The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Pinduoduo Inc ADR 722304102 229,535 3,667,862 SH   DFND   3,667,862 0 0
KE Holdings Inc ADR 482497104 80,503 4,594,952 SH   DFND   4,594,952 0 0
STAAR Surgical Co Common Stock 852312305 51,663 732,296 SH   SOLE   732,296 0 0
Kanzhun Ltd ADR 48553T106 40,355 2,390,698 SH   DFND   2,390,698 0 0
Full Truck Alliance Co Ltd ADR 35969L108 39,365 6,009,876 SH   DFND   6,009,876 0 0
Apple Inc Common Stock 037833100 34,779 251,657 SH   SOLE   251,657 0 0
Sea Ltd ADR 81141R100 33,836 603,681 SH   SOLE   603,681 0 0
Grab Holdings Ltd Common Stock G4124C109 31,034 11,800,000 SH   SOLE   11,800,000 0 0
Taiwan Semiconductor Manufactu ADR 874039100 29,481 430,000 SH   SOLE   430,000 0 0
Microsoft Corp Common Stock 594918104 28,156 120,891 SH   SOLE   120,891 0 0
QUALCOMM Inc Common Stock 747525103 27,669 244,904 SH   SOLE   244,904 0 0
Vipshop Holdings Ltd ADR 92763W103 20,217 2,403,908 SH   DFND   2,403,908 0 0
Alphabet Inc Common Stock 02079K107 19,078 198,423 SH   SOLE   198,423 0 0
Advanced Micro Devices Inc Common Stock 007903107 18,317 289,091 SH   SOLE   289,091 0 0
Tencent Music Entertainment Gr ADR 88034P109 16,308 4,016,687 SH   DFND   4,016,687 0 0
NIO Inc ADR 62914V106 14,639 928,272 SH   DFND   928,272 0 0
ASML Holding NV NY Reg Shrs N07059210 14,063 33,858 SH   SOLE   33,858 0 0
Yum China Holdings Inc Common Stock 98850P109 13,517 285,584 SH   DFND   285,584 0 0
Lufax Holding Ltd ADR 54975P102 13,300 5,236,160 SH   DFND   5,236,160 0 0
Autohome Inc ADR 05278C107 12,828 446,030 SH   DFND   446,030 0 0
TAL Education Group ADR 874080104 10,656 2,157,210 SH   DFND   2,157,210 0 0
Trip.com Group Ltd ADR 89677Q107 10,095 369,655 SH   DFND   369,655 0 0
Tesla Inc Common Stock 88160R101 9,622 36,276 SH   DFND   36,276 0 0
Amazon.com Inc Common Stock 023135106 8,939 79,103 SH   SOLE   79,103 0 0
Li Auto Inc ADR 50202M102 8,526 370,520 SH   DFND   370,520 0 0
360 DigiTech Inc ADR 88557W101 8,002 624,176 SH   DFND   624,176 0 0
JOYY Inc ADR 46591M109 7,542 290,098 SH   DFND   290,098 0 0
Weibo Corp ADR 948596101 7,366 430,755 SH   DFND   430,755 0 0
ZTO Express Cayman Inc ADR 98980A105 6,881 286,338 SH   DFND   286,338 0 0
iQIYI Inc ADR 46267X108 6,276 2,315,943 SH   DFND   2,315,943 0 0
NVIDIA Corp Common Stock 67066G104 5,601 46,142 SH   SOLE   46,142 0 0
Alphabet Inc Common Stock 02079K305 4,609 48,185 SH   SOLE   48,185 0 0
H World Group Ltd ADR 44332N106 4,389 130,849 SH   DFND   130,849 0 0
BeiGene Ltd ADR 07725L102 4,309 31,961 SH   DFND   31,961 0 0
Broadcom Inc Common Stock 11135F101 3,626 8,167 SH   SOLE   8,167 0 0
iShares MSCI Global Gold Miner ETP 46434G855 3,442 183,458 SH   SOLE   183,458 0 0
Meta Platforms Inc Common Stock 30303M102 3,438 25,336 SH   SOLE   25,336 0 0
XPeng Inc ADR 98422D105 3,429 286,966 SH   DFND   286,966 0 0
Vertex Pharmaceuticals Inc Common Stock 92532F100 3,373 11,648 SH   DFND   11,648 0 0
Cisco Systems Inc Common Stock 17275R102 3,355 83,866 SH   SOLE   83,866 0 0
SPDR Gold MiniShares Trust ETP 98149E303 3,339 101,236 SH   SOLE   101,236 0 0
iShares Gold Trust ETP 464285204 3,337 105,848 SH   SOLE   105,848 0 0
