The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 48,301 | 2,005,862 | SH | DFND | 1 | 0 | 2,005,862 | 0 | |
| 5 01 ACQUISITION CORP | COM CL A | 33836P105 | 4,985 | 500,000 | SH | DFND | 1 | 0 | 500,000 | 0 | |
| AC IMMUNE SA | SHS | H00263105 | 67,763 | 8,545,179 | SH | DFND | 1 | 0 | 8,545,179 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 17,560 | 1,000,000 | SH | DFND | 1 | 0 | 1,000,000 | 0 | |
| AILERON THERAPEUTICS INC | COM | 00887A105 | 6,582 | 5,265,555 | SH | DFND | 1 | 0 | 5,265,555 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 7,516 | 1,715,981 | SH | DFND | 1 | 0 | 1,715,981 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 20,970 | 808,710 | SH | DFND | 1 | 0 | 808,710 | 0 | |
| ANGION BIOMEDICA CORP | COM | 03476J107 | 13,495 | 1,036,500 | SH | DFND | 1 | 0 | 1,036,500 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 76,828 | 2,797,822 | SH | DFND | 1 | 0 | 2,797,822 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 196,058 | 651,204 | SH | DFND | 1 | 0 | 651,204 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 15,256 | 7,299,331 | SH | DFND | 1 | 0 | 7,299,331 | 0 | |
| CALLIDITAS THERAPEUTICS AB | SPONSERED ADS | 13124Q106 | 22,080 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 1,308 | 58,900 | SH | DFND | 1 | 0 | 58,900 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 8,781 | 4,346,904 | SH | DFND | 1 | 0 | 4,346,904 | 0 | |
| COGENT BIOSCIENCES | COM | 19240Q201 | 12,427 | 1,532,282 | SH | DFND | 1 | 0 | 1,532,282 | 0 | |
| CONTRAFECT CORP | COM NEW | 212326300 | 17,478 | 3,972,300 | SH | DFND | 1 | 0 | 3,972,300 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 9,822 | 3,678,626 | SH | DFND | 1 | 0 | 3,678,626 | 0 | |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 458 | 24,280 | SH | DFND | 1 | 0 | 24,280 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L601 | 22,324 | 8,929,690 | SH | DFND | 1 | 0 | 8,929,690 | 0 | |
| CULLINAN ONCOLOGY INC | COM | 230031106 | 18,929 | 735,106 | SH | DFND | 1 | 0 | 735,106 | 0 | |
| DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | 20,925 | 918,975 | SH | DFND | 1 | 0 | 918,975 | 0 | |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 8,807 | 1,113,435 | SH | DFND | 1 | 0 | 1,113,435 | 0 | |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 21,580 | 1,590,291 | SH | DFND | 1 | 0 | 1,590,291 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 6,376 | 1,314,656 | SH | DFND | 1 | 0 | 1,314,656 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 70,041 | 2,451,561 | SH | DFND | 1 | 0 | 2,451,561 | 0 | |
| EUCRATES BIOMEDICAL ACQU COR | UNIT 10/23/2027 | G3141W114 | 5,095 | 500,000 | SH | DFND | 1 | 0 | 500,000 | 0 | |
| FORTE BIOSCIENCES INC | COM | 34962G109 | 19,897 | 591,811 | SH | DFND | 1 | 0 | 591,811 | 0 | |
| FORWARD PHARMA A/S | SPONSORD ADS NEW | 34986J204 | 4,545 | 528,514 | SH | DFND | 1 | 0 | 528,514 | 0 | |
| FRAZIER LIFESCIENCES ACQU CO | UNIT 12/09/2025 | G3710A121 | 5,040 | 500,000 | SH | DFND | 1 | 0 | 500,000 | 0 | |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 5,471 | 1,799,694 | SH | DFND | 1 | 0 | 1,799,694 | 0 | |
| GENOCEA BIOSCIENCES INC | COM NEW | 372427401 | 9,389 | 4,012,404 | SH | DFND | 1 | 0 | 4,012,404 | 0 | |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 201,549 | 9,275,156 | SH | DFND | 1 | 0 | 9,275,156 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 22,143 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | |
| GRITSTONE BIO INC | COM | 39868T105 | 16,676 | 1,826,494 | SH | DFND | 1 | 0 | 1,826,494 | 0 | |
| IKENA ONCOLOGY INC | COM | 45175G108 | 24,814 | 1,767,399 | SH | DFND | 1 | 0 | 1,767,399 | 0 | |
