Siren, L.L.C. Portfolio Holdings

Siren, L.L.C.

  • $1.93 Trillion
  • Q2 2025

Siren, L.L.C. has filed its 13F form on August 13, 2025 for Q2 2025 where it was disclosed a total value porftolio of $1.93 Trillion distributed in 111 stocks.

Among their holdings, we can observe that their the top five positions include companies like: Scholar Rock Holding Corp with a value of $328B, Kymera Therapeutics, Inc. with a value of $150B, Bei Gene, Ltd. with a value of $123B, Disc Medicine Inc with a value of $58.2B, and Crinetics Pharmaceuticals, Inc. with a value of $48.6B.

Examining the 13F form we can see an increase of $160B in the current position value, from $1.77T to 1.93T.

Siren, L.L.C. is based out at New York, NY

Below you can find more details about Siren, L.L.C. portfolio as well as his latest detailed transactions.

Portfolio value $1.93 Trillion
Technology: $93.5 Billion
Communication Services: $58.5 Billion
Consumer Cyclical: $19.4 Billion
Healthcare: $7.04 Billion
Consumer Defensive: $3.88 Billion
Real Estate: $1.86 Billion
Utilities: $349 Million
Industrials: $257 Million
Other: $0

Stock Holdings Table Companies Only

Stock Market Cap. Holding Value (Reported) # of Shares. Last Trade Trade History
$1.66B
$328 Billion 16.95% of portfolio
9,250,005
Q4 2024 Reduced 17.85%
$2.18B
$150 Billion 7.74% of portfolio
3,428,150
Q2 2025 Added 5.8%
$23.5B
$123 Billion 6.39% of portfolio
509,990
Q2 2025 Added 2.27%
$1.53B
$48.6 Billion 2.51% of portfolio
1,688,611
Q1 2025 Added 4.91%
$602M
$46 Billion 2.38% of portfolio
4,836,437
Q2 2025 Added 77.94%
$1.61B
$45.5 Billion 2.35% of portfolio
3,460,029
Q2 2025 Added 16.89%
$2.93B
$44.9 Billion 2.32% of portfolio
853,467
Q2 2025 Reduced 18.21%
$2.63B
$44.6 Billion 2.31% of portfolio
2,578,396
Q1 2025 Reduced 8.45%
$10.9B
$42.4 Billion 2.2% of portfolio
245,943
Q2 2025 Reduced 14.41%
$1.88B
$42.2 Billion 2.18% of portfolio
2,669,880
Q1 2025 Reduced 7.99%
$846M
$41.4 Billion 2.14% of portfolio
3,160,298
Q2 2025 Added 86.29%
$200M
$36.8 Billion 1.9% of portfolio
38,918,903
Q1 2025 Added 1,006.84%
$777M
$36.5 Billion 1.89% of portfolio
9,969,495
Q3 2024 New
$3.09B
$34.5 Billion 1.79% of portfolio
938,755
Q2 2025 Added 66.52%
$2.41B
$31.5 Billion 1.63% of portfolio
1,110,610
Q1 2025 Reduced 1.48%
$5.51B
$25.9 Billion 1.34% of portfolio
409,742
Q2 2025 Added 47.64%
$533M
$25.5 Billion 1.32% of portfolio
2,247,347
Q1 2025 Added 12.37%
$141M
$25.4 Billion 1.32% of portfolio
11,014,737
Q2 2025 Added 69.07%
$734M
$24 Billion 1.24% of portfolio
3,696,322
Q1 2025 Reduced 1.44%
$2.04B
$24 Billion 1.24% of portfolio
508,267
Q2 2025 New
-
$21.6 Billion 1.12% of portfolio
-
Q2 2025 Reduced 37.54%
$428M
$21.5 Billion 1.11% of portfolio
3,938,793
Q2 2025 Added 37.54%
$595M
$17.2 Billion 0.89% of portfolio
3,364,814
Q2 2025 Added 31.16%
$2.23B
$17 Billion 0.88% of portfolio
318,647
Q2 2025 New
$201M
$16.9 Billion 0.87% of portfolio
2,911,438
Q2 2025 Added 4.36%
$214M
$14 Billion 0.72% of portfolio
2,012,752
Q2 2025 Added 11.03%
$2.42B
$13.1 Billion 0.68% of portfolio
2,357,520
Q3 2024 New
$698M
$13.1 Billion 0.68% of portfolio
1,612,077
Q3 2024 New
$2.26T
$12.4 Billion 0.64% of portfolio
56,500
Q1 2025 Added 54.79%
$1.77B
$11.5 Billion 0.59% of portfolio
821,513
Q1 2025 Reduced 1.5%
$191M
$11.1 Billion 0.58% of portfolio
8,757,249
Q1 2025 Reduced 1.13%
$377M
$10.2 Billion 0.53% of portfolio
1,007,575
Q3 2024 New
$1.78B
$9.61 Billion 0.5% of portfolio
295,543
Q1 2025 Reduced 1.48%
$3.26B
$9.67 Billion 0.5% of portfolio
515,449
Q2 2025 Added 5.1%
$93.6B
$9.42 Billion 0.49% of portfolio
18,500
Q2 2025 Reduced 26.0%
$332M
$8.99 Billion 0.47% of portfolio
1,193,410
Q1 2025 Reduced 1.48%
$1.21T
$8.93 Billion 0.46% of portfolio
50,703
Q1 2025 Added 624.33%
$129M
$8.56 Billion 0.44% of portfolio
4,000,000
Q3 2024 New
$3.95T
$8.03 Billion 0.42% of portfolio
16,150
Q2 2025 Reduced 43.33%
$456B
$7.9 Billion 0.41% of portfolio
49,985
Q2 2025 Added 12.5%
$8.57B
$7.3 Billion 0.38% of portfolio
170,000
Q4 2024 Reduced 66.0%
$1.27T
$6.91 Billion 0.36% of portfolio
30,500
Q2 2025 Added 7.02%
$181M
$6.41 Billion 0.33% of portfolio
5,208,968
Q4 2024 Reduced 60.78%
$760M
$6.13 Billion 0.32% of portfolio
854,379
Q2 2025 New
$232B
$6.16 Billion 0.32% of portfolio
22,600
Q2 2025 Added 54.79%
$157B
$5.82 Billion 0.3% of portfolio
15,051
Q2 2025 Reduced 22.01%
$572M
$5.82 Billion 0.3% of portfolio
247,216
Q2 2025 Reduced 66.92%
$147B
$5.54 Billion 0.29% of portfolio
52,901
Q4 2024 Added 30.94%
$1.14B
$5.38 Billion 0.28% of portfolio
225,000
Q2 2025 New

Summary

  • Portfolio
  • No. of Stocks 111
  • Current Value $1.93 Trillion
  • Prior Value $1.77 Trillion
  • Filing
  • Period Q2 2025
  • Filing Date August 13, 2025
  • Form Type 13F-HR
  • Activity in Q2 2025
  • New Purchases 15 stocks
  • Additional Purchases 21 stocks
  • Sold out of 0 stocks
  • Reduced holdings in 19 stocks
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