The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 21VIANET GROUP INC | SPONSORED ADR | 90138A103 | 74,692 | 10,778,004 | SH | DFND | 5,18 | 10,778,004 | 0 | 0 | |
| AC IMMUNE SA | SHS | H00263105 | 13,830 | 1,337,500 | SH | DFND | 8,17,20 | 1,337,500 | 0 | 0 | |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 167,784 | 1,505,325 | SH | DFND | 1,2,8,11,14,16 | 1,505,325 | 0 | 0 | |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 6,533,655 | 35,597,989 | SH | DFND | 1,4,14,15,16 | 35,597,989 | 0 | 0 | |
| AMAZON COM INC | COM | 023135106 | 104,520 | 72,215 | SH | DFND | 1,14,16 | 72,215 | 0 | 0 | |
| AMGEN INC | COM | 031162100 | 32,140 | 188,527 | SH | DFND | 1,14,16 | 188,527 | 0 | 0 | |
| AMYRIS INC | COM NEW | 03236M200 | 22,094 | 3,302,585 | SH | DFND | 2,8,11 | 3,302,585 | 0 | 0 | |
| AMYRIS INC | NOTE 6.500% 5/1 | 03236MAC5 | 7,279 | 10,000,000 | PRN | DFND | 2,8,11 | 10,000,000 | 0 | 0 | |
| ANTERO RES CORP | COM | 03674X106 | 193,649 | 9,755,618 | SH | DFND | 6,16 | 9,755,618 | 0 | 0 | |
| BANK AMER CORP | COM | 060505104 | 7,039 | 234,724 | SH | DFND | 1,14,16 | 234,724 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 381,377 | 2,270,100 | SH | DFND | 8,17,20 | 2,270,100 | 0 | 0 | |
| BIOGEN INC | COM | 09062X103 | 32,487 | 118,644 | SH | DFND | 1,14,16 | 118,644 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 281,533 | 3,472,712 | SH | DFND | 2,8,11,17,20 | 3,472,712 | 0 | 0 | |
| BOEING CO | COM | 097023105 | 172,346 | 525,636 | SH | DFND | 6,16 | 525,636 | 0 | 0 | |
| BROADCOM LTD | SHS | Y09827109 | 88,616 | 376,050 | SH | DFND | 1,14,16 | 376,050 | 0 | 0 | |
| CELGENE CORP | COM | 151020104 | 22,785 | 255,406 | SH | DFND | 1,14,16 | 255,406 | 0 | 0 | |
| CENTURYLINK INC | COM | 156700106 | 1,739,303 | 105,861,423 | SH | DFND | 1,14,16,18 | 105,861,423 | 0 | 0 | |
| CHINA BIOLOGIC PRODS HLDGS I | COM | G21515104 | 80,190 | 990,000 | SH | DFND | 8,17,20 | 990,000 | 0 | 0 | |
| COGNEX CORP | COM | 192422103 | 7,237 | 139,192 | SH | DFND | 1,14,16 | 139,192 | 0 | 0 | |
| COHERUS BIOSCIENCES INC | COM | 19249H103 | 72,445 | 6,556,116 | SH | DFND | 8,17,20 | 6,556,116 | 0 | 0 | |
| COUPA SOFTWARE INC | COM | 22266L106 | 1,087 | 23,837 | SH | DFND | 7,9 | 23,837 | 0 | 0 | |
| CTRIP COM INTL LTD | AMERICAN DEP SHS | 22943F100 | 338,318 | 7,256,928 | SH | DFND | 1,4,6,14,16 | 7,256,928 | 0 | 0 | |
| DENALI THERAPEUTICS INC | COM | 24823R105 | 86,842 | 4,410,457 | SH | DFND | 8,17,20 | 4,410,457 | 0 | 0 | |
