Manufacturers Life Insurance Company, The Biotechnology

Manufacturers Life Insurance Company, The

$106 Billion
Q2 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
VRTX Vertex Pharmaceuticals Inc	$99.5B	$244 Million 0.23% of portfolio	546,956	Q2 2025 Added 0.01%
REGN Regeneron Pharmaceuticals, Inc.	$59.7B	$199 Million 0.19% of portfolio	379,537	Q2 2025 Reduced 4.7%
BBIO Bridge Bio Pharma, Inc.	$7.28B	$81.7 Million 0.08% of portfolio	1,891,578	Q2 2025 Added 0.2%
JAZZ Jazz Pharmaceuticals PLC	$7.1B	$58.1 Million 0.06% of portfolio	547,937	Q2 2025 Added 6.31%
ARGX Argenx Se	$35.3B	$34.9 Million 0.03% of portfolio	63,243	Q2 2025 Added 5.95%
ALNY Alnylam Pharmaceuticals, Inc.	$52.9B	$28.3 Million 0.03% of portfolio	86,840	Q2 2025 Reduced 12.17%
INSM Insmed Inc	$16.5B	$22.8 Million 0.02% of portfolio	226,265	Q2 2025 Reduced 28.94%
ACAD Acadia Pharmaceuticals Inc	$4.12B	$17 Million 0.02% of portfolio	787,524	Q2 2025 Reduced 2.06%
UTHR United Therapeutics Corp	$13.7B	$16.4 Million 0.02% of portfolio	57,123	Q2 2025 Reduced 20.4%
RARE Ultragenyx Pharmaceutical Inc.	$1.97B	$14.2 Million 0.01% of portfolio	390,389	Q2 2025 Added 33.07%
AXSM Axsome Therapeutics, Inc.	$4.51B	$14 Million 0.01% of portfolio	133,823	Q2 2025 Added 485.63%
HALO Halozyme Therapeutics, Inc.	$8.95B	$13.4 Million 0.01% of portfolio	257,214	Q2 2025 Reduced 19.62%
MRNA Moderna, Inc.	$10B	$10.8 Million 0.01% of portfolio	390,954	Q2 2025 Added 0.18%
VRNA Verona Pharma PLC	$6.41B	$10.6 Million 0.01% of portfolio	112,011	Q2 2025 Reduced 10.19%
ASND Ascendis Pharma A/S	$10.9B	$10.1 Million 0.01% of portfolio	58,251	Q2 2025 Reduced 26.39%
BPMC Blueprint Medicines Corp	$7.73B	$9.58 Million 0.01% of portfolio	74,708	Q2 2025 Reduced 54.46%
EXEL Exelixis, Inc.	$12.1B	$9.23 Million 0.01% of portfolio	209,367	Q2 2025 Reduced 9.51%
INCY Incyte Corp	$18.2B	$9.09 Million 0.01% of portfolio	133,544	Q2 2025 Reduced 16.33%
BMRN Biomarin Pharmaceutical Inc	$10.6B	$7.62 Million 0.01% of portfolio	138,659	Q2 2025 Reduced 0.44%
RNA Avidity Biosciences, Inc.	$2.41B	$7.48 Million 0.01% of portfolio	263,334	Q2 2025 Reduced 0.45%
SRRK Scholar Rock Holding Corp	$1.66B	$7.41 Million 0.01% of portfolio	209,206	Q2 2025 Reduced 2.88%
AKRO Akero Therapeutics, Inc.	$2.23B	$7.41 Million 0.01% of portfolio	138,834	Q2 2025 Reduced 8.23%
MDGL Madrigal Pharmaceuticals, Inc.	$6.14B	$7.09 Million 0.01% of portfolio	23,416	Q2 2025 Added 2.05%
PCVX Vaxcyte, Inc.	$1.78B	$6.76 Million 0.01% of portfolio	208,010	Q2 2025 Added 35.82%
