Institutional shares held 64 Million
210K calls
575K puts
Total value of holdings $6.32B
$20.8M calls
$56.8M puts
Market Cap $5.51B
55,720,000 Shares Out.
Institutional ownership 114.78%
# of Institutions 246


Latest Institutional Activity in RYTM

Top Purchases

Q2 2025
Polar Capital Holdings PLC Shares Held: 1.25M ($124M)
Q2 2025
Woodline Partners LP Shares Held: 514K ($50.8M)
Q2 2025
Adage Capital Partners Gp, L.L.C. Shares Held: 341K ($33.7M)
Q2 2025
Clearbridge Investments, LLC Shares Held: 312K ($30.9M)
Q2 2025
Renaissance Technologies LLC Shares Held: 315K ($31.1M)

Top Sells

Q2 2025
Primecap Management CO Shares Held: 4.88M ($482M)
Q2 2025
Ra Capital Management, L.P. Shares Held: 5.56M ($550M)
Q2 2025
Balyasny Asset Management LLC Shares Held: 54.1K ($5.35M)
Q2 2025
Janus Henderson Group PLC Shares Held: 1.41M ($140M)
Q2 2025
Invesco Ltd. Shares Held: 68.9K ($6.81M)

About RYTM

Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the treatment of rare genetic diseases of obesity. The company's lead product candidate is IMCIVREE, a potent melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is also developing setmelanotide, which is in Phase II clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, Smith-Magenis syndrome obesity, POMC epigenetic disorders, and other MC4R disorders. Rhythm Pharmaceuticals, Inc. has a collaborative research agreement with the Clinical Registry Investigating Bardet-Biedl Syndrome. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.


Insider Transactions at RYTM

Insider Transaction List

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Date Insider Transaction Ownership Type Shares Traded Value / Price
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Last 12 Months Summary

Buy / Acquisition
693K Shares
From 15 Insiders
Exercise of conversion of derivative security 693K shares
Sell / Disposition
604K Shares
From 11 Insiders
Open market or private sale 604K shares

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