Zhihu Inc ADR 98955N108 3,184 3,003,800 SH   SOLE   3,003,800 0 0
United States Brent Oil Fund L ETP 91167Q100 2,978 108,999 SH   SOLE   108,999 0 0
Visa Inc Common Stock 92826C839 2,949 16,601 SH   SOLE   16,601 0 0
Invesco DB Oil Fund ETP 46140H403 2,947 194,142 SH   SOLE   194,142 0 0
Texas Instruments Inc Common Stock 882508104 2,866 18,515 SH   SOLE   18,515 0 0
United States Oil Fund LP ETP 91232N207 2,784 42,648 SH   SOLE   42,648 0 0
PepsiCo Inc Common Stock 713448108 2,742 16,796 SH   SOLE   16,796 0 0
Adobe Inc Common Stock 00724F101 2,599 9,444 SH   SOLE   9,444 0 0
Costco Wholesale Corp Common Stock 22160K105 2,543 5,385 SH   SOLE   5,385 0 0
Mastercard Inc Common Stock 57636Q104 2,463 8,663 SH   SOLE   8,663 0 0
Lululemon Athletica Inc Common Stock 550021109 2,392 8,555 SH   SOLE   8,555 0 0
Intuit Inc Common Stock 461202103 2,196 5,671 SH   SOLE   5,671 0 0
Daqo New Energy Corp ADR 23703Q203 2,149 40,481 SH   DFND   40,481 0 0
Intel Corp Common Stock 458140100 2,142 83,126 SH   SOLE   83,126 0 0
SPDR Gold Shares ETP 78463V107 2,087 13,492 SH   SOLE   13,492 0 0
Zai Lab Ltd ADR 98887Q104 2,038 59,590 SH   DFND   59,590 0 0
Amgen Inc Common Stock 031162100 2,003 8,886 SH   SOLE   8,886 0 0
PayPal Holdings Inc Common Stock 70450Y103 2,001 23,251 SH   SOLE   23,251 0 0
Estee Lauder Cos Inc/The Common Stock 518439104 1,948 9,021 SH   SOLE   9,021 0 0
JinkoSolar Holding Co Ltd ADR 47759T100 1,939 35,000 SH   DFND   35,000 0 0
Automatic Data Processing Inc Common Stock 053015103 1,897 8,388 SH   SOLE   8,388 0 0
T-Mobile US Inc Common Stock 872590104 1,842 13,730 SH   SOLE   13,730 0 0
Wolfspeed Inc Common Stock 977852102 1,751 16,941 SH   SOLE   16,941 0 0
Accenture PLC Common Stock G1151C101 1,646 6,397 SH   SOLE   6,397 0 0
Comcast Corp Common Stock 20030N101 1,587 54,115 SH   SOLE   54,115 0 0
NIKE Inc Common Stock 654106103 1,561 18,786 SH   SOLE   18,786 0 0
Gilead Sciences Inc Common Stock 375558103 1,502 24,348 SH   SOLE   24,348 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 1,470 2,134 SH   SOLE   2,134 0 0
Analog Devices Inc Common Stock 032654105 1,459 10,473 SH   SOLE   10,473 0 0
Salesforce Inc Common Stock 79466L302 1,454 10,109 SH   SOLE   10,109 0 0
Applied Materials Inc Common Stock 038222105 1,421 17,348 SH   SOLE   17,348 0 0
Honeywell International Inc Common Stock 438516106 1,364 8,170 SH   SOLE   8,170 0 0
Legend Biotech Corp ADR 52490G102 1,347 33,009 SH   DFND   33,009 0 0
VanEck Gold Miners ETF/USA ETP 92189F106 1,289 53,424 SH   SOLE   53,424 0 0
Netflix Inc Common Stock 64110L106 1,255 5,332 SH   SOLE   5,332 0 0
Biogen Inc Common Stock 09062X103 1,239 4,639 SH   SOLE   4,639 0 0
Fiserv Inc Common Stock 337738108 1,214 12,977 SH   SOLE   12,977 0 0
Marriott International Inc/MD Common Stock 571903202 1,196 8,535 SH   SOLE   8,535 0 0
Starbucks Corp Common Stock 855244109 1,160 13,765 SH   SOLE   13,765 0 0
United States 12 Month Oil Fun ETP 91288V103 1,137 35,000 SH   SOLE   35,000 0 0
Micron Technology Inc Common Stock 595112103 1,124 22,429 SH   SOLE   22,429 0 0
International Business Machine Common Stock 459200101 1,090 9,176 SH   SOLE   9,176 0 0
