Institutional shares held 66.9 Million
139K calls
40.7K puts
Total value of holdings $5.66B
$11.7M calls
$3.44M puts
Market Cap $4.15B
49,084,100 Shares Out.
Institutional ownership 136.24%
# of Institutions 296


Latest Institutional Activity in PTGX

Top Purchases

Q3 2025
Marshall Wace, LLP Shares Held: 1.09M ($91.8M)
Q3 2025
Wellington Management Group LLP Shares Held: 1.91M ($161M)
Q3 2025
Janus Henderson Group PLC Shares Held: 1.1M ($93.1M)
Q3 2025
Woodline Partners LP Shares Held: 1.44M ($122M)
Q3 2025
Driehaus Capital Management LLC Shares Held: 1.14M ($96.4M)

Top Sells

Q3 2025
Deep Track Capital, LP Shares Held: 1.72M ($145M)
Q3 2025
Bvf Inc Shares Held: 2.56M ($217M)
Q3 2025
Ubs Group Ag Shares Held: 1.9M ($160M)
Q3 2025
Adage Capital Partners Gp, L.L.C. Shares Held: 718K ($60.8M)
Q3 2025
Jpmorgan Chase & CO Shares Held: 252K ($21.4M)

About PTGX

Protagonist Therapeutics, Inc., a biopharmaceutical company, discovers and develops peptide-based therapeutic drugs to address hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing rusfertide (PTG-300), an injectable hepcidin mimetic that is in Phase II clinical trials for the treatment of patients with polycythemia vera and hereditary hemochromatosis, as well as for the treatment of other blood disorders; PN-943, an oral, alpha-4-beta-7 integrin- specific antagonist peptide that is in Phase II clinical trials for treating inflammatory bowel disease (IBD); and PN-235, an orally delivered interleukin-23 receptor specific antagonist for the treatment of IBD and non-IBD indications. The company has a license and collaboration agreement with Janssen Biotech, Inc. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.


Insider Transactions at PTGX

Insider Transaction List

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Date Insider Transaction Ownership Type Shares Traded Value / Price
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Last 12 Months Summary

Buy / Acquisition
457K Shares
From 14 Insiders
Grant, award, or other acquisition 273K shares
Exercise of conversion of derivative security 184K shares
Sell / Disposition
272K Shares
From 7 Insiders
Payment of exercise price or tax liability 12.6K shares
Bona fide gift 7.42K shares
Open market or private sale 252K shares

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