The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 631 4,334 SH   SOLE   4,334 0 0
3M CO COM 88579Y101 34,030 193,999 SH   SOLE   193,999 0 0
89BIO INC COM 282559103 9,563 488,197 SH   SOLE   488,197 0 0
ABBOTT LABS COM 002824100 68,655 581,208 SH   SOLE   581,208 0 0
ABBOTT LABS COM 002824100 4 31 SH   OTR 1 0 0 31
ABBVIE INC COM 00287Y109 37,836 350,774 SH   SOLE   350,774 0 0
ABBVIE INC COM 00287Y109 1 13 SH   OTR 1 0 0 13
ACADIA PHARMACEUTICALS INC COM 004225108 4,577 275,560 SH   SOLE   275,560 0 0
ACCELERON PHARMA INC COM 00434H108 4 21 SH   OTR 1 0 0 21
ACCELERON PHARMA INC COM 00434H108 79,544 462,218 SH   SOLE   462,218 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 2 6 SH   OTR 1 0 0 6
ACTIVISION BLIZZARD INC COM 00507V109 48,544 627,296 SH   SOLE   627,296 0 0
ACTIVISION BLIZZARD INC COM 00507V109 2 21 SH   OTR 1 0 0 21
ADOBE SYSTEMS INCORPORATED COM 00724F101 3 5 SH   OTR 1 0 0 5
ADOBE SYSTEMS INCORPORATED COM 00724F101 115,229 200,156 SH   SOLE   200,156 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 43,708 404,085 SH   SOLE   404,085 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 4 37 SH   OTR 1 0 0 37
ADVANCED MICRO DEVICES INC COM 007903107 1 13 SH   OTR 1 0 0 13
ADVANCED MICRO DEVICES INC COM 007903107 72,575 705,327 SH   SOLE   705,327 0 0
AFLAC INC COM 001055102 4 81 SH   OTR 1 0 0 81
AFLAC INC COM 001055102 21,355 409,658 SH   SOLE   409,658 0 0
AGILE THERAPEUTICS INC COM 00847L100 28 29,000 SH   SOLE   29,000 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 97,004 615,810 SH   SOLE   615,810 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 7 46 SH   OTR 1 0 0 46
AGNICO EAGLE MINES LTD COM 008474108 414 7,982 SH   SOLE   7,982 0 0
AIR PRODS & CHEMS INC COM 009158106 65,632 256,277 SH   SOLE   256,277 0 0
AIR PRODS & CHEMS INC COM 009158106 5 20 SH   OTR 1 0 0 20
AIRBNB INC COM CL A 009066101 5,572 33,218 SH   SOLE   33,218 0 0
AKAMAI TECHNOLOGIES INC COM 00971T101 2,479 23,702 SH   SOLE   23,702 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.375% 9/0 00971TAL5 9,848 9,000 PRN   SOLE   9,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 2,831 126,667 SH   SOLE   126,667 0 0
AKOYA BIOSCIENCES INC COM 00974H104 590 42,300 SH   SOLE   42,300 0 0
ALBEMARLE CORP COM 012653101 1,837 8,391 SH   SOLE   8,391 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,229 140,000 SH   SOLE   140,000 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 1,743 9,123 SH   SOLE   9,123 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 10,421 70,393 SH   SOLE   70,393 0 0
ALIGN TECHNOLOGY INC COM 016255101 19,534 29,356 SH   SOLE   29,356 0 0
ALLAKOS INC COM 01671P100 9,867 93,204 SH   SOLE   93,204 0 0
ALLEGHANY CORP MD COM 017175100 20,416 32,698 SH   SOLE   32,698 0 0
ALLSTATE CORP COM 020002101 3,551 27,892 SH   SOLE   27,892 0 0
ALLSTATE CORP COM 020002101 2 15 SH   OTR 1 0 0 15
ALLY FINL INC COM 02005N100 19,427 380,571 SH   SOLE   380,571 0 0
ALLY FINL INC COM 02005N100 1,441 1,400 PRN   SOLE   1,400 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 25,126 133,079 SH   SOLE   133,079 0 0
ALPHABET INC CAP STK CL A 02079K305 16 6 SH   OTR 1 0 0 6
ALPHABET INC CAP STK CL A 02079K305 496,197 185,605 SH   SOLE   185,605 0 0
ALPHABET INC CAP STK CL C 02079K107 137,082 51,434 SH   SOLE   51,434 0 0
ALTERYX INC COM CL A 02156B103 1,801 24,634 SH   SOLE   24,634 0 0
AMAZON COM INC COM 023135106 3 1 SH   OTR 1 0 0 1
AMAZON COM INC COM 023135106 168,302 51,235 SH   SOLE   51,235 0 0
AMBARELLA INC SHS G037AX101 30,615 196,587 SH   SOLE   196,587 0 0
AMERESCO INC CL A 02361E108 21,770 372,600 SH   SOLE   372,600 0 0
AMERESCO INC CL A 02361E108 2 39 SH   OTR 1 0 0 39
AMERICAN AIRLS GROUP INC COM 02376R102 267 13,000 SH   SOLE   13,000 0 0
AMERICAN CAMPUS CMNTYS INC COM 024835100 3,694 3,750 PRN   SOLE   3,750 0 0
AMERICAN CAMPUS CMNTYS INC COM 024835100 2,171 44,819 SH   SOLE   44,819 0 0
AMERICAN EAGLE OUTFITTERS IN COM 02553E106 4,715 182,777 SH   SOLE   182,777 0 0
AMERICAN EXPRESS CO COM 025816109 12,602 75,224 SH   SOLE   75,224 0 0
AMERICAN EXPRESS CO COM 025816109 2 14 SH   OTR 1 0 0 14
AMERICAN INTL GROUP INC COM NEW 026874784 3,094 56,365 SH   SOLE   56,365 0 0
AMERICAN TOWER CORP NEW COM 03027X100 23,340 87,944 SH   SOLE   87,944 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 60,116 355,649 SH   SOLE   355,649 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 5 30 SH   OTR 1 0 0 30
AMERIPRISE FINL INC COM 03076C106 2 9 SH   OTR 1 0 0 9
AMERIPRISE FINL INC COM 03076C106 3,617 13,697 SH   SOLE   13,697 0 0
AMERISOURCEBERGEN CORP COM 03073E105 1,254 10,498 SH   SOLE   10,498 0 0
AMETEK INC COM 031100100 2,566 20,695 SH   SOLE   20,695 0 0
AMGEN INC COM 031162100 235,982 1,109,768 SH   SOLE   1,109,768 0 0
AMGEN INC COM 031162100 8 36 SH   OTR 1 0 0 36
AMPHENOL CORP NEW CL A 032095101 2,535 34,613 SH   SOLE   34,613 0 0
ANALOG DEVICES INC COM 032654105 43,775 261,387 SH   SOLE   261,387 0 0
ANDERSONS INC COM 034164103 216 7,000 SH   SOLE   7,000 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 839 99,643 SH   SOLE   99,643 0 0
ANSYS INC COM 03662Q105 53,535 157,256 SH   SOLE   157,256 0 0
ANSYS INC COM 03662Q105 2 6 SH   OTR 1 0 0 6
ANTHEM INC COM 036752103 21,006 56,350 SH   SOLE   56,350 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 8,405 255,030 SH   SOLE   255,030 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 676 10,975 SH   SOLE   10,975 0 0
APPLE INC COM 037833100 478,060 3,378,662 SH   SOLE   3,378,662 0 0
APPLE INC COM 037833100 18 130 SH   OTR 1 0 0 130
APPLIED MATLS INC COM 038222105 83,432 648,145 SH   SOLE   648,145 0 0
APPLIED MATLS INC COM 038222105 1 11 SH   OTR 1 0 0 11
APTIV PLC SHS G6095L109 6 37 SH   OTR 1 0 0 37
ARCH CAP GROUP LTD ORD G0450A105 591 15,491 SH   SOLE   15,491 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 1,638 27,293 SH   SOLE   27,293 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 37,296 626,318 SH   SOLE   626,318 0 0
ARGENX SE SPONSORED ADR 04016X101 14,956 49,526 SH   SOLE   49,526 0 0
ARISTA NETWORKS INC COM 040413106 1,075 3,128 SH   SOLE   3,128 0 0
ARROW ELECTRS INC COM 042735100 3 26 SH   OTR 1 0 0 26
ARROW ELECTRS INC COM 042735100 204 1,818 SH   SOLE   1,818 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 12,261 196,408 SH   SOLE   196,408 0 0
ARVINAS INC COM 04335A105 1 13 SH   OTR 1 0 0 13
ARVINAS INC COM 04335A105 28,399 345,581 SH   SOLE   345,581 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 39,909 250,399 SH   SOLE   250,399 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 5,111 1,468,846 SH   SOLE   1,468,846 0 0
ASSURANT INC COM 04621X108 2,714 17,204 SH   SOLE   17,204 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 15 250 SH   OTR 1 0 0 250
ASTRAZENECA PLC SPONSORED ADR 046353108 61,750 1,028,183 SH   SOLE   1,028,183 0 0
ASURE SOFTWARE INC COM 04649U102 234 26,000 SH   SOLE   26,000 0 0
AT&T INC COM 00206R102 12,421 459,878 SH   SOLE   459,878 0 0
AT&T INC COM 00206R102 6 215 SH   OTR 1 0 0 215
ATHENE HOLDING LTD CL A G0684D107 15,086 219,060 SH   SOLE   219,060 0 0
ATMOS ENERGY CORP COM 049560105 2 22 SH   OTR 1 0 0 22
ATMOS ENERGY CORP COM 049560105 2,696 30,570 SH   SOLE   30,570 0 0
AURORA CANNABIS INC COM 05156X884 99 14,354 SH   SOLE   14,354 0 0
AUTODESK INC COM 052769106 103,523 363,037 SH   SOLE   363,037 0 0
AUTODESK INC COM 052769106 5 16 SH   OTR 1 0 0 16
AUTOMATIC DATA PROCESSING IN COM 053015103 29,240 146,264 SH   SOLE   146,264 0 0
AUTOZONE INC COM 053332102 2,586 1,523 SH   SOLE   1,523 0 0
AVALARA INC COM 05338G106 788 4,510 SH   SOLE   4,510 0 0
AVALONBAY CMNTYS INC COM 053484101 2,805 12,654 SH   SOLE   12,654 0 0
AVANTOR INC COM 05352A100 11,796 288,432 SH   SOLE   288,432 0 0
AVERY DENNISON CORP COM 053611109 6,494 31,341 SH   SOLE   31,341 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 3,906 158,588 SH   SOLE   158,588 0 0
AXSOME THERAPEUTICS INC COM 05464T104 5,063 153,602 SH   SOLE   153,602 0 0
BADGER METER INC COM 056525108 977 9,664 SH   SOLE   9,664 0 0
BAIDU INC SPON ADR REP A 056752108 5,112 33,248 SH   SOLE   33,248 0 0
BAKER HUGHES COMPANY CL A 05722G100 1,519 61,436 SH   SOLE   61,436 0 0
BALL CORP COM 058498106 4 44 SH   OTR 1 0 0 44
BALL CORP COM 058498106 42,701 474,636 SH   SOLE   474,636 0 0
BALLARD PWR SYS INC NEW COM 058586108 4,585 326,505 SH   SOLE   326,505 0 0
BANCO BILBAO VIZCAYA ARGENTA SPONSORED ADR 05946K101 4 602 SH   OTR 1 0 0 602
BANCO BRADESCO S A SP ADR PFD NEW 059460303 569 148,573 SH   SOLE   148,573 0 0
BANCOLOMBIA S A SPON ADR PREF 05968L102 219 6,338 SH   SOLE   6,338 0 0
BANK MONTREAL QUE COM 063671101 18,737 187,726 SH   SOLE   187,726 0 0
BANK NEW YORK MELLON CORP COM 064058100 3,483 67,192 SH   SOLE   67,192 0 0
BANK NEW YORK MELLON CORP COM 064058100 1 28 SH   OTR 1 0 0 28
BANK NOVA SCOTIA B C COM 064149107 31,150 506,216 SH   SOLE   506,216 0 0
BARRICK GOLD CORP COM 067901108 1,564 86,625 SH   SOLE   86,625 0 0
BATH & BODY WORKS INC COM 070830104 1,039 16,483 SH   SOLE   16,483 0 0
BAXTER INTL INC COM 071813109 3,933 48,902 SH   SOLE   48,902 0 0
BCE INC COM NEW 05534B760 283 5,644 SH   SOLE   5,644 0 0
BEAM THERAPEUTICS INC COM 07373V105 6,712 77,147 SH   SOLE   77,147 0 0
BECTON DICKINSON & CO COM 075887109 15,760 64,115 SH   SOLE   64,115 0 0