UnitedHealth Group Inc Common Stock 91324P102 1,082 2,142 SH   SOLE   2,142 0 0
Moderna Inc Common Stock 60770K107 1,057 8,940 SH   SOLE   8,940 0 0
AbbVie Inc Common Stock 00287Y109 1,056 7,870 SH   SOLE   7,870 0 0
Lam Research Corp Common Stock 512807108 1,020 2,786 SH   SOLE   2,786 0 0
Johnson & Johnson Common Stock 478160104 998 6,110 SH   SOLE   6,110 0 0
Berkshire Hathaway Inc Common Stock 084670702 976 3,655 SH   SOLE   3,655 0 0
ON Semiconductor Corp Common Stock 682189105 947 15,194 SH   SOLE   15,194 0 0
Oracle Corp Common Stock 68389X105 945 15,473 SH   SOLE   15,473 0 0
Synopsys Inc Common Stock 871607107 939 3,074 SH   SOLE   3,074 0 0
Intuitive Surgical Inc Common Stock 46120E602 918 4,898 SH   SOLE   4,898 0 0
Mondelez International Inc Common Stock 609207105 911 16,610 SH   SOLE   16,610 0 0
Cadence Design Systems Inc Common Stock 127387108 905 5,538 SH   SOLE   5,538 0 0
KLA Corp Common Stock 482480100 891 2,945 SH   SOLE   2,945 0 0
Autodesk Inc Common Stock 052769106 817 4,372 SH   SOLE   4,372 0 0
iShares iBoxx $ Investment Gra ETP 464287242 809 7,900 SH   DFND   7,900 0 0
Booking Holdings Inc Common Stock 09857L108 802 488 SH   SOLE   488 0 0
NXP Semiconductors NV Common Stock N6596X109 779 5,278 SH   SOLE   5,278 0 0
ServiceNow Inc Common Stock 81762P102 775 2,052 SH   SOLE   2,052 0 0
Paychex Inc Common Stock 704326107 769 6,851 SH   SOLE   6,851 0 0
Exxon Mobil Corp Common Stock 30231G102 737 8,440 SH   SOLE   8,440 0 0
Fortinet Inc Common Stock 34959E109 725 14,750 SH   SOLE   14,750 0 0
CSX Corp Common Stock 126408103 696 26,122 SH   SOLE   26,122 0 0
Activision Blizzard Inc Common Stock 00507V109 690 9,279 SH   SOLE   9,279 0 0
Microchip Technology Inc Common Stock 595017104 681 11,152 SH   SOLE   11,152 0 0
Seagen Inc Common Stock 81181C104 673 4,916 SH   SOLE   4,916 0 0
Eli Lilly & Co Common Stock 532457108 649 2,007 SH   SOLE   2,007 0 0
JPMorgan Chase & Co Common Stock 46625H100 621 5,939 SH   SOLE   5,939 0 0
Pfizer Inc Common Stock 717081103 617 14,091 SH   SOLE   14,091 0 0
Procter & Gamble Co/The Common Stock 742718109 611 4,839 SH   SOLE   4,839 0 0
Cognizant Technology Solutions Common Stock 192446102 602 10,476 SH   SOLE   10,476 0 0
Incyte Corp Common Stock 45337C102 584 8,770 SH   SOLE   8,770 0 0
Charter Communications Inc Common Stock 16119P108 580 1,912 SH   SOLE   1,912 0 0
Home Depot Inc/The Common Stock 437076102 574 2,081 SH   SOLE   2,081 0 0
Keurig Dr Pepper Inc Common Stock 49271V100 571 15,939 SH   SOLE   15,939 0 0
Merck & Co Inc Common Stock 58933Y105 570 6,623 SH   SOLE   6,623 0 0
O'Reilly Automotive Inc Common Stock 67103H107 556 790 SH   SOLE   790 0 0
American Electric Power Co Inc Common Stock 025537101 533 6,167 SH   SOLE   6,167 0 0
Monster Beverage Corp Common Stock 61174X109 527 6,056 SH   SOLE   6,056 0 0
Chevron Corp Common Stock 166764100 524 3,648 SH   SOLE   3,648 0 0
HUTCHMED China Ltd ADR 44842L103 522 58,861 SH   DFND   58,861 0 0
Thermo Fisher Scientific Inc Common Stock 883556102 518 1,022 SH   SOLE   1,022 0 0
Dexcom Inc Common Stock 252131107 496 6,156 SH   SOLE   6,156 0 0
