Siren, L.L.C. Portfolio Holdings

Siren, L.L.C.

  • $1.76 Trillion
  • Q1 2025

Siren, L.L.C. has filed its 13F form on May 14, 2025 for Q1 2025 where it was disclosed a total value porftolio of $1.76 Trillion distributed in 117 stocks.

Among their holdings, we can observe that their the top five positions include companies like: Scholar Rock Holding Corp with a value of $297B, Bei Gene, Ltd. with a value of $136B, Kymera Therapeutics, Inc. with a value of $88.7B, Blueprint Medicines Corp with a value of $64.3B, and Crinetics Pharmaceuticals, Inc. with a value of $56.6B.

Examining the 13F form we can see an decrease of $507B in the current position value, from $2.26T to 1.76T.

Siren, L.L.C. is based out at New York, NY

Below you can find more details about Siren, L.L.C. portfolio as well as his latest detailed transactions.

Portfolio value $1.76 Trillion
Technology: $90.5 Billion
Communication Services: $49.6 Billion
Consumer Cyclical: $21.5 Billion
Financial Services: $4.29 Billion
Consumer Defensive: $3.8 Billion
Real Estate: $2.11 Billion
Industrials: $853 Million
Energy: $494 Million
Other: $162 Million

Stock Holdings Table

Stock Market Cap. Holding Value (Reported) # of Shares. Last Trade Trade History
$1.62B
$297 Billion 16.93% of portfolio
9,250,005
Q4 2024 Reduced 17.85%
$23.5B
$136 Billion 7.73% of portfolio
498,689
Q1 2025 Reduced 23.72%
$2.56B
$88.7 Billion 5.05% of portfolio
3,240,313
Q1 2025 Added 9.11%
$7.66B
$64.3 Billion 3.66% of portfolio
726,167
Q1 2025 New
$1.68B
$56.6 Billion 3.22% of portfolio
1,688,611
Q1 2025 Added 4.91%
$2.01B
$56.4 Billion 3.21% of portfolio
2,578,396
Q1 2025 Reduced 8.45%
Disc Medicine Inc
-
$53.2 Billion 3.03% of portfolio
-
Q1 2025 New
Soleno Therapeutics Inc
-
$52 Billion 2.96% of portfolio
-
Q1 2025 Added 106.74%
$9.92B
$44.8 Billion 2.55% of portfolio
287,366
Q1 2025 Reduced 3.35%
$2.45B
$43.9 Billion 2.5% of portfolio
1,043,467
Q1 2025 Added 33.03%
Bicara Therapeutics Inc
-
$42.6 Billion 2.42% of portfolio
-
Q1 2025 Reduced 0.18%
$1.18B
$42.6 Billion 2.42% of portfolio
2,960,029
Q1 2025 Reduced 1.49%
-
$39.1 Billion 2.23% of portfolio
-
Q1 2025 Reduced 8.76%
$929M
$37.3 Billion 2.12% of portfolio
1,696,444
Q1 2025 Added 131.02%
$1.66B
$34 Billion 1.94% of portfolio
2,669,880
Q1 2025 Reduced 7.99%
$1.55B
$32.8 Billion 1.87% of portfolio
1,110,610
Q1 2025 Reduced 1.48%
$857M
$29.4 Billion 1.67% of portfolio
9,969,495
Q3 2024 New
$599M
$28.4 Billion 1.62% of portfolio
2,717,987
Q1 2025 Added 101.71%
Solid Biosciences Inc
-
$27.4 Billion 1.56% of portfolio
-
Q1 2025 Added 97.81%
$1.99B
$24.6 Billion 1.4% of portfolio
732,761
Q1 2025 Reduced 1.48%
Apogee Therapeutics Inc
-
$22.2 Billion 1.27% of portfolio
-
Q1 2025 Reduced 20.38%
$3.49B
$19.9 Billion 1.13% of portfolio
563,755
Q1 2025 Reduced 1.36%
$357M
$18 Billion 1.03% of portfolio
2,863,793
Q1 2025 Reduced 1.45%
$570M
$17.9 Billion 1.02% of portfolio
747,216
Q1 2025 Reduced 1.48%
$266M
$15.9 Billion 0.9% of portfolio
1,283,555
Q1 2025 Added 16.7%
$237M
$15.4 Billion 0.88% of portfolio
1,812,752
Q1 2025 Reduced 1.45%
$461M
$14.9 Billion 0.85% of portfolio
2,247,347
Q1 2025 Added 12.37%
$3.66B
$14.7 Billion 0.84% of portfolio
277,533
Q1 2025 New
$3.99B
$13.4 Billion 0.76% of portfolio
695,000
Q1 2025 New
Septerna Inc
-
$12.8 Billion 0.73% of portfolio
-
Q4 2024 New
$656M
$12.7 Billion 0.72% of portfolio
1,612,077
Q3 2024 New
$1.95B
$12.3 Billion 0.7% of portfolio
2,357,520
Q3 2024 New
$172M
$12 Billion 0.68% of portfolio
8,757,249
Q1 2025 Reduced 1.13%
$2.04B
$11.2 Billion 0.64% of portfolio
295,543
Q1 2025 Reduced 1.48%
$1.96B
$11.2 Billion 0.64% of portfolio
821,513
Q1 2025 Reduced 1.5%
$3.57T
$10.7 Billion 0.61% of portfolio
28,500
Q1 2025 Added 23.91%
$2.2T
$10.7 Billion 0.61% of portfolio
56,500
Q1 2025 Added 54.79%
$3.28B
$10.2 Billion 0.58% of portfolio
490,449
Q4 2024 Added 1,861.8%
$125M
$9.06 Billion 0.52% of portfolio
6,514,737
Q1 2025 Reduced 1.33%
$399M
$9.03 Billion 0.51% of portfolio
1,193,410
Q1 2025 Reduced 1.48%
$103B
$8.81 Billion 0.5% of portfolio
25,000
Q1 2025 Added 4.17%
$190M
$7.87 Billion 0.45% of portfolio
2,789,833
Q1 2025 Reduced 1.48%
$993B
$7.84 Billion 0.45% of portfolio
50,703
Q1 2025 Added 624.33%
$187B
$7.4 Billion 0.42% of portfolio
19,298
Q1 2025 Added 119.35%
Korro Bio Inc
-
$7.29 Billion 0.42% of portfolio
-
Q3 2024 New
Cartesian Therapeutics Inc
-
$7.42 Billion 0.42% of portfolio
-
Q1 2025 Reduced 1.57%
$203B
$7.27 Billion 0.41% of portfolio
9,126
Q1 2025 Added 62.82%
$118M
$6.76 Billion 0.38% of portfolio
4,000,000
Q3 2024 New
$130B
$6.26 Billion 0.36% of portfolio
52,901
Q4 2024 Added 30.94%

Summary

  • Portfolio
  • No. of Stocks 117
  • Current Value $1.76 Trillion
  • Prior Value $2.26 Trillion
  • Filing
  • Period Q1 2025
  • Filing Date May 14, 2025
  • Form Type 13F-HR
  • Activity in Q1 2025
  • New Purchases 24 stocks
  • Additional Purchases 28 stocks
  • Sold out of 0 stocks
  • Reduced holdings in 41 stocks
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