BEIGENE LTD SPONSORED ADR 07725L102 49,466 136,276 SH   SOLE   136,276 0 0
BEIGENE LTD SPONSORED ADR 07725L102 2 5 SH   OTR 1 0 0 5
BERKLEY W R CORP COM 084423102 3,261 44,562 SH   SOLE   44,562 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 34,166 125,182 SH   SOLE   125,182 0 0
BEST BUY INC COM 086516101 18,717 177,063 SH   SOLE   177,063 0 0
BEYOND MEAT INC COM 08862E109 508 500 PRN   SOLE   500 0 0
BHP GROUP LTD SPONSORED ADS 088606108 4 82 SH   OTR 1 0 0 82
BHP GROUP PLC SPONSORED ADR 05545E209 2 45 SH   OTR 1 0 0 45
BIO RAD LABS INC CL A 090572207 33,448 44,841 SH   SOLE   44,841 0 0
BIO RAD LABS INC CL A 090572207 1 2 SH   OTR 1 0 0 2
BIOATLA INC COM 09077B104 11,911 404,620 SH   SOLE   404,620 0 0
BIOATLA INC COM 09077B104 0 16 SH   OTR 1 0 0 16
BIOGEN INC COM 09062X103 77,152 272,643 SH   SOLE   272,643 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 6,529 47,005 SH   SOLE   47,005 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 21,347 276,207 SH   SOLE   276,207 0 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 822 800 PRN   SOLE   800 0 0
BIONTECH SE SPONSORED ADS 09075V102 30,900 113,197 SH   SOLE   113,197 0 0
BIO-TECHNE CORP COM 09073M104 1 3 SH   OTR 1 0 0 3
BIO-TECHNE CORP COM 09073M104 26,342 54,363 SH   SOLE   54,363 0 0
BK OF AMERICA CORP COM 060505104 10 238 SH   OTR 1 0 0 238
BK OF AMERICA CORP COM 060505104 113,595 2,676,093 SH   SOLE   2,676,093 0 0
BLACKBAUD INC COM 09227Q100 931 13,228 SH   SOLE   13,228 0 0
BLACKBERRY LTD COM 09228F103 146 15,000 SH   SOLE   15,000 0 0
BLACKROCK INC COM 09247X101 9,466 11,287 SH   SOLE   11,287 0 0
BLACKSTONE INC COM 09260D107 4,158 35,743 SH   SOLE   35,743 0 0
BLOOM ENERGY CORP COM CL A 093712107 2,289 122,269 SH   SOLE   122,269 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1 13 SH   OTR 1 0 0 13
BLUEPRINT MEDICINES CORP COM 09627Y109 32,172 312,937 SH   SOLE   312,937 0 0
BOOKING HOLDINGS INC COM 09857L108 2 1 SH   OTR 1 0 0 1
BOOKING HOLDINGS INC COM 09857L108 51,238 21,585 SH   SOLE   21,585 0 0
BOOKING HOLDINGS INC NOTE 0.750% 5/0 09857LAN8 5,916 4,000 PRN   SOLE   4,000 0 0
BOSTON BEER INC CL A 100557107 358 703 SH   SOLE   703 0 0
BOSTON PROPERTIES INC COM 101121101 1,658 15,306 SH   SOLE   15,306 0 0
BOSTON SCIENTIFIC CORP COM 101137107 3,610 83,192 SH   SOLE   83,192 0 0
BP PLC SPONSORED ADR 055622104 1 45 SH   OTR 1 0 0 45
BRIDGEBIO PHARMA INC COM 10806X102 21,338 455,285 SH   SOLE   455,285 0 0
BRIGHT HORIZONS FAM SOL IN D COM 109194100 1,147 8,230 SH   SOLE   8,230 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 22,540 380,950 SH   SOLE   380,950 0 0
BROADCOM INC COM 11135F101 25,341 52,259 SH   SOLE   52,259 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 867 5,204 SH   SOLE   5,204 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 2,011 37,544 SH   SOLE   37,544 0 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 1,360 36,839 SH   SOLE   36,839 0 0
BROWN FORMAN CORP CL B 115637209 1,430 21,335 SH   SOLE   21,335 0 0
BRUKER CORP COM 116794108 4,852 62,128 SH   SOLE   62,128 0 0
BRUNSWICK CORP COM 117043109 3,071 32,240 SH   SOLE   32,240 0 0
BUNGE LIMITED COM G16962105 966 11,874 SH   SOLE   11,874 0 0
BURLINGTON STORES INC COM 122017106 1,089 3,841 SH   SOLE   3,841 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 26,226 173,186 SH   SOLE   173,186 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 2 16 SH   OTR 1 0 0 16
CAESARS ENTERTAINMENT INC NE COM 12769G100 1,342 11,954 SH   SOLE   11,954 0 0
CAI INTERNATIONAL INC COM 12477X106 8,006 143,192 SH   SOLE   143,192 0 0
CAMPBELL SOUP CO COM 134429109 821 19,626 SH   SOLE   19,626 0 0
CANADIAN IMP BK COMM COM 136069101 1,206 10,836 SH   SOLE   10,836 0 0
CANADIAN NAT RES LTD COM 136385101 720 19,706 SH   SOLE   19,706 0 0
CANADIAN NATL RY CO COM 136375102 4,793 41,373 SH   SOLE   41,373 0 0
CANADIAN PAC RY LTD COM 13645T100 1,449 22,203 SH   SOLE   22,203 0 0
CAPITAL ONE FINL CORP COM 14040H105 7,186 44,368 SH   SOLE   44,368 0 0
CARDINAL HEALTH INC COM 14149Y108 1 30 SH   OTR 1 0 0 30
CARDINAL HEALTH INC COM 14149Y108 1,128 22,809 SH   SOLE   22,809 0 0
CARLISLE COS INC COM 142339100 641 3,224 SH   SOLE   3,224 0 0
CARMAX INC COM 143130102 1,079 8,434 SH   SOLE   8,434 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 1,526 61,008 SH   SOLE   61,008 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 2,827 54,617 SH   SOLE   54,617 0 0
CATALENT INC COM 148806102 1,302 9,786 SH   SOLE   9,786 0 0
CATERPILLAR INC COM 149123101 11,112 57,888 SH   SOLE   57,888 0 0
CBOE GLOBAL MKTS INC COM 12503M108 641 5,174 SH   SOLE   5,174 0 0
CBRE GROUP INC CL A 12504L109 16,139 165,773 SH   SOLE   165,773 0 0
CDW CORP COM 12514G108 4,749 26,090 SH   SOLE   26,090 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 9,730 180,222 SH   SOLE   180,222 0 0
CENOVUS ENERGY INC COM 15135U109 110 10,908 SH   SOLE   10,908 0 0
CENTENE CORP DEL COM 15135B101 2,203 35,362 SH   SOLE   35,362 0 0
CENTERPOINT ENERGY INC COM 15189T107 1,687 68,570 SH   SOLE   68,570 0 0
CENTURY BANCORPORATION INC CL A NON VTG 156432106 2,348 20,378 SH   SOLE   20,378 0 0
CERENCE INC COM 156727109 21,867 227,528 SH   SOLE   227,528 0 0
CERIDIAN HCM HLDG INC COM 15677J108 791 7,025 SH   SOLE   7,025 0 0
CERNER CORP COM 156782104 1 20 SH   OTR 1 0 0 20
CERNER CORP COM 156782104 3,906 55,398 SH   SOLE   55,398 0 0
CEVA INC COM 157210105 15,346 359,669 SH   SOLE   359,669 0 0
CF INDS HLDGS INC COM 125269100 654 11,720 SH   SOLE   11,720 0 0
CGI INC CL A SUB VTG 12532H104 675 7,952 SH   SOLE   7,952 0 0
CHANGE HEALTHCARE INC COM 15912K100 11,599 553,958 SH   SOLE   553,958 0 0
CHARLES RIV LABS INTL INC COM 159864107 91,071 220,696 SH   SOLE   220,696 0 0
CHARLES RIV LABS INTL INC COM 159864107 4 9 SH   OTR 1 0 0 9
CHARTER COMMUNICATIONS INC N CL A 16119P108 9,388 12,904 SH   SOLE   12,904 0 0
CHEGG INC COM 163092109 1,623 23,867 SH   SOLE   23,867 0 0
CHEGG INC NOTE 9/0 163092AF6 2,991 3,000 PRN   SOLE   3,000 0 0
CHENIERE ENERGY INC COM NEW 16411R208 1,796 18,390 SH   SOLE   18,390 0 0
CHEVRON CORP NEW COM 166764100 3,928 38,718 SH   SOLE   38,718 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 11,516 902,537 SH   SOLE   902,537 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 22,227 12,230 SH   SOLE   12,230 0 0
CHUNGHWA TELECOM CO LTD SPON ADR NEW11 17133Q502 373 9,483 SH   SOLE   9,483 0 0
CHURCH & DWIGHT INC COM 171340102 3 37 SH   OTR 1 0 0 37
CHURCH & DWIGHT INC COM 171340102 1,942 23,523 SH   SOLE   23,523 0 0
CIA ENERGETICA DE MINAS GERA SP ADR N-V PFD 204409601 199 78,834 SH   SOLE   78,834 0 0
CIGNA CORP NEW COM 125523100 2 11 SH   OTR 1 0 0 11
CIGNA CORP NEW COM 125523100 7,227 36,109 SH   SOLE   36,109 0 0
CINCINNATI FINL CORP COM 172062101 812 7,113 SH   SOLE   7,113 0 0
CINTAS CORP COM 172908105 2,554 6,709 SH   SOLE   6,709 0 0
CISCO SYS INC COM 17275R102 44,514 817,856 SH   SOLE   817,856 0 0
CISCO SYS INC COM 17275R102 4 78 SH   OTR 1 0 0 78
CIT GROUP INC COM NEW 125581801 2,907 55,952 SH   SOLE   55,952 0 0
CITIGROUP INC COM NEW 172967424 4 62 SH   OTR 1 0 0 62
CITIGROUP INC COM NEW 172967424 97,164 1,384,559 SH   SOLE   1,384,559 0 0
CITIZENS FINL GROUP INC COM 174610105 11,122 236,742 SH   SOLE   236,742 0 0
CITRIX SYS INC COM 177376100 1,123 10,459 SH   SOLE   10,459 0 0
CLOROX CO DEL COM 189054109 2,090 12,623 SH   SOLE   12,623 0 0
CLOUDERA INC COM 18914U100 14,530 909,868 SH   SOLE   909,868 0 0
CME GROUP INC COM 12572Q105 4,802 24,831 SH   SOLE   24,831 0 0
CNO FINL GROUP INC COM 12621E103 1,794 76,194 SH   SOLE   76,194 0 0
COCA COLA CO COM 191216100 50,754 967,328 SH   SOLE   967,328 0 0
COGENT BIOSCIENCES INC COM 19240Q201 16,206 1,927,130 SH   SOLE   1,927,130 0 0
COGENT BIOSCIENCES INC COM 19240Q201 1 119 SH   OTR 1 0 0 119
COGNEX CORP COM 192422103 762 9,505 SH   SOLE   9,505 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 2,529 34,075 SH   SOLE   34,075 0 0
COHERENT INC COM 192479103 11,444 45,763 SH   SOLE   45,763 0 0
COLGATE PALMOLIVE CO COM 194162103 23,232 307,397 SH   SOLE   307,397 0 0
COLGATE PALMOLIVE CO COM 194162103 1 19 SH   OTR 1 0 0 19
COMCAST CORP NEW CL A 20030N101 47,837 855,330 SH   SOLE   855,330 0 0
COMCAST CORP NEW CL A 20030N101 6 99 SH   OTR 1 0 0 99
COMERICA INC COM 200340107 701 8,711 SH   SOLE   8,711 0 0
CONAGRA BRANDS INC COM 205887102 1,434 42,336 SH   SOLE   42,336 0 0
CONOCOPHILLIPS COM 20825C104 6,564 96,857 SH   SOLE   96,857 0 0
CONSOLIDATED EDISON INC COM 209115104 3,458 47,642 SH   SOLE   47,642 0 0
CONSTELLATION BRANDS INC CL A 21036P108 2,876 13,649 SH   SOLE   13,649 0 0
CONTINENTAL RES INC COM 212015101 215 4,659 SH   SOLE   4,659 0 0
COOPER COS INC COM NEW 216648402 6,633 16,048 SH   SOLE   16,048 0 0
COPART INC COM 217204106 5,759 41,516 SH   SOLE   41,516 0 0
CORNERSTONE ONDEMAND INC COM 21925Y103 9,581 167,334 SH   SOLE   167,334 0 0
CORNING INC COM 219350105 2,199 60,268 SH   SOLE   60,268 0 0
CORTEVA INC COM 22052L104 921 21,877 SH   SOLE   21,877 0 0
COSTAR GROUP INC COM 22160N109 1,793 20,830 SH   SOLE   20,830 0 0
COSTCO WHSL CORP NEW COM 22160K105 46,579 103,662 SH   SOLE   103,662 0 0
COTY INC COM CL A 222070203 147 18,731 SH   SOLE   18,731 0 0
COUPA SOFTWARE INC COM 22266L106 1,192 5,438 SH   SOLE   5,438 0 0
