Signaturefd, LLC Biotechnology

Signaturefd, LLC

$5.21 Billion
Q4 2024

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
MREO Mereo Biopharma Group PLC	$317M	$2,000 0.0% of portfolio	679	Q2 2024 Reduced 17.2%
NUVL Nuvalent, Inc.	$3.16B	$2,000 0.0% of portfolio	29	Q4 2024 Reduced 3.33%
NUVB Nuvation Bio Inc.	$463M	$2,000 0.0% of portfolio	1,126	Q4 2024 Reduced 32.29%
TERN Terns Pharmaceuticals, Inc.	$110M	$2,000 0.0% of portfolio	376	Q4 2024 Added 16.41%
TGTX Tg Therapeutics, Inc.	$6B	$2,000 0.0% of portfolio	76	Q4 2024 Added 137.5%
QURE Uni Qure N.V.	$663M	$2,000 0.0% of portfolio	152	Q4 2024 Reduced 26.92%
ETNB 89bio, Inc.	$326M	$1,000 0.0% of portfolio	197	Q4 2024 Reduced 7.08%
CRBU Caribou Biosciences, Inc.	$46.8M	$1,000 0.0% of portfolio	750	Q2 2024 Reduced 7.64%
CPRX Catalyst Pharmaceuticals, Inc.	$2.41B	$1,000 0.0% of portfolio	94	Q4 2024 Reduced 10.48%
CRVS Corvus Pharmaceuticals, Inc.	$170M	$1,000 0.0% of portfolio	224	Q4 2024 New
EDIT Editas Medicine, Inc.	$106M	$1,000 0.0% of portfolio	1,440	Q4 2024 Reduced 84.56%
JANX Janux Therapeutics, Inc.	$1.29B	$1,000 0.0% of portfolio	29	Q4 2024 New
KROS Keros Therapeutics, Inc.	$366M	$1,000 0.0% of portfolio	76	Q4 2023 New
ORIC Oric Pharmaceuticals, Inc.	$201M	$1,000 0.0% of portfolio	236	Q4 2024 Reduced 14.18%
PLRX Pliant Therapeutics, Inc.	$71.1M	$1,000 0.0% of portfolio	124	Q3 2024 New
TNGX Tango Therapeutics, Inc.	$129M	$1,000 0.0% of portfolio	346	Q4 2024 New
VERU Veru Inc.	$43.3M	$1,000 0.0% of portfolio	3,000	Q1 2023 Reduced 0.96%
VIR Vir Biotechnology, Inc.	$812M	$1,000 0.0% of portfolio	179	Q4 2024 Reduced 69.4%
ACAD Acadia Pharmaceuticals Inc	$2.38B	$0 0.0% of portfolio	41	Q4 2024 Reduced 89.85%
ANNX Annexon, Inc.	$88.6M	$0 0.0% of portfolio	151	Q2 2024 New
ACLX Arcellx, Inc.	$2.79B	$0 0.0% of portfolio	8	Q4 2024 New
ARCT Arcturus Therapeutics Holdings Inc.	$343M	$0 0.0% of portfolio	20	Q4 2024 Reduced 72.6%
RCUS Arcus Biosciences, Inc.	$599M	$0 0.0% of portfolio	40	Q3 2024 New
ARDX Ardelyx, Inc.	$806M	$0 0.0% of portfolio	93	Q4 2024 Reduced 41.14%
SBTX Silverback Therapeutics, Inc.	$0	$0 0.0% of portfolio	2,956	Q4 2024 Added 5.12%
COGT Cogent Biosciences, Inc.	$305M	$0 0.0% of portfolio	120	Q1 2024 Added 57.89%
IGMS Igm Biosciences, Inc.	$38.2M	$0 0.0% of portfolio	161	Q3 2024 Reduced 15.71%
IMNM Immunome Inc.	$102M	$0 0.0% of portfolio	13	Q4 2024 Reduced 84.52%
ITOS I Teos Therapeutics, Inc.	$261M	$0 0.0% of portfolio	8	Q4 2024 Reduced 99.84%
KALV Kal Vista Pharmaceuticals, Inc.	$316M	$0 0.0% of portfolio	81	Q4 2024 Reduced 74.92%
LRMR Larimar Therapeutics, Inc.	$102M	$0 0.0% of portfolio	8	Q4 2024 Reduced 97.53%
LXRX Lexicon Pharmaceuticals, Inc.	$134M	$0 0.0% of portfolio	388	Q4 2024 Reduced 66.95%
MRSN Mersana Therapeutics, Inc.	$35M	$0 0.0% of portfolio	286	Q4 2024 New
NKTR Nektar Therapeutics	$146M	$0 0.0% of portfolio	200	Q4 2023 Reduced 93.75%
OLMA Olema Pharmaceuticals, Inc.	$197M	$0 0.0% of portfolio	162	Q2 2024 New
PROK Prokidney Corp Ord Shs Cl A(Cy	$62.8M	$0 0.0% of portfolio	150	Q3 2023 Added 15.38%
RLAY Relay Therapeutics, Inc.	$385M	$0 0.0% of portfolio	160	Q4 2024 New
RVNC Revance Therapeutics, Inc.	$212M	$0 0.0% of portfolio	235	Q4 2024 Added 158.24%
SANA Sana Biotechnology, Inc.	$337M	$0 0.0% of portfolio	597	Q4 2024 Reduced 15.8%
TSHA Taysha Gene Therapies, Inc.	$84.6M	$0 0.0% of portfolio	282	Q4 2024 Added 61.14%
TBPH Theravance Biopharma, Inc.	$651M	$0 0.0% of portfolio	85	Q3 2024 Reduced 73.19%
TYRA Tyra Biosciences, Inc.	$421M	$0 0.0% of portfolio	24	Q4 2024 New
URGN Uro Gen Pharma Ltd.	$221M	$0 0.0% of portfolio	22	Q4 2024 Reduced 94.21%
VCEL Vericel Corp	$1.87B	$0 0.0% of portfolio	11	Q4 2024 New
VYGR Voyager Therapeutics, Inc.	$133M	$0 0.0% of portfolio	115	Q4 2024 New
KMPH Kempharm, Inc	$170M	$0 0.0% of portfolio	181	Q3 2024 New

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