The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
21VIANET GROUP INC SPONSORED ADR 90138A103 104,547 10,778,004 SH   DFND 5,18 10,778,004 0 0
AC IMMUNE SA SHS H00263105 12,466 1,337,500 SH   DFND 8,17,20 1,337,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 186,886 1,505,325 SH   DFND 1,2,8,11,14,16 1,505,325 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 6,585,441 35,495,289 SH   DFND 1,4,14,15,16 35,495,289 0 0
AMAZON COM INC COM 023135106 111,962 65,868 SH   DFND 1,14,16 65,868 0 0
AMGEN INC COM 031162100 34,800 188,527 SH   DFND 1,14,16 188,527 0 0
AMYRIS INC COM NEW 03236M200 2,321 363,155 SH   DFND 2,8,11 363,155 0 0
AMYRIS INC NOTE 6.500% 5/1 03236MAC5 8,409 10,000,000 PRN   DFND 2,8,11 10,000,000 0 0
ANTERO RES CORP COM 03674X106 208,282 9,755,618 SH   DFND 6,16 9,755,618 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 12,660 1,422,475 SH   DFND 8,17,20 1,422,475 0 0
BEIGENE LTD SPONSORED ADR 07725L102 348,982 2,270,100 SH   DFND 8,17,20 2,270,100 0 0
BIOGEN INC COM 09062X103 34,435 118,644 SH   DFND 1,14,16 118,644 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 327,129 3,472,712 SH   DFND 2,8,11,17,20 3,472,712 0 0
BOEING CO COM 097023105 176,356 525,636 SH   DFND 6,16 525,636 0 0
BROADCOM INC COM 11135F101 95,127 392,050 SH   DFND 1,14,16 392,050 0 0
CELGENE CORP COM 151020104 20,284 255,406 SH   DFND 1,14,16 255,406 0 0
CENTURYLINK INC COM 156700106 2,296,470 123,201,207 SH   DFND 1,14,16,18 123,201,207 0 0
CHINA BIOLOGIC PRODS HLDGS I COM G21515104 98,337 990,000 SH   DFND 8,17,20 990,000 0 0
COGNEX CORP COM 192422103 6,209 139,192 SH   DFND 1,14,16 139,192 0 0
COHERUS BIOSCIENCES INC COM 19249H103 91,786 6,556,116 SH   DFND 8,17,20 6,556,116 0 0
COUPA SOFTWARE INC COM 22266L106 2,316 37,217 SH   DFND 7,9 37,217 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 345,647 7,256,928 SH   DFND 1,4,6,14,16 7,256,928 0 0
DENALI THERAPEUTICS INC COM 24823R105 67,259 4,410,457 SH   DFND 8,17,20 4,410,457 0 0
DISNEY WALT CO COM DISNEY 254687106 7,400 70,600 SH   DFND 1,14,16 70,600 0 0
DOWDUPONT INC COM 26078J100 402,074 6,099,429 SH   DFND 1,6,14,16 6,099,429 0 0
EMERSON ELEC CO COM 291011104 8,567 123,908 SH   DFND 1,14,16 123,908 0 0
EROS INTL PLC SHS NEW G3788M114 35,819 2,755,310 SH   DFND 4,13,14,16 2,755,310 0 0
EVOQUA WATER TECHNOLOGIES CO COM 30057T105 123,773 6,037,705 SH   DFND 7,9 6,037,705 0 0
FTS INTERNATIONAL INC COM 30283W104 592,628 41,617,144 SH   DFND 7 41,617,144 0 0
GILEAD SCIENCES INC COM 375558103 788,153 11,125,816 SH   DFND 1,8,14,16,17,20 11,125,816 0 0
GLOBAL PMTS INC COM 37940X102 97,685 876,176 SH   DFND 8,10 876,176 0 0
GRACE W R & CO DEL NEW COM 38388F108 160,366 2,187,501 SH   DFND 6,16 2,187,501 0 0
HDFC BANK LTD ADR REPS 3 SHS 40415F101 146,100 1,391,165 SH   DFND 6,16 1,391,165 0 0
HOMOLOGY MEDICINES INC COM 438083107 65,694 3,220,293 SH   DFND 8,17,20 3,220,293 0 0
ICICI BK LTD ADR 45104G104 69,378 8,639,819 SH   DFND 2,6,8,16 8,639,819 0 0
IHS MARKIT LTD SHS G47567105 766,680 14,861,018 SH   DFND 5,18 14,861,018 0 0
ILLUMINA INC COM 452327109 77,436 277,261 SH   DFND 1,14,16 277,261 0 0
INCYTE CORP COM 45337C102 16,895 252,160 SH   DFND 1,14,16 252,160 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 21,629 790,527 SH   DFND 6,8,16,17 790,527 0 0
JD COM INC SPON ADR CL A 47215P106 284,591 7,306,572 SH   DFND 6,16 7,306,572 0 0
KKR REAL ESTATE FIN TR INC COM 48251K100 48,244 2,439,024 SH   DFND 1,14,16 2,439,024 0 0
MASTERCARD INCORPORATED CL A 57636Q104 283,129 1,440,714 SH   DFND 1,8,10,14,16 1,440,714 0 0
MEDTRONIC PLC SHS G5960L103 9,186 107,300 SH   DFND 1,14,16 107,300 0 0
NETSHOES CAYMAN LTD COM G6455X107 302 127,501 SH   DFND 7 127,501 0 0
NEWFIELD EXPL CO COM 651290108 191,363 6,326,046 SH   DFND 1,14,16 6,326,046 0 0
OKTA INC CL A 679295105 355 7,046 SH   DFND 7,9 7,046 0 0
PAYPAL HLDGS INC COM 70450Y103 507,208 6,091,124 SH   DFND 4,8,10,14,16 6,091,124 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 195,428 5,174,168 SH   DFND 1,2,8,11,14,16,17,20 5,174,168 0 0
PPG INDS INC COM 693506107 179,209 1,727,645 SH   DFND 1,14,16 1,727,645 0 0
REGENERON PHARMACEUTICALS COM 75886F107 65,762 190,621 SH   DFND 1,8,14,16,17,20 190,621 0 0
ROCKWELL AUTOMATION INC COM 773903109 7,382 44,409 SH   DFND 1,14,16 44,409 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 208,423 2,868,867 SH   DFND 6,16 2,868,867 0 0
SPDR SERIES TRUST S&P TRANSN ETF 78464A532 24,518 388,458 SH   DFND 1,14,16 388,458 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 311,349 1,503,087 SH   DFND 2,8,11 1,503,087 0 0
TUNIU CORP SPONSORED ADS CL 89977P106 69,407 8,194,444 SH   DFND 5,18 8,194,444 0 0
TURQUOISE HILL RES LTD COM 900435108 207,927 73,213,884 SH   DFND 3,18,19 73,213,884 0 0
UNIVAR INC COM 91336L107 369,407 14,078,012 SH   DFND 3,18,19 14,078,012 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 41,569 244,582 SH   DFND 1,14,16 244,582 0 0
VIRTU FINL INC CL A 928254101 448,177 16,880,503 SH   DFND 1,7,9,14,16 16,880,503 0 0
VISA INC COM CL A 92826C839 569,666 4,300,992 SH   DFND 1,8,10,14,16 4,300,992 0 0
WORLDPAY INC CL A 981558109 198,413 2,426,186 SH   DFND 1,8,10,14,16 2,426,186 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 243,535 12,176,750 SH   DFND 1,14,16 12,176,750 0 0