COUPA SOFTWARE INC NOTE 0.375% 6/1 22266LAF3 3,482 3,000 PRN   SOLE   3,000 0 0
COUPANG INC CL A 22266T109 3,763 3,600 PRN   SOLE   3,600 0 0
COVANTA HLDG CORP COM 22282E102 12,392 615,930 SH   SOLE   615,930 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 2,319 9,436 SH   SOLE   9,436 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 31,807 183,525 SH   SOLE   183,525 0 0
CROWN HLDGS INC COM 228368106 2,339 23,212 SH   SOLE   23,212 0 0
CROWN HLDGS INC COM 228368106 2 18 SH   OTR 1 0 0 18
CSX CORP COM 126408103 7,423 249,606 SH   SOLE   249,606 0 0
CSX CORP COM 126408103 2 67 SH   OTR 1 0 0 67
CUMMINS INC COM 231021106 3,581 15,949 SH   SOLE   15,949 0 0
CURIS INC COM NEW 231269200 1 120 SH   OTR 1 0 0 120
CURIS INC COM NEW 231269200 23,663 3,022,186 SH   SOLE   3,022,186 0 0
CURIS INC COM NEW 231269200 676 700 PRN   SOLE   700 0 0
CVS HEALTH CORP COM 126650100 4 49 SH   OTR 1 0 0 49
CVS HEALTH CORP COM 126650100 28,448 335,249 SH   SOLE   335,249 0 0
CYTOKINETICS INC COM NEW 23282W605 18,346 513,344 SH   SOLE   513,344 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1 214 SH   OTR 1 0 0 214
CYTOMX THERAPEUTICS INC COM 23284F105 16,825 3,305,726 SH   SOLE   3,305,726 0 0
D R HORTON INC COM 23331A109 3,135 37,333 SH   SOLE   37,333 0 0
DANAHER CORPORATION COM 235851102 14 47 SH   OTR 1 0 0 47
DANAHER CORPORATION COM 235851102 244,820 804,199 SH   SOLE   804,199 0 0
DARDEN RESTAURANTS INC COM 237194105 1,773 11,703 SH   SOLE   11,703 0 0
DARLING INGREDIENTS INC COM 237266101 45,869 637,980 SH   SOLE   637,980 0 0
DARLING INGREDIENTS INC COM 237266101 3 43 SH   OTR 1 0 0 43
DATADOG INC CL A COM 23804L103 7,357 52,047 SH   SOLE   52,047 0 0
DATADOG INC NOTE 0.125% 6/1 23804LAB9 826 500 PRN   SOLE   500 0 0
DAVITA INC COM 23918K108 2,707 23,288 SH   SOLE   23,288 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 24,060 708,090 SH   SOLE   708,090 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 1 27 SH   OTR 1 0 0 27
DEERE & CO COM 244199105 10,396 31,027 SH   SOLE   31,027 0 0
DELL TECHNOLOGIES INC CL C 24703L202 1 13 SH   OTR 1 0 0 13
DELL TECHNOLOGIES INC CL C 24703L202 6,295 60,507 SH   SOLE   60,507 0 0
DENALI THERAPEUTICS INC COM 24823R105 3,218 63,781 SH   SOLE   63,781 0 0
DENTSPLY SIRONA INC COM 24906P109 2,538 43,727 SH   SOLE   43,727 0 0
DEVON ENERGY CORP NEW COM 25179M103 2,114 59,546 SH   SOLE   59,546 0 0
DEXCOM INC COM 252131107 2,903 5,308 SH   SOLE   5,308 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 3 17 SH   OTR 1 0 0 17
DIAGEO PLC SPON ADR NEW 25243Q205 3,479 18,029 SH   SOLE   18,029 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 7,930 393,390 SH   SOLE   393,390 0 0
DIGITAL RLTY TR INC COM 253868103 2,016 13,957 SH   SOLE   13,957 0 0
DIGITAL TURBINE INC COM NEW 25400W102 4,051 58,930 SH   SOLE   58,930 0 0
DILLARDS INC CL A 254067101 257 1,487 SH   SOLE   1,487 0 0
DISCOVER FINL SVCS COM 254709108 4,797 39,053 SH   SOLE   39,053 0 0
DISCOVERY INC COM SER C 25470F302 714 29,404 SH   SOLE   29,404 0 0
DISH NETWORK CORPORATION CL A 25470M109 656 15,088 SH   SOLE   15,088 0 0
DISNEY WALT CO COM 254687106 8 46 SH   OTR 1 0 0 46
DISNEY WALT CO COM 254687106 107,137 633,338 SH   SOLE   633,338 0 0
DLOCAL LTD CLASS A COM G29018101 9,286 170,200 SH   SOLE   170,200 0 0
DOCUSIGN INC COM 256163106 14,868 57,759 SH   SOLE   57,759 0 0
DOLLAR GEN CORP NEW COM 256677105 9,311 43,891 SH   SOLE   43,891 0 0
DOLLAR TREE INC COM 256746108 1,204 12,578 SH   SOLE   12,578 0 0
DOMINION ENERGY INC COM 25746U109 4,184 57,300 SH   SOLE   57,300 0 0
DOMINOS PIZZA INC COM 25754A201 590 1,237 SH   SOLE   1,237 0 0
DOMTAR CORP COM NEW 257559203 17,234 315,996 SH   SOLE   315,996 0 0
DOVER CORP COM 260003108 2 12 SH   OTR 1 0 0 12
DOVER CORP COM 260003108 2,798 17,992 SH   SOLE   17,992 0 0
DOW INC COM 260557103 4,702 81,691 SH   SOLE   81,691 0 0
DROPBOX INC CL A 26210C104 7,047 241,194 SH   SOLE   241,194 0 0
DSP GROUPS INC COM 23332B106 6,268 286,076 SH   SOLE   286,076 0 0
DUPONT DE NEMOURS INC COM 26614N102 13,980 205,627 SH   SOLE   205,627 0 0
DYNE THERAPEUTICS INC COM 26818M108 5,252 323,393 SH   SOLE   323,393 0 0
EATON CORP PLC SHS G29183103 2 16 SH   OTR 1 0 0 16
EBAY INC. COM 278642103 3,919 56,250 SH   SOLE   56,250 0 0
ECHO GLOBAL LOGISTICS INC COM 27875T101 6,684 140,098 SH   SOLE   140,098 0 0
ECHO GLOBAL LOGISTICS INC COM 27875T101 1,627 1,500 PRN   SOLE   1,500 0 0
ECOLAB INC COM 278865100 12,717 60,961 SH   SOLE   60,961 0 0
EDISON INTL COM 281020107 2,903 52,338 SH   SOLE   52,338 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 13,013 114,949 SH   SOLE   114,949 0 0
ELANCO ANIMAL HEALTH INC COM 28414H103 717 22,491 SH   SOLE   22,491 0 0
ELECTRONIC ARTS INC COM 285512109 9,499 66,782 SH   SOLE   66,782 0 0
EMCOR GROUP INC COM 29084Q100 4,629 40,122 SH   SOLE   40,122 0 0
EMERSON ELEC CO COM 291011104 62,622 664,806 SH   SOLE   664,806 0 0
ENBRIDGE INC COM 29250N105 15,222 382,182 SH   SOLE   382,182 0 0
ENPHASE ENERGY INC COM 29355A107 2 15 SH   OTR 1 0 0 15
ENPHASE ENERGY INC COM 29355A107 23,169 154,496 SH   SOLE   154,496 0 0
ENTERGY CORP NEW COM 29364G103 1,206 12,142 SH   SOLE   12,142 0 0
ENTERGY CORP NEW COM 29364G103 2 17 SH   OTR 1 0 0 17
ENVIVA PARTNERS LP COM UNIT 29414J107 3,786 70,001 SH   SOLE   70,001 0 0
EOG RES INC COM 26875P101 2,788 34,735 SH   SOLE   34,735 0 0
EPAM SYS INC COM 29414B104 908 1,592 SH   SOLE   1,592 0 0
EPIZYME INC COM 29428V104 340 66,329 SH   SOLE   66,329 0 0
EQUIFAX INC COM 294429105 1,719 6,782 SH   SOLE   6,782 0 0
EQUINIX INC COM 29444U700 45,550 57,651 SH   SOLE   57,651 0 0
EQUINIX INC COM 29444U700 3 4 SH   OTR 1 0 0 4
EQUINOR ASA SPONSORED ADR 29446M102 2 59 SH   OTR 1 0 0 59
EQUITY LIFESTYLE PPTYS INC COM 29472R108 623 7,974 SH   SOLE   7,974 0 0
EQUITY LIFESTYLE PPTYS INC COM 29472R108 1 17 SH   OTR 1 0 0 17
EQUITY RESIDENTIAL SH BEN INT 29476L107 10,943 135,237 SH   SOLE   135,237 0 0
ERICSSON ADR B SEK 10 294821608 3,989 356,210 SH   SOLE   356,210 0 0
ESSA PHARMA INC COM NEW 29668H708 2,404 300,505 SH   SOLE   300,505 0 0
ESSA PHARMA INC COM NEW 29668H708 0 20 SH   OTR 1 0 0 20
ESSENTIAL UTILS INC COM 29670G102 1,646 35,712 SH   SOLE   35,712 0 0
ESSEX PPTY TR INC COM 297178105 1,548 4,842 SH   SOLE   4,842 0 0
ETF MANAGERS TR PRIME CYBR SCRTY 26924G201 1,202 19,767 SH   SOLE   19,767 0 0
ETF MANAGERS TR WEDBUSH VID GAME 26924G706 208 2,485 SH   SOLE   2,485 0 0
ETSY INC COM 29786A106 10,421 50,114 SH   SOLE   50,114 0 0
EVEREST RE GROUP LTD COM G3223R108 1,477 5,891 SH   SOLE   5,891 0 0
EVERSOURCE ENERGY COM 30040W108 3,172 38,799 SH   SOLE   38,799 0 0
EXACT SCIENCES CORP COM 30063P105 1 15 SH   OTR 1 0 0 15
EXACT SCIENCES CORP COM 30063P105 22,033 230,844 SH   SOLE   230,844 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 4,495 4,000 PRN   SOLE   4,000 0 0
EXCHANGE TRADED CONCEPTS TR EMQQ EM INTERN 301505889 514 10,370 SH   SOLE   10,370 0 0
EXELIXIS INC COM 30161Q104 57,893 2,738,680 SH   SOLE   2,738,680 0 0
EXELIXIS INC COM 30161Q104 3 123 SH   OTR 1 0 0 123
EXELON CORP COM 30161N101 5,694 117,791 SH   SOLE   117,791 0 0
EXPEDIA GROUP INC COM NEW 30212P303 1,268 7,736 SH   SOLE   7,736 0 0
EXPEDITORS INTL WASH INC COM 302130109 1,456 12,221 SH   SOLE   12,221 0 0
EXPEDITORS INTL WASH INC COM 302130109 3 23 SH   OTR 1 0 0 23
EXTRA SPACE STORAGE INC COM 30225T102 979 5,827 SH   SOLE   5,827 0 0
EXXON MOBIL CORP COM 30231G102 22,329 379,626 SH   SOLE   379,626 0 0
FACEBOOK INC CL A 30303M102 4 13 SH   OTR 1 0 0 13
FACEBOOK INC CL A 30303M102 191,226 563,465 SH   SOLE   563,465 0 0
FASTENAL CO COM 311900104 2 32 SH   OTR 1 0 0 32
FASTENAL CO COM 311900104 2,924 56,650 SH   SOLE   56,650 0 0
FATE THERAPEUTICS INC COM 31189P102 14,860 250,729 SH   SOLE   250,729 0 0
FATE THERAPEUTICS INC COM 31189P102 0 8 SH   OTR 1 0 0 8
FEDEX CORP COM 31428X106 3,480 15,869 SH   SOLE   15,869 0 0
FERRO CORP COM 315405100 2,515 123,663 SH   SOLE   123,663 0 0
FIBROGEN INC COM 31572Q808 2,948 288,484 SH   SOLE   288,484 0 0
FIDELITY NATIONAL FINANCIAL FNF GROUP COM 31620R303 721 15,894 SH   SOLE   15,894 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 5,765 47,377 SH   SOLE   47,377 0 0
FIFTH THIRD BANCORP COM 316773100 3,434 80,915 SH   SOLE   80,915 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 1,961 10,168 SH   SOLE   10,168 0 0
FISERV INC COM 337738108 5,167 47,621 SH   SOLE   47,621 0 0
FIVE BELOW INC COM 33829M101 8,449 47,790 SH   SOLE   47,790 0 0
FIVE9 INC COM 338307101 13,749 86,075 SH   SOLE   86,075 0 0
FLAGSTAR BANCORP INC COM PAR .001 337930705 561 11,041 SH   SOLE   11,041 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 1,124 4,304 SH   SOLE   4,304 0 0
FMC CORP COM NEW 302491303 1,013 11,068 SH   SOLE   11,068 0 0
FOMENTO ECONOMICO MEXICANO S SPON ADR UNITS 344419106 259 2,984 SH   SOLE   2,984 0 0
FORD MTR CO DEL COM 345370860 5,544 391,575 SH   SOLE   391,575 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 6,787 292,692 SH   SOLE   292,692 0 0
FORTERRA INC COM 34960W106 17,313 734,897 SH   SOLE   734,897 0 0
FORTINET INC COM 34959E109 8,656 29,640 SH   SOLE   29,640 0 0
FORTIVE CORP COM 34959J108 1,853 26,255 SH   SOLE   26,255 0 0
FORTIVE CORP NOTE 0.875% 2/1 34959JAK4 18,877 18,500 PRN   SOLE   18,500 0 0
