Institutional shares held 136 Million
862K calls
582K puts
Total value of holdings $5.26B
$33.2M calls
$22.4M puts
Market Cap $5.43B
141,940,992 Shares Out.
Institutional ownership 96.01%
# of Institutions 403


Latest Institutional Activity in IONS

Top Purchases

Q3 2024
Capital World Investors Shares Held: 7.83M ($300M)
Q3 2024
Wellington Management Group LLP Shares Held: 8.74M ($334M)
Q3 2024
Marshall Wace, LLP Shares Held: 1.92M ($73.5M)
Q3 2024
T. Rowe Price Investment Management, Inc. Shares Held: 14.2M ($542M)
Q3 2024
Vanguard Group Inc Shares Held: 15.1M ($576M)

Top Sells

Q3 2024
Bvf Inc Shares Held: 1.45M ($55.5M)
Q3 2024
Pictet Asset Management Holding Sa Shares Held: 1.3M ($49.9M)
Q3 2024
Clearbridge Investments, LLC Shares Held: 1.7M ($65.1M)
Q3 2024
Bellevue Group Ag Shares Held: 7.87M ($301M)
Q3 2024
Schonfeld Strategic Advisors LLC Shares Held: 363K ($13.9M)

About IONS

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of TTR amyloidosis; Olezarsen for patients with severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Tofersen to inhibit the production of superoxide dismutase 1. In addition, the company develops medicines for metabolic diseases, infectious diseases, renal diseases, ophthalmic diseases, and cancer. It has a strategic collaboration with Biogen Inc.; and collaboration and license agreement with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.


Insider Transactions at IONS

Insider Transaction List

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Date Insider Transaction Ownership Type Shares Traded Value / Price
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Last 12 Months Summary

Buy / Acquisition
745K Shares
From 31 Insiders
Exercise of conversion of derivative security 668K shares
Grant, award, or other acquisition 73.1K shares
Other acquisition or disposition 3.33K shares
Sell / Disposition
577K Shares
From 17 Insiders
Open market or private sale 522K shares
Payment of exercise price or tax liability 54.8K shares

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