Manufacturers Life Insurance Company, The Biotechnology

Manufacturers Life Insurance Company, The

$109 Billion
Q4 2024

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
CLDX Celldex Therapeutics, Inc.	$1.06B	$2.64 Million 0.0% of portfolio	104,376	Q4 2024 Reduced 1.32%
BNTX Bio N Tech Se	$29.1B	$2.62 Million 0.0% of portfolio	22,983	Q4 2024 Added 9.81%
ARWR Arrowhead Pharmaceuticals, Inc.	$2.11B	$2.6 Million 0.0% of portfolio	138,294	Q4 2024 Reduced 2.64%
TARS Tarsus Pharmaceuticals, Inc.	$1.34B	$2.59 Million 0.0% of portfolio	46,777	Q4 2024 Added 42.05%
WVE Wave Life Sciences Ltd.	$939M	$2.57 Million 0.0% of portfolio	207,687	Q4 2024 Added 23.52%
CORT Corcept Therapeutics Inc	$7.79B	$2.51 Million 0.0% of portfolio	49,759	Q4 2024 Reduced 2.43%
LEGN Legend Biotech Corp	$6.1B	$2.5 Million 0.0% of portfolio	76,793	Q4 2024 Reduced 0.27%
REPL Replimune Group, Inc.	$695M	$2.35 Million 0.0% of portfolio	194,004	Q4 2024 Added 5.32%
XNCR Xencor Inc	$974M	$2.31 Million 0.0% of portfolio	100,373	Q4 2024 Reduced 8.52%
DYN Dyne Therapeutics, Inc.	$720M	$2.29 Million 0.0% of portfolio	97,395	Q4 2024 Reduced 8.3%
TGTX Tg Therapeutics, Inc.	$4.46B	$2.27 Million 0.0% of portfolio	75,327	Q4 2024 Reduced 4.88%
IDYA Ideaya Biosciences, Inc.	$1.01B	$2.12 Million 0.0% of portfolio	82,602	Q4 2024 Reduced 16.04%
IOVA Iovance Biotherapeutics, Inc.	$879M	$2.07 Million 0.0% of portfolio	279,627	Q4 2024 Reduced 10.35%
ADMA Adma Biologics, Inc.	$3.12B	$2.07 Million 0.0% of portfolio	120,612	Q4 2024 Reduced 4.82%
IMNM Immunome Inc.	$126M	$1.94 Million 0.0% of portfolio	189,060	Q4 2024 Added 14.24%
RCKT Rocket Pharmaceuticals, Inc.	$792M	$1.92 Million 0.0% of portfolio	152,489	Q4 2024 Added 0.13%
AXSM Axsome Therapeutics, Inc.	$5.62B	$1.89 Million 0.0% of portfolio	22,317	Q4 2024 Reduced 1.35%
PTCT Ptc Therapeutics, Inc.	$3.71B	$1.88 Million 0.0% of portfolio	41,574	Q4 2024 Reduced 3.3%
MRUS Merus N.V.	$1.84B	$1.77 Million 0.0% of portfolio	42,085	Q4 2024 Reduced 17.95%
BCYC Bicycle Therapeutics PLC	$372M	$1.74 Million 0.0% of portfolio	124,497	Q4 2024 Reduced 4.02%
ARVN Arvinas, Inc.	$974M	$1.72 Million 0.0% of portfolio	89,540	Q4 2024 Reduced 0.96%
APLS Apellis Pharmaceuticals, Inc.	$3.01B	$1.69 Million 0.0% of portfolio	52,897	Q4 2024 Reduced 13.6%
VCYT Veracyte, Inc.	$2.94B	$1.59 Million 0.0% of portfolio	40,186	Q4 2024 Reduced 4.13%
GERN Geron Corp	$967M	$1.59 Million 0.0% of portfolio	448,886	Q4 2024 Reduced 35.46%
