Manufacturers Life Insurance Company, The Biotechnology

Manufacturers Life Insurance Company, The

$100 Billion
Q1 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
VRTX Vertex Pharmaceuticals Inc	$114B	$265 Million 0.26% of portfolio	546,904	Q1 2025 Added 0.28%
REGN Regeneron Pharmaceuticals, Inc.	$64.7B	$253 Million 0.25% of portfolio	398,236	Q1 2025 Added 11.74%
BBIO Bridge Bio Pharma, Inc.	$4.94B	$65.3 Million 0.07% of portfolio	1,887,763	Q1 2025 Added 0.1%
JAZZ Jazz Pharmaceuticals PLC	$6.77B	$64 Million 0.06% of portfolio	515,407	Q1 2025 Added 45.81%
ARGX Argenx Se	$32.5B	$35.3 Million 0.04% of portfolio	59,694	Q1 2025 Reduced 3.89%
ALNY Alnylam Pharmaceuticals, Inc.	$35.7B	$26.7 Million 0.03% of portfolio	98,869	Q1 2025 Reduced 9.38%
INSM Insmed Inc	$9.15B	$24.3 Million 0.02% of portfolio	318,392	Q1 2025 Added 1.66%
UTHR United Therapeutics Corp	$14B	$22.1 Million 0.02% of portfolio	71,761	Q1 2025 Reduced 41.81%
HALO Halozyme Therapeutics, Inc.	$7.6B	$20.4 Million 0.02% of portfolio	320,017	Q1 2025 Added 12.73%
BPMC Blueprint Medicines Corp	$6.06B	$14.5 Million 0.01% of portfolio	164,055	Q1 2025 Reduced 7.04%
ZLAB Zai Lab LTD	$3.07B	$14.5 Million 0.01% of portfolio	401,082	Q1 2025 Added 150.09%
ACAD Acadia Pharmaceuticals Inc	$3.56B	$13.4 Million 0.01% of portfolio	804,119	Q1 2025 Added 28.04%
RPRX Royalty Pharma PLC	$14.2B	$13.3 Million 0.01% of portfolio	428,775	Q1 2025 Added 182.17%
BGNE Bei Gene, Ltd.	$23.5B	$12.8 Million 0.01% of portfolio	56,248	Q1 2025 Reduced 5.99%
SRPT Sarepta Therapeutics, Inc.	$3.32B	$12.6 Million 0.01% of portfolio	197,620	Q1 2025 Added 2.05%
ASND Ascendis Pharma A/S	$9.04B	$12.3 Million 0.01% of portfolio	79,132	Q1 2025 Reduced 4.61%
MRNA Moderna, Inc.	$10.5B	$11.1 Million 0.01% of portfolio	390,266	Q1 2025 Reduced 88.32%
TECH Bio Techne Corp	$1.83B	$10.9 Million 0.01% of portfolio	186,018	Q1 2025 Reduced 5.29%
RARE Ultragenyx Pharmaceutical Inc.	$2.5B	$10.6 Million 0.01% of portfolio	293,374	Q1 2025 Added 35.45%
BMRN Biomarin Pharmaceutical Inc	$10.7B	$9.84 Million 0.01% of portfolio	139,267	Q1 2025 Reduced 9.74%
INCY Incyte Corp	$14.3B	$9.66 Million 0.01% of portfolio	159,605	Q1 2025 Reduced 13.67%
SMMT Summit Therapeutics Inc.	$5.19B	$8.99 Million 0.01% of portfolio	466,164	Q1 2025 Reduced 2.23%
EXEL Exelixis, Inc.	$13.6B	$8.54 Million 0.01% of portfolio	231,380	Q1 2025 Reduced 2.52%
RVMD Revolution Medicines, Inc.	$3.49B	$8.49 Million 0.01% of portfolio	240,095	Q1 2025 Added 1.08%
VRNA Verona Pharma PLC	$4.6B	$7.92 Million 0.01% of portfolio	124,721	Q1 2025 Reduced 1.59%
