The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 25,701 3,196,642 SH   SOLE   3,196,642 0 0
89BIO INC COM 282559103 15,262 2,636,000 SH   SOLE   2,636,000 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 37,902 3,778,818 SH   SOLE   3,778,818 0 0
ADICET BIO INC COM 007002108 11,739 825,508 SH   SOLE   825,508 0 0
AGENUS INC COM NEW 00847G705 53,966 26,325,000 SH   SOLE   26,325,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 26,931 790,926 SH   SOLE   790,926 0 0
ALBIREO PHARMA INC COM 01345P106 21,502 1,110,624 SH   SOLE   1,110,624 0 0
ALLAKOS INC COM 01671P100 27,654 4,518,575 SH   SOLE   4,518,575 0 0
ANAPTYSBIO INC COM 032724106 9,184 360,000 SH   SOLE   360,000 0 0
ARDELYX INC COM 039697107 17,681 14,858,000 SH   SOLE   14,858,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 82,608 800,000 SH   SOLE   800,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 103,260 1,000,000 SH Call SOLE   1,000,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 4,920 3,000,000 SH   SOLE   3,000,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 42,694 5,677,372 SH   SOLE   5,677,372 0 0
BEAM THERAPEUTICS INC COM 07373V105 47,640 1,000,000 SH   SOLE   1,000,000 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 67,454 2,900,000 SH   SOLE   2,900,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 62,633 738,863 SH   SOLE   738,863 0 0
CENTURY THERAPEUTICS INC COM 15673T100 9,145 924,641 SH   SOLE   924,641 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 58,980 3,000,000 SH   SOLE   3,000,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 20,681 1,053,000 SH   SOLE   1,053,000 0 0
DICE THERAPEUTICS INC COM 23345J104 20,280 1,000,000 SH   SOLE   1,000,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 40,439 3,184,200 SH   SOLE   3,184,200 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 33,204 3,374,394 SH   SOLE   3,374,394 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 37,765 5,636,587 SH   SOLE   5,636,587 0 0
FATE THERAPEUTICS INC COM 31189P102 29,382 1,311,113 SH   SOLE   1,311,113 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 19,283 966,573 SH   SOLE   966,573 0 0
FULCRUM THERAPEUTICS INC COM 359616109 7,287 900,711 SH   SOLE   900,711 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 5,803 499,400 SH   SOLE   499,400 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 22,241 326,600 SH   SOLE   326,600 0 0
GRITSTONE BIO INC COM 39868T105 117 45,500 SH   SOLE   45,500 0 0
HERON THERAPEUTICS INC COM 427746102 36,074 8,548,387 SH   SOLE   8,548,387 0 0
HOOKIPA PHARMA INC COM 43906K100 6,748 5,035,998 SH   SOLE   5,035,998 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 90,533 1,462,800 SH   SOLE   1,462,800 0 0
IMMUNOVANT INC COM 45258J102 55,020 9,860,246 SH   SOLE   9,860,246 0 0
INOZYME PHARMA INC COM 45790W108 8,710 3,250,000 SH   SOLE   3,250,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 16,788 300,000 SH   SOLE   300,000 0 0
IVERIC BIO INC COM 46583P102 35,880 2,000,000 SH Call SOLE   2,000,000 0 0
IVERIC BIO INC COM 46583P102 125,580 7,000,000 SH   SOLE   7,000,000 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 114,763 861,000 SH   SOLE   861,000 0 0
JOUNCE THERAPEUTICS INC COM 481116101 9,968 4,259,653 SH   SOLE   4,259,653 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 26,466 1,824,000 SH   SOLE   1,824,000 0 0
KEROS THERAPEUTICS INC COM 492327101 9,349 248,500 SH   SOLE   248,500 0 0
KURA ONCOLOGY INC COM 50127T109 43,522 3,186,083 SH   SOLE   3,186,083 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 7,556 5,359,000 SH   SOLE   5,359,000 0 0
NKARTA INC COM 65487U108 37,043 2,814,844 SH   SOLE   2,814,844 0 0
NOVOCURE LTD ORD SHS G6674U108 98,300 1,293,761 SH   SOLE   1,293,761 0 0
NURIX THERAPEUTICS INC COM 67080M103 26,759 2,053,621 SH   SOLE   2,053,621 0 0
NUVATION BIO INC COM CL A 67080N101 20,889 9,325,540 SH   SOLE   9,325,540 0 0
PASSAGE BIO INC COM 702712100 1,799 1,439,062 SH   SOLE   1,439,062 0 0
PLIANT THERAPEUTICS INC COM 729139105 29,241 1,399,744 SH   SOLE   1,399,744 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 7,961 316,800 SH Put SOLE   316,800 0 0
RELMADA THERAPEUTICS INC COM 75955J402 4,339 117,200 SH Call SOLE   117,200 0 0
RELMADA THERAPEUTICS INC COM 75955J402 17,061 460,861 SH   SOLE   460,861 0 0
REPARE THERAPEUTICS INC COM 760273102 37,939 3,127,667 SH   SOLE   3,127,667 0 0
SCHRODINGER INC COM 80810D103 4,247 170,000 SH   SOLE   170,000 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 19,584 1,951,580 SH   SOLE   1,951,580 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 67,594 2,369,210 SH   SOLE   2,369,210 0 0
THIRD HARMONIC BIO INC COM 88427A107 24,058 1,268,220 SH   SOLE   1,268,220 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 98,560 4,000,000 SH   SOLE   4,000,000 0 0
TRICIDA INC COM 89610F101 8,098 772,700 SH Call SOLE   772,700 0 0
TRICIDA INC COM 89610F101 12,342 1,177,680 SH   SOLE   1,177,680 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 28,913 2,829,094 SH   SOLE   2,829,094 0 0
VERVE THERAPEUTICS INC COM 92539P101 26,621 775,000 SH   SOLE   775,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 21,505 2,363,188 SH   SOLE   2,363,188 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 40,411 1,970,290 SH   SOLE   1,970,290 0 0