The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adobe Inc Common Stock 00724F101 15,766 33,165 SH   SOLE   33,165 0 0
Aerojet Rocketdyne Holdings Inc Common Stock 007800105 4,228 90,029 SH   SOLE   90,029 0 0
AeroVironment Inc Common Stock 008073108 65,079 560,739 SH   SOLE   560,739 0 0
Alibaba Group Holding Ltd ADR 01609W102 133,958 590,826 SH   SOLE   590,826 0 0
Align Technology Inc Common Stock 016255101 6,615 12,215 SH   SOLE   12,215 0 0
Allegheny Technologies Inc Common Stock 01741R102 746 35,406 SH   SOLE   35,406 0 0
Alphabet Inc Common Stock 02079K107 119,041 57,546 SH   SOLE   57,546 0 0
Altair Engineering Inc Common Stock 021369103 24,201 386,786 SH   SOLE   386,786 0 0
Amazon.com Inc Common Stock 023135106 43,063 13,918 SH   SOLE   13,918 0 0
AMETEK Inc Common Stock 031100100 7,197 56,347 SH   SOLE   56,347 0 0
ANSYS Inc Common Stock 03662Q105 57,539 169,452 SH   SOLE   169,452 0 0
Apple Inc Common Stock 037833100 72,562 594,039 SH   SOLE   594,039 0 0
AquaBounty Technologies Inc Common Stock 03842K200 48,557 7,247,378 SH   SOLE   7,247,378 0 0
Arcturus Therapeutics Holdings Inc Common Stock 03969T109 137,607 3,331,889 SH   SOLE   3,331,889 0 0
Autodesk Inc Common Stock 052769106 41,862 151,043 SH   SOLE   151,043 0 0
Baidu Inc ADR 056752108 1,115,497 5,127,543 SH   SOLE   4,688,247 329,127 110,169
Renishaw PLC Common Stock G75006117 27,726 313,442 SH   SOLE   313,442 0 0
CareDx Inc Common Stock 14167L103 303,738 4,460,824 SH   SOLE   4,460,824 0 0
Carpenter Technology Corp Common Stock 144285103 750 18,218 SH   SOLE   18,218 0 0
Castle Biosciences Inc Common Stock 14843C105 177,810 2,597,288 SH   SOLE   2,597,288 0 0
Cellectis SA ADR 15117K103 103,425 5,117,526 SH   SOLE   5,117,526 0 0
Cerus Corp Common Stock 157085101 153,507 25,541,955 SH   SOLE   23,600,810 616,222 1,324,923
Codexis Inc Common Stock 192005106 143,786 6,281,617 SH   SOLE   6,281,617 0 0
Deere & Co Common Stock 244199105 132,551 354,282 SH   SOLE   354,282 0 0
DuPont de Nemours Inc Common Stock 26614N102 603 7,808 SH   SOLE   7,808 0 0
Eastman Chemical Co Common Stock 277432100 658 5,978 SH   SOLE   5,978 0 0
Editas Medicine Inc Common Stock 28106W103 367,581 8,751,923 SH   SOLE   7,487,570 1,033,435 230,918
ExOne Co/The Common Stock 302104104 83,948 2,676,905 SH   SOLE   2,413,344 0 263,561
Facebook Inc Common Stock 30303M102 90,429 307,029 SH   SOLE   307,029 0 0
FARO Technologies Inc Common Stock 311642102 7,935 91,661 SH   SOLE   91,661 0 0
Fate Therapeutics Inc Common Stock 31189P102 540,422 6,554,546 SH   SOLE   6,554,546 0 0
General Electric Co Common Stock 369604103 5,483 417,583 SH   SOLE   417,583 0 0
Grayscale Bitcoin Trust BTC Open-End Fund 389637109 434,141 8,675,881 SH   SOLE   8,011,293 658,408 6,180
Guardant Health Inc Common Stock 40131M109 107,351 703,250 SH   SOLE   703,250 0 0
Guidewire Software Inc Common Stock 40171V100 41,604 409,367 SH   SOLE   409,367 0 0
HDFC Bank Ltd ADR 40415F101 42,452 546,426 SH   SOLE   546,426 0 0