Palo Alto Networks Inc Common Stock 697435105 490 2,994 SH   SOLE   2,994 0 0
Apellis Pharmaceuticals Inc Common Stock 03753U106 482 7,050 SH   SOLE   7,050 0 0
Illumina Inc Common Stock 452327109 481 2,521 SH   SOLE   2,521 0 0
Global Blood Therapeutics Inc Common Stock 37890U108 479 7,030 SH   SOLE   7,030 0 0
SpringWorks Therapeutics Inc Common Stock 85205L107 479 16,803 SH   SOLE   16,803 0 0
Biohaven Ltd Common Stock G1110E107 478 3,160 SH   SOLE   3,160 0 0
ChemoCentryx Inc Common Stock 16383L106 478 9,252 SH   SOLE   9,252 0 0
Neurocrine Biosciences Inc Common Stock 64125C109 475 4,473 SH   SOLE   4,473 0 0
CRISPR Therapeutics AG Common Stock H17182108 465 7,113 SH   SOLE   7,113 0 0
Cintas Corp Common Stock 172908105 465 1,197 SH   SOLE   1,197 0 0
Fidelity National Information Common Stock 31620M106 464 6,146 SH   SOLE   6,146 0 0
Kraft Heinz Co/The Common Stock 500754106 463 13,883 SH   SOLE   13,883 0 0
IVERIC bio Inc Common Stock 46583P102 460 25,624 SH   SOLE   25,624 0 0
Abbott Laboratories Common Stock 002824100 459 4,748 SH   SOLE   4,748 0 0
Danaher Corp Common Stock 235851102 458 1,774 SH   SOLE   1,774 0 0
Halozyme Therapeutics Inc Common Stock 40637H109 455 11,505 SH   SOLE   11,505 0 0
Ionis Pharmaceuticals Inc Common Stock 462222100 450 10,170 SH   SOLE   10,170 0 0
Ironwood Pharmaceuticals Inc Common Stock 46333X108 449 43,304 SH   SOLE   43,304 0 0
ACADIA Pharmaceuticals Inc Common Stock 004225108 448 27,407 SH   SOLE   27,407 0 0
BioCryst Pharmaceuticals Inc Common Stock 09058V103 446 35,417 SH   SOLE   35,417 0 0
Horizon Therapeutics Plc Common Stock G46188101 446 7,207 SH   SOLE   7,207 0 0
PTC Therapeutics Inc Common Stock 69366J200 446 8,881 SH   SOLE   8,881 0 0
United Therapeutics Corp Common Stock 91307C102 446 2,131 SH   SOLE   2,131 0 0
Sarepta Therapeutics Inc Common Stock 803607100 445 4,022 SH   SOLE   4,022 0 0
IDEXX Laboratories Inc Common Stock 45168D104 444 1,364 SH   SOLE   1,364 0 0
Prothena Corp PLC Common Stock G72800108 444 7,329 SH   SOLE   7,329 0 0
Sage Therapeutics Inc Common Stock 78667J108 444 11,341 SH   SOLE   11,341 0 0
Alkermes PLC Common Stock G01767105 443 19,839 SH   SOLE   19,839 0 0
Coca-Cola Co/The Common Stock 191216100 442 7,882 SH   SOLE   7,882 0 0
Rhythm Pharmaceuticals Inc Common Stock 76243J105 442 18,035 SH   SOLE   18,035 0 0
Exelon Corp Common Stock 30161N101 441 11,772 SH   SOLE   11,772 0 0
Bristol-Myers Squibb Co Common Stock 110122108 439 6,182 SH   SOLE   6,182 0 0
CTI BioPharma Corp Common Stock 12648L601 437 75,133 SH   SOLE   75,133 0 0
Denali Therapeutics Inc Common Stock 24823R105 437 14,254 SH   SOLE   14,254 0 0
BioMarin Pharmaceutical Inc Common Stock 09061G101 435 5,126 SH   SOLE   5,126 0 0
Amicus Therapeutics Inc Common Stock 03152W109 435 41,712 SH   SOLE   41,712 0 0
Karuna Therapeutics Inc Common Stock 48576A100 431 1,914 SH   SOLE   1,914 0 0
Alnylam Pharmaceuticals Inc Common Stock 02043Q107 427 2,134 SH   SOLE   2,134 0 0
Dynavax Technologies Corp Common Stock 268158201 427 40,888 SH   SOLE   40,888 0 0
Bank of America Corp Common Stock 060505104 424 14,027 SH   SOLE   14,027 0 0