FOLD Amicus Therapeutics, Inc.	$2.74B	$1.48 Million 0.0% of portfolio	156,788	Q4 2024 Reduced 2.62%
VCEL Vericel Corp	$2.69B	$1.41 Million 0.0% of portfolio	25,593	Q4 2024 Reduced 2.01%
CPRX Catalyst Pharmaceuticals, Inc.	$2.39B	$1.26 Million 0.0% of portfolio	60,366	Q4 2024 Reduced 2.34%
OCUL Ocular Therapeutix, Inc	$560M	$1.09 Million 0.0% of portfolio	127,803	Q4 2024 Reduced 1.84%
EWTX Edgewise Therapeutics, Inc.	$1.6B	$1.07 Million 0.0% of portfolio	40,170	Q4 2024 Added 4.58%
ORIC Oric Pharmaceuticals, Inc.	$331M	$1.05 Million 0.0% of portfolio	130,188	Q4 2024 Reduced 0.35%
ALLO Allogene Therapeutics, Inc.	$293M	$1.03 Million 0.0% of portfolio	484,715	Q4 2024 Reduced 0.27%
LGND Ligand Pharmaceuticals Inc	$2.03B	$1 Million 0.0% of portfolio	9,373	Q4 2024 Added 9.06%
VKTX Viking Therapeutics, Inc.	$2.34B	$992,000 0.0% of portfolio	24,676	Q4 2024 Added 0.19%
IMVT Immunovant, Inc.	$3.55B	$987,000 0.0% of portfolio	35,908	Q4 2024 Reduced 2.1%
PLRX Pliant Therapeutics, Inc.	$148M	$985,000 0.0% of portfolio	74,826	Q4 2024 Reduced 0.59%
TRDA Entrada Therapeutics, Inc.	$422M	$977,000 0.0% of portfolio	56,557	Q4 2024 Reduced 0.52%
PRTA Prothena Corp Public LTD CO	$665M	$972,000 0.0% of portfolio	70,184	Q4 2024 Reduced 18.46%
VRDN Viridian Therapeutics, Inc.\De	$654M	$953,000 0.0% of portfolio	49,720	Q4 2024 Added 101.04%
KOD Kodiak Sciences Inc.	$274M	$902,000 0.0% of portfolio	90,691	Q4 2024 New
RLAY Relay Therapeutics, Inc.	$481M	$901,000 0.0% of portfolio	218,872	Q4 2024 Added 1.54%
MIRM Mirum Pharmaceuticals, Inc.	$1.84B	$894,000 0.0% of portfolio	21,625	Q4 2024 Reduced 2.21%
MNKD Mannkind Corp	$1.39B	$865,000 0.0% of portfolio	134,613	Q4 2024 Reduced 2.97%
RXRX Recursion Pharmaceuticals, Inc.	$1.9B	$843,000 0.0% of portfolio	124,714	Q4 2024 Added 0.05%
ANNX Annexon, Inc.	$145M	$815,000 0.0% of portfolio	159,019	Q4 2024 Reduced 0.36%
GLUE Monte Rosa Therapeutics, Inc.	$317M	$814,000 0.0% of portfolio	117,412	Q4 2024 Reduced 0.39%
PHVS Pharvaris N.V.	$583M	$785,000 0.0% of portfolio	40,978	Q4 2024 Reduced 8.69%
BCRX Biocryst Pharmaceuticals Inc	$1.68B	$778,000 0.0% of portfolio	103,531	Q4 2024 Reduced 65.39%
ARQT Arcutis Biotherapeutics, Inc.	$769M	$709,000 0.0% of portfolio	50,956	Q4 2024 Reduced 2.95%
HRMY Harmony Biosciences Holdings, Inc.	$2.31B	$667,000 0.0% of portfolio	19,385	Q4 2024 Added 12.44%
IMTX Immatics N.V.	$385M	$663,000 0.0% of portfolio	93,279	Q4 2024 Reduced 43.39%

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