FOX CORP CL A COM 35137L105 450 11,209 SH   SOLE   11,209 0 0
FOX CORP CL B COM 35137L204 1,055 28,435 SH   SOLE   28,435 0 0
FRANCO NEV CORP COM 351858105 667 5,132 SH   SOLE   5,132 0 0
FRANKLIN RESOURCES INC COM 354613101 1,262 42,458 SH   SOLE   42,458 0 0
FREEPORT-MCMORAN INC CL B 35671D857 1,137 34,958 SH   SOLE   34,958 0 0
FRESHPET INC COM 358039105 1,983 13,901 SH   SOLE   13,901 0 0
FTI CONSULTING INC COM 302941109 8,855 65,738 SH   SOLE   65,738 0 0
GALLAGHER ARTHUR J & CO COM 363576109 1,330 8,949 SH   SOLE   8,949 0 0
GARMIN LTD SHS H2906T109 3 18 SH   OTR 1 0 0 18
GARTNER INC COM 366651107 3,364 11,069 SH   SOLE   11,069 0 0
GATX CORP COM 361448103 893 9,975 SH   SOLE   9,975 0 0
GENERAC HLDGS INC COM 368736104 2,283 5,586 SH   SOLE   5,586 0 0
GENERAL ELECTRIC CO COM NEW 369604301 9,262 89,900 SH   SOLE   89,900 0 0
GENERAL MLS INC COM 370334104 6,964 116,416 SH   SOLE   116,416 0 0
GENERAL MTRS CO COM 37045V100 5,514 104,615 SH   SOLE   104,615 0 0
GENMAB A/S SPONSORED ADS 372303206 5,957 136,316 SH   SOLE   136,316 0 0
GENMAB A/S SPONSORED ADS 372303206 6 132 SH   OTR 1 0 0 132
GENUINE PARTS CO COM 372460105 1,383 11,409 SH   SOLE   11,409 0 0
GILDAN ACTIVEWEAR INC COM 375916103 3,872 105,994 SH   SOLE   105,994 0 0
GILEAD SCIENCES INC COM 375558103 108,793 1,557,588 SH   SOLE   1,557,588 0 0
GILEAD SCIENCES INC COM 375558103 2 23 SH   OTR 1 0 0 23
GLADSTONE COMMERCIAL CORP COM 376536108 210 10,000 SH   SOLE   10,000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 4 92 SH   OTR 1 0 0 92
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 8,511 334,041 SH   SOLE   334,041 0 0
GLOBAL PMTS INC COM 37940X102 2,484 15,766 SH   SOLE   15,766 0 0
GLOBAL X FDS GLOBAL X COPPER 37954Y830 463 13,550 SH   SOLE   13,550 0 0
GLOBAL X FDS LITHIUM BTRY ETF 37954Y855 215 2,624 SH   SOLE   2,624 0 0
GLOBUS MED INC CL A 379577208 4,520 59,000 SH   SOLE   59,000 0 0
GOLD FIELDS LTD SPONSORED ADR 38059T106 179 22,021 SH   SOLE   22,021 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 4,078 10,788 SH   SOLE   10,788 0 0
GOODYEAR TIRE & RUBR CO COM 382550101 231 13,031 SH   SOLE   13,031 0 0
GRAINGER W W INC COM 384802104 2,870 7,303 SH   SOLE   7,303 0 0
GREAT WESTERN BANCORP INC COM 391416104 8,959 273,640 SH   SOLE   273,640 0 0
GREENSKY INC CL A 39572G100 8,662 774,796 SH   SOLE   774,796 0 0
GUARDANT HEALTH INC COM 40131M109 15,546 124,366 SH   SOLE   124,366 0 0
GUARDANT HEALTH INC COM 40131M109 1 6 SH   OTR 1 0 0 6
HALLIBURTON CO COM 406216101 5,802 268,377 SH   SOLE   268,377 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 28,392 697,961 SH   SOLE   697,961 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1 18 SH   OTR 1 0 0 18
HANNON ARMSTRONG SUST INFR C COM 41068X100 22,874 427,724 SH   SOLE   427,724 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 2 45 SH   OTR 1 0 0 45
HARPOON THERAPEUTICS INC COM 41358P106 3,867 489,481 SH   SOLE   489,481 0 0
HARPOON THERAPEUTICS INC COM 41358P106 0 33 SH   OTR 1 0 0 33
HARTFORD FINL SVCS GROUP INC COM 416515104 2,518 35,848 SH   SOLE   35,848 0 0
HASBRO INC COM 418056107 8,400 94,153 SH   SOLE   94,153 0 0
HCA HEALTHCARE INC COM 40412C101 6,056 24,951 SH   SOLE   24,951 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 3,703 50,669 SH   SOLE   50,669 0 0
HEADHUNTER GROUP PLC SPONSORED ADS 42207L106 8,715 178,600 SH   SOLE   178,600 0 0
HEALTHPEAK PROPERTIES INC COM 42250P103 1,509 45,088 SH   SOLE   45,088 0 0
HEICO CORP NEW CL A 422806208 1,070 9,032 SH   SOLE   9,032 0 0
HELMERICH & PAYNE INC COM 423452101 8,759 319,585 SH   SOLE   319,585 0 0
HENRY JACK & ASSOC INC COM 426281101 6,562 40,001 SH   SOLE   40,001 0 0
HENRY SCHEIN INC COM 806407102 274 3,592 SH   SOLE   3,592 0 0
HERON THERAPEUTICS INC COM 427746102 1,784 166,916 SH   SOLE   166,916 0 0
HERSHEY CO COM 427866108 4 22 SH   OTR 1 0 0 22
HERSHEY CO COM 427866108 5,132 30,321 SH   SOLE   30,321 0 0
HESS CORP COM 42809H107 1,759 22,525 SH   SOLE   22,525 0 0
HEWLETT PACKARD ENTERPRISE C COM 42824C109 1,987 139,428 SH   SOLE   139,428 0 0
HILL-ROM HLDGS INC COM 431475102 9,262 61,750 SH   SOLE   61,750 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 923 800 PRN   SOLE   800 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 20,527 155,382 SH   SOLE   155,382 0 0
HOLOGIC INC COM 436440101 39,509 535,300 SH   SOLE   535,300 0 0
HOLOGIC INC COM 436440101 2 28 SH   OTR 1 0 0 28
HOME DEPOT INC COM 437076102 81,226 247,454 SH   SOLE   247,454 0 0
HOME DEPOT INC COM 437076102 6 17 SH   OTR 1 0 0 17
HONEYWELL INTL INC COM 438516106 3,851 18,141 SH   SOLE   18,141 0 0
HORMEL FOODS CORP COM 440452100 1,045 25,492 SH   SOLE   25,492 0 0
HOST HOTELS & RESORTS INC COM 44107P104 1,128 69,074 SH   SOLE   69,074 0 0
HOWMET AEROSPACE INC COM 443201108 779 24,980 SH   SOLE   24,980 0 0
HP INC COM 40434L105 2 61 SH   OTR 1 0 0 61
HP INC COM 40434L105 19,585 715,858 SH   SOLE   715,858 0 0
HUAZHU GROUP LTD NOTE 0.375%11/0 16949NAC3 680 600 PRN   SOLE   600 0 0
HUBSPOT INC COM 443573100 4,075 6,028 SH   SOLE   6,028 0 0
HUMANA INC COM 444859102 6,930 17,808 SH   SOLE   17,808 0 0
HUNTINGTON BANCSHARES INC COM 446150104 6,849 443,021 SH   SOLE   443,021 0 0
HUNTINGTON INGALLS INDS INC COM 446413106 375 1,943 SH   SOLE   1,943 0 0
ICICI BANK LIMITED ADR 45104G104 3,307 175,250 SH   SOLE   175,250 0 0
IDEX CORP COM 45167R104 7,415 35,833 SH   SOLE   35,833 0 0
IDEX CORP COM 45167R104 1 6 SH   OTR 1 0 0 6
IDEXX LABS INC COM 45168D104 27,254 43,826 SH   SOLE   43,826 0 0
IHS MARKIT LTD SHS G47567105 32,140 275,609 SH   SOLE   275,609 0 0
ILLINOIS TOOL WKS INC COM 452308109 23,493 113,701 SH   SOLE   113,701 0 0
ILLUMINA INC COM 452327109 90,709 223,645 SH   SOLE   223,645 0 0
ILLUMINA INC COM 452327109 1 2 SH   OTR 1 0 0 2
ILLUMINA INC NOTE 8/1 452327AK5 3,386 2,900 PRN   SOLE   2,900 0 0
IMMUNOGEN INC COM 45253H101 14,531 2,562,839 SH   SOLE   2,562,839 0 0
IMMUNOGEN INC COM 45253H101 1 96 SH   OTR 1 0 0 96
INCYTE CORP COM 45337C102 51,082 742,718 SH   SOLE   742,718 0 0
INCYTE CORP COM 45337C102 2 22 SH   OTR 1 0 0 22
INFOSYS LTD SPONSORED ADR 456788108 6,074 272,998 SH   SOLE   272,998 0 0
INGERSOLL RAND INC COM 45687V106 1,666 33,058 SH   SOLE   33,058 0 0
INGREDION INC COM 457187102 268 3,011 SH   SOLE   3,011 0 0
INOVALON HLDGS INC COM CL A 45781D101 9,302 230,880 SH   SOLE   230,880 0 0
INSMED INC COM PAR $.01 457669307 24,222 879,547 SH   SOLE   879,547 0 0
INSMED INC NOTE 1.750% 1/1 457669AA7 312 300 PRN   SOLE   300 0 0
INSULET CORP COM 45784P101 1,096 3,855 SH   SOLE   3,855 0 0
INTEGRA RES CORP COM NEW 45826T301 28 12,500 SH   SOLE   12,500 0 0
INTEL CORP COM 458140100 4 75 SH   OTR 1 0 0 75
INTEL CORP COM 458140100 28,324 531,632 SH   SOLE   531,632 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 13,566 101,127 SH   SOLE   101,127 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 6,638 57,815 SH   SOLE   57,815 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 16,444 118,365 SH   SOLE   118,365 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 4 32 SH   OTR 1 0 0 32
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 3,254 24,332 SH   SOLE   24,332 0 0
INTERNATIONAL PAPER CO COM 460146103 1,360 24,313 SH   SOLE   24,313 0 0
INTERPUBLIC GROUP COS INC COM 460690100 35,579 970,286 SH   SOLE   970,286 0 0
INTERPUBLIC GROUP COS INC COM 460690100 1 31 SH   OTR 1 0 0 31
INTRA-CELLULAR THERAPIES INC COM 46116X101 18,097 485,466 SH   SOLE   485,466 0 0
INTUIT COM 461202103 42,216 78,253 SH   SOLE   78,253 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 45,449 45,718 SH   SOLE   45,718 0 0
INVITATION HOMES INC COM 46187W107 19,563 510,405 SH   SOLE   510,405 0 0
IONIS PHARMACEUTICALS INC COM 462222100 24,361 726,359 SH   SOLE   726,359 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 20,926 848,618 SH   SOLE   848,618 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 1 34 SH   OTR 1 0 0 34
IQVIA HLDGS INC COM 46266C105 50,592 211,213 SH   SOLE   211,213 0 0
IQVIA HLDGS INC COM 46266C105 2 10 SH   OTR 1 0 0 10
IRON MTN INC NEW COM 46284V101 637 14,653 SH   SOLE   14,653 0 0
ISHARES INC MSCI CDA ETF 464286509 4,113 113,314 SH   SOLE   113,314 0 0
ISHARES TR GL CLEAN ENE ETF 464288224 459 21,200 SH   SOLE   21,200 0 0
ISHARES TR ISHARES SEMICDTR 464287523 655 1,470 SH   SOLE   1,470 0 0
ISHARES TR U.S. MED DVC ETF 464288810 260 4,140 SH   SOLE   4,140 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 749 141,665 SH   SOLE   141,665 0 0
ITEOS THERAPEUTICS INC COM 46565G104 14,180 525,213 SH   SOLE   525,213 0 0
ITEOS THERAPEUTICS INC COM 46565G104 1 31 SH   OTR 1 0 0 31
IVERIC BIO INC COM 46583P102 19,735 1,215,272 SH   SOLE   1,215,272 0 0
JACKSON FINANCIAL INC COM CL A 46817M107 1,359 52,281 SH   SOLE   52,281 0 0
JAZZ INVESTMENTS I LTD NOTE 1.500% 8/1 472145AD3 2,536 2,500 PRN   SOLE   2,500 0 0
JBG SMITH PPTYS COM 46590V100 2,985 100,819 SH   SOLE   100,819 0 0
JD.COM INC SPON ADR CL A 47215P106 1,418 19,635 SH   SOLE   19,635 0 0
JEFFERIES FINL GROUP INC COM 47233W109 549 14,793 SH   SOLE   14,793 0 0
JOHNSON & JOHNSON COM 478160104 158,644 982,360 SH   SOLE   982,360 0 0
JOHNSON & JOHNSON COM 478160104 11 66 SH   OTR 1 0 0 66
JOUNCE THERAPEUTICS INC COM 481116101 0 16 SH   OTR 1 0 0 16
JOUNCE THERAPEUTICS INC COM 481116101 2,507 337,382 SH   SOLE   337,382 0 0
