Siren, L.L.C. Portfolio Holdings

Siren, L.L.C.

  • $1.93 Trillion
  • Q2 2025

Siren, L.L.C. has filed its 13F form on August 13, 2025 for Q2 2025 where it was disclosed a total value porftolio of $1.93 Trillion distributed in 111 stocks.

Among their holdings, we can observe that their the top five positions include companies like: Scholar Rock Holding Corp with a value of $328B, Kymera Therapeutics, Inc. with a value of $150B, Bei Gene, Ltd. with a value of $123B, Disc Medicine Inc with a value of $58.2B, and Crinetics Pharmaceuticals, Inc. with a value of $48.6B.

Examining the 13F form we can see an increase of $160B in the current position value, from $1.77T to 1.93T.

Siren, L.L.C. is based out at New York, NY

Below you can find more details about Siren, L.L.C. portfolio as well as his latest detailed transactions.

Portfolio value $1.93 Trillion
Technology: $93.5 Billion
Communication Services: $58.5 Billion
Consumer Cyclical: $19.4 Billion
Healthcare: $7.04 Billion
Consumer Defensive: $3.88 Billion
Real Estate: $1.86 Billion
Utilities: $349 Million
Industrials: $257 Million
Other: $0

Stock Holdings Table

Stock Market Cap. Holding Value (Reported) # of Shares. Last Trade Trade History
$1.27T
$6.91 Billion 0.36% of portfolio
30,500
Q2 2025 Added 7.02%
$181M
$6.41 Billion 0.33% of portfolio
5,208,968
Q4 2024 Reduced 60.78%
$760M
$6.13 Billion 0.32% of portfolio
854,379
Q2 2025 New
$232B
$6.16 Billion 0.32% of portfolio
22,600
Q2 2025 Added 54.79%
Cartesian Therapeutics Inc
-
$5.85 Billion 0.3% of portfolio
-
Q1 2025 Reduced 1.57%
$157B
$5.82 Billion 0.3% of portfolio
15,051
Q2 2025 Reduced 22.01%
$572M
$5.82 Billion 0.3% of portfolio
247,216
Q2 2025 Reduced 66.92%
Spyre Therapeutics Inc
-
$5.52 Billion 0.29% of portfolio
-
Q1 2025 Reduced 1.44%
Sionna Therapeutics Inc
-
$5.64 Billion 0.29% of portfolio
-
Q1 2025 New
$147B
$5.54 Billion 0.29% of portfolio
52,901
Q4 2024 Added 30.94%
Sagimet Biosciences Inc
-
$5.52 Billion 0.29% of portfolio
-
Q3 2024 New
$1.14B
$5.38 Billion 0.28% of portfolio
225,000
Q2 2025 New
Korro Bio Inc
-
$5.23 Billion 0.27% of portfolio
-
Q3 2024 New
$172B
$5.27 Billion 0.27% of portfolio
5,126
Q2 2025 Reduced 43.83%
$37.5B
$5.16 Billion 0.27% of portfolio
38,425
Q2 2025 Reduced 18.98%
Agenus Inc
-
$4.86 Billion 0.25% of portfolio
-
Q2 2025 Added 112.85%
Rapport Therapeutics Inc
-
$4.3 Billion 0.22% of portfolio
-
Q1 2025 Reduced 1.49%
Instil Bio Inc
-
$4.25 Billion 0.22% of portfolio
-
Q1 2025 Added 5.98%
$13.4B
$4.15 Billion 0.21% of portfolio
75,229
Q2 2025 Reduced 14.25%
$35.9M
$3.89 Billion 0.2% of portfolio
2,082,000
Q1 2025 New
$7.87B
$3.88 Billion 0.2% of portfolio
72,000
Q2 2025 Reduced 9.43%
$37.7M
$3.65 Billion 0.19% of portfolio
3,255,826
Q1 2025 Reduced 2.24%
$203M
$3.39 Billion 0.18% of portfolio
720,720
Q3 2024 New
$228M
$3.27 Billion 0.17% of portfolio
411,191
Q2 2025 Reduced 79.1%
Neumora Therapeutics Inc
-
$3.2 Billion 0.17% of portfolio
-
Q1 2025 Reduced 0.86%
$136M
$3.17 Billion 0.16% of portfolio
1,552,183
Q1 2025 Reduced 1.45%
Nebius Group Nv
-
$2.82 Billion 0.15% of portfolio
-
Q2 2025 Reduced 63.57%
$92.3M
$2.6 Billion 0.13% of portfolio
1,046,517
Q3 2024 New
Lexeo Therapeutics Inc
-
$2.43 Billion 0.13% of portfolio
-
Q3 2024 New
$52.5B
$2.35 Billion 0.12% of portfolio
11,500
Q1 2025 Added 91.67%
$173B
$2.23 Billion 0.12% of portfolio
14,000
Q1 2025 Reduced 6.67%
$3.53B
$1.92 Billion 0.1% of portfolio
28,000
Q2 2025 Added 60.0%
$23B
$1.86 Billion 0.1% of portfolio
105,000
Q1 2025 Added 75.0%
$36.6M
$1.87 Billion 0.1% of portfolio
690,170
Q1 2025 New
$20.3B
$1.67 Billion 0.09% of portfolio
3,000
Q2 2025 New
Tourmaline Bio Inc
-
$1.46 Billion 0.08% of portfolio
-
Q3 2024 New
$245B
$1.58 Billion 0.08% of portfolio
5,076
Q2 2025 New
Bioage Labs Inc
-
$1.58 Billion 0.08% of portfolio
-
Q1 2025 Reduced 1.44%
$3.41B
$1.58 Billion 0.08% of portfolio
35,000
Q2 2025 New
$220M
$1.45 Billion 0.07% of portfolio
591,263
Q1 2025 Reduced 1.46%
$1.08T
$1.27 Billion 0.07% of portfolio
4,000
Q2 2025 Reduced 55.56%
Birkenstock Holding PLC
-
$1.23 Billion 0.06% of portfolio
-
Q2 2025 New
Sail Point Inc
-
$1.14 Billion 0.06% of portfolio
-
Q2 2025 Reduced 47.37%
$321M
$1.13 Billion 0.06% of portfolio
125,000
Q1 2025 Added 257.14%
Primo Brands Corp
-
$1.11 Billion 0.06% of portfolio
-
Q2 2025 New
$239M
$950 Million 0.05% of portfolio
2,968,925
Q1 2025 Reduced 0.46%
$2.64B
$960 Million 0.05% of portfolio
60,000
Q2 2025 New
Hookipa Pharma Inc
-
$711 Million 0.04% of portfolio
-
Q3 2024 New
$8.64B
$684 Million 0.04% of portfolio
10,000
Q1 2025 Reduced 50.0%

Summary

  • Portfolio
  • No. of Stocks 111
  • Current Value $1.93 Trillion
  • Prior Value $1.77 Trillion
  • Filing
  • Period Q2 2025
  • Filing Date August 13, 2025
  • Form Type 13F-HR
  • Activity in Q2 2025
  • New Purchases 15 stocks
  • Additional Purchases 21 stocks
  • Sold out of 0 stocks
  • Reduced holdings in 19 stocks
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