KYMR Kymera Therapeutics, Inc.	$2.18B	$6.64 Million 0.01% of portfolio	152,165	Q2 2025 Added 6.72%
TECH Bio Techne Corp	$2.07B	$6.32 Million 0.01% of portfolio	122,811	Q2 2025 Reduced 33.98%
RVMD Revolution Medicines, Inc.	$3.09B	$6.12 Million 0.01% of portfolio	166,386	Q2 2025 Reduced 30.7%
CYTK Cytokinetics Inc	$3.23B	$5.79 Million 0.01% of portfolio	175,279	Q2 2025 Added 4.53%
SMMT Summit Therapeutics Inc.	$5.17B	$5.61 Million 0.01% of portfolio	263,641	Q2 2025 Reduced 43.44%
RPRX Royalty Pharma PLC	$15.7B	$5.29 Million 0.01% of portfolio	146,952	Q2 2025 Reduced 65.73%
PTGX Protagonist Therapeutics, Inc	$2.68B	$5.24 Million 0.0% of portfolio	94,801	Q2 2025 Reduced 21.55%
MLTX Moon Lake Immunotherapeutics	$2.04B	$5.19 Million 0.0% of portfolio	109,969	Q2 2025 Reduced 11.96%
NUVL Nuvalent, Inc.	$3.29B	$5.05 Million 0.0% of portfolio	66,195	Q2 2025 Added 11.35%
CRNX Crinetics Pharmaceuticals, Inc.	$1.53B	$4.46 Million 0.0% of portfolio	154,980	Q2 2025 Added 14.98%
DNLI Denali Therapeutics Inc.	$1.77B	$4.41 Million 0.0% of portfolio	315,102	Q2 2025 Added 22.07%
AGIO Agios Pharmaceuticals, Inc.	$1.94B	$4.39 Million 0.0% of portfolio	132,083	Q2 2025 Added 0.39%
ROIV Roivant Sciences Ltd.	$8.15B	$4.35 Million 0.0% of portfolio	385,949	Q2 2025 Added 16.32%
RYTM Rhythm Pharmaceuticals, Inc.	$5.51B	$4.31 Million 0.0% of portfolio	68,132	Q2 2025 Added 5.82%
CNTA Centessa Pharmaceuticals PLC	$1.61B	$4.17 Million 0.0% of portfolio	317,574	Q2 2025 Added 4.93%
ACLX Arcellx, Inc.	$3.19B	$3.96 Million 0.0% of portfolio	60,155	Q2 2025 Reduced 30.72%
KRYS Krystal Biotech, Inc.	$3.69B	$3.39 Million 0.0% of portfolio	24,680	Q2 2025 Reduced 23.75%
VERA Vera Therapeutics, Inc.	$572M	$3.3 Million 0.0% of portfolio	139,864	Q2 2025 Reduced 1.09%
IONS Ionis Pharmaceuticals Inc	$5.85B	$3.29 Million 0.0% of portfolio	83,386	Q2 2025 Reduced 0.06%
MRUS Merus N.V.	$2.93B	$3.15 Million 0.0% of portfolio	59,893	Q2 2025 Added 20.01%
LEGN Legend Biotech Corp	$6.19B	$2.98 Million 0.0% of portfolio	84,081	Q2 2025 Added 16.28%
TGTX Tg Therapeutics, Inc.	$3.94B	$2.86 Million 0.0% of portfolio	79,370	Q2 2025 Reduced 2.16%
IMNM Immunome Inc.	$120M	$2.61 Million 0.0% of portfolio	280,816	Q2 2025 Added 3.57%
IMCR Immunocore Holdings PLC	$1.4B	$2.6 Million 0.0% of portfolio	82,738	Q2 2025 Reduced 12.83%
BEAM Beam Therapeutics Inc.	$1.19B	$2.55 Million 0.0% of portfolio	150,027	Q2 2025 Reduced 12.06%
CLDX Celldex Therapeutics, Inc.	$1.11B	$2.53 Million 0.0% of portfolio	124,546	Q2 2025 Added 31.4%

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