Siren, L.L.C. Portfolio Holdings

Siren, L.L.C.

  • $2.56 Trillion
  • Q3 2025

Siren, L.L.C. has filed its 13F form on November 13, 2025 for Q3 2025 where it was disclosed a total value porftolio of $2.56 Trillion distributed in 117 stocks.

Among their holdings, we can observe that their the top five positions include companies like: Scholar Rock Holding Corp with a value of $344B, Kymera Therapeutics, Inc. with a value of $194B, Bei Gene, Ltd. with a value of $168B, Arrowhead Pharmaceuticals, Inc. with a value of $92.1B, and Bicara Therapeutics Inc with a value of $82.4B.

Examining the 13F form we can see an increase of $624B in the current position value, from $1.93T to 2.56T.

Siren, L.L.C. is based out at New York, NY

Below you can find more details about Siren, L.L.C. portfolio as well as his latest detailed transactions.

Portfolio value $2.56 Trillion
Technology: $123 Billion
Communication Services: $57.5 Billion
Consumer Cyclical: $21.1 Billion
Consumer Defensive: $5.26 Billion
Real Estate: $2.76 Billion
Financial Services: $938 Million
Industrials: $302 Million
Healthcare: $145 Million
Other: $0

Stock Holdings Table

Stock Market Cap. Holding Value (Reported) # of Shares. Last Trade Trade History
$117M
$8.68 Billion 0.34% of portfolio
4,000,000
Q3 2024 New
Nebius Group Nv
-
$8.15 Billion 0.32% of portfolio
-
Q3 2025 Added 42.35%
Neumora Therapeutics Inc
-
$7.93 Billion 0.31% of portfolio
-
Q1 2025 Reduced 0.86%
$1.46T
$7.88 Billion 0.31% of portfolio
28,200
Q3 2025 Reduced 7.54%
$237B
$7.13 Billion 0.28% of portfolio
30,100
Q3 2025 Added 33.19%
$390M
$7.08 Billion 0.28% of portfolio
1,193,410
Q1 2025 Reduced 1.48%
$465B
$6.99 Billion 0.27% of portfolio
37,485
Q3 2025 Reduced 25.01%
$169B
$6.56 Billion 0.26% of portfolio
7,126
Q3 2025 Added 39.02%
Spyre Therapeutics Inc
-
$6.18 Billion 0.24% of portfolio
-
Q1 2025 Reduced 1.44%
Cartesian Therapeutics Inc
-
$5.76 Billion 0.23% of portfolio
-
Q1 2025 Reduced 1.57%
$163B
$5.74 Billion 0.22% of portfolio
43,401
Q3 2025 Reduced 17.96%
$151B
$5.31 Billion 0.21% of portfolio
15,051
Q2 2025 Reduced 22.01%
$24.2M
$5.37 Billion 0.21% of portfolio
2,072,767
Q3 2025 Added 200.33%
$1.65T
$5.15 Billion 0.2% of portfolio
21,203
Q3 2025 Reduced 58.18%
$5.87B
$5.07 Billion 0.2% of portfolio
107,116
Q2 2025 Reduced 18.61%
Sagimet Biosciences Inc
-
$4.97 Billion 0.19% of portfolio
-
Q3 2024 New
$53.8B
$4.69 Billion 0.18% of portfolio
32,925
Q3 2025 Reduced 14.31%
$347M
$4.41 Billion 0.17% of portfolio
1,165,957
Q3 2025 New
Agenus Inc
-
$4.1 Billion 0.16% of portfolio
-
Q2 2025 Added 112.85%
$153M
$3.97 Billion 0.16% of portfolio
1,046,517
Q3 2024 New
Lexeo Therapeutics Inc
-
$4.01 Billion 0.16% of portfolio
-
Q3 2024 New
$35.9M
$3.96 Billion 0.15% of portfolio
2,082,000
Q1 2025 New
V Tv Therapeutics Inc
-
$3.81 Billion 0.15% of portfolio
-
Q3 2025 New
$195M
$3.52 Billion 0.14% of portfolio
720,720
Q3 2024 New
Instil Bio Inc
-
$3.64 Billion 0.14% of portfolio
-
Q1 2025 Added 5.98%
Core Weave Inc
-
$3.28 Billion 0.13% of portfolio
-
Q3 2025 New
$156M
$3.31 Billion 0.13% of portfolio
1,552,183
Q1 2025 Reduced 1.45%
$9.05B
$3.29 Billion 0.13% of portfolio
62,000
Q3 2025 Reduced 13.89%
$112M
$3.23 Billion 0.13% of portfolio
700,000
Q3 2025 New
$61.4B
$2.74 Billion 0.11% of portfolio
13,450
Q3 2025 Added 16.96%
$3.86B
$2.89 Billion 0.11% of portfolio
64,000
Q3 2025 Added 82.86%
$21.1B
$2.76 Billion 0.11% of portfolio
145,000
Q3 2025 Added 38.1%
Tenax Therapeutics Inc
-
$2.68 Billion 0.1% of portfolio
-
Q3 2025 New
$4.41B
$2.58 Billion 0.1% of portfolio
30,000
Q3 2025 Added 7.14%
Bioage Labs Inc
-
$2.25 Billion 0.09% of portfolio
-
Q1 2025 Reduced 1.44%
$187B
$2.33 Billion 0.09% of portfolio
14,000
Q1 2025 Reduced 6.67%
$38.4B
$1.97 Billion 0.08% of portfolio
77,050
Q3 2025 New
Generation Bio CO
-
$1.82 Billion 0.07% of portfolio
-
Q3 2025 New
Kalaris Therapeutics Inc
-
$1.84 Billion 0.07% of portfolio
-
Q3 2025 Added 12.63%
$19B
$1.87 Billion 0.07% of portfolio
4,000
Q3 2025 Added 33.33%
$875M
$1.86 Billion 0.07% of portfolio
47,500
Q3 2025 New
$3.5B
$1.67 Billion 0.07% of portfolio
90,000
Q3 2025 Added 50.0%
$123B
$1.52 Billion 0.06% of portfolio
2,173
Q3 2025 New
Niq Global Intelligence PLC
-
$1.49 Billion 0.06% of portfolio
-
Q3 2025 New
Primo Brands Corp
-
$1.66 Billion 0.06% of portfolio
-
Q3 2025 Added 100.0%
$7.02B
$1.36 Billion 0.05% of portfolio
7,000
Q3 2025 New
$8.64B
$1.06 Billion 0.04% of portfolio
12,500
Q3 2025 New
$2.72B
$938 Million 0.04% of portfolio
20,000
Q3 2025 New
Sail Point Inc
-
$1.1 Billion 0.04% of portfolio
-
Q2 2025 Reduced 47.37%

Summary

  • Portfolio
  • No. of Stocks 117
  • Current Value $2.56 Trillion
  • Prior Value $1.93 Trillion
  • Filing
  • Period Q3 2025
  • Filing Date November 13, 2025
  • Form Type 13F-HR
  • Activity in Q3 2025
  • New Purchases 24 stocks
  • Additional Purchases 24 stocks
  • Sold out of 0 stocks
  • Reduced holdings in 14 stocks
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