The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACELYRIN Inc | COM | 00445A100 | 5,431,148 | 1,729,665 | SH | DFND | 2 | 1,729,665 | 0 | 0 | ||
| Achilles Therapeutics PLC | SPONSORED ADS | 00449L102 | 861,128 | 755,375 | SH | DFND | 2 | 755,375 | 0 | 0 | ||
| Adobe Inc | COM | 00724F101 | 3,912,295 | 8,798 | SH | DFND | 2 | 8,798 | 0 | 0 | ||
| Allovir Inc | COM | 019818103 | 2,770,810 | 6,597,167 | SH | DFND | 2 | 6,597,167 | 0 | 0 | ||
| Alphabet Inc | CAP STK CL A | 02079K305 | 1,325,100 | 7,000 | SH | DFND | 2 | 7,000 | 0 | 0 | ||
| Amazon.com Inc | COM | 023135106 | 8,007,735 | 36,500 | SH | DFND | 2 | 36,500 | 0 | 0 | ||
| Apellis Pharmaceuticals Inc | COM | 03753U106 | 89,866,793 | 2,816,258 | SH | DFND | 2 | 2,816,258 | 0 | 0 | ||
| Apogee Therapeutics Inc | COM | 03770N101 | 33,853,823 | 747,325 | SH | DFND | 2 | 747,325 | 0 | 0 | ||
| Applied Therapeutics Inc | COM | 03828A101 | 1,398,832 | 1,633,768 | SH | DFND | 2 | 1,633,768 | 0 | 0 | ||
| Arcus Biosciences Inc | COM | 03969F109 | 24,003,827 | 1,612,077 | SH | DFND | 1 | 1,612,077 | 0 | 0 | ||
| argenx SE | SPONSORED ADR | 04016X101 | 70,752,675 | 115,045 | SH | DFND | 2 | 115,045 | 0 | 0 | ||
| Arrowhead Pharmaceuticals Inc | COM | 04280A100 | 54,551,603 | 2,901,681 | SH | DFND | 2 | 2,901,681 | 0 | 0 | ||
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | 40,932,182 | 297,321 | SH | DFND | 2 | 297,321 | 0 | 0 | ||
| Avidity Biosciences Inc | COM | 05370A108 | 32,781,739 | 1,127,295 | SH | DFND | 2 | 1,127,295 | 0 | 0 | ||
| Beigene Ltd | SPONSORED ADR | 07725L102 | 120,748,806 | 653,721 | SH | DFND | 2 | 653,721 | 0 | 0 | ||
| Bicara Therapeutics Inc | COM | 055477103 | 57,012,646 | 3,272,827 | SH | DFND | 2 | 3,272,827 | 0 | 0 | ||
| Bicycle Therapeutics PLC | SPONSORED ADS | 088786108 | 25,751,572 | 1,839,398 | SH | DFND | 2 | 1,839,398 | 0 | 0 | ||
| BIOAGE Labs Inc | COM | 09077V100 | 2,246,520 | 388,000 | SH | DFND | 2 | 388,000 | 0 | 0 | ||
| Black Diamond Therapeutics Inc | COM | 09203E105 | 2,239,546 | 1,046,517 | SH | DFND | 2 | 1,046,517 | 0 | 0 | ||
| Boeing Co | COM | 097023105 | 4,425,000 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Caribou Biosciences Inc | COM | 142038108 | 167,502 | 105,347 | SH | DFND | 2 | 105,347 | 0 | 0 | ||
| Cartesian Therapeutics Inc | COM NEW | 816212302 | 10,248,747 | 572,236 | SH | DFND | 2 | 572,236 | 0 | 0 | ||
| Centessa Pharmaceuticals PLC | SPONSORED ADS | 152309100 | 50,328,340 | 3,004,677 | SH | DFND | 2 | 3,004,677 | 0 | 0 | ||