HP Inc Common Stock 40434L105 31,288 985,456 SH   SOLE   985,456 0 0
Hexcel Corp Common Stock 428291108 745 13,307 SH   SOLE   13,307 0 0
HubSpot Inc Common Stock 443573100 74,136 163,219 SH   SOLE   163,219 0 0
Incyte Corp Common Stock 45337C102 242,847 2,988,149 SH   SOLE   2,988,149 0 0
Intellia Therapeutics Inc Common Stock 45826J105 771,404 9,611,911 SH   SOLE   7,778,015 1,427,842 406,054
Interactive Brokers Group Inc Common Stock 45841N107 219 3,002 SH   SOLE   3,002 0 0
Intercontinental Exchange Inc Common Stock 45866F104 627,317 5,617,092 SH   SOLE   5,268,406 259,279 89,407
Intuit Inc Common Stock 461202103 76,489 199,680 SH   SOLE   199,680 0 0
Intuitive Surgical Inc Common Stock 46120E602 36,840 49,855 SH   SOLE   49,855 0 0
OC Oerlikon Corp AG Common Stock H59187106 5,364 462,333 SH   SOLE   462,333 0 0
Invitae Corp Common Stock 46185L103 916,192 23,977,808 SH   SOLE   20,810,440 2,373,199 794,169
Ionis Pharmaceuticals Inc Common Stock 462222100 231,197 5,142,271 SH   SOLE   5,142,271 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 624,546 19,726,650 SH   SOLE   18,981,913 466,145 278,592
Iridium Communications Inc Common Stock 46269C102 427,150 10,355,147 SH   SOLE   9,466,700 705,771 182,676
JD.com Inc ADR 47215P106 392,282 4,651,745 SH   SOLE   4,651,745 0 0
SGL Carbon SE Common Stock D6949M108 788 112,500 SH   SOLE   112,500 0 0
Kaiser Aluminum Corp Common Stock 483007704 5,086 46,030 SH   SOLE   46,030 0 0
Komatsu Ltd ADR 500458401 106,587 3,412,965 SH   SOLE   3,412,965 0 0
Kratos Defense & Security Solutions Inc Common Stock 50077B207 143,000 5,241,941 SH   SOLE   5,241,941 0 0
Henkel AG & Co KGaA Preference D3207M110 689 5,962 SH   SOLE   5,962 0 0
Bertrandt AG Common Stock D1014N107 4,900 90,559 SH   SOLE   90,559 0 0
LendingClub Corp Common Stock 52603A208 120,074 7,268,414 SH   SOLE   6,466,326 183,369 618,719
LendingTree Inc Common Stock 52603B107 367,018 1,723,091 SH   SOLE   1,489,736 177,145 56,210
Dassault Systemes SE Common Stock F2457H472 27,110 126,494 SH   SOLE   126,494 0 0
Lincoln Electric Holdings Inc Common Stock 533900106 4,863 39,556 SH   SOLE   39,556 0 0
Siemens AG Common Stock D69671218 5,410 32,880 SH   SOLE   32,880 0 0
Materialise NV ADR 57667T100 267,533 7,441,821 SH   SOLE   7,177,635 75,126 189,060
MercadoLibre Inc Common Stock 58733R102 188,842 128,277 SH   SOLE   119,102 9,175 0
Microsoft Corp Common Stock 594918104 25,739 109,170 SH   SOLE   109,170 0 0
Bezeq The Israeli Telecommunication Corp Ltd Common Stock M2012Q100 6,297 5,896,764 SH   SOLE   5,896,764 0 0
Moog Inc Common Stock 615394202 4,879 58,675 SH   SOLE   58,675 0 0
Danel Adir Yeoshua Ltd Common Stock M27013107 6,706 40,911 SH   SOLE   40,911 0 0
Hilan Ltd Common Stock M5299H123 6,311 133,407 SH   SOLE   133,407 0 0
Nano Dimension Ltd ADR 63008G203 111,389 12,967,241 SH   SOLE   12,967,241 0 0
NanoString Technologies Inc Common Stock 63009R109 217,825 3,314,947 SH   SOLE   3,193,514 121,433 0