RNA Avidity Biosciences, Inc.	$1.59B	$7.81 Million 0.01% of portfolio	264,513	Q1 2025 Added 0.08%
MDGL Madrigal Pharmaceuticals, Inc.	$4.58B	$7.6 Million 0.01% of portfolio	22,945	Q1 2025 Reduced 4.71%
SRRK Scholar Rock Holding Corp	$1.59B	$6.93 Million 0.01% of portfolio	215,405	Q1 2025 Added 1.26%
CYTK Cytokinetics Inc	$2.88B	$6.74 Million 0.01% of portfolio	167,684	Q1 2025 Reduced 11.06%
AKRO Akero Therapeutics, Inc.	$2.22B	$6.12 Million 0.01% of portfolio	151,290	Q1 2025 Added 21.43%
PTGX Protagonist Therapeutics, Inc	$2.26B	$5.84 Million 0.01% of portfolio	120,850	Q1 2025 Reduced 2.81%
KRYS Krystal Biotech, Inc.	$3.21B	$5.84 Million 0.01% of portfolio	32,366	Q1 2025 Reduced 8.07%
CORT Corcept Therapeutics Inc	$8.43B	$5.82 Million 0.01% of portfolio	50,977	Q1 2025 Added 2.45%
PCVX Vaxcyte, Inc.	$1.88B	$5.78 Million 0.01% of portfolio	153,152	Q1 2025 Reduced 3.39%
ACLX Arcellx, Inc.	$2.71B	$5.7 Million 0.01% of portfolio	86,828	Q1 2025 Reduced 11.68%
MLTX Moon Lake Immunotherapeutics	$1.42B	$4.88 Million 0.0% of portfolio	124,904	Q1 2025 Reduced 12.47%
SWTX Spring Works Therapeutics, Inc.	$2.9B	$4.64 Million 0.0% of portfolio	105,217	Q1 2025 Reduced 74.19%
CRNX Crinetics Pharmaceuticals, Inc.	$1.59B	$4.52 Million 0.0% of portfolio	134,793	Q1 2025 Reduced 9.51%
CNTA Centessa Pharmaceuticals PLC	$1.21B	$4.35 Million 0.0% of portfolio	302,646	Q1 2025 Reduced 4.63%
NUVL Nuvalent, Inc.	$3.16B	$4.22 Million 0.0% of portfolio	59,449	Q1 2025 Added 22.9%
KYMR Kymera Therapeutics, Inc.	$1.61B	$3.9 Million 0.0% of portfolio	142,587	Q1 2025 Reduced 3.2%
AGIO Agios Pharmaceuticals, Inc.	$1.63B	$3.86 Million 0.0% of portfolio	131,571	Q1 2025 Added 7.76%
DNLI Denali Therapeutics Inc.	$1.8B	$3.51 Million 0.0% of portfolio	258,132	Q1 2025 Added 23.79%
RYTM Rhythm Pharmaceuticals, Inc.	$3.3B	$3.41 Million 0.0% of portfolio	64,386	Q1 2025 Added 7.37%
VERA Vera Therapeutics, Inc.	$522M	$3.4 Million 0.0% of portfolio	141,409	Q1 2025 Added 10.15%
ROIV Roivant Sciences Ltd.	$7.66B	$3.35 Million 0.0% of portfolio	331,802	Q1 2025 Reduced 1.84%
BEAM Beam Therapeutics Inc.	$1.2B	$3.33 Million 0.0% of portfolio	170,608	Q1 2025 Added 18.89%
TGTX Tg Therapeutics, Inc.	$5.02B	$3.2 Million 0.0% of portfolio	81,125	Q1 2025 Added 7.7%
TARS Tarsus Pharmaceuticals, Inc.	$1.15B	$2.87 Million 0.0% of portfolio	55,837	Q1 2025 Added 19.37%
IMCR Immunocore Holdings PLC	$1.37B	$2.82 Million 0.0% of portfolio	94,919	Q1 2025 Reduced 16.85%

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