Joseph Loscalzo Ionis Pharmaceuticals Inc (IONS) insider trading activity

Joseph Loscalzo is Director of IONIS PHARMACEUTICALS INC. Currently has a direct ownership of 36,330 shares of IONS, which is worth approximately $2.54 Million. The most recent transaction as insider was on Sep 03, 2025, when has been sold 16,000 shares (Common Stock) at a price of $60.15 per share, resulting in proceeds of $962,400. This information was disclosed in a Form 4 filing with the Securities and Exchange Commission (SEC).

Shares Held (Direct Ownership) 36.3K

12.65% 3M change

20.61% 12M change

Total Value Held $2.54 Million

JOSEPH LOSCALZO Transaction History

Date	Transaction	Value	Shares Traded	Shares Held
Sep 03 2025	SELL Open market or private sale	$962,400 $60.15 p/Share	16,000 Reduced 30.58%	36,330 Common Stock
Sep 03 2025	BUY Exercise of conversion of derivative security	$390,720 $24.42 p/Share	16,000 Added 23.42%	52,330 Common Stock
Jul 15 2025	BUY Exercise of conversion of derivative security	-	4,079 Added 10.09%	36,330 Common Stock
Nov 12 2024	SELL Open market or private sale	$511,412 $37.86 p/Share	13,508 Reduced 29.52%	32,251 Common Stock
Jul 15 2024	BUY Exercise of conversion of derivative security	-	4,677 Added 9.27%	45,759 Common Stock
Jul 17 2023	BUY Exercise of conversion of derivative security	-	7,110 Added 14.75%	41,082 Common Stock
Jul 15 2022	BUY Exercise of conversion of derivative security	-	7,998 Added 19.06%	33,972 Common Stock
Jul 15 2021	BUY Exercise of conversion of derivative security	-	8,666 Added 25.02%	25,974 Common Stock

Also insider at

LPTX

LEAP THERAPEUTICS, INC. Healthcare

Director

Joseph Loscalzo

Director

Carlsbad, CA

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