Cytokinetics Inc Common Stock 23282W605 423 8,738 SH   SOLE   8,738 0 0
Bluebird Bio Inc Common Stock 09609G100 422 66,715 SH   SOLE   66,715 0 0
Verve Therapeutics Inc Common Stock 92539P101 422 12,292 SH   SOLE   12,292 0 0
Xcel Energy Inc Common Stock 98389B100 419 6,541 SH   SOLE   6,541 0 0
MercadoLibre Inc Common Stock 58733R102 418 505 SH   SOLE   505 0 0
Exelixis Inc Common Stock 30161Q104 417 26,611 SH   SOLE   26,611 0 0
Intellia Therapeutics Inc Common Stock 45826J105 414 7,393 SH   SOLE   7,393 0 0
Blueprint Medicines Corp Common Stock 09627Y109 413 6,262 SH   SOLE   6,262 0 0
Insmed Inc Common Stock 457669307 413 19,185 SH   SOLE   19,185 0 0
Arcus Biosciences Inc Common Stock 03969F109 411 15,720 SH   SOLE   15,720 0 0
I-Mab ADR 44975P103 410 102,157 SH   SOLE   102,157 0 0
Vir Biotechnology Inc Common Stock 92764N102 410 21,284 SH   SOLE   21,284 0 0
Arrowhead Pharmaceuticals Inc Common Stock 04280A100 408 12,351 SH   SOLE   12,351 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 407 42,531 SH   SOLE   42,531 0 0
Airbnb Inc Common Stock 009066101 402 3,831 SH   SOLE   3,831 0 0
Amphenol Corp Common Stock 032095101 402 6,009 SH   SOLE   6,009 0 0
Celldex Therapeutics Inc Common Stock 15117B202 401 14,278 SH   SOLE   14,278 0 0
Ultragenyx Pharmaceutical Inc Common Stock 90400D108 401 9,673 SH   SOLE   9,673 0 0
Beam Therapeutics Inc Common Stock 07373V105 395 8,283 SH   SOLE   8,283 0 0
Natera Inc Common Stock 632307104 394 9,002 SH   SOLE   9,002 0 0
Veracyte Inc Common Stock 92337F107 394 23,762 SH   SOLE   23,762 0 0
Mirati Therapeutics Inc Common Stock 60468T105 393 5,620 SH   SOLE   5,620 0 0
Electronic Arts Inc Common Stock 285512109 389 3,363 SH   SOLE   3,363 0 0
Prometheus Biosciences Inc Common Stock 74349U108 385 6,532 SH   SOLE   6,532 0 0
Roper Technologies Inc Common Stock 776696106 383 1,066 SH   SOLE   1,066 0 0
Exact Sciences Corp Common Stock 30063P105 381 11,718 SH   SOLE   11,718 0 0
Twist Bioscience Corp Common Stock 90184D100 381 10,817 SH   SOLE   10,817 0 0
Fate Therapeutics Inc Common Stock 31189P102 380 16,952 SH   SOLE   16,952 0 0
ANSYS Inc Common Stock 03662Q105 378 1,703 SH   SOLE   1,703 0 0
Enphase Energy Inc Common Stock 29355A107 377 1,359 SH   SOLE   1,359 0 0
Motorola Solutions Inc Common Stock 620076307 377 1,682 SH   SOLE   1,682 0 0
CVS Health Corp Common Stock 126650100 375 3,934 SH   SOLE   3,934 0 0
Walmart Inc Common Stock 931142103 374 2,886 SH   SOLE   2,886 0 0
Editas Medicine Inc Common Stock 28106W103 368 30,092 SH   SOLE   30,092 0 0
Dollar Tree Inc Common Stock 256746108 367 2,698 SH   SOLE   2,698 0 0
Marvell Technology Inc Common Stock 573874104 366 8,519 SH   SOLE   8,519 0 0
REVOLUTION Medicines Inc Common Stock 76155X100 363 18,417 SH   SOLE   18,417 0 0
Ross Stores Inc Common Stock 778296103 358 4,252 SH   SOLE   4,252 0 0
Catalyst Pharmaceuticals Inc Common Stock 14888U101 357 27,825 SH   SOLE   27,825 0 0
TE Connectivity Ltd Common Stock H84989104 357 3,239 SH   SOLE   3,239 0 0
Crowdstrike Holdings Inc Common Stock 22788C105 352 2,138 SH   SOLE   2,138 0 0
PACCAR Inc Common Stock 693718108 352 4,210 SH   SOLE   4,210 0 0