Elbit Systems Ltd Common Stock M3760D101 49,232 344,279 SH   SOLE   344,279 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 171 6,300 SH   SOLE   6,300 0 0
Partner Communications Co Ltd Common Stock M78465107 6,310 1,304,896 SH   SOLE   1,304,896 0 0
Netflix Inc Common Stock 64110L106 69,642 133,501 SH   SOLE   133,501 0 0
Nice Ltd ADR 653656108 4,905 22,504 SH   SOLE   22,504 0 0
FirstRand Ltd Common Stock S5202Z131 30 13,580 SH   SOLE   13,580 0 0
NVIDIA Corp Common Stock 67066G104 216,303 405,115 SH   SOLE   405,115 0 0
NuVasive Inc Common Stock 670704105 5,331 81,321 SH   SOLE   81,321 0 0
Matrix IT Ltd Common Stock M6859E153 6,376 266,444 SH   SOLE   266,444 0 0
Toray Industries Inc Common Stock J89494116 609 94,508 SH   SOLE   94,508 0 0
PTC Inc Common Stock 69370C100 26,027 189,081 SH   SOLE   189,081 0 0
Pacific Biosciences of California Inc Common Stock 69404D108 709,543 21,301,191 SH   SOLE   20,654,514 413,947 232,730
One Software Technologies Ltd Common Stock M75260113 6,327 48,615 SH   SOLE   48,615 0 0
PayPal Holdings Inc Common Stock 70450Y103 407,881 1,679,629 SH   SOLE   1,558,336 110,602 10,691
Personalis Inc Common Stock 71535D106 140,420 5,705,827 SH   SOLE   5,705,827 0 0
Straumann Holding AG Common Stock H8300N119 27,109 21,662 SH   SOLE   21,662 0 0
Pinduoduo Inc ADR 722304102 112,078 837,156 SH   SOLE   837,156 0 0
Pinterest Inc Common Stock 72352L106 229,119 3,094,949 SH   SOLE   3,094,949 0 0
Pluristem Therapeutics Inc Common Stock 72940R300 17,121 3,589,322 SH   SOLE   3,589,322 0 0
Proto Labs Inc Common Stock 743713109 444,978 3,654,854 SH   SOLE   3,126,453 386,403 141,998
Redhill Biopharma Ltd ADR 757468103 5,678 775,698 SH   SOLE   775,698 0 0
Roku Inc Common Stock 77543R102 1,628,082 4,997,644 SH   SOLE   4,429,891 447,706 120,047
Charles Schwab Corp/The Common Stock 808513105 46,557 714,287 SH   SOLE   714,287 0 0
Seres Therapeutics Inc Common Stock 81750R102 244,114 11,855,947 SH   SOLE   10,210,569 1,341,432 303,946
Shopify Inc Common Stock 82509L107 1,187,853 1,073,523 SH   SOLE   992,842 64,581 16,100
Snap Inc Common Stock 83304A106 165,966 3,173,955 SH   SOLE   3,173,955 0 0
Splunk Inc Common Stock 848637104 1,194 8,813 SH   SOLE   8,813 0 0
Square Inc Common Stock 852234103 2,492,627 10,978,316 SH   SOLE   10,014,653 737,361 226,302
Stryker Corp Common Stock 863667101 4,662 19,138 SH   SOLE   19,138 0 0
Syros Pharmaceuticals Inc Common Stock 87184Q107 57,684 7,711,724 SH   SOLE   7,032,971 186,593 492,160
Taiwan Semiconductor Manufacturing Co Ltd ADR 874039100 47,019 397,524 SH   SOLE   397,524 0 0
Teladoc Health Inc Common Stock 87918A105 2,621,595 14,424,180 SH   SOLE   13,420,301 771,257 232,622
Tencent Holdings Ltd ADR 88032Q109 548,025 6,867,476 SH   SOLE   6,438,407 373,500 55,569
Teradyne Inc Common Stock 880770102 350,086 2,877,103 SH   SOLE   2,779,946 58,658 38,499
Tesla Inc Common Stock 88160R101 3,864,324 5,785,523 SH   SOLE   5,351,827 429,044 4,652
Teva Pharmaceutical Industries Ltd ADR 881624209 5,768 499,844 SH   SOLE   499,844 0 0
Trade Desk Inc/The Common Stock 88339J105 121,241 186,049 SH   SOLE   186,049 0 0
