The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 8,867 524,683 SH   DFND 2 524,683 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 13,442 556,142 SH   DFND 2 556,142 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 225,082 1,061,207 SH   DFND 2 330,588 0 730,619
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 18,929 89,244 SH   DFND 1 89,244 0 0
ALIGN TECHNOLOGY INC COM 016255101 19,094 68,428 SH   DFND 2 68,428 0 0
ALLSTATE CORP COM 020002101 406 3,614 SH   DFND 2 3,614 0 0
ALLSTATE CORP COM 020002101 672 5,978 SH   DFND 1 5,978 0 0
ALPHABET INC CAP STK CL C 02079K107 619,457 463,312 SH   DFND 2 279,658 0 183,654
ALPHABET INC CAP STK CL C 02079K107 30,225 22,606 SH   DFND 1 22,606 0 0
ALPHABET INC CAP STK CL A 02079K305 1,164 869 SH   DFND 2 0 0 869
AMARIN CORP PLC SPONS ADR NEW 023111206 13,107 611,329 SH   DFND 2 611,329 0 0
AMAZON INC COM 023135106 29,360 15,889 SH   DFND 1 15,889 0 0
AMAZON INC COM 023135106 498,841 269,959 SH   DFND 2 145,643 0 124,316
AMDOCS LTD SHS G02602103 1,427 19,766 SH   DFND 1 19,766 0 0
AMDOCS LTD SHS G02602103 760 10,526 SH   DFND 2 10,526 0 0
AMERICAN TOWER CORP NEW COM 03027X100 21,358 92,932 SH   DFND 1 92,932 0 0
AMERICAN TOWER CORP NEW COM 03027X100 433,800 1,887,566 SH   DFND 2 1,134,924 0 752,642
ANNALY CAP MGMT INC COM 035710409 1,808 191,925 SH   DFND 1 191,925 0 0
ANNALY CAP MGMT INC COM 035710409 1,009 107,136 SH   DFND 2 107,136 0 0
ANTHEM INC COM 036752103 35,511 117,575 SH   DFND 2 117,575 0 0
ANTHEM INC COM 036752103 1,398 4,628 SH   DFND 1 4,628 0 0
AT&T INC COM 00206R102 848 21,701 SH   DFND 1 21,701 0 0
AT&T INC COM 00206R102 437 11,176 SH   DFND 2 11,176 0 0
ATLANTICA YIELD PLC SHS G0751N103 931 35,281 SH   DFND 2 35,281 0 0
ATLANTICA YIELD PLC SHS G0751N103 1,803 68,340 SH   DFND 1 68,340 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 117 1,459 SH   DFND 2 1,459 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 83 1,037 SH   DFND 1 1,037 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16,972 311,751 SH   DFND 2 311,751 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 13,854 163,851 SH   DFND 2 163,851 0 0
CARA THERAPEUTICS INC COM 140755109 11,333 703,460 SH   DFND 2 703,460 0 0
CENTENE CORP DEL COM 15135B101 29,326 466,458 SH   DFND 2 466,458 0 0
COCA COLA CO COM 191216100 21,051 380,333 SH   DFND 1 380,333 0 0
COCA COLA CO COM 191216100 402,531 7,272,468 SH   DFND 2 4,458,931 0 2,813,537
COHERUS BIOSCIENCES INC COM 19249H103 14,556 808,464 SH   DFND 2 808,464 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 270 1,899 SH   DFND 1 1,899 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 470 3,307 SH   DFND 2 3,307 0 0
CVS HEALTH CORP COM 126650100 38,335 516,015 SH   DFND 2 516,015 0 0
DEX INC COM 252131107 22,560 103,137 SH   DFND 2 103,137 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 5,699 996,412 SH   DFND 2 996,412 0 0
ECOLAB INC COM 278865100 538,414 2,789,854 SH   DFND 2 1,670,320 0 1,119,534
