Jim Simons Spero Therapeutics, Inc. Transaction History

Renaissance Technologies LLC

$70.6 Billion
Q3 2025

A detailed history of Jim Simons (Renaissance Technologies LLC) transactions in Spero Therapeutics, Inc. stock. As of the latest transaction made, Renaissance Technologies LLC holds 1,452,765 shares of SPRO stock, worth $3.5 Million. This represents 0.0% of its overall portfolio holdings.

Number of Shares

1,452,765

Previous 832,165 74.58%

Holding current value

$3.5 Million

Previous $2.41 Million 13.18%

% of portfolio

0.0%

Previous 0.0%

24 transactions

Quarter	Operation	Price Per share	shares change	shares Held
Q3 2025 Nov 13, 2025	BUY	$1.83 - $3.04 $1.14 Million - $1.89 Million	620,600 Added 74.58%	1,452,765 $2.73 Million
Q2 2025 Aug 13, 2025	SELL	$0.56 - $3.02 $77,695 - $419,000	-138,742 Reduced 14.29%	832,165 $2.41 Million
Q1 2025 May 14, 2025	SELL	$0.72 - $1.1 $96,972 - $148,152	-134,684 Reduced 12.18%	970,907 $699,000
Q4 2024 Feb 13, 2025	BUY	$0.92 - $1.33 $120,462 - $174,147	130,938 Added 13.43%	1,105,591 $1.15 Million
Q3 2024 Nov 13, 2024	SELL	$1.19 - $1.5 $1,545 - $1,948	-1,299 Reduced 0.13%	974,653 $1.31 Million
Q2 2024 Aug 09, 2024	BUY	$1.27 - $1.8 $154,294 - $218,685	121,492 Added 14.22%	975,952 $1.27 Million
Q1 2024 May 13, 2024	BUY	$1.35 - $1.79 $414,443 - $549,521	306,995 Added 56.08%	854,460 $1.47 Million
Q4 2023 Feb 13, 2024	BUY	$1.0 - $1.47 $300 - $441	300 Added 0.05%	547,465 $805,000
Q3 2023 Nov 14, 2023	SELL	$1.2 - $1.63 $55,519 - $75,413	-46,266 Reduced 7.8%	547,165 $662,000
Q2 2023 Aug 11, 2023	BUY	$1.42 - $1.95 $260,046 - $357,105	183,131 Added 44.63%	593,431 $860,000
Q1 2023 May 12, 2023	BUY	$1.35 - $2.0 $90,990 - $134,800	67,400 Added 19.66%	410,300 $595,000
Q4 2022 Feb 13, 2023	BUY	$1.55 - $2.12 $198,710 - $271,784	128,200 Added 59.71%	342,900 $593,000
Q3 2022 Nov 14, 2022	SELL	$0.68 - $2.2 $492,535 - $1.59 Million	-724,317 Reduced 77.14%	214,700 $429,000
Q2 2022 Aug 12, 2022	BUY	$0.74 - $7.44 $614,138 - $6.17 Million	829,917 Added 760.69%	939,017 $696,000
Q1 2022 May 13, 2022	BUY	$7.87 - $15.15 $858,617 - $1.65 Million	109,100 New	109,100 $949,000
Q4 2020 Feb 10, 2021	SELL	$11.65 - $22.07 $1.78 Million - $3.38 Million	-153,203 Closed	0 $0
Q3 2020 Nov 13, 2020	SELL	$8.96 - $14.12 $1.58 Million - $2.5 Million	-176,700 Reduced 53.56%	153,203 $1.71 Million
Q2 2020 Aug 13, 2020	BUY	$7.27 - $14.18 $40,712 - $79,408	5,600 Added 1.73%	329,903 $4.46 Million
Q1 2020 May 14, 2020	SELL	$5.27 - $10.41 $73,253 - $144,699	-13,900 Reduced 4.11%	324,303 $2.62 Million
Q4 2019 Feb 13, 2020	BUY	$9.46 - $12.16 $807,884 - $1.04 Million	85,400 Added 33.78%	338,203 $3.25 Million
Q3 2019 Nov 13, 2019	BUY	$9.01 - $12.55 $341,479 - $475,645	37,900 Added 17.64%	252,803 $2.68 Million
Q2 2019 Aug 12, 2019	BUY	$10.25 - $14.36 $1.04 Million - $1.46 Million	101,600 Added 89.67%	214,903 $2.47 Million
Q1 2019 May 14, 2019	BUY	$6.26 - $13.31 $440,704 - $937,024	70,400 Added 164.09%	113,303 $1.45 Million
Q4 2018 Feb 13, 2019	BUY	$5.69 - $11.28 $244,118 - $483,945	42,903 New	42,903 $264,000

Others Institutions Holding SPRO

# of Institutions

Shares Held

10.6M

Call Options Held

Put Options Held

65.7K

View Full List

About Spero Therapeutics, Inc.

Ticker SPRO
Exchange NASDAQ
Sector Healthcare
Industry Biotechnology
Shares Outstandng 35,067,500
Market Cap $84.5M
Description
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to ...

More about SPRO

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