Opaleye Management Inc. Rhythm Pharmaceuticals, Inc. Transaction History

Opaleye Management Inc.

$418 Million
Q2 2025

A detailed history of Opaleye Management Inc. transactions in Rhythm Pharmaceuticals, Inc. stock. As of the latest transaction made, Opaleye Management Inc. holds 475,000 shares of RYTM stock, worth $47.4 Million. This represents 7.18% of its overall portfolio holdings.

Number of Shares

475,000

Previous 475,000 -0.0%

Holding current value

$47.4 Million

Previous $30 Million -0.0%

% of portfolio

7.18%

Previous 7.18%

15 transactions

Quarter	Operation	Price Per share	shares change	shares Held
Q2 2025 Aug 14, 2025	SELL	$46.95 - $68.11 $704,250 - $1.02 Million	-15,000 Reduced 3.06%	475,000 $30 Million
Q1 2025 May 15, 2025	SELL	$48.56 - $61.02 $485,600 - $610,200	-10,000 Reduced 2.0%	490,000 $26 Million
Q3 2024 Nov 14, 2024	SELL	$40.81 - $55.0 $612,150 - $825,000	-15,000 Reduced 2.91%	500,000 $26.2 Million
Q1 2024 May 15, 2024	SELL	$39.12 - $52.44 $3.72 Million - $4.98 Million	-95,000 Reduced 15.57%	515,000 $22.3 Million
Q4 2023 Feb 14, 2024	SELL	$21.39 - $49.64 $919,770 - $2.13 Million	-43,000 Reduced 6.58%	610,000 $28 Million
Q3 2023 Nov 14, 2023	SELL	$15.81 - $27.8 $1.3 Million - $2.28 Million	-82,000 Reduced 11.16%	653,000 $15 Million
Q4 2022 Feb 10, 2023	SELL	$22.21 - $30.25 $1.67 Million - $2.27 Million	-75,000 Reduced 9.26%	735,000 $21.4 Million
Q3 2022 Nov 14, 2022	BUY	$4.3 - $30.85 $1.93 Million - $13.8 Million	448,000 Added 123.76%	810,000 $19.8 Million
Q2 2022 Aug 15, 2022	BUY	$3.12 - $12.25 $1.13 Million - $4.43 Million	362,000 New	362,000 $1.5 Million
Q1 2021 May 18, 2021	SELL	$20.25 - $39.49 $2.33 Million - $4.54 Million	-115,000 Closed	0 $0
Q4 2020 Feb 12, 2021	BUY	$21.17 - $32.61 $2.43 Million - $3.75 Million	115,000 New	115,000 $3.42 Million
Q1 2020 May 15, 2020	SELL	$13.16 - $22.9 $1.45 Million - $2.53 Million	-110,500 Closed	0 $0
Q4 2019 Feb 14, 2020	BUY	$19.53 - $25.5 $2.16 Million - $2.82 Million	110,500 New	110,500 $2.54 Million
Q1 2018 May 14, 2018	SELL	$19.9 - $32.25 $762,170 - $1.24 Million	-38,300 Closed	0 $0
Q4 2017 Feb 09, 2018	BUY	$22.0 - $30.51 $842,600 - $1.17 Million	38,300	38,300 $1.11 Million

Others Institutions Holding RYTM

# of Institutions

246

Shares Held

63.9M

Call Options Held

210K

Put Options Held

575K

View Full List

About RHYTHM PHARMACEUTICALS, INC.

Ticker RYTM
Exchange NASDAQ
Sector Healthcare
Industry Biotechnology
Shares Outstandng 55,720,000
Market Cap $5.56B
Description
Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the treatment of rare genetic diseases of obesity. The company's lead product candidate is IMCIVREE, a potent melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convert...

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Opaleye Management Inc. Rhythm Pharmaceuticals, Inc. Transaction History