Brian Birchler Ionis Pharmaceuticals Inc (IONS) insider trading activity

Brian Birchler is EVP, Corp and Development Ops of IONIS PHARMACEUTICALS INC. Currently has a direct ownership of 48,826 shares of IONS, which is worth approximately $3.49 Million. The most recent transaction as insider was on Nov 06, 2025, when has been sold 8,000 shares (Common Stock) at a price of $76.17 per share, resulting in proceeds of $609,360. This information was disclosed in a Form 4 filing with the Securities and Exchange Commission (SEC).

Shares Held (Direct Ownership) 48.8K

14.08% 3M change

5.76% 12M change

Total Value Held $3.49 Million

Brian Birchler Transaction History

Date	Transaction	Value	Shares Traded	Shares Held
Nov 06 2025	SELL Open market or private sale	$609,360 $76.17 p/Share	8,000 Reduced 14.08%	48,826 Common Stock
Oct 15 2025	SELL Open market or private sale	$897,457 $72.23 p/Share	12,425 Reduced 17.94%	56,826 Common Stock
Oct 15 2025	BUY Exercise of conversion of derivative security	$668,092 $53.77 p/Share	12,425 Added 15.21%	69,251 Common Stock
Oct 14 2025	SELL Open market or private sale	$826,544 $72.03 p/Share	11,475 Reduced 16.8%	56,826 Common Stock
Oct 14 2025	BUY Exercise of conversion of derivative security	$617,010 $53.77 p/Share	11,475 Added 14.38%	68,301 Common Stock
Aug 29 2025	BUY Other acquisition or disposition	$4,599 $27.71 p/Share	166 Added 0.29%	56,826 Common Stock
Apr 16 2025	SELL Open market or private sale	$19,291 $28.37 p/Share	680 Reduced 1.19%	56,660 Common Stock

Apr 15 2025	BUY Exercise of conversion of derivative security	-	1,875 Added 3.17%	57,340 Common Stock
Feb 28 2025	BUY Other acquisition or disposition	$11,678 $28.21 p/Share	414 Added 0.74%	55,465 Common Stock
Jan 16 2025	SELL Open market or private sale	$176,580 $32.7 p/Share	5,400 Reduced 8.93%	55,051 Common Stock
Jan 15 2025	BUY Exercise of conversion of derivative security	-	14,283 Added 19.11%	60,451 Common Stock
Aug 30 2024	BUY Other acquisition or disposition	$463 $38.64 p/Share	12 Added 0.03%	46,168 Common Stock
Apr 16 2024	SELL Open market or private sale	$37,702 $41.66 p/Share	905 Reduced 1.92%	46,156 Common Stock
Apr 15 2024	BUY Exercise of conversion of derivative security	-	1,875 Added 3.83%	47,061 Common Stock
Feb 29 2024	BUY Other acquisition or disposition	$20,789 $34.42 p/Share	604 Added 1.32%	45,186 Common Stock
Jan 17 2024	SELL Open market or private sale	$226,738 $50.42 p/Share	4,497 Reduced 9.16%	44,582 Common Stock
Jan 16 2024	BUY Exercise of conversion of derivative security	-	12,080 Added 19.75%	49,079 Common Stock
Dec 28 2023	SELL Payment of exercise price or tax liability	$556,964 $50.5 p/Share	11,029 Reduced 22.96%	36,999 Common Stock
Dec 28 2023	BUY Exercise of conversion of derivative security	$544,410 $47.34 p/Share	11,500 Added 19.32%	48,028 Common Stock
Apr 18 2023	SELL Open market or private sale	$24,528 $36.5 p/Share	672 Reduced 1.81%	36,528 Common Stock
Apr 17 2023	BUY Exercise of conversion of derivative security	-	1,875 Added 4.8%	37,200 Common Stock

Brian Birchler

EVP, Corp and Development Ops

Carlsbad, CA

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