Opaleye Management Inc. Purchases and Sells in Q3 2025

Opaleye Management Inc.

$600 Million
Q3 2025

Top Buys

Incresed Positions

9 operations

Stock	Shares change	Price Range	Shares Held	Trade History
LQDA	140K + 5.66%	$12.06 - $28.85 $1.69M - $4.04M	2.62M $60M
STOK	120K + 21.33%	$11.48 - $24.73 $1.38M - $2.97M	682K $16M
DERM	876K + 922.17%	$6.9 - $8.54 $6.04M - $7.48M	971K $6.88M
SRPT	85K + 17.0%	$11.93 - $21.97 $1.01M - $1.87M	585K $11.3M
EWTX	10K + 2.04%	$12.61 - $16.59 $126K - $166K	500K $8.11M
CDXS	195K + 1.55%	$2.35 - $3.33 $458K - $649K	12.8M $31.2M

New Holdings

11 operations

Stock	Shares change	Price Range	Shares Held	Trade History
ALKS	450K New	$26.13 - $30.46 $11.8M - $13.7M	450K $13.5M
ANNX	2.6M New	$2.05 - $3.37 $5.33M - $8.76M	2.6M $7.75M
PLX	2.58M New	$1.38 - $2.23 $3.56M - $5.75M	2.58M $5.75M
TMCI	702K New	$5.34 - $7.7 $3.75M - $5.41M	702K $4.71M
ADCT	683K New	$2.64 - $4.02 $1.8M - $2.74M	683K $2.73M
CABA	809K New	$1.33 - $2.47 $1.08M - $2M	809K $1.88M

Top Sells

Reduced Positions

11 operations

Stock	Shares change	Price Range	Shares Held	Trade History
ARVN	-692K - 41.2%	$6.24 - $8.53 $4.32M - $5.9M	988K $8.42M
ZNTL	-1.61M - 83.55%	$1.19 - $1.99 $1.91M - $3.2M	317K $477K
OCUP	-120K - 9.84%	N/A	1.1M $1.08M
ALUMIS INC	-110K - 14.19%	N/A	665K $0
ZYMEWORKS INC	-110K - 52.38%	N/A	100K $0
PEPG	-165K - 68.75%	$1.01 - $5.88 $167K - $970K	75K $346K

Activity Summary All Purchases 20 New Holdings 11 Increased Positions 9 All Sells 11 Reductions 11 Sold out 0 Calls 0 Puts 0

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