Travere Therapeutics Inc Common Stock 89422G107 349 14,145 SH   SOLE   14,145 0 0
Walt Disney Co/The Common Stock 254687106 348 3,692 SH   SOLE   3,692 0 0
VeriSign Inc Common Stock 92343E102 348 2,004 SH   SOLE   2,004 0 0
Royal Caribbean Cruises Ltd Common Stock V7780T103 346 9,137 SH   SOLE   9,137 0 0
McDonald's Corp Common Stock 580135101 344 1,490 SH   SOLE   1,490 0 0
CareDx Inc Common Stock 14167L103 342 20,073 SH   SOLE   20,073 0 0
Allogene Therapeutics Inc Common Stock 019770106 341 31,608 SH   SOLE   31,608 0 0
Emergent BioSolutions Inc Common Stock 29089Q105 339 16,148 SH   SOLE   16,148 0 0
Elevance Health Inc Common Stock 036752103 337 741 SH   SOLE   741 0 0
Medtronic PLC Common Stock G5960L103 332 4,108 SH   SOLE   4,108 0 0
Bridgebio Pharma Inc Common Stock 10806X102 331 33,350 SH   SOLE   33,350 0 0
Old Dominion Freight Line Inc Common Stock 679580100 331 1,329 SH   SOLE   1,329 0 0
JD.com Inc ADR 47215P106 327 6,503 SH   DFND   6,503 0 0
Verisk Analytics Inc Common Stock 92345Y106 326 1,913 SH   SOLE   1,913 0 0
Carnival Corp Common Stock 143658300 324 46,116 SH   SOLE   46,116 0 0
Verizon Communications Inc Common Stock 92343V104 323 8,505 SH   SOLE   8,505 0 0
Fastenal Co Common Stock 311900104 321 6,970 SH   SOLE   6,970 0 0
AstraZeneca PLC ADR 046353108 318 5,792 SH   SOLE   5,792 0 0
Walgreens Boots Alliance Inc Common Stock 931427108 317 10,081 SH   SOLE   10,081 0 0
Sorrento Therapeutics Inc Common Stock 83587F202 316 200,990 SH   SOLE   200,990 0 0
TG Therapeutics Inc Common Stock 88322Q108 315 53,150 SH   SOLE   53,150 0 0
Constellation Energy Corp Common Stock 21037T109 313 3,765 SH   SOLE   3,765 0 0
NextEra Energy Inc Common Stock 65339F101 312 3,979 SH   SOLE   3,979 0 0
ImmunoGen Inc Common Stock 45253H101 311 65,128 SH   SOLE   65,128 0 0
MannKind Corp Common Stock 56400P706 309 100,058 SH   SOLE   100,058 0 0
Wells Fargo & Co Common Stock 949746101 309 7,681 SH   SOLE   7,681 0 0
Workday Inc Common Stock 98138H101 307 2,015 SH   SOLE   2,015 0 0
Global Payments Inc Common Stock 37940X102 306 2,831 SH   SOLE   2,831 0 0
Atlassian Corp Common Stock 049468101 305 1,447 SH   SOLE   1,447 0 0
Relay Therapeutics Inc Common Stock 75943R102 302 13,483 SH   SOLE   13,483 0 0
Copart Inc Common Stock 217204106 301 2,830 SH   SOLE   2,830 0 0
Cigna Corp Common Stock 125523100 298 1,073 SH   SOLE   1,073 0 0
Madrigal Pharmaceuticals Inc Common Stock 558868105 295 4,538 SH   SOLE   4,538 0 0
Cerevel Therapeutics Holdings Common Stock 15678U128 294 10,400 SH   SOLE   10,400 0 0
Align Technology Inc Common Stock 016255101 289 1,397 SH   SOLE   1,397 0 0
Keysight Technologies Inc Common Stock 49338L103 288 1,830 SH   SOLE   1,830 0 0
Arista Networks Inc Common Stock 040413106 283 2,504 SH   SOLE   2,504 0 0
Zentalis Pharmaceuticals Inc Common Stock 98943L107 274 12,628 SH   SOLE   12,628 0 0
Scorpio Tankers Inc Common Stock Y7542C130 274 6,508 SH   DFND   6,508 0 0
Novavax Inc Common Stock 670002401 273 15,017 SH   SOLE   15,017 0 0
uniQure NV Common Stock N90064101 271 14,470 SH   SOLE   14,470 0 0
Kymera Therapeutics Inc Common Stock 501575104 269 12,342 SH   SOLE   12,342 0 0
