Institutional shares held 148 Million
872K calls
432K puts
Total value of holdings $6.08B
$35.9M calls
$17.8M puts
Market Cap $5.85B
141,940,992 Shares Out.
Institutional ownership 104.08%
# of Institutions 406


Latest Institutional Activity in IONS

Top Purchases

Q2 2025
Adage Capital Partners Gp, L.L.C. Shares Held: 3.8M ($156M)
Q2 2025
Polar Capital Holdings PLC Shares Held: 1M ($41.2M)
Q2 2025
Two Sigma Advisers, LP Shares Held: 2.67M ($110M)
Q2 2025
Massachusetts Financial Services CO Shares Held: 519K ($21.4M)
Q2 2025
Norges Bank Shares Held: 450K ($18.5M)

Top Sells

Q2 2025
Wellington Management Group LLP Shares Held: 6.35M ($261M)
Q2 2025
Invesco Ltd. Shares Held: 256K ($10.6M)
Q2 2025
Ubs Group Ag Shares Held: 1.53M ($63M)
Q2 2025
State Street Corp Shares Held: 4.53M ($187M)
Q2 2025
Hudson Bay Capital Management LP Shares Held: 750K ($30.9M)

About IONS

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of TTR amyloidosis; Olezarsen for patients with severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Tofersen to inhibit the production of superoxide dismutase 1. In addition, the company develops medicines for metabolic diseases, infectious diseases, renal diseases, ophthalmic diseases, and cancer. It has a strategic collaboration with Biogen Inc.; and collaboration and license agreement with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.


Insider Transactions at IONS

Insider Transaction List

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Date Insider Transaction Ownership Type Shares Traded Value / Price
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Last 12 Months Summary

Buy / Acquisition
362K Shares
From 33 Insiders
Exercise of conversion of derivative security 290K shares
Open market or private purchase 20K shares
Grant, award, or other acquisition 48.5K shares
Other acquisition or disposition 3.15K shares
Sell / Disposition
217K Shares
From 13 Insiders
Open market or private sale 217K shares

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