| Couchbase Inc | COM | 22207T101 | 935,400 | 60,000 | SH | DFND | 2 | 60,000 | 0 | 0 | ||
| Crinetics Pharmaceuticals Inc | COM | 22663K107 | 82,301,507 | 1,609,652 | SH | DFND | 2 | 1,609,652 | 0 | 0 | ||
| CrowdStrike Holdings Inc | CL A | 22788C105 | 8,211,840 | 24,000 | SH | DFND | 2 | 24,000 | 0 | 0 | ||
| Cullinan Therapeutics Inc | COM | 230031106 | 14,754,328 | 1,211,357 | SH | DFND | 2 | 1,211,357 | 0 | 0 | ||
| Cyclerion Therapeutics Inc | COM | 23255M204 | 374,019 | 116,155 | SH | DFND | 2 | 116,155 | 0 | 0 | ||
| Cytokinetics Inc | COM NEW | 23282W605 | 18,925,274 | 402,323 | SH | DFND | 2 | 402,323 | 0 | 0 | ||
| Datadog Inc | CL A COM | 23804L103 | 4,347,428 | 30,425 | SH | DFND | 2 | 30,425 | 0 | 0 | ||
| Denali Therapeutics Inc | COM | 24823R105 | 16,997,491 | 834,028 | SH | DFND | 2 | 834,028 | 0 | 0 | ||
| Dollar Tree Inc | COM | 256746108 | 749,400 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | ||
| Dynatrace Inc | COM NEW | 268150109 | 4,496,321 | 82,729 | SH | DFND | 2 | 82,729 | 0 | 0 | ||
| Dyne Therapeutics Inc | COM | 26818M108 | 31,746,063 | 1,347,456 | SH | DFND | 2 | 1,347,456 | 0 | 0 | ||
| Edgewise Therapeutics Inc | COM | 28036F105 | 19,606,958 | 734,343 | SH | DFND | 2 | 734,343 | 0 | 0 | ||
| Elastic NV | ORD SHS | N14506104 | 2,477,000 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Erasca Inc | COM | 29479A108 | 22,231,519 | 8,857,179 | SH | DFND | 2 | 8,857,179 | 0 | 0 | ||
| Ferrari NV | COM | N3167Y103 | 854,493 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | ||
| Foghorn Therapeutics Inc. | COM | 344174107 | 3,401,798 | 720,720 | SH | DFND | 2 | 720,720 | 0 | 0 | ||
| Freeport-McMoRan Inc | CL B | 35671D857 | 2,856,000 | 75,000 | SH | DFND | 2 | 75,000 | 0 | 0 | ||
| Generation Bio Co | COM | 37148K100 | 3,161,697 | 2,982,733 | SH | DFND | 2 | 2,982,733 | 0 | 0 | ||
| Gossamer Bio Inc | COM | 38341P102 | 187,252 | 207,000 | SH | Call | DFND | 2 | 207,000 | 0 | 0 | |
| Gossamer Bio Inc | COM | 38341P102 | 4,712,032 | 5,208,968 | SH | DFND | 2 | 5,208,968 | 0 | 0 | ||
| HCA Healthcare Inc | COM | 40412C101 | 1,125,563 | 3,750 | SH | DFND | 2 | 3,750 | 0 | 0 | ||
| HOOKIPA Pharma Inc | COM NEW | 43906K209 | 1,138,946 | 566,640 | SH | DFND | 2 | 566,640 | 0 | 0 | ||
| IGM Biosciences Inc | COM | 449585108 | 20,348,878 | 3,330,422 | SH | DFND | 2 | 3,330,422 | 0 | 0 | ||
| IHS Holding Limited | ORD SHS | G4701H109 | 6,883,958 | 2,357,520 | SH | DFND | 1 | 2,357,520 | 0 | 0 | ||