| IMMUNOVANT INC | COM | 45258J102 | 13,461 | 1,273,516 | SH | DFND | 1 | 0 | 1,273,516 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 25,067 | 8,383,645 | SH | DFND | 1 | 0 | 8,383,645 | 0 | |
| INVENTIVA SA | ADS | 46124U107 | 1,455 | 107,000 | SH | DFND | 1 | 0 | 107,000 | 0 | |
| JANUX THERAPEUTICS INC | COM | 47103J105 | 29,358 | 1,176,681 | SH | DFND | 1 | 0 | 1,176,681 | 0 | |
| JIYA ACQUISITION CORP | COM CL A | 47760M102 | 2,982 | 300,000 | SH | DFND | 1 | 0 | 300,000 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 34,092 | 1,635,112 | SH | DFND | 1 | 0 | 1,635,112 | 0 | |
| KYMERA THERAPEUTICS INC | COM | 501575104 | 127,587 | 2,630,658 | SH | DFND | 1 | 0 | 2,630,658 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 38,528 | 8,394,000 | SH | DFND | 1 | 0 | 8,394,000 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 10,066 | 3,532,057 | SH | DFND | 1 | 0 | 3,532,057 | 0 | |
| MERUS N V | COM | N5749R100 | 153,496 | 7,285,071 | SH | DFND | 1 | 0 | 7,285,071 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 22,339 | 2,856,599 | SH | DFND | 1 | 0 | 2,856,599 | 0 | |
| NGM BIOPHARMACEUTICALS INC | COM | 62921N105 | 18,833 | 955,000 | SH | DFND | 1 | 0 | 955,000 | 0 | |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 186,389 | 6,661,503 | SH | DFND | 1 | 0 | 6,661,503 | 0 | |
| OVID THERAPEUTICS INC | COM | 690469101 | 25,927 | 6,631,051 | SH | DFND | 1 | 0 | 6,631,051 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 20,407 | 5,328,239 | SH | DFND | 1 | 0 | 5,328,239 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 168,484 | 3,754,095 | SH | DFND | 1 | 0 | 3,754,095 | 0 | |
| RAIN THERAPEUTICS INC | COM | 75082Q105 | 30,240 | 1,945,949 | SH | DFND | 1 | 0 | 1,945,949 | 0 | |
| RELAY THERAPEUTICS INC | COM | 75943R102 | 107,509 | 2,938,202 | SH | DFND | 1 | 0 | 2,938,202 | 0 | |
| REPARE THERAPEUTICS INC | COM | 760273102 | 116,064 | 3,722,398 | SH | DFND | 1 | 0 | 3,722,398 | 0 | |
| REPLIMUNE GROUP INC | COM | 76029N106 | 35,305 | 918,928 | SH | DFND | 1 | 0 | 918,928 | 0 | |
| RESEARCH ALLIANCE CORP II | COM CL A | 760873109 | 5,000 | 500,000 | SH | DFND | 1 | 0 | 500,000 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 78,875 | 2,485,049 | SH | DFND | 1 | 0 | 2,485,049 | 0 | |
| REZOLUTE INC | COM NEW | 76200L309 | 2,723 | 190,815 | SH | DFND | 1 | 0 | 190,815 | 0 | |
| SELECTA BIOSCIENCES INC | COM | 816212104 | 7,079 | 1,693,456 | SH | DFND | 1 | 0 | 1,693,456 | 0 | |
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 17,007 | 666,666 | SH | DFND | 1 | 0 | 666,666 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 29,846 | 2,137,978 | SH | DFND | 1 | 0 | 2,137,978 | 0 | |
| SUTRO BIOPHARMA INC | COM | 869367102 | 15,371 | 826,825 | SH | DFND | 1 | 0 | 826,825 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 42,692 | 2,486,429 | SH | DFND | 1 | 0 | 2,486,429 | 0 | |
| THERAPEUTICS ACQUISITION COR | COM CL A | 88339T103 | 28,498 | 2,772,226 | SH | DFND | 1 | 0 | 2,772,226 | 0 | |
| VERASTEM INC | COM | 92337C104 | 45,935 | 11,286,258 | SH | DFND | 1 | 0 | 11,286,258 | 0 | |
| VIRACTA THERAPEUTICS INC | COM | 92765F108 | 35,088 | 3,094,174 | SH | DFND | 1 | 0 | 3,094,174 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 6,403 | 350,081 | SH | DFND | 1 | 0 | 350,081 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 5,511 | 847,879 | SH | DFND | 1 | 0 | 847,879 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 29,267 | 1,571,778 | SH | DFND | 1 | 0 | 1,571,778 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 120,038 | 3,530,543 | SH | DFND | 1 | 0 | 3,530,543 | 0 | |