JPMORGAN CHASE & CO COM 46625H100 48,816 298,234 SH   SOLE   298,234 0 0
KADMON HLDGS INC COM 48283N106 5,992 687,970 SH   SOLE   687,970 0 0
KANSAS CITY SOUTHERN COM NEW 485170302 10,243 37,848 SH   SOLE   37,848 0 0
KARUNA THERAPEUTICS INC COM 48576A100 6,697 54,750 SH   SOLE   54,750 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 4,176 717,624 SH   SOLE   717,624 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 0 44 SH   OTR 1 0 0 44
KELLOGG CO COM 487836108 2,188 34,229 SH   SOLE   34,229 0 0
KELLOGG CO COM 487836108 2 29 SH   OTR 1 0 0 29
KEROS THERAPEUTICS INC COM 492327101 9,531 240,946 SH   SOLE   240,946 0 0
KEURIG DR PEPPER INC COM 49271V100 1,875 54,904 SH   SOLE   54,904 0 0
KEURIG DR PEPPER INC COM 49271V100 1 34 SH   OTR 1 0 0 34
KEYCORP COM 493267108 8,652 400,217 SH   SOLE   400,217 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 41,147 250,462 SH   SOLE   250,462 0 0
KIMBERLY-CLARK CORP COM 494368103 4,192 31,651 SH   SOLE   31,651 0 0
KIMCO RLTY CORP COM 49446R109 226 10,900 SH   SOLE   10,900 0 0
KINDER MORGAN INC DEL COM 49456B101 19,246 1,150,421 SH   SOLE   1,150,421 0 0
KINROSS GOLD CORP COM 496902404 242 45,069 SH   SOLE   45,069 0 0
KKR & CO INC COM 48251W104 4,543 74,633 SH   SOLE   74,633 0 0
KLA CORP COM NEW 482480100 16,984 50,774 SH   SOLE   50,774 0 0
KODIAK SCIENCES INC COM 50015M109 3,185 33,186 SH   SOLE   33,186 0 0
KRAFT HEINZ CO COM 500754106 2,484 67,461 SH   SOLE   67,461 0 0
KRATON CORP COM 50077C106 2,275 49,852 SH   SOLE   49,852 0 0
KROGER CO COM 501044101 7,998 197,827 SH   SOLE   197,827 0 0
KROGER CO COM 501044101 3 79 SH   OTR 1 0 0 79
KULICKE & SOFFA INDS INC COM 501242101 5,775 99,098 SH   SOLE   99,098 0 0
KURA ONCOLOGY INC COM 50127T109 17,724 946,321 SH   SOLE   946,321 0 0
KURA ONCOLOGY INC COM 50127T109 1 36 SH   OTR 1 0 0 36
KYMERA THERAPEUTICS INC COM 501575104 1 17 SH   OTR 1 0 0 17
KYMERA THERAPEUTICS INC COM 501575104 23,200 394,974 SH   SOLE   394,974 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 14,548 51,695 SH   SOLE   51,695 0 0
LAM RESEARCH CORP COM 512807108 16,784 29,490 SH   SOLE   29,490 0 0
LAMB WESTON HLDGS INC COM 513272104 703 11,455 SH   SOLE   11,455 0 0
LANDMARK INFRASTRCTUR PARTR COM UNIT LTD 51508J108 7,740 473,397 SH   SOLE   473,397 0 0
LAS VEGAS SANDS CORP COM 517834107 807 22,041 SH   SOLE   22,041 0 0
LAS VEGAS SANDS CORP COM 517834107 1,204 1,000 PRN   SOLE   1,000 0 0
LAUDER ESTEE COS INC CL A 518439104 2 5 SH   OTR 1 0 0 5
LAUDER ESTEE COS INC CL A 518439104 60,398 201,382 SH   SOLE   201,382 0 0
LEMONADE INC COM 52567D107 369 5,500 SH   SOLE   5,500 0 0
LENNAR CORP CL A 526057104 1,262 13,476 SH   SOLE   13,476 0 0
LENNOX INTL INC COM 526107107 2,712 9,218 SH   SOLE   9,218 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 1,216 7,039 SH   SOLE   7,039 0 0
LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 677 14,257 SH   SOLE   14,257 0 0
LILLY ELI & CO COM 532457108 31,779 137,547 SH   SOLE   137,547 0 0
LINCOLN NATL CORP IND COM 534187109 1,056 15,360 SH   SOLE   15,360 0 0
LINDE PLC SHS G5494J103 1 5 SH   OTR 1 0 0 5
LITHIUM AMERS CORP NEW COM NEW 53680Q207 948 42,463 SH   SOLE   42,463 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 1,020 11,198 SH   SOLE   11,198 0 0
LKQ CORP COM 501889208 1,835 36,468 SH   SOLE   36,468 0 0
LOEWS CORP COM 540424108 2,243 41,601 SH   SOLE   41,601 0 0
LOUISIANA PAC CORP COM 546347105 12,939 210,842 SH   SOLE   210,842 0 0
LOWES COS INC COM 548661107 52,737 259,981 SH   SOLE   259,981 0 0
LULULEMON ATHLETICA INC COM 550021109 21,324 52,693 SH   SOLE   52,693 0 0
LUMEN TECHNOLOGIES INC COM 550241103 849 68,566 SH   SOLE   68,566 0 0
LUMENTUM HLDGS INC NOTE 0.500%12/1 55024UAD1 1,323 1,200 PRN   SOLE   1,200 0 0
LYDALL INC COM 550819106 6,327 101,884 SH   SOLE   101,884 0 0
LYFT INC CL A COM 55087P104 7,702 143,732 SH   SOLE   143,732 0 0
M & T BK CORP COM 55261F104 1,318 8,824 SH   SOLE   8,824 0 0
MACERICH CO COM 554382101 6,360 380,634 SH   SOLE   380,634 0 0
MACROGENICS INC COM 556099109 12,741 608,499 SH   SOLE   608,499 0 0
MACROGENICS INC COM 556099109 1 24 SH   OTR 1 0 0 24
MACYS INC COM 55616P104 5,141 227,508 SH   SOLE   227,508 0 0
MAGELLAN HEALTH INC COM NEW 559079207 18,325 193,817 SH   SOLE   193,817 0 0
MAGNA INTL INC COM 559222401 683 9,083 SH   SOLE   9,083 0 0
MANPOWERGROUP INC WIS COM 56418H100 15,296 141,268 SH   SOLE   141,268 0 0
MANULIFE FINL CORP COM 56501R106 1,209 62,815 SH   SOLE   62,815 0 0
MARATHON OIL CORP COM 565849106 1,038 75,948 SH   SOLE   75,948 0 0
MARATHON PETE CORP COM 56585A102 2,177 35,217 SH   SOLE   35,217 0 0
MARKEL CORP COM 570535104 464 388 SH   SOLE   388 0 0
MARKETAXESS HLDGS INC COM 57060D108 915 2,176 SH   SOLE   2,176 0 0
MARRIOTT INTL INC NEW CL A 571903202 2,946 19,891 SH   SOLE   19,891 0 0
MARSH & MCLENNAN COS INC COM 571748102 5,474 36,149 SH   SOLE   36,149 0 0
MARSH & MCLENNAN COS INC COM 571748102 1 8 SH   OTR 1 0 0 8
MARTIN MARIETTA MATLS INC COM 573284106 4,347 12,724 SH   SOLE   12,724 0 0
MARVELL TECHNOLOGY INC COM 573874104 2,775 46,011 SH   SOLE   46,011 0 0
MASCO CORP COM 574599106 12,229 220,158 SH   SOLE   220,158 0 0
MASCO CORP COM 574599106 2 37 SH   OTR 1 0 0 37
MASIMO CORP COM 574795100 5,709 21,090 SH   SOLE   21,090 0 0
MASTEC INC COM 576323109 26,673 309,161 SH   SOLE   309,161 0 0
MASTEC INC COM 576323109 3 32 SH   OTR 1 0 0 32
MASTERCARD INCORPORATED CL A 57636Q104 65,457 188,275 SH   SOLE   188,275 0 0
MASTERCARD INCORPORATED CL A 57636Q104 2 7 SH   OTR 1 0 0 7
MATCH GROUP INC NEW COM 57667L107 2,100 13,380 SH   SOLE   13,380 0 0
MATERIALISE NV SPONSORED ADS 57667T100 201 10,000 SH   SOLE   10,000 0 0
MATTEL INC COM 577081102 9,598 517,174 SH   SOLE   517,174 0 0
MATTERPORT INC COM CL A 577096100 428 400 PRN   SOLE   400 0 0
MCCORMICK & CO INC COM NON VTG 579780206 21,819 269,282 SH   SOLE   269,282 0 0
MCCORMICK & CO INC COM NON VTG 579780206 2 19 SH   OTR 1 0 0 19
MCDONALDS CORP COM 580135101 60,268 249,973 SH   SOLE   249,973 0 0
MCDONALDS CORP COM 580135101 2 7 SH   OTR 1 0 0 7
MCKESSON CORP COM 58155Q103 1,701 8,534 SH   SOLE   8,534 0 0
MEDALLIA INC COM 584021109 6,086 179,682 SH   SOLE   179,682 0 0
MEDTRONIC PLC SHS G5960L103 6 51 SH   OTR 1 0 0 51
MERCADOLIBRE INC COM 58733R102 75,771 45,120 SH   SOLE   45,120 0 0
MERCK & CO INC COM 58933Y105 14 192 SH   OTR 1 0 0 192
MERCK & CO INC COM 58933Y105 275,115 3,662,987 SH   SOLE   3,662,987 0 0
MERIDIAN BANCORP INC MD COM 58958U103 310 14,912 SH   SOLE   14,912 0 0
MERSANA THERAPEUTICS INC COM 59045L106 19,074 2,022,816 SH   SOLE   2,022,816 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1 79 SH   OTR 1 0 0 79
MERUS N V COM N5749R100 1 47 SH   OTR 1 0 0 47
MESA LABS INC COM 59064R109 1,995 6,597 SH   SOLE   6,597 0 0
METLIFE INC COM 59156R108 3 50 SH   OTR 1 0 0 50
METLIFE INC COM 59156R108 4,234 68,595 SH   SOLE   68,595 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 25,267 18,345 SH   SOLE   18,345 0 0
MGM RESORTS INTERNATIONAL COM 552953101 2,257 52,309 SH   SOLE   52,309 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 2,464 16,056 SH   SOLE   16,056 0 0
MICRON TECHNOLOGY INC COM 595112103 15,394 216,892 SH   SOLE   216,892 0 0
MICRON TECHNOLOGY INC COM 595112103 2 24 SH   OTR 1 0 0 24
MICROSOFT CORP COM 594918104 718,027 2,547,027 SH   SOLE   2,547,027 0 0
MICROSOFT CORP COM 594918104 26 92 SH   OTR 1 0 0 92
MID-AMER APT CMNTYS INC COM 59522J103 1,275 6,827 SH   SOLE   6,827 0 0
MIRATI THERAPEUTICS INC COM 60468T105 67,790 383,204 SH   SOLE   383,204 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3 15 SH   OTR 1 0 0 15
MOBILE TELESYSTEMS PJSC SPONSORED ADR 607409109 10,951 1,136,000 SH   SOLE   1,136,000 0 0
MODERNA INC COM 60770K107 80,261 208,555 SH   SOLE   208,555 0 0
MOHAWK INDS INC COM 608190104 1,691 9,531 SH   SOLE   9,531 0 0
MOLINA HEALTHCARE INC COM 60855R100 722 2,662 SH   SOLE   2,662 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 656 14,134 SH   SOLE   14,134 0 0
MONDELEZ INTL INC CL A 609207105 32,433 557,479 SH   SOLE   557,479 0 0
MONDELEZ INTL INC CL A 609207105 1 25 SH   OTR 1 0 0 25
MONGODB INC CL A 60937P106 1,959 4,155 SH   SOLE   4,155 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 2,922 32,894 SH   SOLE   32,894 0 0
MOODYS CORP COM 615369105 10,770 30,330 SH   SOLE   30,330 0 0
MORGAN STANLEY COM NEW 617446448 5 50 SH   OTR 1 0 0 50
MORGAN STANLEY COM NEW 617446448 46,524 478,126 SH   SOLE   478,126 0 0
MORPHOSYS AG SPONSORED ADS 617760202 1 57 SH   OTR 1 0 0 57
MORPHOSYS AG SPONSORED ADS 617760202 3,161 268,778 SH   SOLE   268,778 0 0
MOSAIC CO NEW COM 61945C103 1,990 55,710 SH   SOLE   55,710 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 7,894 33,979 SH   SOLE   33,979 0 0
MSCI INC COM 55354G100 2,611 4,292 SH   SOLE   4,292 0 0
NASDAQ INC COM 631103108 216 1,117 SH   SOLE   1,117 0 0
NATERA INC COM 632307104 982 8,815 SH   SOLE   8,815 0 0
NATIONAL FUEL GAS CO COM 636180101 564 10,738 SH   SOLE   10,738 0 0
NATIONAL HEALTH INVS INC COM 63633D104 535 10,000 SH   SOLE   10,000 0 0
NATURA &CO HLDG S A ADS 63884N108 171 10,298 SH   SOLE   10,298 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 952 155,000 SH   SOLE   155,000 0 0
NEOGENOMICS INC COM NEW 64049M209 1 16 SH   OTR 1 0 0 16
