D. E. Shaw & Co., Inc. Biotechnology

D. E. Shaw & Co., Inc.

$100 Billion
Q1 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
AKRO Akero Therapeutics, Inc.	$2.34B	$492,000 0.0% of portfolio	12,159	Q1 2025 Reduced 66.04%
OCUL Ocular Therapeutix, Inc	$917M	$440,000 0.0% of portfolio	60,123	Q1 2025 Added 91.36%
RCUS Arcus Biosciences, Inc.	$712M	$439,000 0.0% of portfolio	56,041	Q1 2025 New
ACET Adicet Bio, Inc.	$31.2M	$384,000 0.0% of portfolio	505,469	Q1 2025 Reduced 40.33%
FATE Fate Therapeutics Inc	$121M	$342,000 0.0% of portfolio	433,192	Q1 2025 Reduced 71.81%
RXRX Recursion Pharmaceuticals, Inc.	$1.13B	$322,000 0.0% of portfolio	60,906	Q1 2025 New
MGTX Meira G Tx Holdings PLC	$374M	$303,000 0.0% of portfolio	44,811	Q1 2025 Reduced 63.76%
KALV Kal Vista Pharmaceuticals, Inc.	$384M	$296,000 0.0% of portfolio	25,720	Q1 2025 Reduced 64.9%
SRPT Sarepta Therapeutics, Inc.	$1.13B	$281,000 0.0% of portfolio	4,406	Q1 2025 Added 25.89%
VERV Verve Therapeutics, Inc.	$667M	$260,000 0.0% of portfolio	57,104	Q1 2025 Added 50.34%
ALT Altimmune, Inc.	$201M	$252,000 0.0% of portfolio	50,516	Q1 2025 Reduced 89.01%
CGEM Cullinan Oncology, Inc.	$380M	$238,000 0.0% of portfolio	31,494	Q1 2025 Reduced 35.64%
NTLA Intellia Therapeutics, Inc.	$971M	$230,000 0.0% of portfolio	32,396	Q1 2025 Reduced 3.53%
PRTA Prothena Corp Public LTD CO	$314M	$220,000 0.0% of portfolio	17,803	Q1 2025 New
SVRA Savara Inc	$275M	$155,000 0.0% of portfolio	56,260	Q1 2025 Reduced 20.27%
AKBA Akebia Therapeutics, Inc.	$708M	$140,000 0.0% of portfolio	73,161	Q1 2025 Reduced 11.49%
KMPH Kempharm, Inc	$170M	$135,000 0.0% of portfolio	27,370	Q1 2025 Added 9.15%
IMTX Immatics N.V.	$492M	$132,000 0.0% of portfolio	29,463	Q1 2025 Added 19.12%
IOVA Iovance Biotherapeutics, Inc.	$519M	$130,000 0.0% of portfolio	39,276	Q1 2025 Added 27.47%
CCCC C4 Therapeutics, Inc.	$112M	$126,000 0.0% of portfolio	79,275	Q1 2025 Added 3.66%
RAPT Rapt Therapeutics, Inc.	$375M	$102,000 0.0% of portfolio	83,923	Q1 2025 Reduced 89.1%
STRO Sutro Biopharma, Inc.	$48M	$102,000 0.0% of portfolio	158,037	Q1 2025 Added 0.22%
ATXS Astria Therapeutics, Inc.	$94.6M	$100,000 0.0% of portfolio	18,757	Q1 2025 Added 64.9%
BMEA Biomea Fusion, Inc.	$53M	$96,000 0.0% of portfolio	45,238	Q1 2025 Reduced 61.22%
TNGX Tango Therapeutics, Inc.	$594M	$93,000 0.0% of portfolio	68,269	Q1 2025 Reduced 40.55%
SANA Sana Biotechnology, Inc.	$976M	$87,000 0.0% of portfolio	51,962	Q1 2025 New
FDMT 4 D Molecular Therapeutics, Inc.	$149M	$81,000 0.0% of portfolio	25,340	Q1 2025 Reduced 29.68%
NKTR Nektar Therapeutics	$4.61B	$78,000 0.0% of portfolio	115,190	Q1 2025 Reduced 34.25%
VTYX Ventyx Biosciences, Inc.	$181M	$76,000 0.0% of portfolio	66,193	Q1 2025 Added 26.73%
FHTX Foghorn Therapeutics Inc.	$258M	$54,000 0.0% of portfolio	14,875	Q1 2025 Reduced 85.18%
INZY Inozyme Pharma, Inc.	$161M	$48,000 0.0% of portfolio	53,381	Q1 2025 Added 199.67%
ALXO Alx Oncology Holdings Inc	$22M	$47,000 0.0% of portfolio	75,900	Q1 2025 Reduced 70.34%
ERAS Erasca, Inc.	$209M	$43,000 0.0% of portfolio	31,429	Q1 2025 Reduced 91.49%
LYEL Lyell Immunopharma, Inc.	$2.58B	$41,000 0.0% of portfolio	77,178	Q1 2025 Reduced 92.01%
MGNX Macrogenics Inc	$94.6M	$36,000 0.0% of portfolio	28,700	Q1 2025 New
ANVS Annovis Bio, Inc.	$21.6M	$28,000 0.0% of portfolio	18,789	Q1 2025 New
BDTX Black Diamond Therapeutics, Inc.	$118M	$27,000 0.0% of portfolio	17,854	Q1 2025 Added 3.1%
NUVB Nuvation Bio Inc.	$545M	$21,000 0.0% of portfolio	12,100	Q1 2025 Reduced 74.47%
SBTX Silverback Therapeutics, Inc.	$0	$0 0.0% of portfolio	33,797	Q1 2025 Reduced 55.95%

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