3D Systems Corp Common Stock 88554D205 58,819 2,143,547 SH   SOLE   2,143,547 0 0
3M Co Common Stock 88579Y101 731 3,792 SH   SOLE   3,792 0 0
Trimble Inc Common Stock 896239100 218,609 2,810,249 SH   SOLE   2,810,249 0 0
Twilio Inc Common Stock 90138F102 932,715 2,737,162 SH   SOLE   2,482,948 208,592 45,622
Twist Bioscience Corp Common Stock 90184D100 748,798 6,045,520 SH   SOLE   5,796,015 139,968 109,537
2U Inc Common Stock 90214J101 452,531 11,837,072 SH   SOLE   9,936,908 1,449,362 450,802
Ultra Clean Holdings Inc Common Stock 90385V107 6,944 119,648 SH   SOLE   119,648 0 0
United Parcel Service Inc Common Stock 911312106 4,887 28,750 SH   SOLE   28,750 0 0
Veracyte Inc Common Stock 92337F107 409,429 7,617,287 SH   SOLE   7,404,211 213,076 0
Verisk Analytics Inc Common Stock 92345Y106 634 3,588 SH   SOLE   3,588 0 0
Workday Inc Common Stock 98138H101 81,293 327,228 SH   SOLE   327,228 0 0
Xilinx Inc Common Stock 983919101 29,942 241,660 SH   SOLE   241,660 0 0
Xerox Holdings Corp Common Stock 98421M106 687 28,303 SH   SOLE   28,303 0 0
Zillow Group Inc Common Stock 98954M200 1,300,633 10,032,650 SH   SOLE   9,104,846 721,655 206,149
Koninklijke DSM NV Common Stock N5017D122 615 3,625 SH   SOLE   3,625 0 0
Arkema SA Common Stock F0392W125 660 5,435 SH   SOLE   5,435 0 0
MGI Digital Graphic Technology Common Stock F4090S113 23,904 412,659 SH   SOLE   412,659 0 0
Sandvik AB Common Stock W74857165 681 24,871 SH   SOLE   24,871 0 0
Hexagon AB Common Stock W40063104 7,031 76,061 SH   SOLE   76,061 0 0
Cellcom Israel Ltd Common Stock M2196U109 4,983 1,332,925 SH   SOLE   1,332,925 0 0
Evonik Industries AG Common Stock D2R90Y117 702 19,793 SH   SOLE   19,793 0 0
Fattal Holdings 1998 Ltd Common Stock M4148G105 6,150 56,905 SH   SOLE   56,905 0 0
Meituan Common Stock G59669104 87,854 2,290,458 SH   SOLE   2,290,458 0 0
SLM Solutions Group AG Common Stock D6T690109 22,106 1,064,114 SH   SOLE   1,064,114 0 0
ZhongAn Online P&C Insurance Co Ltd Common Stock Y989DF109 114,265 18,941,138 SH   SOLE   18,941,138 0 0
Adyen NV Common Stock N3501V104 128,337 57,380 SH   SOLE   57,380 0 0
Atlassian Corp PLC Common Stock G06242104 60,114 285,226 SH   SOLE   285,226 0 0
Medtronic PLC Common Stock G5960L103 4,701 39,796 SH   SOLE   39,796 0 0
Sapiens International Corp NV Common Stock G7T16G103 5,816 182,947 SH   SOLE   182,947 0 0
CRISPR Therapeutics AG Common Stock H17182108 1,010,179 8,290,350 SH   SOLE   7,367,516 704,010 218,824
Spotify Technology SA Common Stock L8681T102 1,042,681 3,891,325 SH   SOLE   3,510,239 289,115 91,971
Allot Ltd Common Stock M0854Q105 6,886 431,153 SH   SOLE   431,153 0 0
AudioCodes Ltd Common Stock M15342104 5,121 189,795 SH   SOLE   189,795 0 0
Camtek Ltd/Israel Common Stock M20791105 7,711 257,883 SH   SOLE   257,883 0 0
Ceragon Networks Ltd Common Stock M22013102 4,378 1,161,214 SH   SOLE   1,161,214 0 0
Check Point Software Technologies Ltd Common Stock M22465104 5,372 47,974 SH   SOLE   47,974 0 0