ECOLAB INC COM 278865100 27,571 142,861 SH   DFND 1 142,861 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 22,337 95,747 SH   DFND 2 95,747 0 0
EXACT SCIENCES CORP COM 30063P105 16,548 178,932 SH   DFND 2 178,932 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 1,162 8,357 SH   DFND 1 8,357 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 561 4,031 SH   DFND 2 4,031 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 336,679 2,866,575 SH   DFND 2 1,831,182 0 1,035,393
FIRST REP BK SAN FRANCISCO C COM 33616C100 15,947 135,776 SH   DFND 1 135,776 0 0
FISERV INC COM 337738108 864 7,476 SH   DFND 2 7,476 0 0
FISERV INC COM 337738108 1,591 13,758 SH   DFND 1 13,758 0 0
FRANCO NEVADA CORP COM 351858105 1,134 10,980 SH   DFND 2 10,980 0 0
FRANCO NEVADA CORP COM 351858105 810 7,846 SH   DFND 1 7,846 0 0
GLAUKOS CORP COM 377322102 9,108 167,212 SH   DFND 2 167,212 0 0
GLOBAL PMTS INC COM 37940X102 720 3,944 SH   DFND 2 3,944 0 0
GLOBAL PMTS INC COM 37940X102 1,325 7,259 SH   DFND 1 7,259 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 9,774 93,473 SH   DFND 2 93,473 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 202,005 3,187,700 SH   DFND 2 1,443,982 0 1,743,718
HDFC BANK LTD SPONSORED ADS 40415F101 13,750 216,979 SH   DFND 1 216,979 0 0
HERON THERAPEUTICS INC COM 427746102 16,499 702,069 SH   DFND 2 702,069 0 0
HOME DEPOT INC COM 437076102 592,363 2,712,533 SH   DFND 2 1,626,946 0 1,085,587
HOME DEPOT INC COM 437076102 30,657 140,383 SH   DFND 1 140,383 0 0
HUMANA INC COM 444859102 20,159 55,000 SH   DFND 2 55,000 0 0
ICICI BK LTD ADR 45104G104 6,065 401,893 SH   DFND 1 401,893 0 0
ICICI BK LTD ADR 45104G104 72,393 4,797,441 SH   DFND 2 1,482,643 0 3,314,798
ILLUMINA INC COM 452327109 19,234 57,978 SH   DFND 2 57,978 0 0
IMMUNOMEDICS INC COM 452907108 9,310 440,000 SH   DFND 2 440,000 0 0
INSMED INC COM PAR $.01 457669307 10,581 443,110 SH   DFND 2 443,110 0 0
INSULET CORP COM 45784P101 9,914 57,908 SH   DFND 2 57,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 778 8,408 SH   DFND 1 8,408 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 428 4,629 SH   DFND 2 4,629 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 24,791 41,937 SH   DFND 2 41,937 0 0
JOHNSON & JOHNSON COM 478160104 670 4,595 SH   DFND 2 4,595 0 0
JOHNSON & JOHNSON COM 478160104 1,310 8,981 SH   DFND 1 8,981 0 0
LHC GROUP INC COM 50187A107 13,178 95,657 SH   DFND 2 95,657 0 0
MERCADOLIBRE INC COM 58733R102 196 343 SH   DFND 1 343 0 0
MERCADOLIBRE INC COM 58733R102 254 444 SH   DFND 2 444 0 0
MERCK & CO INC COM 58933Y105 20,621 226,728 SH   DFND 2 226,728 0 0
MICROSOFT CORP COM 594918104 587,115 3,722,986 SH   DFND 2 2,379,875 0 1,343,111
MICROSOFT CORP COM 594918104 26,493 167,996 SH   DFND 1 167,996 0 0
MONDELEZ INTL INC CL A 609207105 35,611 646,536 SH   DFND 2 646,536 0 0
MONDELEZ INTL INC CL A 609207105 284 5,148 SH   DFND 1 5,148 0 0
MSCI INC COM 55354G100 181,685 703,713 SH   DFND 2 386,488 0 317,225
MSCI INC COM 55354G100 11,034 42,738 SH   DFND 1 42,738 0 0
MYOKARDIA INC COM 62857M105 8,524 116,950 SH   DFND 2 116,950 0 0