Linde PLC Common Stock G5494J103 269 996 SH   SOLE   996 0 0
Skyworks Solutions Inc Common Stock 83088M102 269 3,149 SH   SOLE   3,149 0 0
Kura Oncology Inc Common Stock 50127T109 265 19,380 SH   SOLE   19,380 0 0
Agios Pharmaceuticals Inc Common Stock 00847X104 264 9,340 SH   SOLE   9,340 0 0
Altimmune Inc Common Stock 02155H200 264 20,640 SH   SOLE   20,640 0 0
ConocoPhillips Common Stock 20825C104 262 2,559 SH   SOLE   2,559 0 0
Philip Morris International In Common Stock 718172109 261 3,139 SH   SOLE   3,139 0 0
Deciphera Pharmaceuticals Inc Common Stock 24344T101 257 13,887 SH   SOLE   13,887 0 0
Zoetis Inc Common Stock 98978V103 256 1,725 SH   SOLE   1,725 0 0
Baidu Inc ADR 056752108 254 2,166 SH   SOLE   2,166 0 0
Datadog Inc Common Stock 23804L103 254 2,866 SH   SOLE   2,866 0 0
Humana Inc Common Stock 444859102 254 523 SH   SOLE   523 0 0
Karyopharm Therapeutics Inc Common Stock 48576U106 251 45,924 SH   SOLE   45,924 0 0
Krystal Biotech Inc Common Stock 501147102 250 3,591 SH   SOLE   3,591 0 0
Stryker Corp Common Stock 863667101 250 1,232 SH   SOLE   1,232 0 0
Rocket Pharmaceuticals Inc Common Stock 77313F106 249 15,578 SH   SOLE   15,578 0 0
Lowe's Cos Inc Common Stock 548661107 246 1,308 SH   SOLE   1,308 0 0
Syndax Pharmaceuticals Inc Common Stock 87164F105 242 10,064 SH   SOLE   10,064 0 0
Union Pacific Corp Common Stock 907818108 242 1,243 SH   SOLE   1,243 0 0
Raytheon Technologies Corp Common Stock 75513E101 241 2,943 SH   SOLE   2,943 0 0
United Parcel Service Inc Common Stock 911312106 239 1,482 SH   SOLE   1,482 0 0
eBay Inc Common Stock 278642103 238 6,459 SH   SOLE   6,459 0 0
Becton Dickinson and Co Common Stock 075887109 237 1,062 SH   SOLE   1,062 0 0
Ocugen Inc Common Stock 67577C105 237 132,938 SH   SOLE   132,938 0 0
PMV Pharmaceuticals Inc Common Stock 69353Y103 237 19,884 SH   SOLE   19,884 0 0
Lucid Group Inc Common Stock 549498103 236 16,889 SH   SOLE   16,889 0 0
HP Inc Common Stock 40434L105 230 9,248 SH   SOLE   9,248 0 0
Avid Bioservices Inc Common Stock 05368M106 229 11,979 SH   SOLE   11,979 0 0
Arcutis Biotherapeutics Inc Common Stock 03969K108 228 11,947 SH   SOLE   11,947 0 0
Boston Scientific Corp Common Stock 101137107 228 5,875 SH   SOLE   5,875 0 0
Enanta Pharmaceuticals Inc Common Stock 29251M106 227 4,381 SH   SOLE   4,381 0 0
Gartner Inc Common Stock 366651107 225 812 SH   SOLE   812 0 0
Myriad Genetics Inc Common Stock 62855J104 225 11,783 SH   SOLE   11,783 0 0
Vericel Corp Common Stock 92346J108 225 9,701 SH   SOLE   9,701 0 0
Corning Inc Common Stock 219350105 222 7,638 SH   SOLE   7,638 0 0
Charles Schwab Corp/The Common Stock 808513105 222 3,092 SH   SOLE   3,092 0 0
Zscaler Inc Common Stock 98980G102 221 1,347 SH   SOLE   1,347 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 220 127,683 SH   SOLE   127,683 0 0
McKesson Corp Common Stock 58155Q103 219 645 SH   SOLE   645 0 0
Morgan Stanley Common Stock 617446448 219 2,769 SH   SOLE   2,769 0 0
AT&T Inc Common Stock 00206R102 217 14,163 SH   SOLE   14,163 0 0
Intercept Pharmaceuticals Inc Common Stock 45845P108 216 15,508 SH   SOLE   15,508 0 0