NEOGENOMICS INC COM NEW 64049M209 12,547 260,104 SH   SOLE   260,104 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 0 55 SH   OTR 1 0 0 55
NEOLEUKIN THERAPEUTICS INC COM 64049K104 6,204 858,118 SH   SOLE   858,118 0 0
NETAPP INC COM 64110D104 1,157 12,887 SH   SOLE   12,887 0 0
NETFLIX INC COM 64110L106 22,070 36,162 SH   SOLE   36,162 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,817 81,503 SH   SOLE   81,503 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 1 10 SH   OTR 1 0 0 10
NEW GOLD INC CDA COM 644535106 116 109,650 SH   SOLE   109,650 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 877 427,854 SH   SOLE   427,854 0 0
NEWELL BRANDS INC COM 651229106 1,741 78,661 SH   SOLE   78,661 0 0
NEWMONT CORP COM 651639106 13,888 255,780 SH   SOLE   255,780 0 0
NEWMONT CORP COM 651639106 1 20 SH   OTR 1 0 0 20
NEXTERA ENERGY INC COM 65339F101 28,334 360,861 SH   SOLE   360,861 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 36,958 490,439 SH   SOLE   490,439 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 4 47 SH   OTR 1 0 0 47
NGM BIOPHARMACEUTICALS INC COM 62921N105 11,856 564,059 SH   SOLE   564,059 0 0
NIKE INC CL B 654106103 89,924 619,209 SH   SOLE   619,209 0 0
NIKE INC CL B 654106103 4 26 SH   OTR 1 0 0 26
NIO INC SPON ADS 62914V106 3,545 99,503 SH   SOLE   99,503 0 0
NKARTA INC COM 65487U108 1,891 67,992 SH   SOLE   67,992 0 0
NKARTA INC COM 65487U108 0 4 SH   OTR 1 0 0 4
NOMAD FOODS LTD USD ORD SHS G6564A105 6,382 231,587 SH   SOLE   231,587 0 0
NORFOLK SOUTHN CORP COM 655844108 14,711 61,490 SH   SOLE   61,490 0 0
NORTHERN TR CORP COM 665859104 4,399 40,801 SH   SOLE   40,801 0 0
NORTONLIFELOCK INC COM 668771108 2,426 95,907 SH   SOLE   95,907 0 0
NOVAVAX INC COM NEW 670002401 24,001 115,779 SH   SOLE   115,779 0 0
NOVOCURE LTD ORD SHS G6674U108 0 3 SH   OTR 1 0 0 3
NOVO-NORDISK A S ADR 670100205 2 23 SH   OTR 1 0 0 23
NU SKIN ENTERPRISES INC CL A 67018T105 2,435 60,171 SH   SOLE   60,171 0 0
NUANCE COMMUNICATIONS INC COM 67020Y100 26,096 474,152 SH   SOLE   474,152 0 0
NUCOR CORP COM 670346105 16,379 166,305 SH   SOLE   166,305 0 0
NURIX THERAPEUTICS INC COM 67080M103 16,626 554,978 SH   SOLE   554,978 0 0
NURIX THERAPEUTICS INC COM 67080M103 1 18 SH   OTR 1 0 0 18
NUTRIEN LTD COM 67077M108 921 14,189 SH   SOLE   14,189 0 0
NUVATION BIO INC COM CL A 67080N101 2,853 287,079 SH   SOLE   287,079 0 0
NUVATION BIO INC COM CL A 67080N101 0 20 SH   OTR 1 0 0 20
NVIDIA CORPORATION COM 67066G104 124,894 602,914 SH   SOLE   602,914 0 0
NVR INC COM 62944T105 1,103 230 SH   SOLE   230 0 0
OCCIDENTAL PETE CORP COM 674599105 1,640 55,431 SH   SOLE   55,431 0 0
OKTA INC CL A 679295105 2,348 9,893 SH   SOLE   9,893 0 0
OKTA INC NOTE 0.375% 6/1 679295AF2 2,343 1,950 PRN   SOLE   1,950 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 5,069 17,725 SH   SOLE   17,725 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 9,440 342,551 SH   SOLE   342,551 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 1 21 SH   OTR 1 0 0 21
OMNICOM GROUP INC COM 681919106 1,472 20,314 SH   SOLE   20,314 0 0
OMNICOM GROUP INC COM 681919106 2 24 SH   OTR 1 0 0 24
ON SEMICONDUCTOR CORP COM 682189105 4 80 SH   OTR 1 0 0 80
ON SEMICONDUCTOR CORP COM 682189105 79,982 1,747,559 SH   SOLE   1,747,559 0 0
ONEOK INC NEW COM 682680103 2,417 41,679 SH   SOLE   41,679 0 0
ORACLE CORP COM 68389X105 11,381 130,627 SH   SOLE   130,627 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 2,353 3,851 SH   SOLE   3,851 0 0
ORIX CORP SPONSORED ADR 686330101 1 11 SH   OTR 1 0 0 11
ORMAT TECHNOLOGIES INC COM 686688102 1,183 17,755 SH   SOLE   17,755 0 0
ORTHOPEDIATRICS CORP COM 68752L100 5,797 88,496 SH   SOLE   88,496 0 0
OTIS WORLDWIDE CORP COM 68902V107 2 26 SH   OTR 1 0 0 26
OTIS WORLDWIDE CORP COM 68902V107 30,577 371,639 SH   SOLE   371,639 0 0
OUTSET MED INC COM 690145107 5,861 118,555 SH   SOLE   118,555 0 0
OWENS CORNING NEW COM 690742101 50,588 591,699 SH   SOLE   591,699 0 0
OWENS CORNING NEW COM 690742101 3 32 SH   OTR 1 0 0 32
PACCAR INC COM 693718108 3,464 43,894 SH   SOLE   43,894 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 7,165 280,431 SH   SOLE   280,431 0 0
PACIRA BIOSCIENCES INC COM 695127100 11,477 204,960 SH   SOLE   204,960 0 0
PACKAGING CORP AMER COM 695156109 806 5,861 SH   SOLE   5,861 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 10,672 206,350 SH   SOLE   206,350 0 0
PALO ALTO NETWORKS INC COM 697435105 99,776 208,309 SH   SOLE   208,309 0 0
PALO ALTO NETWORKS INC COM 697435105 2 5 SH   OTR 1 0 0 5
PALO ALTO NETWORKS INC NOTE 0.375% 6/0 697435AF2 2,445 1,224,250 PRN   SOLE   1,224,250 0 0
PALO ALTO NETWORKS INC NOTE 0.750% 7/0 697435AD7 546 300 PRN   SOLE   300 0 0
PARKER-HANNIFIN CORP COM 701094104 8,156 29,168 SH   SOLE   29,168 0 0
PAYCHEX INC COM 704326107 5,641 50,164 SH   SOLE   50,164 0 0
PAYCOM SOFTWARE INC COM 70432V102 1,415 2,855 SH   SOLE   2,855 0 0
PAYPAL HLDGS INC COM 70450Y103 96,116 369,393 SH   SOLE   369,393 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 4,086 46,936 SH   SOLE   46,936 0 0
PEMBINA PIPELINE CORP COM 706327103 471 14,877 SH   SOLE   14,877 0 0
PEOPLES UNITED FINANCIAL INC COM 712704105 212 12,163 SH   SOLE   12,163 0 0
PEPSICO INC COM 713448108 26,684 177,415 SH   SOLE   177,415 0 0
PEPSICO INC COM 713448108 4 28 SH   OTR 1 0 0 28
PERKINELMER INC COM 714046109 4,705 27,153 SH   SOLE   27,153 0 0
PERSONALIS INC COM 71535D106 6,577 341,846 SH   SOLE   341,846 0 0
PERSONALIS INC COM 71535D106 0 21 SH   OTR 1 0 0 21
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 201 19,450 SH   SOLE   19,450 0 0
PFIZER INC COM 717081103 5,761 133,948 SH   SOLE   133,948 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 3,363 1,081,258 SH   SOLE   1,081,258 0 0
PHILLIPS 66 COM 718546104 2 22 SH   OTR 1 0 0 22
PHILLIPS 66 COM 718546104 3,017 43,081 SH   SOLE   43,081 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 5,489 1,061,834 SH   SOLE   1,061,834 0 0
PINDUODUO INC NOTE 12/0 722304AC6 6,118 5,142,455 PRN   SOLE   5,142,455 0 0
PINDUODUO INC SPONSORED ADS 722304102 1,464 16,149 SH   SOLE   16,149 0 0
PINTEREST INC CL A 72352L106 1,670 32,786 SH   SOLE   32,786 0 0
PIONEER NAT RES CO COM 723787107 1,784 10,713 SH   SOLE   10,713 0 0
PLANET FITNESS INC CL A 72703H101 6,073 77,320 SH   SOLE   77,320 0 0
PLUG POWER INC COM NEW 72919P202 1,022 40,025 SH   SOLE   40,025 0 0
PNC FINL SVCS GROUP INC COM 693475105 32,982 168,591 SH   SOLE   168,591 0 0
POOL CORP COM 73278L105 242 556 SH   SOLE   556 0 0
POWER INTEGRATIONS INC COM 739276103 24,108 243,555 SH   SOLE   243,555 0 0
POWER INTEGRATIONS INC COM 739276103 2 24 SH   OTR 1 0 0 24
PPD INC COM 69355F102 31,342 669,870 SH   SOLE   669,870 0 0
PPG INDS INC COM 693506107 2,739 19,152 SH   SOLE   19,152 0 0
PRECISION BIOSCIENCES INC COM 74019P108 7,306 633,162 SH   SOLE   633,162 0 0
PRICE T ROWE GROUP INC COM 74144T108 3,379 17,179 SH   SOLE   17,179 0 0
PRINCIPAL FINANCIAL GROUP IN COM 74251V102 1,719 26,695 SH   SOLE   26,695 0 0
PROCTER AND GAMBLE CO COM 742718109 117,136 837,919 SH   SOLE   837,919 0 0
PROCTER AND GAMBLE CO COM 742718109 7 48 SH   OTR 1 0 0 48
PROGRESSIVE CORP COM 743315103 3,156 34,913 SH   SOLE   34,913 0 0
PROLOGIS INC. COM 74340W103 32,285 257,402 SH   SOLE   257,402 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 1,482 83,646 SH   SOLE   83,646 0 0
PRUDENTIAL FINL INC COM 744320102 4 38 SH   OTR 1 0 0 38
PRUDENTIAL FINL INC COM 744320102 5,601 53,246 SH   SOLE   53,246 0 0
PTC INC COM 69370C100 52,639 439,444 SH   SOLE   439,444 0 0
PTC THERAPEUTICS INC COM 69366J200 10,172 273,374 SH   SOLE   273,374 0 0
PUBLIC STORAGE COM 74460D109 5,785 19,472 SH   SOLE   19,472 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 2,535 41,631 SH   SOLE   41,631 0 0
PULTE GROUP INC COM 745867101 2,037 44,359 SH   SOLE   44,359 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 502 500 PRN   SOLE   500 0 0
QORVO INC COM 74736K101 2,513 15,029 SH   SOLE   15,029 0 0
QUALCOMM INC COM 747525103 83,281 645,715 SH   SOLE   645,715 0 0
QUALCOMM INC COM 747525103 1 7 SH   OTR 1 0 0 7
QUEST DIAGNOSTICS INC COM 74834L100 9,960 68,549 SH   SOLE   68,549 0 0
RADIUS HEALTH INC COM NEW 750469207 5,002 403,068 SH   SOLE   403,068 0 0
RADNET INC COM 750491102 1 20 SH   OTR 1 0 0 20
RADNET INC COM 750491102 9,853 336,191 SH   SOLE   336,191 0 0
RAVEN INDS INC COM 754212108 6,069 105,343 SH   SOLE   105,343 0 0
RAYMOND JAMES FINL INC COM 754730109 3,539 38,356 SH   SOLE   38,356 0 0
REALTY INCOME CORP COM 756109104 1,420 21,901 SH   SOLE   21,901 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 378 82,523 SH   SOLE   82,523 0 0
REGENERON PHARMACEUTICALS COM 75886F107 235,182 388,631 SH   SOLE   388,631 0 0
REGENERON PHARMACEUTICALS COM 75886F107 7 12 SH   OTR 1 0 0 12
REGIONS FINANCIAL CORP NEW COM 7591EP100 30,131 1,414,013 SH   SOLE   1,414,013 0 0
RELAY THERAPEUTICS INC COM 75943R102 17,748 562,918 SH   SOLE   562,918 0 0
RELAY THERAPEUTICS INC COM 75943R102 1 20 SH   OTR 1 0 0 20
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 1,166 23,235 SH   SOLE   23,235 0 0
REPLIGEN CORP COM 759916109 4,064 14,064 SH   SOLE   14,064 0 0
REPLIMUNE GROUP INC COM 76029N106 15,475 522,106 SH   SOLE   522,106 0 0
