The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AC IMMUNE SA | SHS | H00263105 | 78,377 | 11,342,505 | SH | DFND | 1 | 0 | 11,342,505 | 0 | |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 5,997 | 282,862 | SH | DFND | 1 | 0 | 282,862 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 3,277 | 1,137,764 | SH | DFND | 1 | 0 | 1,137,764 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 23,883 | 1,690,237 | SH | DFND | 1 | 0 | 1,690,237 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 535 | 38,574 | SH | DFND | 1 | 0 | 38,574 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 3,293 | 25,000 | SH | DFND | 1 | 0 | 25,000 | 0 | |
| BIOLINERX LTD | SPONSORED ADS | 09071M205 | 2,305 | 1,733,036 | SH | DFND | 1 | 0 | 1,733,036 | 0 | |
| BLACK DIAMOND THERAPEUTICS INC | COM | 09203E105 | 9,451 | 378,788 | SH | DFND | 1 | 0 | 378,788 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 42,445 | 9,559,642 | SH | DFND | 1 | 0 | 9,559,642 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 9,487 | 3,825,315 | SH | DFND | 1 | 0 | 3,825,315 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 4,551 | 2,156,740 | SH | DFND | 1 | 0 | 2,156,740 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L601 | 6,375 | 6,929,690 | SH | DFND | 1 | 0 | 6,929,690 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 46,432 | 3,938,280 | SH | DFND | 1 | 0 | 3,938,280 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 30,082 | 3,921,973 | SH | DFND | 1 | 0 | 3,921,973 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 463 | 68,054 | SH | DFND | 1 | 0 | 68,054 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 3,338 | 625,000 | SH | DFND | 1 | 0 | 625,000 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 9,682 | 2,420,565 | SH | DFND | 1 | 0 | 2,420,565 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 17,667 | 7,783,001 | SH | DFND | 1 | 0 | 7,783,001 | 0 | |
| FORWARD PHARMA A/S | SPONSORD ADS NEW | 34986J204 | 5,378 | 925,724 | SH | DFND | 1 | 0 | 925,724 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 1,503 | 7,674 | SH | DFND | 1 | 0 | 7,674 | 0 | |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 6,340 | 1,832,484 | SH | DFND | 1 | 0 | 1,832,484 | 0 | |
| GAMIDA CELL LTD | SHS | M47364100 | 3,020 | 1,000,000 | SH | DFND | 1 | 0 | 1,000,000 | 0 | |
| GENOCEA BIOSCIENCES INC | COM NEW | 372427401 | 3,613 | 2,100,305 | SH | DFND | 1 | 0 | 2,100,305 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 16,785 | 7,361,801 | SH | DFND | 1 | 0 | 7,361,801 | 0 | |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 5,293 | 1,284,829 | SH | DFND | 1 | 0 | 1,284,829 | 0 | |
| IMMUNOVANT INC | COM | 45258J102 | 15,565 | 999,996 | SH | DFND | 1 | 0 | 999,996 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 14,599 | 17,426,968 | SH | DFND | 1 | 0 | 17,426,968 | 0 | |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 91,937 | 1,944,517 | SH | DFND | 1 | 0 | 1,944,517 | 0 | |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 6,821 | 1,564,373 | SH | DFND | 1 | 0 | 1,564,373 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 24,225 | 2,434,696 | SH | DFND | 1 | 0 | 2,434,696 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 8,124 | 5,046,272 | SH | DFND | 1 | 0 | 5,046,272 | 0 | |
| MERSANA THERAPEUTICS INC | COM | 59045L106 | 13,831 | 2,372,400 | SH | DFND | 1 | 0 | 2,372,400 | 0 | |
| MERUS N V | COM | N5749R100 | 42,890 | 3,544,654 | SH | DFND | 1 | 0 | 3,544,654 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 37,880 | 2,850,271 | SH | DFND | 1 | 0 | 2,850,271 | 0 | |
| NOVUS THERAPEUTICS INC | COM | 67011N105 | 267 | 684,813 | SH | DFND | 1 | 0 | 684,813 | 0 | |
| OVID THERAPEUTICS INC | COM | 690469101 | 3,832 | 1,286,004 | SH | DFND | 1 | 0 | 1,286,004 | 0 | |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | 17,469 | 676,561 | SH | DFND | 1 | 0 | 676,561 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 13,390 | 5,872,762 | SH | DFND | 1 | 0 | 5,872,762 | 0 | |
| PREVAIL THERAPEUTICS INC | COM | 74140Y101 | 5,260 | 431,483 | SH | DFND | 1 | 0 | 431,483 | 0 | |
| PRINCIPIA BIOPHARMA INC | COM | 74257L108 | 94,034 | 1,583,595 | SH | DFND | 1 | 0 | 1,583,595 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 4,889 | 692,430 | SH | DFND | 1 | 0 | 692,430 | 0 | |
| REGULUS THERAPEUTICS INC | COM NEW | 75915K200 | 734 | 1,592,923 | SH | DFND | 1 | 0 | 1,592,923 | 0 | |
| REPLIMUNE GROUP INC | COM | 76029N106 | 19,693 | 1,975,209 | SH | DFND | 1 | 0 | 1,975,209 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 30,632 | 1,398,070 | SH | DFND | 1 | 0 | 1,398,070 | 0 | |
| SELECTA BIOSCIENCES INC | COM | 816212104 | 8,699 | 3,609,472 | SH | DFND | 1 | 0 | 3,609,472 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 4,552 | 563,393 | SH | DFND | 1 | 0 | 563,393 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 885 | 951,701 | SH | DFND | 1 | 0 | 951,701 | 0 | |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 74,726 | 2,767,630 | SH | DFND | 1 | 0 | 2,767,630 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM | 867328700 | 2,570 | 6,194,925 | SH | DFND | 1 | 0 | 6,194,925 | 0 | |
| SURFACE ONCOLOGY INC | COM | 86877M209 | 1,838 | 983,051 | SH | DFND | 1 | 0 | 983,051 | 0 | |
| SUTRO BIOPHARMA INC | COM | 869367102 | 4,850 | 475,482 | SH | DFND | 1 | 0 | 475,482 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 23,473 | 2,139,784 | SH | DFND | 1 | 0 | 2,139,784 | 0 | |
| VERASTEM INC | COM | 92337C104 | 16,709 | 6,328,994 | SH | DFND | 1 | 0 | 6,328,994 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 11,717 | 1,171,728 | SH | DFND | 1 | 0 | 1,171,728 | 0 | |
| XENCOR INC | COM | 98401F105 | 50,476 | 1,689,300 | SH | DFND | 1 | 0 | 1,689,300 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 30,327 | 2,674,338 | SH | DFND | 1 | 0 | 2,674,338 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 56,438 | 2,773,385 | SH | DFND | 1 | 0 | 2,773,385 | 0 | |