Ligand Pharmaceuticals Inc Common Stock 53220K504 216 2,503 SH   SOLE   2,503 0 0
Cogent Biosciences Inc Common Stock 19240Q201 215 14,390 SH   SOLE   14,390 0 0
Sirius XM Holdings Inc Common Stock 82968B103 215 37,608 SH   SOLE   37,608 0 0
Edwards Lifesciences Corp Common Stock 28176E108 213 2,575 SH   SOLE   2,575 0 0
REGENXBIO Inc Common Stock 75901B107 213 8,055 SH   SOLE   8,055 0 0
CDW Corp/DE Common Stock 12514G108 212 1,357 SH   SOLE   1,357 0 0
S&P Global Inc Common Stock 78409V104 210 687 SH   SOLE   687 0 0
EPAM Systems Inc Common Stock 29414B104 208 573 SH   SOLE   573 0 0
FibroGen Inc Common Stock 31572Q808 204 15,662 SH   SOLE   15,662 0 0
Xencor Inc Common Stock 98401F105 204 7,855 SH   SOLE   7,855 0 0
American Tower Corp REIT 03027X100 202 942 SH   SOLE   942 0 0
Centene Corp Common Stock 15135B101 201 2,578 SH   SOLE   2,578 0 0
Protagonist Therapeutics Inc Common Stock 74366E102 201 23,848 SH   SOLE   23,848 0 0
Myovant Sciences Ltd Common Stock G637AM102 200 11,153 SH   SOLE   11,153 0 0
EQRx Inc Common Stock 26886C107 199 40,228 SH   SOLE   40,228 0 0
Agenus Inc Common Stock 00847G705 197 95,871 SH   SOLE   95,871 0 0
Anavex Life Sciences Corp Common Stock 032797300 194 18,815 SH   SOLE   18,815 0 0
Gossamer Bio Inc Common Stock 38341P102 189 15,769 SH   SOLE   15,769 0 0
Arcturus Therapeutics Holdings Common Stock 03969T109 188 12,713 SH   SOLE   12,713 0 0
Coherus Biosciences Inc Common Stock 19249H103 178 18,473 SH   SOLE   18,473 0 0
Sana Biotechnology Inc Common Stock 799566104 177 29,495 SH   SOLE   29,495 0 0
Heron Therapeutics Inc Common Stock 427746102 175 41,391 SH   SOLE   41,391 0 0
Vaxart Inc Common Stock 92243A200 158 72,516 SH   SOLE   72,516 0 0
Hewlett Packard Enterprise Co Common Stock 42824C109 156 13,052 SH   SOLE   13,052 0 0
Nkarta Inc Common Stock 65487U108 146 11,085 SH   SOLE   11,085 0 0
Kezar Life Sciences Inc Common Stock 49372L100 145 16,821 SH   SOLE   16,821 0 0
Atara Biotherapeutics Inc Common Stock 046513107 139 36,673 SH   SOLE   36,673 0 0
ImmunityBio Inc Common Stock 45256X103 138 27,804 SH   SOLE   27,804 0 0
Sangamo Therapeutics Inc Common Stock 800677106 136 27,723 SH   SOLE   27,723 0 0
Viatris Inc Common Stock 92556V106 133 15,557 SH   SOLE   15,557 0 0
Recursion Pharmaceuticals Inc Common Stock 75629V104 126 11,859 SH   SOLE   11,859 0 0
Alector Inc Common Stock 014442107 122 12,866 SH   SOLE   12,866 0 0
Norwegian Cruise Line Holdings Common Stock G66721104 120 10,598 SH   SOLE   10,598 0 0
Lyell Immunopharma Inc Common Stock 55083R104 104 14,191 SH   SOLE   14,191 0 0
Mersana Therapeutics Inc Common Stock 59045L106 99 14,695 SH   SOLE   14,695 0 0
ADMA Biologics Inc Common Stock 000899104 97 39,858 SH   SOLE   39,858 0 0
Seres Therapeutics Inc Common Stock 81750R102 90 14,070 SH   SOLE   14,070 0 0
Geron Corp Common Stock 374163103 89 37,938 SH   SOLE   37,938 0 0
Point Biopharma Global Inc Common Stock 730541109 79 10,212 SH   SOLE   10,212 0 0
MiMedx Group Inc Common Stock 602496101 32 11,207 SH   SOLE   11,207 0 0
Alaunos Therapeutics Inc Common Stock 98973P101 26 15,167 SH   SOLE   15,167 0 0
Adagene Inc ADR 005329107 13 10,310 SH   SOLE   10,310 0 0