| Instil Bio Inc | COM NEW | 45783C200 | 3,673,546 | 192,433 | SH | DFND | 2 | 192,433 | 0 | 0 | ||
| Intel Corp | COM | 458140100 | 802,000 | 40,000 | SH | DFND | 2 | 40,000 | 0 | 0 | ||
| Ionis Pharmaceuticals Inc | COM | 462222100 | 8,740,000 | 250,000 | SH | DFND | 2 | 250,000 | 0 | 0 | ||
| IONQ Inc | COM | 46222L108 | 7,100,900 | 170,000 | SH | DFND | 1 | 170,000 | 0 | 0 | ||
| Iovance Biotherapeutics Inc | COM | 462260100 | 8,184,696 | 1,106,040 | SH | DFND | 2 | 1,106,040 | 0 | 0 | ||
| Ironwood Pharmaceuticals Inc | COM CL A | 46333X108 | 489,657 | 110,532 | SH | DFND | 2 | 110,532 | 0 | 0 | ||
| Janux Therapeutics Inc | COM | 47103J105 | 9,369,500 | 175,000 | SH | DFND | 2 | 175,000 | 0 | 0 | ||
| Jfrog Ltd | ORD SHS | M6191J100 | 3,532,612 | 120,116 | SH | DFND | 2 | 120,116 | 0 | 0 | ||
| Kanzhun Ltd | SPONSORED ADS | 48553T106 | 345,000 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Ke Holdings Inc | SPONSORED ADS | 482497104 | 1,105,200 | 60,000 | SH | DFND | 2 | 60,000 | 0 | 0 | ||
| Korro Bio Inc | COM | 500946108 | 15,944,972 | 418,833 | SH | DFND | 2 | 418,833 | 0 | 0 | ||
| Kronos Bio Inc | COM | 50107A104 | 800,806 | 842,954 | SH | DFND | 2 | 842,954 | 0 | 0 | ||
| Kura Oncology Inc | COM | 50127T109 | 11,670,895 | 1,339,942 | SH | DFND | 2 | 1,339,942 | 0 | 0 | ||
| Kymera Therapeutics Inc | COM | 501575104 | 119,472,359 | 2,969,733 | SH | DFND | 2 | 2,969,733 | 0 | 0 | ||
| Lexeo Therapeutics Inc | COM | 52886X107 | 3,970,602 | 603,435 | SH | DFND | 2 | 603,435 | 0 | 0 | ||
| Lexicon Pharmaceuticals Inc | COM NEW | 528872302 | 28,799,988 | 38,918,903 | SH | DFND | 2 | 38,918,903 | 0 | 0 | ||
| Madrigal Pharmaceuticals Inc | COM | 558868105 | 38,861,923 | 125,942 | SH | DFND | 2 | 125,942 | 0 | 0 | ||
| Marvell Technology Inc | COM | 573874104 | 552,250 | 5,000 | SH | DFND | 2 | 5,000 | 0 | 0 | ||
| Merus NV | COM | N5749R100 | 32,984,525 | 784,412 | SH | DFND | 2 | 784,412 | 0 | 0 | ||
| Meta Platforms Inc | CL A | 30303M102 | 585,510 | 1,000 | SH | DFND | 2 | 1,000 | 0 | 0 | ||
| Microsoft Corp | COM | 594918104 | 9,694,500 | 23,000 | SH | DFND | 2 | 23,000 | 0 | 0 | ||
| Monday.Com Ltd | SHS | M7S64H106 | 470,880 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | ||
| Nebius Group NV | SHS CLASS A | N97284108 | 3,324,000 | 120,000 | SH | DFND | 2 | 120,000 | 0 | 0 | ||
| Neumora Therapeutics Inc | COM | 640979100 | 46,598,660 | 4,396,100 | SH | DFND | 2 | 4,396,100 | 0 | 0 | ||
| New Oriental Education & Technology Group Inc | SPON ADR | 647581206 | 4,396,330 | 68,500 | SH | DFND | 2 | 68,500 | 0 | 0 | ||
