Michael Mano Karyopharm Therapeutics Inc. (KPTI) insider trading activity

Michael Mano is SVP, General Counsel&Secretary of Karyopharm Therapeutics Inc.. Currently has a direct ownership of 21,425 shares of KPTI, which is worth approximately $134,120. The most recent transaction as insider was on Sep 15, 2025, when has been sold 234 shares (Common Stock) at a price of $6.43 per share, resulting in proceeds of $1,504. This information was disclosed in a Form 4 filing with the Securities and Exchange Commission (SEC).

Shares Held (Direct Ownership) 21.4K

1.8% 3M change

92.18% 12M change

Total Value Held $134,120

Michael Mano Transaction History

Date	Transaction	Value	Shares Traded	Shares Held
Sep 15 2025	SELL Open market or private sale	$1,504 $6.43 p/Share	234 Reduced 1.08%	21,425 Common Stock
Sep 12 2025	BUY Grant, award, or other acquisition	-	612 Added 2.75%	21,659 Common Stock
Mar 04 2025	SELL Open market or private sale	$17,567 $6.29 p/Share	2,793 Reduced 11.72%	21,047 Common Stock
Feb 28 2025	BUY Grant, award, or other acquisition	-	5,583 Added 18.97%	23,840 Common Stock
Sep 04 2024	SELL Open market or private sale	$2,859 $0.72 p/Share	3,971 Reduced 1.43%	273,881 Common Stock
Mar 01 2024	SELL Open market or private sale	$4,291 $1.2 p/Share	3,576 Reduced 1.27%	277,852 Common
Feb 29 2024	SELL Open market or private sale	$19,858 $1.17 p/Share	16,973 Reduced 5.69%	281,428 Common
Feb 28 2024	BUY Grant, award, or other acquisition	-	147,000 Added 33.0%	298,401 Common Stock
Jan 24 2024	BUY Grant, award, or other acquisition	-	9,167 Added 5.71%	151,401 Common Stock
Sep 01 2023	SELL Open market or private sale	$5,171 $1.33 p/Share	3,888 Reduced 2.66%	142,234 Common Stock
Mar 01 2023	SELL Open market or private sale	$20,840 $3.03 p/Share	6,878 Reduced 4.5%	146,122 Common Stock
Feb 28 2023	BUY Grant, award, or other acquisition	-	70,000 Added 31.39%	153,000 Common Stock
Aug 31 2022	BUY Grant, award, or other acquisition	-	20,000 Added 19.42%	83,000 Common Stock
Feb 28 2022	BUY Grant, award, or other acquisition	-	63,000 Added 50.0%	63,000 Common Stock

Michael Mano

SVP, General Counsel&Secretary

Newton, MA

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