NEW RESIDENTIAL INVT CORP COM NEW 64828T201 449 27,869 SH   DFND 2 27,869 0 0
NEW RESIDENTIAL INVT CORP COM NEW 64828T201 713 44,260 SH   DFND 1 44,260 0 0
NEXTERA ENERGY INC COM 65339F101 299,168 1,235,416 SH   DFND 2 763,084 0 472,332
NEXTERA ENERGY INC COM 65339F101 13,579 56,076 SH   DFND 1 56,076 0 0
NOVOCURE LTD ORD SHS G6674U108 14,055 166,784 SH   DFND 2 166,784 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 142 4,146 SH   DFND 1 4,146 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 179 5,245 SH   DFND 2 5,245 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 7,985 334,366 SH   DFND 2 334,366 0 0
PROCTER & GAMBLE CO COM 742718109 459,205 3,676,578 SH   DFND 2 2,205,636 0 1,470,942
PROCTER & GAMBLE CO COM 742718109 22,574 180,734 SH   DFND 1 180,734 0 0
PROGRESSIVE CORP OHIO COM 743315103 775 10,703 SH   DFND 2 10,703 0 0
PROGRESSIVE CORP OHIO COM 743315103 1,415 19,548 SH   DFND 1 19,548 0 0
SAREPTA THERAPEUTICS INC COM 803607100 18,753 145,329 SH   DFND 2 145,329 0 0
SERVICE CORP INTL COM 817565104 37,568 816,159 SH   DFND 2 816,159 0 0
SERVICE CORP INTL COM 817565104 616 13,376 SH   DFND 1 13,376 0 0
STARBUCKS CORP COM 855244109 31,705 360,615 SH   DFND 2 360,615 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 10,616 998,677 SH   DFND 2 998,677 0 0
STORE CAP CORP COM 862121100 910 24,443 SH   DFND 2 24,443 0 0
STORE CAP CORP COM 862121100 1,577 42,351 SH   DFND 1 42,351 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 34,846 599,766 SH   DFND 2 386,363 0 213,403
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 16,189 278,637 SH   DFND 1 278,637 0 0
TELADOC HEALTH INC COM 87918A105 16,312 194,834 SH   DFND 2 194,834 0 0
TELEFLEX INC COM 879369106 19,951 53,000 SH   DFND 2 53,000 0 0
THERAPEUTICSMD INC COM 88338N107 7,719 3,189,834 SH   DFND 2 3,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 637,232 1,961,497 SH   DFND 2 1,252,309 0 709,188
THERMO FISHER SCIENTIFIC INC COM 883556102 30,011 92,377 SH   DFND 1 92,377 0 0
TJX COS INC NEW COM 872540109 846 13,861 SH   DFND 1 13,861 0 0
TJX COS INC NEW COM 872540109 454 7,443 SH   DFND 2 7,443 0 0
UNITEDHEALTH GROUP INC COM 91324P102 1,512 5,144 SH   DFND 1 5,144 0 0
UNITEDHEALTH GROUP INC COM 91324P102 844 2,870 SH   DFND 2 2,870 0 0
US BANCORP DEL COM NEW 902973304 43,214 728,854 SH   DFND 2 728,854 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 15,011 68,557 SH   DFND 2 68,557 0 0
VISA INC COM CL A 92826C839 1,071,844 5,704,333 SH   DFND 2 3,440,228 0 2,264,105
VISA INC COM CL A 92826C839 54,965 292,520 SH   DFND 1 292,520 0 0
VOCERA MUNICATIONS INC COM 92857F107 5,295 255,058 SH   DFND 2 255,058 0 0
WEYERHAEUSER CO COM 962166104 32,822 1,086,829 SH   DFND 2 1,086,829 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 811 27,256 SH   DFND 2 27,256 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 1,473 49,526 SH   DFND 1 49,526 0 0
WILLIS TOWERS WATSON PUB LTD SHS G96629103 462 2,288 SH   DFND 2 2,288 0 0
WILLIS TOWERS WATSON PUB LTD SHS G96629103 660 3,266 SH   DFND 1 3,266 0 0