| NewAmsterdam Pharma Company NV | ORDINARY SHARES | N62509109 | 53,857,897 | 2,095,638 | SH | DFND | 2 | 2,095,638 | 0 | 0 | ||
| Nu Holdings Ltd | ORD SHS CL A | G6683N103 | 518,000 | 50,000 | SH | DFND | 2 | 50,000 | 0 | 0 | ||
| NVIDIA Corp | COM | 67066G104 | 6,571,078 | 48,932 | SH | DFND | 2 | 48,932 | 0 | 0 | ||
| Occidental Petroleum Corp | COM | 674599105 | 741,150 | 15,000 | SH | DFND | 2 | 15,000 | 0 | 0 | ||
| Omega Therapeutics Inc | COMMON STOCK | 68217N105 | 986,824 | 1,323,530 | SH | DFND | 2 | 1,323,530 | 0 | 0 | ||
| Oric Pharmaceuticals Inc | COM | 68622P109 | 8,131,130 | 1,007,575 | SH | DFND | 1 | 1,007,575 | 0 | 0 | ||
| Ovid Therapeutics Inc | COM | 690469101 | 2,661,045 | 2,850,000 | SH | DFND | 2 | 2,850,000 | 0 | 0 | ||
| Palo Alto Networks Inc | COM | 697435105 | 1,091,760 | 6,000 | SH | DFND | 2 | 6,000 | 0 | 0 | ||
| PayPal Holdings Inc | COM | 70450Y103 | 1,280,250 | 15,000 | SH | DFND | 2 | 15,000 | 0 | 0 | ||
| PDD Holdings Inc | SPONSORED ADS | 722304102 | 5,130,868 | 52,901 | SH | DFND | 2 | 52,901 | 0 | 0 | ||
| Phathom Pharmaceuticals Inc | COM | 71722W107 | 3,741,314 | 460,753 | SH | DFND | 2 | 460,753 | 0 | 0 | ||
| Procore Technologies Inc | COM | 74275K108 | 1,498,600 | 20,000 | SH | DFND | 2 | 20,000 | 0 | 0 | ||
| ProQR Therapeutics NV | SHS EURO | N71542109 | 4,173,750 | 1,575,000 | SH | DFND | 2 | 1,575,000 | 0 | 0 | ||
| Prothena Corporation PLC | SHS | G72800108 | 15,232,784 | 1,099,840 | SH | DFND | 2 | 1,099,840 | 0 | 0 | ||
| Qualcomm Inc | COM | 747525103 | 2,304,300 | 15,000 | SH | DFND | 2 | 15,000 | 0 | 0 | ||
| Rapport Therapeutics Inc | COM | 75383L102 | 6,815,655 | 384,197 | SH | DFND | 2 | 384,197 | 0 | 0 | ||
| Regenxbio Inc | COM | 75901B107 | 2,195,320 | 284,000 | SH | DFND | 2 | 284,000 | 0 | 0 | ||
| Remitly Global Inc | COM | 75960P104 | 10,505,184 | 465,449 | SH | DFND | 1 | 465,449 | 0 | 0 | ||
| Remitly Global Inc | COM | 75960P104 | 564,250 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Revolution Medicines Inc | COM | 76155X100 | 24,999,510 | 571,548 | SH | DFND | 2 | 571,548 | 0 | 0 | ||
| Rocket Pharmaceuticals Inc | COM | 77313F106 | 7,542,000 | 600,000 | SH | DFND | 2 | 600,000 | 0 | 0 | ||
| Sagimet Biosciences Inc | COM SER A | 786700104 | 3,261,470 | 724,771 | SH | DFND | 2 | 724,771 | 0 | 0 | ||
| Scholar Rock Holding Corp | COM | 80706P103 | 399,785,216 | 9,250,005 | SH | DFND | 2 | 9,250,005 | 0 | 0 | ||
