Patrick R. O'Neil Ionis Pharmaceuticals Inc (IONS) insider trading activity

Patrick R. O'Neil is EVP CLO & General Counsel of IONIS PHARMACEUTICALS INC. Currently has a direct ownership of 53,889 shares of IONS, which is worth approximately $3.77 Million. The most recent transaction as insider was on Oct 06, 2025, when has been sold 13,441 shares (Common Stock) at a price of $69.58 per share, resulting in proceeds of $935,224. This information was disclosed in a Form 4 filing with the Securities and Exchange Commission (SEC).

Shares Held (Direct Ownership) 53.9K

5.12% 3M change

10.26% 12M change

Total Value Held $3.77 Million

PATRICK R. O'NEIL Transaction History

Date	Transaction	Value	Shares Traded	Shares Held
Oct 06 2025	SELL Open market or private sale	$935,224 $69.58 p/Share	13,441 Reduced 19.96%	53,889 Common Stock
Oct 06 2025	BUY Exercise of conversion of derivative security	$539,274 $52.87 p/Share	10,200 Added 13.16%	67,330 Common Stock
Oct 02 2025	SELL Open market or private sale	$4,377,106 $67.69 p/Share	64,664 Reduced 53.09%	57,130 Common Stock
Oct 02 2025	BUY Exercise of conversion of derivative security	$3,804,183 $58.83 p/Share	64,664 Added 41.38%	91,591 Common Stock
Sep 30 2025	SELL Open market or private sale	$959,010 $64.68 p/Share	14,827 Reduced 20.61%	57,130 Common Stock
Sep 30 2025	BUY Exercise of conversion of derivative security	$841,877 $56.78 p/Share	14,827 Added 17.08%	71,957 Common Stock
Sep 29 2025	SELL Open market or private sale	$675,927 $64.54 p/Share	10,473 Reduced 15.49%	57,130 Common Stock
Sep 29 2025	BUY Exercise of conversion of derivative security	$594,656 $56.78 p/Share	10,473 Added 13.41%	67,603 Common Stock
Sep 12 2025	SELL Open market or private sale	$109,786 $64.58 p/Share	1,700 Reduced 2.89%	57,130 Common Stock
Sep 12 2025	BUY Exercise of conversion of derivative security	$96,526 $56.78 p/Share	1,700 Added 2.81%	58,830 Common Stock
Sep 09 2025	SELL Open market or private sale	$1,355,760 $64.56 p/Share	21,000 Reduced 26.88%	57,130 Common Stock
Sep 09 2025	BUY Exercise of conversion of derivative security	$1,235,430 $58.83 p/Share	21,000 Added 26.54%	58,130 Common Stock
Sep 03 2025	SELL Open market or private sale	$4,699,377 $61.15 p/Share	76,850 Reduced 91.29%	7,330 Common Stock
Sep 03 2025	BUY Exercise of conversion of derivative security	$3,175,442 $41.32 p/Share	76,850 Added 57.36%	57,130 Common Stock
Sep 02 2025	SELL Open market or private sale	$711,355 $54.51 p/Share	13,050 Reduced 18.6%	57,130 Common Stock
Sep 02 2025	BUY Exercise of conversion of derivative security	$425,430 $32.6 p/Share	13,050 Added 15.68%	70,180 Common Stock
Aug 29 2025	BUY Other acquisition or disposition	$9,172 $27.71 p/Share	331 Added 0.58%	57,130 Common Stock
Feb 28 2025	BUY Other acquisition or disposition	$15,628 $28.21 p/Share	554 Added 0.97%	56,799 Common Stock
Feb 20 2025	SELL Open market or private sale	$39,046 $32.35 p/Share	1,207 Reduced 2.1%	56,245 Common Stock
Feb 04 2025	SELL Open market or private sale	$194,937 $31.62 p/Share	6,165 Reduced 9.69%	57,452 Common Stock
Jan 31 2025	SELL Open market or private sale	$45,680 $32.49 p/Share	1,406 Reduced 2.16%	63,617 Common Stock
Jan 30 2025	BUY Grant, award, or other acquisition	-	3,820 Added 5.55%	65,023 Common Stock
Jan 16 2025	SELL Open market or private sale	$241,628 $32.83 p/Share	7,360 Reduced 10.73%	61,203 Common Stock
Jan 15 2025	BUY Exercise of conversion of derivative security	-	19,690 Added 22.31%	68,563 Common Stock
Aug 30 2024	BUY Other acquisition or disposition	$9,505 $38.64 p/Share	246 Added 0.5%	48,873 Common Stock

PRO

Patrick R. O'Neil

EVP CLO & General Counsel

Carlsbad, CA

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