| DISNEY WALT CO | COM DISNEY | 254687106 | 7,091 | 70,600 | SH | DFND | 1,14,16 | 70,600 | 0 | 0 | |
| DOWDUPONT INC | COM | 26078J100 | 382,881 | 6,009,749 | SH | DFND | 1,6,14,16 | 6,009,749 | 0 | 0 | |
| EMERSON ELEC CO | COM | 291011104 | 8,463 | 123,908 | SH | DFND | 1,14,16 | 123,908 | 0 | 0 | |
| EROS INTL PLC | SHS NEW | G3788M114 | 30,033 | 2,755,310 | SH | DFND | 4,13,14,16 | 2,755,310 | 0 | 0 | |
| EVOQUA WATER TECHNOLOGIES CO | COM | 30057T105 | 128,543 | 6,037,705 | SH | DFND | 7,9 | 6,037,705 | 0 | 0 | |
| FTS INTERNATIONAL INC | COM | 30283W104 | 765,339 | 41,617,144 | SH | DFND | 7 | 41,617,144 | 0 | 0 | |
| GILEAD SCIENCES INC | COM | 375558103 | 838,775 | 11,125,816 | SH | DFND | 1,8,14,16,17,20 | 11,125,816 | 0 | 0 | |
| GLOBAL PMTS INC | COM | 37940X102 | 27,697 | 248,362 | SH | DFND | 8,10 | 248,362 | 0 | 0 | |
| GOLDMAN SACHS GROUP INC | COM | 38141G104 | 1,544 | 6,132 | SH | DFND | 1,14,16 | 6,132 | 0 | 0 | |
| GRACE W R & CO DEL NEW | COM | 38388F108 | 133,941 | 2,187,501 | SH | DFND | 6,16 | 2,187,501 | 0 | 0 | |
| HDFC BANK LTD | ADR REPS 3 SHS | 40415F101 | 63,299 | 640,870 | SH | DFND | 6,16 | 640,870 | 0 | 0 | |
| HOMOLOGY MEDICINES INC | COM | 438083107 | 60,219 | 3,220,293 | SH | DFND | 8,17,20 | 3,220,293 | 0 | 0 | |
| ICICI BK LTD | ADR | 45104G104 | 76,462 | 8,639,819 | SH | DFND | 2,6,8,16 | 8,639,819 | 0 | 0 | |
| IHS MARKIT LTD | SHS | G47567105 | 716,896 | 14,861,018 | SH | DFND | 5,18 | 14,861,018 | 0 | 0 | |
| ILLUMINA INC | COM | 452327109 | 65,550 | 277,261 | SH | DFND | 1,14,16 | 277,261 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 21,012 | 252,160 | SH | DFND | 1,14,16 | 252,160 | 0 | 0 | |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 | 16,672 | 790,527 | SH | DFND | 6,8,16,17 | 790,527 | 0 | 0 | |
| JD COM INC | SPON ADR CL A | 47215P106 | 295,843 | 7,306,572 | SH | DFND | 6,16 | 7,306,572 | 0 | 0 | |
| JPMORGAN CHASE & CO | COM | 46625H100 | 8,602 | 78,220 | SH | DFND | 1,14,16 | 78,220 | 0 | 0 | |
| KKR REAL ESTATE FIN TR INC | COM | 48251K100 | 48,927 | 2,439,024 | SH | DFND | 1,14,16 | 2,439,024 | 0 | 0 | |
| MASTERCARD INCORPORATED | CL A | 57636Q104 | 219,350 | 1,252,283 | SH | DFND | 1,8,10,14,16 | 1,252,283 | 0 | 0 | |
| MEDTRONIC PLC | SHS | G5960L103 | 5,054 | 63,000 | SH | DFND | 1,14,16 | 63,000 | 0 | 0 | |
| MONSANTO CO NEW | COM | 61166W101 | 50,081 | 429,184 | SH | DFND | 1,14,16 | 429,184 | 0 | 0 | |
| MORGAN STANLEY | COM NEW | 617446448 | 1,741 | 32,273 | SH | DFND | 1,14,16 | 32,273 | 0 | 0 | |
