Adage Capital Partners Gp, L.L.C. Biotechnology

Adage Capital Partners Gp, L.L.C.

$51.6 Billion
Q1 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
AXSM Axsome Therapeutics, Inc.	$4.41B	$5.6 Million 0.01% of portfolio	48,000	Q1 2025 Reduced 20.0%
HRMY Harmony Biosciences Holdings, Inc.	$1.92B	$5.58 Million 0.01% of portfolio	168,000	Q1 2025 Reduced 66.4%
ABUS Arbutus Biopharma Corp	$517M	$5.5 Million 0.01% of portfolio	1,575,941	Q1 2025 Reduced 4.54%
IMNM Immunome Inc.	$106M	$5.22 Million 0.01% of portfolio	775,000	Q1 2025 Added 55.0%
CABA Cabaletta Bio, Inc.	$51.9M	$5.05 Million 0.01% of portfolio	3,634,473	Q4 2024 Added 19.69%
TCRX T Scan Therapeutics, Inc.	$27.3M	$4.83 Million 0.01% of portfolio	3,500,000	Q4 2024 Reduced 20.45%
INZY Inozyme Pharma, Inc.	$160M	$4.7 Million 0.01% of portfolio	5,160,000	Q4 2024 Reduced 9.05%
CRDF Cardiff Oncology, Inc.	$137M	$4.54 Million 0.01% of portfolio	1,445,000	Q1 2025 Added 11.82%
STTK Shattuck Labs, Inc.	$40.3M	$4.44 Million 0.01% of portfolio	4,675,000	Q4 2024 Added 61.21%
MREO Mereo Biopharma Group PLC	$351M	$3.83 Million 0.01% of portfolio	1,700,756	Q1 2025 Reduced 80.48%
KOD Kodiak Sciences Inc.	$185M	$3.73 Million 0.01% of portfolio	1,325,707	Q1 2025 Added 16.34%
KALV Kal Vista Pharmaceuticals, Inc.	$298M	$3.19 Million 0.01% of portfolio	276,000	Q1 2025 Reduced 8.0%
ATXS Astria Therapeutics, Inc.	$88.9M	$3.14 Million 0.01% of portfolio	588,200	Q1 2025 Reduced 17.53%
TRVI Trevi Therapeutics, Inc.	$348M	$2.77 Million 0.01% of portfolio	440,000	Q1 2025 Reduced 82.4%
CCCC C4 Therapeutics, Inc.	$69.9M	$2.48 Million 0.0% of portfolio	1,550,000	Q4 2024 Added 198.08%
VCEL Vericel Corp	$1.97B	$2.06 Million 0.0% of portfolio	46,200	Q1 2025 Reduced 35.65%
PEPG Pep Gen Inc.	$34.3M	$1.9 Million 0.0% of portfolio	1,350,000	Q1 2025 Added 68.75%
JAZZ Jazz Pharmaceuticals PLC	$6.74B	$1.61 Million 0.0% of portfolio	13,000	Q1 2025 New
IMUX Immunic, Inc.	$22.6M	$1.52 Million 0.0% of portfolio	1,398,600	Q4 2024 Reduced 75.0%
ANTX An2 Therapeutics, Inc.	$21.3M	$1.36 Million 0.0% of portfolio	1,000,000	Q1 2025 Added 219.88%
STRO Sutro Biopharma, Inc.	$43.3M	$1.3 Million 0.0% of portfolio	2,000,000	Q4 2024 Reduced 11.12%
GLYC Glycomimetics Inc	$696M	$1.07 Million 0.0% of portfolio	5,091,231	Q4 2024 New
BMEA Biomea Fusion, Inc.	$52.7M	$1.07 Million 0.0% of portfolio	500,000	Q4 2024 Reduced 44.44%
IKNA Ikena Oncology, Inc.	$49.3M	$1.02 Million 0.0% of portfolio	800,000	Q4 2024 Reduced 19.02%
APLT Applied Therapeutics Inc.	$16.3M	$961,000 0.0% of portfolio	1,961,629	Q4 2024 Reduced 52.3%
IMVT Immunovant, Inc.	$3.55B	$583,000 0.0% of portfolio	21,200	Q1 2025 Reduced 92.93%
VERU Veru Inc.	$48.1M	$490,000 0.0% of portfolio	1,000,000	Q1 2025 Reduced 56.52%
OVID Ovid Therapeutics Inc.	$21.1M	$356,000 0.0% of portfolio	1,150,000	Q1 2025 Added 15.0%

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