| Sea Ltd | SPONSORED ADS | 81141R100 | 2,652,500 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Seer Inc | COM CL A | 81578P106 | 9,240,000 | 4,000,000 | SH | DFND | 2 | 4,000,000 | 0 | 0 | ||
| SEMrush Holdings Inc | CL A COM | 81686C104 | 415,800 | 35,000 | SH | DFND | 2 | 35,000 | 0 | 0 | ||
| Septerna Inc | COM | 81734D104 | 50,437,571 | 2,202,514 | SH | DFND | 2 | 2,202,514 | 0 | 0 | ||
| ServiceNow Inc | COM | 81762P102 | 5,941,973 | 5,605 | SH | DFND | 2 | 5,605 | 0 | 0 | ||
| Silence Therapeutics PLC | ADS | 82686Q101 | 19,482,578 | 2,831,770 | SH | DFND | 2 | 2,831,770 | 0 | 0 | ||
| Soleno Therapeutics Inc | COM | 834203309 | 15,814,219 | 351,818 | SH | DFND | 2 | 351,818 | 0 | 0 | ||
| Solid Biosciences Inc | COM NEW | 83422E204 | 14,996,164 | 3,749,041 | SH | DFND | 2 | 3,749,041 | 0 | 0 | ||
| SpringWorks Therapeutics Inc | COM | 85205L107 | 49,776,337 | 1,377,701 | SH | DFND | 2 | 1,377,701 | 0 | 0 | ||
| Spyre Therapeutics Inc | COM NEW | 00773J202 | 8,706,720 | 374,000 | SH | DFND | 2 | 374,000 | 0 | 0 | ||
| Stoke Therapeutics Inc | COM | 86150R107 | 22,060,000 | 2,000,000 | SH | DFND | 2 | 2,000,000 | 0 | 0 | ||
| Taboola.com Ltd | ORD SHS | M8744T106 | 36,388,657 | 9,969,495 | SH | DFND | 1 | 9,969,495 | 0 | 0 | ||
| Taiwan Semiconductor Manufacturing Co Ltd | SPONSORED ADS | 874039100 | 2,962,350 | 15,000 | SH | DFND | 2 | 15,000 | 0 | 0 | ||
| Tango Therapeutics Inc | COM | 87583X109 | 8,046,042 | 2,603,897 | SH | DFND | 2 | 2,603,897 | 0 | 0 | ||
| Taysha Gene Therapies Inc | COM SHS | 877619106 | 11,422,282 | 6,602,475 | SH | DFND | 2 | 6,602,475 | 0 | 0 | ||
| Tourmaline Bio Inc | COM | 89157D105 | 1,854,119 | 91,426 | SH | DFND | 2 | 91,426 | 0 | 0 | ||
| Trevi Therapeutics Inc | COM | 89532M101 | 11,972,967 | 2,906,060 | SH | DFND | 2 | 2,906,060 | 0 | 0 | ||
| Upstream Bio Inc | COM | 91678A107 | 13,152,000 | 800,000 | SH | DFND | 2 | 800,000 | 0 | 0 | ||
| Vaxcyte Inc | COM | 92243G108 | 24,557,263 | 299,991 | SH | DFND | 2 | 299,991 | 0 | 0 | ||
| Vera Therapeutics Inc | CL A | 92337R101 | 32,075,485 | 758,465 | SH | DFND | 2 | 758,465 | 0 | 0 | ||
| Vigil Neuroscience Inc | COM | 92673K108 | 3,384,765 | 1,991,038 | SH | DFND | 2 | 1,991,038 | 0 | 0 | ||
| WAVE Life Sciences Ltd | SHS | Y95308105 | 46,393,574 | 3,750,491 | SH | DFND | 2 | 3,750,491 | 0 | 0 | ||
| Workiva Inc | COM CL A | 98139A105 | 1,095,000 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | ||
| Xenon Pharmaceuticals Inc | COM | 98420N105 | 29,155,745 | 743,769 | SH | DFND | 2 | 743,769 | 0 | 0 | ||