Compugen Ltd Common Stock M25722105 123,888 14,422,362 SH   SOLE   14,070,300 219,844 132,218
CyberArk Software Ltd Common Stock M2682V108 4,787 37,011 SH   SOLE   37,011 0 0
Evogene Ltd Common Stock M4119S104 24,175 4,796,679 SH   SOLE   4,796,679 0 0
Fiverr International Ltd Common Stock M4R82T106 5,367 24,713 SH   SOLE   24,713 0 0
Ituran Location and Control Ltd Common Stock M6158M104 6,770 318,892 SH   SOLE   318,892 0 0
Nova Measuring Instruments Ltd Common Stock M7516K103 6,845 75,210 SH   SOLE   75,210 0 0
Radware Ltd Common Stock M81873107 5,706 218,772 SH   SOLE   218,772 0 0
Stratasys Ltd Common Stock M85548101 269,885 10,420,260 SH   SOLE   8,139,415 1,527,641 753,204
Taro Pharmaceutical Industries Ltd Common Stock M8737E108 5,799 78,627 SH   SOLE   78,627 0 0
Tower Semiconductor Ltd Common Stock M87915274 5,522 196,917 SH   SOLE   196,917 0 0
UroGen Pharma Ltd Common Stock M96088105 5,686 291,870 SH   SOLE   291,870 0 0
Wix.com Ltd Common Stock M98068105 6,733 24,114 SH   SOLE   24,114 0 0
NXP Semiconductors NV Common Stock N6596X109 116,862 580,421 SH   SOLE   580,421 0 0
DocuSign Inc Common Stock 256163106 647,378 3,197,720 SH   SOLE   3,056,146 106,151 35,423
Zscaler Inc Common Stock 98980G102 107 621 SH   SOLE   621 0 0
GMO internet Inc Common Stock J1822R104 23 800 SH   SOLE   800 0 0
Discovery Ltd Common Stock S2192Y109 48,849 5,438,981 SH   SOLE   5,438,981 0 0
Inmode Ltd Common Stock M5425M103 7,379 101,962 SH   SOLE   101,962 0 0
Perion Network Ltd Common Stock M78673114 8,086 451,724 SH   SOLE   451,724 0 0
Silvergate Capital Corp Common Stock 82837P408 275,720 1,939,369 SH   SOLE   1,939,369 0 0
Meituan ADR 58533E103 161 2,055 SH   SOLE   2,055 0 0
Z Holdings Corp Common Stock J9894K105 71,151 14,293,530 SH   SOLE   14,293,530 0 0
Sea Ltd ADR 81141R100 707,879 3,171,074 SH   SOLE   2,924,996 188,718 57,360
Z Holdings Corp ADR 98877X101 567 57,245 SH   SOLE   57,245 0 0
Pure Storage Inc Common Stock 74624M102 708,402 32,887,736 SH   SOLE   29,671,107 2,638,808 577,821
Synopsys Inc Common Stock 871607107 381,024 1,537,753 SH   SOLE   1,469,312 45,794 22,647
HUYA Inc ADR 44852D108 214,054 10,988,392 SH   SOLE   10,020,754 735,617 232,021
RADA Electronic Industries Ltd Common Stock M81863124 6,955 579,065 SH   SOLE   579,065 0 0
PagerDuty Inc Common Stock 69553P100 401,600 9,982,602 SH   SOLE   8,614,212 1,041,802 326,588
Caterpillar Inc Common Stock 149123101 88,567 381,967 SH   SOLE   381,967 0 0
Arconic Corp Common Stock 03966V107 3,965 156,152 SH   SOLE   156,152 0 0
Lightspeed POS Inc Common Stock 53227R106 1,054 16,774 SH   SOLE   16,774 0 0
Adaptive Biotechnologies Corp Common Stock 00650F109 139,860 3,473,910 SH   SOLE   3,473,910 0 0
10X Genomics Inc Common Stock 88025U109 634,246 3,504,121 SH   SOLE   3,168,614 263,960 71,547
Crowdstrike Holdings Inc Common Stock 22788C105 60,981 334,124 SH   SOLE   334,124 0 0
Bitcoin Fund/The Closed-End Fund 09175G104 12,887 199,331 SH   SOLE   0 0 199,331
Schrodinger Inc/United States Common Stock 80810D103 195,443 2,561,846 SH   SOLE   2,561,846 0 0
