Signaturefd, LLC Biotechnology

Signaturefd, LLC

$5.4 Billion
Q2 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
MNKD Mannkind Corp	$1.01B	$2,000 0.0% of portfolio	602	Q1 2024 Reduced 81.16%
NUVB Nuvation Bio Inc.	$511M	$2,000 0.0% of portfolio	1,083	Q2 2025 Reduced 3.82%
VERV Verve Therapeutics, Inc.	$664M	$2,000 0.0% of portfolio	196	Q2 2025 Reduced 93.39%
VIR Vir Biotechnology, Inc.	$760M	$2,000 0.0% of portfolio	574	Q2 2025 New
WVE Wave Life Sciences Ltd.	$688M	$2,000 0.0% of portfolio	310	Q2 2025 New
XERS Xeris Biopharma Holdings, Inc.	$696M	$2,000 0.0% of portfolio	631	Q2 2025 Added 61.38%
ACAD Acadia Pharmaceuticals Inc	$3.65B	$1,000 0.0% of portfolio	81	Q2 2025 New
ALLO Allogene Therapeutics, Inc.	$204M	$1,000 0.0% of portfolio	1,553	Q2 2025 Reduced 78.99%
ALT Altimmune, Inc.	$206M	$1,000 0.0% of portfolio	318	Q2 2025 Added 132.12%
AUPH Aurinia Pharmaceuticals Inc.	$1.26B	$1,000 0.0% of portfolio	179	Q2 2025 Reduced 38.28%
CELC Celcuity Inc.	$208M	$1,000 0.0% of portfolio	124	Q2 2025 New
DAWN Day One Biopharmaceuticals, Inc.	$483M	$1,000 0.0% of portfolio	175	Q2 2025 Reduced 28.86%
IMNM Immunome Inc.	$132M	$1,000 0.0% of portfolio	204	Q2 2025 New
TGTX Tg Therapeutics, Inc.	$5.43B	$1,000 0.0% of portfolio	48	Q2 2025 Added 37.14%
VCYT Veracyte, Inc.	$1.68B	$1,000 0.0% of portfolio	41	Q2 2025 Reduced 36.92%
VERU Veru Inc.	$45.7M	$1,000 0.0% of portfolio	3,000	Q1 2023 Reduced 0.96%
ABEO Abeona Therapeutics Inc.	$39.3M	$0 0.0% of portfolio	175	Q2 2025 New
ACLX Arcellx, Inc.	$2.98B	$0 0.0% of portfolio	9	Q2 2025 Reduced 62.5%
ARDX Ardelyx, Inc.	$679M	$0 0.0% of portfolio	93	Q4 2024 Reduced 41.14%
SBTX Silverback Therapeutics, Inc.	$0	$0 0.0% of portfolio	2,812	Q1 2025 Reduced 4.87%
BEAM Beam Therapeutics Inc.	$1.52B	$0 0.0% of portfolio	25	Q2 2025 Reduced 93.67%
COGT Cogent Biosciences, Inc.	$819M	$0 0.0% of portfolio	101	Q2 2025 Reduced 52.13%
CRMD Cor Medix Inc.	$459M	$0 0.0% of portfolio	37	Q2 2025 New
TRDA Entrada Therapeutics, Inc.	$200M	$0 0.0% of portfolio	53	Q2 2025 New
IOVA Iovance Biotherapeutics, Inc.	$494M	$0 0.0% of portfolio	544	Q2 2025 Reduced 90.25%
MREO Mereo Biopharma Group PLC	$222M	$0 0.0% of portfolio	187	Q2 2025 New
MLTX Moon Lake Immunotherapeutics	$1.98B	$0 0.0% of portfolio	11	Q2 2025 New
CDXC Chroma Dex Corp.	$420M	$0 0.0% of portfolio	44	Q2 2025 New
ORIC Oric Pharmaceuticals, Inc.	$441M	$0 0.0% of portfolio	83	Q2 2025 Reduced 64.83%
PGEN Precigen, Inc.	$316M	$0 0.0% of portfolio	677	Q2 2025 New
SNDX Syndax Pharmaceuticals Inc	$583M	$0 0.0% of portfolio	73	Q2 2025 Reduced 94.76%
TARS Tarsus Pharmaceuticals, Inc.	$1.13B	$0 0.0% of portfolio	23	Q2 2025 Added 53.33%
TBPH Theravance Biopharma, Inc.	$750M	$0 0.0% of portfolio	85	Q3 2024 Reduced 73.19%
TYRA Tyra Biosciences, Inc.	$432M	$0 0.0% of portfolio	43	Q2 2025 New
VRDN Viridian Therapeutics, Inc.\De	$677M	$0 0.0% of portfolio	19	Q2 2025 Reduced 98.11%

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