REPLIMUNE GROUP INC COM 76029N106 1 35 SH   OTR 1 0 0 35
REPUBLIC SVCS INC COM 760759100 2,166 18,043 SH   SOLE   18,043 0 0
REPUBLIC SVCS INC COM 760759100 5 38 SH   OTR 1 0 0 38
RESMED INC COM 761152107 4,790 18,176 SH   SOLE   18,176 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 4,556 74,389 SH   SOLE   74,389 0 0
REVOLUTION MEDICINES INC COM 76155X100 13,462 489,364 SH   SOLE   489,364 0 0
REVOLUTION MEDICINES INC COM 76155X100 0 18 SH   OTR 1 0 0 18
RIGEL PHARMACEUTICALS INC COM NEW 766559603 8,064 2,221,696 SH   SOLE   2,221,696 0 0
RINGCENTRAL INC CL A 76680R206 1,120 5,149 SH   SOLE   5,149 0 0
RINGCENTRAL INC NOTE 3/0 76680RAF4 1,487 1,500 PRN   SOLE   1,500 0 0
RIO TINTO PLC SPONSORED ADR 767204100 2 27 SH   OTR 1 0 0 27
ROBERT HALF INTL INC COM 770323103 19,651 195,870 SH   SOLE   195,870 0 0
ROCKWELL AUTOMATION INC COM 773903109 71,866 244,421 SH   SOLE   244,421 0 0
ROCKWELL AUTOMATION INC COM 773903109 4 12 SH   OTR 1 0 0 12
ROGERS COMMUNICATIONS INC CL B 775109200 700 14,997 SH   SOLE   14,997 0 0
ROKU INC COM CL A 77543R102 1,952 6,229 SH   SOLE   6,229 0 0
ROPER TECHNOLOGIES INC COM 776696106 3,250 7,285 SH   SOLE   7,285 0 0
ROSS STORES INC COM 778296103 2,444 22,458 SH   SOLE   22,458 0 0
ROYAL BK CDA COM 780087102 4 40 SH   OTR 1 0 0 40
ROYAL BK CDA COM 780087102 124,020 1,246,729 SH   SOLE   1,246,729 0 0
ROYAL CARIBBEAN GROUP NOTE 4.250% 6/1 780153BB7 427 300 PRN   SOLE   300 0 0
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 4 100 SH   OTR 1 0 0 100
S&P GLOBAL INC COM 78409V104 2 4 SH   OTR 1 0 0 4
S&P GLOBAL INC COM 78409V104 39,562 93,115 SH   SOLE   93,115 0 0
SAGE THERAPEUTICS INC COM 78667J108 8,200 185,058 SH   SOLE   185,058 0 0
SAILPOINT TECHNOLOGIES HLDGS COM 78781P105 31,547 735,725 SH   SOLE   735,725 0 0
SALESFORCE COM INC COM 79466L302 2 9 SH   OTR 1 0 0 9
SALESFORCE COM INC COM 79466L302 103,121 380,227 SH   SOLE   380,227 0 0
SANTANDER CONSUMER USA HLDGS COM 80283M101 6,315 151,457 SH   SOLE   151,457 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 2,396 7,247 SH   SOLE   7,247 0 0
SCHLUMBERGER LTD COM STK 806857108 18,169 613,000 SH   SOLE   613,000 0 0
SCHWAB CHARLES CORP COM 808513105 3 44 SH   OTR 1 0 0 44
SCHWAB CHARLES CORP COM 808513105 49,496 679,550 SH   SOLE   679,550 0 0
SCORE MEDIA & GAMING INC CL A SUB VTG SHS 80919D202 2,993 87,448 SH   SOLE   87,448 0 0
SEA LTD SPONSORD ADS 81141R100 475 1,490 SH   SOLE   1,490 0 0
SEAGEN INC COM 81181C104 5 32 SH   OTR 1 0 0 32
SEAGEN INC COM 81181C104 150,435 885,992 SH   SOLE   885,992 0 0
SEER INC COM CL A 81578P106 1,070 31,000 SH   SOLE   31,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 779 750 PRN   SOLE   750 0 0
SELECT MED HLDGS CORP COM 81619Q105 3,256 90,022 SH   SOLE   90,022 0 0
SEMPRA COM 816851109 5,026 39,733 SH   SOLE   39,733 0 0
SERVICENOW INC COM 81762P102 28,659 46,058 SH   SOLE   46,058 0 0
SHAW COMMUNICATIONS INC CL B CONV 82028K200 318 10,956 SH   SOLE   10,956 0 0
SHERWIN WILLIAMS CO COM 824348106 1 5 SH   OTR 1 0 0 5
SHERWIN WILLIAMS CO COM 824348106 24,421 87,307 SH   SOLE   87,307 0 0
SHINHAN FINANCIAL GROUP CO L SPN ADR RESTRD 824596100 360 10,700 SH   SOLE   10,700 0 0
SHOPIFY INC CL A 82509L107 20,778 15,312 SH   SOLE   15,312 0 0
SHOPIFY INC NOTE 0.125%11/0 82509LAA5 1,842 1,500 PRN   SOLE   1,500 0 0
SILICON LABORATORIES INC COM 826919102 36,650 261,495 SH   SOLE   261,495 0 0
SILICON LABORATORIES INC NOTE 0.625% 6/1 826919AD4 645 500 PRN   SOLE   500 0 0
SIMON PPTY GROUP INC NEW COM 828806109 2,607 20,062 SH   SOLE   20,062 0 0
SIRIUS XM HOLDINGS INC COM 82968B103 201 32,995 SH   SOLE   32,995 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 1,447 8,781 SH   SOLE   8,781 0 0
SL GREEN RLTY CORP COM 78440X804 352 4,965 SH   SOLE   4,965 0 0
SLEEP NUMBER CORP COM 83125X103 3,297 35,272 SH   SOLE   35,272 0 0
SLM CORP COM 78442P106 5,704 324,090 SH   SOLE   324,090 0 0
SMITH A O CORP COM 831865209 1 24 SH   OTR 1 0 0 24
SMITH A O CORP COM 831865209 2,458 40,247 SH   SOLE   40,247 0 0
SMUCKER J M CO COM NEW 832696405 9,563 79,677 SH   SOLE   79,677 0 0
SNAP INC CL A 83304A106 3,700 50,087 SH   SOLE   50,087 0 0
SNAP ON INC COM 833034101 1,418 6,786 SH   SOLE   6,786 0 0
SNOWFLAKE INC CL A 833445109 5,173 17,106 SH   SOLE   17,106 0 0
SOCIEDAD QUIMICA Y MINERA DE SPON ADR SER B 833635105 71,952 1,339,455 SH   SOLE   1,339,455 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 23,737 89,503 SH   SOLE   89,503 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 2 8 SH   OTR 1 0 0 8
SOLITON INC COM 834251100 4,868 239,086 SH   SOLE   239,086 0 0
SONY GROUP CORPORATION SPONSORED ADR 835699307 4 38 SH   OTR 1 0 0 38
SONY GROUP CORPORATION SPONSORED ADR 835699307 4,196 37,949 SH   SOLE   37,949 0 0
SOUTHERN COPPER CORP COM 84265V105 16,050 285,900 SH   SOLE   285,900 0 0
SOUTHERN COPPER CORP COM 84265V105 3,746 3,250 PRN   SOLE   3,250 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 750 500 PRN   SOLE   500 0 0
SPDR INDEX SHS FDS PORTFOLIO EMG MK 78463X509 258 6,072 SH   SOLE   6,072 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 4,408 574,000 SH Put SOLE   574,000 0 0
SPLUNK INC COM 848637104 26,067 180,140 SH   SOLE   180,140 0 0
SPLUNK INC NOTE 1.125% 6/1 848637AF1 6,616 2,634,000 PRN   SOLE   2,634,000 0 0
SPORTSMANS WHSE HLDGS INC COM 84920Y106 12,479 709,064 SH   SOLE   709,064 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 1 9 SH   OTR 1 0 0 9
SPRINGWORKS THERAPEUTICS INC COM 85205L107 8,934 140,825 SH   SOLE   140,825 0 0
SPROUTS FMRS MKT INC COM 85208M102 933 40,252 SH   SOLE   40,252 0 0
SQUARE INC CL A 852234103 6,663 27,783 SH   SOLE   27,783 0 0
STAMPS COM INC COM NEW 852857200 9,187 27,857 SH   SOLE   27,857 0 0
STANLEY BLACK & DECKER INC COM 854502101 18,082 103,148 SH   SOLE   103,148 0 0
STANLEY BLACK & DECKER INC COM 854502101 1 7 SH   OTR 1 0 0 7
STARBUCKS CORP COM 855244109 2 22 SH   OTR 1 0 0 22
STARBUCKS CORP COM 855244109 91,582 830,262 SH   SOLE   830,262 0 0
STATE STR CORP COM 857477103 3,689 43,544 SH   SOLE   43,544 0 0
STEEL DYNAMICS INC COM 858119100 1,151 19,682 SH   SOLE   19,682 0 0
STRYKER CORPORATION COM 863667101 54,143 205,314 SH   SOLE   205,314 0 0
STRYKER CORPORATION COM 863667101 3 11 SH   OTR 1 0 0 11
SUMITOMO MITSUI FINL GROUP I SPONSORED ADR 86562M209 1 138 SH   OTR 1 0 0 138
SUN CMNTYS INC COM 866674104 963 5,203 SH   SOLE   5,203 0 0
SUN LIFE FINANCIAL INC. COM 866796105 950 18,464 SH   SOLE   18,464 0 0
SUNCOR ENERGY INC NEW COM 867224107 605 29,199 SH   SOLE   29,199 0 0
SUNRUN INC COM 86771W105 641 14,567 SH   SOLE   14,567 0 0
SVB FINANCIAL GROUP COM 78486Q101 2,149 3,323 SH   SOLE   3,323 0 0
SYNCHRONY FINANCIAL COM 87165B103 15,927 325,850 SH   SOLE   325,850 0 0
SYNOPSYS INC COM 871607107 3 10 SH   OTR 1 0 0 10
SYNOPSYS INC COM 871607107 32,500 108,552 SH   SOLE   108,552 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 2,612 584,272 SH   SOLE   584,272 0 0
SYSCO CORP COM 871829107 3,228 41,127 SH   SOLE   41,127 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 2 19 SH   OTR 1 0 0 19
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 92,519 828,690 SH   SOLE   828,690 0 0
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS 874060205 1 76 SH   OTR 1 0 0 76
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 1,713 11,118 SH   SOLE   11,118 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 280 57,920 SH   SOLE   57,920 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 4,248 35,587 SH   SOLE   35,587 0 0
TARGA RES CORP COM 87612G101 205 4,167 SH   SOLE   4,167 0 0
TARGET CORP COM 87612E106 2 7 SH   OTR 1 0 0 7
TARGET CORP COM 87612E106 33,215 145,197 SH   SOLE   145,197 0 0
TC ENERGY CORP COM 87807B107 993 20,633 SH   SOLE   20,633 0 0
TE CONNECTIVITY LTD REG SHS H84989104 2 18 SH   OTR 1 0 0 18
TECK RESOURCES LTD CL B 878742204 913 36,672 SH   SOLE   36,672 0 0
TELADOC HEALTH INC COM 87918A105 5,342 42,130 SH   SOLE   42,130 0 0
TELADOC HEALTH INC NOTE 1.250% 6/0 87918AAF2 2,030 2,000 PRN   SOLE   2,000 0 0
TELEDYNE TECHNOLOGIES INC COM 879360105 1,075 2,502 SH   SOLE   2,502 0 0
TELEFLEX INCORPORATED COM 879369106 977 2,596 SH   SOLE   2,596 0 0
TELEFONICA BRASIL SA NEW ADR 87936R205 101 13,078 SH   SOLE   13,078 0 0
TELEFONICA S A SPONSORED ADR 879382208 2 361 SH   OTR 1 0 0 361
TELUS CORPORATION COM 87971M103 411 18,703 SH   SOLE   18,703 0 0
TERADYNE INC COM 880770102 907 8,304 SH   SOLE   8,304 0 0
TERNIUM SA SPONSORED ADS 880890108 43,131 1,019,700 SH   SOLE   1,019,700 0 0
TESLA INC COM 88160R101 2 2 SH   OTR 1 0 0 2
TESLA INC COM 88160R101 93,265 120,274 SH   SOLE   120,274 0 0
TETRA TECH INC NEW COM 88162G103 39,762 266,266 SH   SOLE   266,266 0 0
TETRA TECH INC NEW COM 88162G103 4 29 SH   OTR 1 0 0 29
TEXAS INSTRS INC COM 882508104 2 10 SH   OTR 1 0 0 10
TEXAS INSTRS INC COM 882508104 57,006 296,597 SH   SOLE   296,597 0 0
TG THERAPEUTICS INC COM 88322Q108 11,780 353,969 SH   SOLE   353,969 0 0
TG THERAPEUTICS INC COM 88322Q108 0 14 SH   OTR 1 0 0 14
THERMO FISHER SCIENTIFIC INC COM 883556102 208,982 365,798 SH   SOLE   365,798 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 10 17 SH   OTR 1 0 0 17
THOMSON REUTERS CORP. COM NEW 884903709 13,678 123,735 SH   SOLE   123,735 0 0
TILLYS INC CL A 886885102 1,681 120,000 SH   SOLE   120,000 0 0