Slack Technologies Inc Common Stock 83088V102 192 4,735 SH   SOLE   4,735 0 0
TCS Group Holding PLC GDR 87238U203 77,375 1,334,047 SH   SOLE   1,334,047 0 0
Phreesia Inc Common Stock 71944F106 66,517 1,276,726 SH   SOLE   1,276,726 0 0
Virgin Galactic Holdings Inc Common Stock 92766K106 52,919 1,727,671 SH   SOLE   1,727,671 0 0
Workhorse Group Inc Common Stock 98138J206 55,072 3,999,408 SH   SOLE   3,999,408 0 0
Adyen NV ADR 00783V104 81,003 1,810,940 SH   SOLE   1,810,940 0 0
Cie Generale des Etablissements Michelin SCA Common Stock F61824144 5,408 36,059 SH   SOLE   36,059 0 0
voestalpine AG Common Stock A9101Y103 721 17,367 SH   SOLE   17,367 0 0
Yeahka Ltd Common Stock G9835C108 87,478 12,712,000 SH   SOLE   12,712,000 0 0
Accolade Inc Common Stock 00437E102 240,774 5,306,902 SH   SOLE   5,306,902 0 0
Berkeley Lights Inc Common Stock 084310101 256,976 5,115,992 SH   SOLE   5,115,992 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100 369,406 1,719,046 SH   SOLE   1,719,046 0 0
BYD Co Ltd ADR 05606L100 53,408 1,234,435 SH   SOLE   1,234,435 0 0
Biondvax Pharmaceuticals Ltd ADR 09073Q105 37 9,778 SH   SOLE   9,778 0 0
Kamada Ltd Common Stock M6240T109 5,288 866,366 SH   SOLE   866,366 0 0
BATM Advanced Communications Ltd Common Stock M19199112 5,526 4,174,208 SH   SOLE   4,174,208 0 0
Gamida Cell Ltd Common Stock M47364100 5,423 670,324 SH   SOLE   670,324 0 0
Gilat Satellite Networks Ltd Common Stock M51474118 6,852 655,093 SH   SOLE   655,093 0 0
PolyPid Ltd Common Stock M8001Q118 5,292 577,747 SH   SOLE   577,747 0 0
Silicom Ltd Common Stock M84116108 6,221 137,871 SH   SOLE   137,871 0 0
Nintendo Co Ltd ADR 654445303 442,706 6,252,905 SH   SOLE   5,562,959 545,522 144,424
Organovo Holdings Inc Common Stock 68620A203 5,844 606,221 SH   SOLE   602,693 3,528 0
Surface Oncology Inc Common Stock 86877M209 31,740 4,069,255 SH   SOLE   4,069,255 0 0
Takeda Pharmaceutical Co Ltd ADR 874060205 341,775 18,717,144 SH   SOLE   18,717,144 0 0
Niu Technologies ADR 65481N100 68,264 1,862,592 SH   SOLE   1,862,592 0 0
Thermo Fisher Scientific Inc Common Stock 883556102 110,349 241,791 SH   SOLE   241,791 0 0
Exact Sciences Corp Common Stock 30063P105 1,205,607 9,148,635 SH   SOLE   8,404,723 594,597 149,315
Snowflake Inc Common Stock 833445109 22 98 SH   SOLE   98 0 0
Unity Software Inc Common Stock 91332U101 812,174 8,096,637 SH   SOLE   7,510,902 424,492 161,243
Beam Therapeutics Inc Common Stock 07373V105 382,519 4,779,104 SH   SOLE   4,779,104 0 0
Novartis AG Common Stock H5820Q150 618,936 7,219,265 SH   SOLE   6,984,729 155,467 79,069
Regeneron Pharmaceuticals Inc Common Stock 75886F107 576,743 1,218,970 SH   SOLE   1,155,645 60,867 2,458
Repare Therapeutics Inc Common Stock 760273102 41,695 1,358,589 SH   SOLE   1,358,589 0 0
MarketAxess Holdings Inc Common Stock 57060D108 16,528 33,195 SH   SOLE   33,195 0 0
Agora Inc ADR 00851L103 86,283 1,716,390 SH   SOLE   1,716,390 0 0
KE Holdings Inc ADR 482497104 546,555 9,592,049 SH   SOLE   8,776,600 641,970 173,479
