Manufacturers Life Insurance Company, The Biotechnology

Manufacturers Life Insurance Company, The

$100 Billion
Q1 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
AXSM Axsome Therapeutics, Inc.	$4.4B	$2.67 Million 0.0% of portfolio	22,851	Q1 2025 Added 2.39%
IONS Ionis Pharmaceuticals Inc	$5.95B	$2.52 Million 0.0% of portfolio	83,440	Q1 2025 Reduced 70.85%
ADMA Adma Biologics, Inc.	$3.35B	$2.48 Million 0.0% of portfolio	125,226	Q1 2025 Added 3.83%
LEGN Legend Biotech Corp	$7.37B	$2.45 Million 0.0% of portfolio	72,310	Q1 2025 Reduced 5.84%
PTCT Ptc Therapeutics, Inc.	$3.32B	$2.2 Million 0.0% of portfolio	43,160	Q1 2025 Added 3.81%
MRUS Merus N.V.	$2.9B	$2.1 Million 0.0% of portfolio	49,906	Q1 2025 Added 18.58%
REPL Replimune Group, Inc.	$139M	$2.03 Million 0.0% of portfolio	208,078	Q1 2025 Added 7.25%
JANX Janux Therapeutics, Inc.	$1.1B	$1.86 Million 0.0% of portfolio	68,745	Q1 2025 Added 8.24%
IMNM Immunome Inc.	$132M	$1.82 Million 0.0% of portfolio	271,130	Q1 2025 Added 43.41%
CLDX Celldex Therapeutics, Inc.	$1.05B	$1.72 Million 0.0% of portfolio	94,785	Q1 2025 Reduced 9.19%
CPRX Catalyst Pharmaceuticals, Inc.	$2.15B	$1.53 Million 0.0% of portfolio	63,165	Q1 2025 Added 4.64%
FOLD Amicus Therapeutics, Inc.	$1.74B	$1.33 Million 0.0% of portfolio	162,623	Q1 2025 Added 3.72%
WVE Wave Life Sciences Ltd.	$688M	$1.26 Million 0.0% of portfolio	155,786	Q1 2025 Reduced 24.99%
EWTX Edgewise Therapeutics, Inc.	$855M	$1.25 Million 0.0% of portfolio	56,988	Q1 2025 Added 41.87%
VCYT Veracyte, Inc.	$1.68B	$1.23 Million 0.0% of portfolio	41,426	Q1 2025 Added 3.09%
IDYA Ideaya Biosciences, Inc.	$1.06B	$1.18 Million 0.0% of portfolio	72,310	Q1 2025 Reduced 12.46%
VCEL Vericel Corp	$1.79B	$1.18 Million 0.0% of portfolio	26,506	Q1 2025 Added 3.57%
BCYC Bicycle Therapeutics PLC	$248M	$1.17 Million 0.0% of portfolio	138,249	Q1 2025 Added 11.05%
XNCR Xencor Inc	$549M	$1.08 Million 0.0% of portfolio	101,407	Q1 2025 Added 1.03%
RCKT Rocket Pharmaceuticals, Inc.	$255M	$1.03 Million 0.0% of portfolio	154,687	Q1 2025 Added 1.44%
LGND Ligand Pharmaceuticals Inc	$2.24B	$1.03 Million 0.0% of portfolio	9,769	Q1 2025 Added 4.22%
MIRM Mirum Pharmaceuticals, Inc.	$1.92B	$1.01 Million 0.0% of portfolio	22,353	Q1 2025 Added 3.37%
IMVT Immunovant, Inc.	$3.55B	$969,000 0.0% of portfolio	35,224	Q1 2025 Reduced 1.9%
ARQT Arcutis Biotherapeutics, Inc.	$876M	$908,000 0.0% of portfolio	58,093	Q1 2025 Added 14.01%
IOVA Iovance Biotherapeutics, Inc.	$494M	$905,000 0.0% of portfolio	271,826	Q1 2025 Reduced 2.79%
ARWR Arrowhead Pharmaceuticals, Inc.	$1.58B	$836,000 0.0% of portfolio	65,685	Q1 2025 Reduced 52.5%
VRDN Viridian Therapeutics, Inc.\De	$677M	$811,000 0.0% of portfolio	60,235	Q1 2025 Added 21.15%
PRTA Prothena Corp Public LTD CO	$306M	$807,000 0.0% of portfolio	65,231	Q1 2025 Reduced 7.06%
BCRX Biocryst Pharmaceuticals Inc	$1.61B	$793,000 0.0% of portfolio	105,769	Q1 2025 Added 2.16%
TVTX Travere Therapeutics, Inc.	$1B	$743,000 0.0% of portfolio	41,489	Q1 2025 Added 51.76%
HRMY Harmony Biosciences Holdings, Inc.	$2.17B	$735,000 0.0% of portfolio	22,154	Q1 2025 Added 14.28%
RXRX Recursion Pharmaceuticals, Inc.	$1.18B	$727,000 0.0% of portfolio	137,484	Q1 2025 Added 10.24%
ORIC Oric Pharmaceuticals, Inc.	$441M	$723,000 0.0% of portfolio	129,657	Q1 2025 Reduced 0.41%
ALLO Allogene Therapeutics, Inc.	$204M	$709,000 0.0% of portfolio	485,866	Q1 2025 Added 0.24%
MNKD Mannkind Corp	$1.01B	$698,000 0.0% of portfolio	138,812	Q1 2025 Added 3.12%
PHVS Pharvaris N.V.	$781M	$643,000 0.0% of portfolio	40,978	Q4 2024 Reduced 8.69%
ARDX Ardelyx, Inc.	$679M	$593,000 0.0% of portfolio	120,962	Q1 2025 Added 3.28%
VKTX Viking Therapeutics, Inc.	$2.46B	$579,000 0.0% of portfolio	23,981	Q1 2025 Reduced 2.82%
ARVN Arvinas, Inc.	$403M	$572,000 0.0% of portfolio	81,537	Q1 2025 Reduced 8.94%
APLS Apellis Pharmaceuticals, Inc.	$2.19B	$545,000 0.0% of portfolio	24,937	Q1 2025 Reduced 52.86%
GLUE Monte Rosa Therapeutics, Inc.	$264M	$544,000 0.0% of portfolio	117,307	Q1 2025 Reduced 0.09%
RLAY Relay Therapeutics, Inc.	$446M	$538,000 0.0% of portfolio	205,579	Q1 2025 Reduced 6.07%
LQDA Liquidia Corp	$1.07B	$531,000 0.0% of portfolio	36,065	Q1 2025 Added 64.93%
INVA Innoviva, Inc.	$1.34B	$523,000 0.0% of portfolio	28,862	Q1 2025 Added 8.45%
OCUL Ocular Therapeutix, Inc	$889M	$522,000 0.0% of portfolio	71,304	Q1 2025 Reduced 44.21%
SNDX Syndax Pharmaceuticals Inc	$583M	$512,000 0.0% of portfolio	41,670	Q1 2025 Reduced 2.84%
TRDA Entrada Therapeutics, Inc.	$200M	$510,000 0.0% of portfolio	56,472	Q1 2025 Reduced 0.15%
HRTX Heron Therapeutics, Inc.	$226M	$504,000 0.0% of portfolio	229,332	Q1 2025 Added 417.85%
NVAX Novavax Inc	$565M	$489,000 0.0% of portfolio	76,330	Q1 2025 Added 3.84%
SANA Sana Biotechnology, Inc.	$926M	$487,000 0.0% of portfolio	290,095	Q1 2025 Reduced 5.88%

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