stock M19199112 347 696,776 SH   SOLE   696,776 0 0
Enlivex Therapeutics Ltd Common Stock M4130Y106 323 38,536 SH   SOLE   38,536 0 0
Inmode Ltd Common Stock M5425M103 540 13,786 SH   SOLE   13,786 0 0
Perion Network Ltd Common Stock M78673114 426 68,451 SH   SOLE   68,451 0 0
Silvergate Capital Corp Common Stock 82837P408 246 15,471 SH   SOLE   15,471 0 0
Zip Co Ltd Common Stock Q9899L134 390 156,718 SH   SOLE   156,718 0 0
Cornerstone OnDemand Inc Common Stock 21925Y103 834 14,243 SH   SOLE   14,243 0 0
Alteryx Inc Common Stock 02156B103 5,744 57,396 SH   SOLE   57,396 0 0
Meituan Dianping ADR 58533E103 372 14,389 SH   SOLE   14,389 0 0
Z Holdings Corp Common Stock J9894K105 1,292 305,100 SH   SOLE   305,100 0 0
Sea Ltd ADR 81141R100 2,702 67,191 SH   SOLE   67,191 0 0
Z Holdings Corp ADR 98877X101 210 24,935 SH   SOLE   24,935 0 0