Fastly Inc Common Stock 31188V100 96,450 1,433,563 SH   SOLE   1,433,563 0 0
Cloudflare Inc Common Stock 18915M107 66,218 942,466 SH   SOLE   942,466 0 0
Palantir Technologies Inc Common Stock 69608A108 433,950 18,632,471 SH   SOLE   17,628,771 647,600 356,100
Raven Industries Inc Common Stock 754212108 53,867 1,405,340 SH   SOLE   1,405,340 0 0
Zoom Video Communications Inc Common Stock 98980L101 964,624 3,002,347 SH   SOLE   2,784,682 157,985 59,680
Honeywell International Inc Common Stock 438516106 704 3,245 SH   SOLE   3,245 0 0
Alphabet Inc Common Stock 02079K305 6 3 SH   SOLE   3 0 0
Roche Holding AG ADR 771195104 328,770 8,105,763 SH   SOLE   8,105,763 0 0
Sarepta Therapeutics Inc Common Stock 803607100 138,648 1,860,293 SH   SOLE   1,860,293 0 0
Opendoor Technologies Inc Common Stock 683712103 246,680 11,641,318 SH   SOLE   11,641,318 0 0
BASE Inc Common Stock J0433G101 32,554 2,260,400 SH   SOLE   2,260,400 0 0
Kaspi.KZ JSC GDR 48581R205 10,776 151,780 SH   SOLE   151,780 0 0
908 Devices Inc Common Stock 65443P102 52,034 1,072,866 SH   SOLE   1,072,866 0 0
Magna International Inc Common Stock 559222401 62,254 707,109 SH   SOLE   707,109 0 0
Peloton Interactive Inc Common Stock 70614W100 113,730 1,011,477 SH   SOLE   1,011,477 0 0
Veeva Systems Inc Common Stock 922475108 219,052 838,508 SH   SOLE   838,508 0 0
Grayscale Ethereum Trust Open-End Fund 389638107 11,433 639,069 SH   SOLE   0 639,069 0
Bristol-Myers Squibb Co Common Stock 110122108 137,618 2,179,919 SH   SOLE   2,179,919 0 0
SPDR S&P 500 ETF Trust ETP 78462F103 22 55 SH   SOLE   55 0 0
1Life Healthcare Inc Common Stock 68269G107 42,920 1,098,269 SH   SOLE   1,098,269 0 0
PyroGenesis Canada Inc Common Stock 74734T104 1,420 211,000 SH   SOLE   211,000 0 0
Arad Ltd Common Stock M1492B104 5,688 395,760 SH   SOLE   395,760 0 0
Augwind Energy Tech Storage Ltd Common Stock M6058P108 4,505 193,616 SH   SOLE   193,616 0 0
Bet Shemesh Engines Holdings 1997 Ltd Common Stock M20119109 5,894 278,364 SH   SOLE   278,364 0 0
Electra Consumer Products 1970 Ltd Common Stock M3798N105 6,827 158,105 SH   SOLE   158,105 0 0
E&M Computing Ltd Common Stock M4026X105 8,659 1,213,008 SH   SOLE   1,213,008 0 0
Ham-Let Israel-Canada Ltd Common Stock M5257K100 6,094 318,886 SH   SOLE   318,886 0 0
Intercure Ltd Common Stock M549GJ103 8,376 5,139,550 SH   SOLE   5,139,550 0 0
Itamar Medical Ltd Common Stock M61483109 5,167 6,710,537 SH   SOLE   6,710,537 0 0
Magic Software Enterprises Ltd Common Stock 559166103 5,139 331,141 SH   SOLE   331,141 0 0
Malam - Team Ltd Common Stock M87437105 6,201 219,895 SH   SOLE   219,895 0 0
Plasson Industries Ltd Common Stock M7933B108 5,755 120,887 SH   SOLE   120,887 0 0
RoboGroup T.E.K Ltd Common Stock M20330102 4,615 2,674,171 SH   SOLE   2,674,171 0 0
Desktop Metal Inc Common Stock 25058X105 15,355 1,030,570 SH   SOLE   1,030,570 0 0
DarioHealth Corp Common Stock 23725P209 5,231 271,619 SH   SOLE   271,619 0 0