| NETSHOES CAYMAN LTD | COM | G6455X107 | 12,261 | 2,071,127 | SH | DFND | 7 | 2,071,127 | 0 | 0 | |
| NEWFIELD EXPL CO | COM | 651290108 | 154,482 | 6,326,046 | SH | DFND | 1,14,16 | 6,326,046 | 0 | 0 | |
| OKTA INC | CL A | 679295105 | 281 | 7,046 | SH | DFND | 7,9 | 7,046 | 0 | 0 | |
| PAYPAL HLDGS INC | COM | 70450Y103 | 428,498 | 5,647,793 | SH | DFND | 4,8,10,14,16 | 5,647,793 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 159,497 | 4,883,568 | SH | DFND | 2,8,11,17,20 | 4,883,568 | 0 | 0 | |
| PPG INDS INC | COM | 693506107 | 192,805 | 1,727,645 | SH | DFND | 1,14,16 | 1,727,645 | 0 | 0 | |
| RADIUS HEALTH INC | COM NEW | 750469207 | 695 | 19,344 | SH | DFND | 7 | 19,344 | 0 | 0 | |
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 65,642 | 190,621 | SH | DFND | 1,8,14,16,17,20 | 190,621 | 0 | 0 | |
| ROCKWELL AUTOMATION INC | COM | 773903109 | 7,736 | 44,409 | SH | DFND | 1,14,16 | 44,409 | 0 | 0 | |
| ROYAL DUTCH SHELL PLC | SPON ADR B | 780259107 | 187,997 | 2,868,867 | SH | DFND | 6,16 | 2,868,867 | 0 | 0 | |
| SENSEONICS HLDGS INC | COM | 81727U105 | 848 | 282,582 | SH | DFND | 7 | 282,582 | 0 | 0 | |
| SPDR SERIES TRUST | S&P REGL BKG | 78464A698 | 9,216 | 152,603 | SH | DFND | 1,14,16 | 152,603 | 0 | 0 | |
| SPDR SERIES TRUST | S&P TRANSN ETF | 78464A532 | 24,395 | 388,458 | SH | DFND | 1,14,16 | 388,458 | 0 | 0 | |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 310,327 | 1,503,087 | SH | DFND | 2,8,11 | 1,503,087 | 0 | 0 | |
| TUNIU CORP | SPONSORED ADS CL | 89977P106 | 49,331 | 8,194,444 | SH | DFND | 5,18 | 8,194,444 | 0 | 0 | |
| TURQUOISE HILL RES LTD | COM | 900435108 | 224,767 | 73,213,884 | SH | DFND | 3,18,19 | 73,213,884 | 0 | 0 | |
| UNIVAR INC | COM | 91336L107 | 390,665 | 14,078,012 | SH | DFND | 3,18,19 | 14,078,012 | 0 | 0 | |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 39,862 | 244,582 | SH | DFND | 1,14,16 | 244,582 | 0 | 0 | |
| VIRTU FINL INC | CL A | 928254101 | 670,907 | 20,330,503 | SH | DFND | 1,7,9,14,16 | 20,330,503 | 0 | 0 | |
| VISA INC | COM CL A | 92826C839 | 496,985 | 4,154,702 | SH | DFND | 1,8,10,14,16 | 4,154,702 | 0 | 0 | |
| WELLS FARGO CO NEW | COM | 949746101 | 4,051 | 77,303 | SH | DFND | 1,14,16 | 77,303 | 0 | 0 | |
| WORLDPAY INC | CL A | 981558109 | 184,074 | 2,238,248 | SH | DFND | 1,8,10,14,16 | 2,238,248 | 0 | 0 | |
| ZTO EXPRESS CAYMAN INC | SPONSORED ADR | 98980A105 | 182,529 | 12,176,750 | SH | DFND | 1,14,16 | 12,176,750 | 0 | 0 | |