Institutional shares held 35.2 Million
264K calls
0 puts
Total value of holdings $174M
$1.31M calls
$0 puts
Market Cap $226M
45,556,000 Shares Out.
Institutional ownership 77.24%
# of Institutions 135


Latest Institutional Activity in PBYI

Top Purchases

Q3 2025
Russell Investments Group, Ltd. Shares Held: 965K ($4.78M)
Q3 2025
Marshall Wace, LLP Shares Held: 558K ($2.76M)
Q3 2025
O'Shaughnessy Asset Management, LLC Shares Held: 828K ($4.1M)
Q3 2025
Renaissance Technologies LLC Shares Held: 2.15M ($10.6M)
Q3 2025
Ritholtz Wealth Management Shares Held: 471K ($2.33M)

Top Sells

Q3 2025
Millennium Management LLC Shares Held: 106K ($523K)
Q3 2025
Two Sigma Advisers, LP Shares Held: 73.2K ($362K)
Q3 2025
Los Angeles Capital Management LLC Shares Held: 274K ($1.36M)
Q3 2025
D. E. Shaw & Co., Inc. Shares Held: 499K ($2.47M)
Q3 2025
Two Sigma Investments, LP Shares Held: 56.1K ($278K)

About PBYI

Puma Biotechnology, Inc., a biopharmaceutical company, focuses on the development and commercialization of products to enhance cancer care in the United States and internationally. The company's drug candidates include PB272 neratinib (oral) for the patients with early stage HER2-overexpressed/amplified breast cancer; PB272 (neratinib, oral) for the use of neratinib in combination with capecitabine for the treatment of adult patients with advanced or metastatic HER2-positive breast cancer; PB272 (neratinib, oral) for HER2 mutation-positive solid tumors. It has a license agreement with Pfizer, Inc.; and sub-license agreement with Specialised Therapeutics Asia Pte Ltd., CANbridge BIOMED Limited, Pint Pharma International SA, Knight Therapeutics, Inc., Pierre Fabre Medicament SAS, and Bixink Therapeutics Co., Ltd. The company was founded in 2010 and is headquartered in Los Angeles, California.


Insider Transactions at PBYI

Insider Transaction List

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Date Insider Transaction Ownership Type Shares Traded Value / Price
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Last 12 Months Summary

Buy / Acquisition
545K Shares
From 11 Insiders
Grant, award, or other acquisition 545K shares
Sell / Disposition
265K Shares
From 11 Insiders
Open market or private sale 265K shares

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