Enlivex Therapeutics Ltd Common Stock M4130Y106 5,283 476,414 SH   SOLE   476,414 0 0
Experience Investment Corp Common Stock 30217C208 30,799 2,744,999 SH   SOLE   2,744,999 0 0
JFrog Ltd Common Stock M6191J100 4,040 91,060 SH   SOLE   91,060 0 0
Eastman Kodak Co Common Stock 277461406 575 73,084 SH   SOLE   73,084 0 0
Kornit Digital Ltd Common Stock M6372Q113 6,053 61,070 SH   SOLE   61,070 0 0
Lockheed Martin Corp Common Stock 539830109 102,261 276,755 SH   SOLE   276,755 0 0
Nano-X Imaging Ltd Common Stock M70700105 3,898 94,053 SH   SOLE   94,053 0 0
PACCAR Inc Common Stock 693718108 293,409 3,157,652 SH   SOLE   2,724,925 344,432 88,295
SolarEdge Technologies Inc Common Stock 83417M104 5,300 18,439 SH   SOLE   18,439 0 0
Skillz Inc Common Stock 83067L109 114,473 6,012,260 SH   SOLE   6,012,260 0 0
Teledyne Technologies Inc Common Stock 879360105 88,925 214,977 SH   SOLE   214,977 0 0
Twitter Inc Common Stock 90184L102 495,884 7,793,240 SH   SOLE   7,082,389 585,409 125,442
AbbVie Inc Common Stock 00287Y109 59,858 553,117 SH   SOLE   553,117 0 0
Butterfly Network Inc Common Stock 124155102 88,969 5,286,325 SH   SOLE   5,286,325 0 0
CM Life Sciences Inc Common Stock 18978W109 63,008 4,231,546 SH   SOLE   4,231,546 0 0
Signify Health Inc Common Stock 82671G100 49,567 1,694,034 SH   SOLE   1,694,034 0 0
ARK Innovation ETF ETP 00214Q104 2,171 18,101 SH   SOLE   18,101 0 0
Ping An Healthcare and Technology Co Ltd Common Stock G71139102 50,296 4,010,500 SH   SOLE   4,010,500 0 0
Bill.com Holdings Inc Common Stock 090043100 24,605 169,108 SH   SOLE   169,108 0 0
DraftKings Inc Common Stock 26142R104 268,345 4,375,424 SH   SOLE   4,227,724 93,000 54,700
Atlas Crest Investment Corp Common Stock 049284102 14,668 1,459,498 SH   SOLE   1,459,498 0 0
One Common Stock G7000X105 24,385 2,103,928 SH   SOLE   2,103,928 0 0
Vuzix Corp Common Stock 92921W300 53,017 2,084,017 SH   SOLE   2,084,017 0 0
ARK Genomic Revolution ETF ETP 00214Q302 953 10,735 SH   SOLE   10,735 0 0
Seer Inc Common Stock 81578P106 42,431 848,274 SH   SOLE   848,274 0 0
iShares Russell 1000 Growth ETF ETP 464287614 795 3,270 SH   SOLE   3,270 0 0
Airbus SE Common Stock N0280G100 1,013 8,928 SH   SOLE   8,928 0 0
Thales SA Common Stock F9156M108 2,512 25,234 SH   SOLE   25,234 0 0
Komatsu Ltd Common Stock J35759125 2,880 93,188 SH   SOLE   93,188 0 0
Boeing Co/The Common Stock 097023105 2,290 8,990 SH   SOLE   8,990 0 0
Garmin Ltd Common Stock H2906T109 1,292 9,797 SH   SOLE   9,797 0 0
HEICO Corp Common Stock 422806109 724 5,756 SH   SOLE   5,756 0 0
L3Harris Technologies Inc Common Stock 502431109 3,164 15,613 SH   SOLE   15,613 0 0
The 3D Printing ETF ETP 00214Q500 3,891 100,170 SH   SOLE   100,170 0 0
ROBLOX Corp Common Stock 771049103 33,509 516,877 SH   SOLE   516,877 0 0
Reinvent Technology Partners Common Stock G7483N129 457 45,000 SH   SOLE   45,000 0 0
Jaws Spitfire Acquisition Corp Common Stock G50740102 8,164 796,478 SH   SOLE   796,478 0 0
Spirit AeroSystems Holdings Inc Common Stock 848574109 2,046 42,063 SH   SOLE   42,063 0 0