Institutional shares held 136 Million
862K calls
582K puts
Total value of holdings $4.65B
$29.4M calls
$19.8M puts
Market Cap $4.67B
141,940,992 Shares Out.
Institutional ownership 96.05%
# of Institutions 408


Latest Institutional Activity in IONS

Top Purchases

Q4 2024
Sovran Advisors, LLC Shares Held: 172K ($5.65M)
Q4 2024
Assenagon Asset Management S.A. Shares Held: 142K ($4.67M)
Q4 2024
Swedbank Ab Shares Held: 124K ($4.08M)
Q4 2024
Abrdn PLC Shares Held: 402K ($13.2M)
Q4 2024
Sg Americas Securities, LLC Shares Held: 23.9K ($787K)

Top Sells

Q4 2024
International Assets Investment Management, LLC Shares Held: 8.21K ($270K)
Q4 2024
Sumitomo Mitsui Trust Holdings, Inc. Shares Held: 157K ($5.15M)
Q4 2024
Davenport & CO LLC Shares Held: 62.7K ($2.06M)
Q4 2024
Sicart Associates LLC Shares Held: 186K ($6.11M)
Q4 2024
Sonora Investment Management Group, LLC Shares Held: 149K ($4.89M)

About IONS

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of TTR amyloidosis; Olezarsen for patients with severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Tofersen to inhibit the production of superoxide dismutase 1. In addition, the company develops medicines for metabolic diseases, infectious diseases, renal diseases, ophthalmic diseases, and cancer. It has a strategic collaboration with Biogen Inc.; and collaboration and license agreement with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.


Insider Transactions at IONS

Insider Transaction List

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Date Insider Transaction Ownership Type Shares Traded Value / Price
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Last 12 Months Summary

Buy / Acquisition
397K Shares
From 33 Insiders
Exercise of conversion of derivative security 315K shares
Open market or private purchase 5K shares
Grant, award, or other acquisition 73.1K shares
Other acquisition or disposition 3.33K shares
Sell / Disposition
205K Shares
From 15 Insiders
Open market or private sale 205K shares

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