Pamela J. Cramer Rhythm Pharmaceuticals, Inc. (RYTM) insider trading activity

Pamela J. Cramer is Chief Human Resources Officer of RHYTHM PHARMACEUTICALS, INC.. Currently has a direct ownership of 20,814 shares of RYTM, which is worth approximately $2.07 Million. The most recent transaction as insider was on Nov 20, 2025, when has been sold 3,350 shares (Common Stock) at a price of $105.0 per share, resulting in proceeds of $351,750. This information was disclosed in a Form 4 filing with the Securities and Exchange Commission (SEC).

Shares Held (Direct Ownership) 20.8K

0% 3M change

54.18% 12M change

Total Value Held $2.07 Million

Pamela J. Cramer Transaction History

Date	Transaction	Value	Shares Traded	Shares Held
Nov 20 2025	SELL Open market or private sale	$351,750 $105.0 p/Share	3,350 Reduced 13.86%	20,814 Common Stock
Nov 20 2025	BUY Exercise of conversion of derivative security	$91,622 $27.35 p/Share	3,350 Added 12.18%	24,164 Common Stock
Nov 10 2025	SELL Open market or private sale	$351,500 $100.0 p/Share	3,515 Reduced 14.45%	20,814 Common Stock
Nov 10 2025	BUY Exercise of conversion of derivative security	$23,902 $6.8 p/Share	3,515 Added 12.62%	24,329 Common Stock
Nov 07 2025	SELL Open market or private sale	$1,912,265 $98.82 p/Share	19,351 Reduced 48.18%	20,814 Common Stock
Nov 07 2025	BUY Exercise of conversion of derivative security	$249,821 $12.91 p/Share	19,351 Added 32.51%	40,165 Common Stock
Jul 29 2025	SELL Open market or private sale	$130,613 $85.93 p/Share	1,520 Reduced 6.81%	20,814 Common Stock

Jul 26 2025	BUY Exercise of conversion of derivative security	-	3,125 Added 12.27%	22,334 Common Stock
Jul 09 2025	SELL Open market or private sale	$1,205,428 $77.41 p/Share	15,572 Reduced 44.77%	19,209 Common Stock
Jul 09 2025	BUY Exercise of conversion of derivative security	$265,969 $17.08 p/Share	15,572 Added 30.93%	34,781 Common Stock
Jun 06 2025	SELL Open market or private sale	$478,459 $68.05 p/Share	7,031 Reduced 26.79%	19,209 Common Stock
Jun 06 2025	BUY Exercise of conversion of derivative security	$47,810 $6.8 p/Share	7,031 Added 21.13%	26,240 Common Stock
Apr 29 2025	SELL Open market or private sale	$457,647 $65.09 p/Share	7,031 Reduced 26.79%	19,209 Common Stock
Apr 29 2025	BUY Exercise of conversion of derivative security	$47,810 $6.8 p/Share	7,031 Added 21.13%	26,240 Common Stock
Apr 08 2025	SELL Open market or private sale	$1,242,278 $59.84 p/Share	20,760 Reduced 51.94%	19,209 Common Stock
Apr 08 2025	BUY Exercise of conversion of derivative security	$354,580 $17.08 p/Share	20,760 Added 34.18%	39,969 Common Stock
Feb 19 2025	SELL Open market or private sale	$56,190 $57.22 p/Share	982 Reduced 4.86%	19,209 Common Stock
Feb 16 2025	BUY Exercise of conversion of derivative security	-	3,300 Added 14.05%	20,191 Common Stock
Feb 11 2025	SELL Open market or private sale	$40,328 $57.53 p/Share	701 Reduced 3.98%	16,891 Common Stock
Feb 09 2025	BUY Exercise of conversion of derivative security	-	2,344 Added 11.76%	17,592 Common Stock
Feb 04 2025	SELL Open market or private sale	$53,605 $59.43 p/Share	902 Reduced 5.59%	15,248 Common Stock
Feb 01 2025	BUY Exercise of conversion of derivative security	-	2,650 Added 14.1%	16,150 Common Stock
Nov 07 2024	SELL Open market or private sale	$304,720 $65.0 p/Share	4,688 Reduced 25.78%	13,500 Common Stock
Nov 07 2024	BUY Exercise of conversion of derivative security	$89,165 $19.02 p/Share	4,688 Added 20.49%	18,188 Common Stock
Nov 06 2024	SELL Open market or private sale	$281,220 $60.0 p/Share	4,687 Reduced 25.77%	13,500 Common Stock

PJC

Pamela J. Cramer

Chief Human Resources Officer

Boston, MA

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