TJX COS INC NEW COM 872540109 47,318 717,190 SH   SOLE   717,190 0 0
T-MOBILE US INC COM 872590104 4,130 32,324 SH   SOLE   32,324 0 0
TOPBUILD CORP COM 89055F103 32,662 159,483 SH   SOLE   159,483 0 0
TOPBUILD CORP COM 89055F103 3 17 SH   OTR 1 0 0 17
TORONTO DOMINION BK ONT COM NEW 891160509 7,395 111,730 SH   SOLE   111,730 0 0
TOTALENERGIES SE SPONSORED ADS 89151E109 1 20 SH   OTR 1 0 0 20
TOYOTA MOTOR CORP SP ADR REP2COM 892331307 6 35 SH   OTR 1 0 0 35
TPI COMPOSITES INC COM 87266J104 1,140 33,783 SH   SOLE   33,783 0 0
TRACTOR SUPPLY CO COM 892356106 3,768 18,597 SH   SOLE   18,597 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 3 17 SH   OTR 1 0 0 17
TRANSUNION COM 89400J107 3,355 29,875 SH   SOLE   29,875 0 0
TRAVELERS COMPANIES INC COM 89417E109 3,625 23,846 SH   SOLE   23,846 0 0
TRAVELERS COMPANIES INC COM 89417E109 2 10 SH   OTR 1 0 0 10
TREACE MED CONCEPTS INC COM 89455T109 861 32,000 SH   SOLE   32,000 0 0
TREX CO INC COM 89531P105 20,254 198,711 SH   SOLE   198,711 0 0
TREX CO INC COM 89531P105 2 21 SH   OTR 1 0 0 21
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 1 52 SH   OTR 1 0 0 52
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 20,197 1,150,228 SH   SOLE   1,150,228 0 0
TRIMBLE INC COM 896239100 6 79 SH   OTR 1 0 0 79
TRIMBLE INC COM 896239100 113,050 1,374,524 SH   SOLE   1,374,524 0 0
TRIPLE-S MGMT CORP COM 896749108 6,232 176,192 SH   SOLE   176,192 0 0
TRUIST FINL CORP COM 89832Q109 5,350 91,215 SH   SOLE   91,215 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 34,582 520,604 SH   SOLE   520,604 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1 21 SH   OTR 1 0 0 21
TWILIO INC CL A 90138F102 11,354 35,588 SH   SOLE   35,588 0 0
TWIST BIOSCIENCE CORP COM 90184D100 7,791 72,841 SH   SOLE   72,841 0 0
TWITTER INC COM 90184L102 5,507 5,900 PRN   SOLE   5,900 0 0
TWITTER INC COM 90184L102 2,815 46,622 SH   SOLE   46,622 0 0
TYLER TECHNOLOGIES INC COM 902252105 915 1,996 SH   SOLE   1,996 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,508 33,657 SH   SOLE   33,657 0 0
UGI CORP NEW COM 902681105 1,602 37,599 SH   SOLE   37,599 0 0
ULTA BEAUTY INC COM 90384S303 2,464 6,826 SH   SOLE   6,826 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,462 49,480 SH   SOLE   49,480 0 0
UMPQUA HLDGS CORP COM 904214103 11,774 581,439 SH   SOLE   581,439 0 0
UNDER ARMOUR INC CL A 904311107 688 500 PRN   SOLE   500 0 0
UNDER ARMOUR INC CL A 904311107 1,085 53,784 SH   SOLE   53,784 0 0
UNDER ARMOUR INC CL C 904311206 1,149 65,611 SH   SOLE   65,611 0 0
UNILEVER PLC SPON ADR NEW 904767704 1,591 29,340 SH   SOLE   29,340 0 0
UNILEVER PLC SPON ADR NEW 904767704 3 49 SH   OTR 1 0 0 49
UNION PAC CORP COM 907818108 12,623 64,402 SH   SOLE   64,402 0 0
UNION PAC CORP COM 907818108 536 500 PRN   SOLE   500 0 0
UNITED AIRLS HLDGS INC COM 910047109 229 4,822 SH   SOLE   4,822 0 0
UNITED PARCEL SERVICE INC CL B 911312106 16,926 92,953 SH   SOLE   92,953 0 0
UNITED RENTALS INC COM 911363109 6,575 18,738 SH   SOLE   18,738 0 0
UNITEDHEALTH GROUP INC COM 91324P102 141,498 362,145 SH   SOLE   362,145 0 0
UNITEDHEALTH GROUP INC COM 91324P102 6 15 SH   OTR 1 0 0 15
UNIVERSAL DISPLAY CORP COM 91347P105 36,959 216,195 SH   SOLE   216,195 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 1 8 SH   OTR 1 0 0 8
US BANCORP DEL COM NEW 902973304 5,037 84,742 SH   SOLE   84,742 0 0
V F CORP COM 918204108 2,541 37,937 SH   SOLE   37,937 0 0
VAIL RESORTS INC COM 91879Q109 9,996 29,926 SH   SOLE   29,926 0 0
VALERO ENERGY CORP COM 91913Y100 2,211 31,339 SH   SOLE   31,339 0 0
VALMONT INDS INC COM 920253101 3,097 13,174 SH   SOLE   13,174 0 0
VANECK ETF TRUST RARE EARTH/STRTG 92189H805 1,054 10,210 SH   SOLE   10,210 0 0
VANGUARD INDEX FDS LARGE CAP ETF 922908637 237 1,180 SH   SOLE   1,180 0 0
VARONIS SYS INC COM 922280102 39,807 654,207 SH   SOLE   654,207 0 0
VEEVA SYS INC CL A COM 922475108 5,898 20,467 SH   SOLE   20,467 0 0
VENTAS INC COM 92276F100 1,685 30,520 SH   SOLE   30,520 0 0
VEONEER INC COM 92336X109 6,555 192,470 SH   SOLE   192,470 0 0
VEREIT INC COM 92339V308 770 17,014 SH   SOLE   17,014 0 0
VERISIGN INC COM 92343E102 2 9 SH   OTR 1 0 0 9
VERISIGN INC COM 92343E102 1,445 7,051 SH   SOLE   7,051 0 0
VERISK ANALYTICS INC COM 92345Y106 1,823 9,104 SH   SOLE   9,104 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 4 83 SH   OTR 1 0 0 83
VERIZON COMMUNICATIONS INC COM 92343V104 53,181 984,693 SH   SOLE   984,693 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 107,527 592,822 SH   SOLE   592,822 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1 7 SH   OTR 1 0 0 7
VIACOMCBS INC CL B 92556H206 1,486 37,607 SH   SOLE   37,607 0 0
VIATRIS INC COM 92556V106 3,689 272,237 SH   SOLE   272,237 0 0
VIEWRAY INC COM 92672L107 1 75 SH   OTR 1 0 0 75
VIEWRAY INC COM 92672L107 8,939 1,239,817 SH   SOLE   1,239,817 0 0
VISA INC COM CL A 92826C839 6 28 SH   OTR 1 0 0 28
VISA INC COM CL A 92826C839 115,870 520,201 SH   SOLE   520,201 0 0
VMWARE INC CL A COM 928563402 2 11 SH   OTR 1 0 0 11
VMWARE INC CL A COM 928563402 28,398 190,984 SH   SOLE   190,984 0 0
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 1 71 SH   OTR 1 0 0 71
VONAGE HLDGS CORP COM 92886T201 1,428 7,570,000 SH Call SOLE   7,570,000 0 0
VORNADO RLTY TR SH BEN INT 929042109 987 23,494 SH   SOLE   23,494 0 0
VOYA FINANCIAL INC COM 929089100 270 4,405 SH   SOLE   4,405 0 0
VTEX SHS CL A G9470A102 5,492 267,000 SH   SOLE   267,000 0 0
VULCAN MATLS CO COM 929160109 1,588 9,390 SH   SOLE   9,390 0 0
WABTEC COM 929740108 8,041 93,274 SH   SOLE   93,274 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 3,224 68,530 SH   SOLE   68,530 0 0
WALMART INC COM 931142103 6,072 43,566 SH   SOLE   43,566 0 0
WASTE CONNECTIONS INC COM 94106B101 3 21 SH   OTR 1 0 0 21
WASTE CONNECTIONS INC COM 94106B101 34,903 277,174 SH   SOLE   277,174 0 0
WASTE MGMT INC DEL COM 94106L109 92,115 616,756 SH   SOLE   616,756 0 0
WASTE MGMT INC DEL COM 94106L109 10 67 SH   OTR 1 0 0 67
WATERS CORP COM 941848103 10,656 29,825 SH   SOLE   29,825 0 0
WAYFAIR INC CL A 94419L101 990 3,876 SH   SOLE   3,876 0 0
WAYFAIR INC NOTE 0.625%10/0 94419LAM3 1,000 1,000 PRN   SOLE   1,000 0 0
WELLS FARGO CO NEW COM 949746101 14,204 306,059 SH   SOLE   306,059 0 0
WELLTOWER INC COM 95040Q104 2,977 36,129 SH   SOLE   36,129 0 0
WEST FRASER TIMBER CO LTD COM 952845105 295 3,505 SH   SOLE   3,505 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 22,868 53,868 SH   SOLE   53,868 0 0
WESTERN DIGITAL CORP. COM 958102105 891 15,794 SH   SOLE   15,794 0 0
WESTERN DIGITAL CORP. NOTE 1.500% 2/0 958102AP0 9,280 9,000 PRN   SOLE   9,000 0 0
WESTERN UN CO COM 959802109 2,360 116,705 SH   SOLE   116,705 0 0
WESTROCK CO COM 96145D105 948 19,022 SH   SOLE   19,022 0 0
WEYERHAEUSER CO MTN BE COM NEW 962166104 1,701 47,827 SH   SOLE   47,827 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 592 15,748 SH   SOLE   15,748 0 0
WHIRLPOOL CORP COM 963320106 857 4,203 SH   SOLE   4,203 0 0
WILEY JOHN & SONS INC CL A 968223206 929 17,803 SH   SOLE   17,803 0 0
WILLIAMS COS INC COM 969457100 2,614 100,775 SH   SOLE   100,775 0 0
WORKDAY INC CL A 98138H101 3,111 12,450 SH   SOLE   12,450 0 0
WORKIVA INC COM CL A 98139A105 1,410 10,000 SH   SOLE   10,000 0 0
WP CAREY INC COM 92936U109 1,111 15,216 SH   SOLE   15,216 0 0
WYNN RESORTS LTD COM 983134107 747 8,814 SH   SOLE   8,814 0 0
XENCOR INC COM 98401F105 1 24 SH   OTR 1 0 0 24
XENCOR INC COM 98401F105 20,829 637,776 SH   SOLE   637,776 0 0
XENON PHARMACEUTICALS INC COM 98420N105 10,936 715,722 SH   SOLE   715,722 0 0
XILINX INC COM 983919101 18,778 124,372 SH   SOLE   124,372 0 0
XP INC CL A G98239109 4,981 124,000 SH   SOLE   124,000 0 0
XPENG INC ADS 98422D105 333 9,375 SH   SOLE   9,375 0 0
XYLEM INC COM 98419M100 3 26 SH   OTR 1 0 0 26
XYLEM INC COM 98419M100 38,411 310,585 SH   SOLE   310,585 0 0
YAMANA GOLD INC COM 98462Y100 163 41,343 SH   SOLE   41,343 0 0
YETI HLDGS INC COM 98585X104 3,499 40,839 SH   SOLE   40,839 0 0
Y-MABS THERAPEUTICS INC COM 984241109 0 12 SH   OTR 1 0 0 12
Y-MABS THERAPEUTICS INC COM 984241109 5,085 178,169 SH   SOLE   178,169 0 0
YUM BRANDS INC COM 988498101 1,948 15,928 SH   SOLE   15,928 0 0
YUM CHINA HLDGS INC COM 98850P109 616 10,600 SH   SOLE   10,600 0 0
ZAI LAB LTD ADR 98887Q104 1 7 SH   OTR 1 0 0 7
ZAI LAB LTD ADR 98887Q104 10,993 104,308 SH   SOLE   104,308 0 0
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 11,611 22,528 SH   SOLE   22,528 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 13,895 208,512 SH   SOLE   208,512 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 1 14 SH   OTR 1 0 0 14
ZILLOW GROUP INC CL C CAP STK 98954M200 1,104 12,522 SH   SOLE   12,522 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 10,333 70,600 SH   SOLE   70,600 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 485 500 PRN   SOLE   500 0 0
ZIONS BANCORPORATION N A COM 989701107 442 7,147 SH   SOLE   7,147 0 0
ZOETIS INC CL A 98978V103 10,324 53,180 SH   SOLE   53,180 0 0
ZOGENIX INC COM NEW 98978L204 8,153 536,758 SH   SOLE   536,758 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 3,086 11,801 SH   SOLE   11,801 0 0
ZSCALER INC COM 98980G102 9,773 37,272 SH   SOLE   37,272 0 0
ZYNGA INC CL A 98986T108 194 25,700 SH   SOLE   25,700 0 0