Manufacturers Life Insurance Company, The Biotechnology

Manufacturers Life Insurance Company, The

$100 Billion
Q1 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
AVIR Atea Pharmaceuticals, Inc.	$286M	$91,000 0.0% of portfolio	30,569	Q1 2025 Reduced 5.48%
MRVI Maravai Lifesciences Holdings, Inc.	$333M	$91,000 0.0% of portfolio	41,368	Q1 2025 Reduced 28.21%
KMPH Kempharm, Inc	$170M	$91,000 0.0% of portfolio	18,544	Q1 2025 Added 5.12%
PHAT Phathom Pharmaceuticals, Inc.	$309M	$90,000 0.0% of portfolio	14,462	Q1 2025 Added 3.37%
TSVT 2seventy Bio, Inc.	$189M	$89,000 0.0% of portfolio	18,031	Q1 2025 Reduced 3.82%
STOK Stoke Therapeutics, Inc.	$535M	$88,000 0.0% of portfolio	13,237	Q1 2025 Reduced 0.5%
TSHA Taysha Gene Therapies, Inc.	$126M	$88,000 0.0% of portfolio	63,797	Q1 2025 Added 1.25%
PGEN Precigen, Inc.	$316M	$83,000 0.0% of portfolio	56,280	Q1 2025 New
CABA Cabaletta Bio, Inc.	$47.6M	$79,000 0.0% of portfolio	57,036	Q1 2025 Added 1.36%
CDXS Codexis, Inc.	$200M	$76,000 0.0% of portfolio	28,392	Q1 2025 Added 3.01%
CMPX Compass Therapeutics, Inc.	$311M	$75,000 0.0% of portfolio	39,501	Q1 2025 Reduced 5.91%
ABSI Absci Corp	$337M	$74,000 0.0% of portfolio	29,590	Q1 2025 Reduced 2.89%
TERN Terns Pharmaceuticals, Inc.	$216M	$69,000 0.0% of portfolio	25,165	Q1 2025 Added 3.23%
OCGN Ocugen, Inc.	$223M	$68,000 0.0% of portfolio	96,231	Q1 2025 Reduced 6.82%
FULC Fulcrum Therapeutics, Inc.	$367M	$64,000 0.0% of portfolio	22,411	Q1 2025 Reduced 4.51%
ITOS I Teos Therapeutics, Inc.	$360M	$64,000 0.0% of portfolio	10,882	Q1 2025 Added 0.89%
YMAB Y M Abs Therapeutics, Inc.	$193M	$61,000 0.0% of portfolio	13,939	Q1 2025 Added 0.88%
FDMT 4 D Molecular Therapeutics, Inc.	$146M	$60,000 0.0% of portfolio	18,592	Q1 2025 Added 0.62%
GBIO Generation Bio Co.	$252M	$57,000 0.0% of portfolio	143,980	Q1 2025 Reduced 0.77%
OLMA Olema Pharmaceuticals, Inc.	$184M	$57,000 0.0% of portfolio	15,296	Q1 2025 Added 1.14%
CRDF Cardiff Oncology, Inc.	$167M	$55,000 0.0% of portfolio	17,724	Q1 2025 Added 14.44%
HUMA Humacyte, Inc.	$237M	$55,000 0.0% of portfolio	32,553	Q1 2025 Reduced 25.9%
ADGI Adagio Therapeutics, Inc.	$505M	$53,000 0.0% of portfolio	16,093	Q1 2025 New
PRLD Prelude Therapeutics Inc	$30.9M	$53,000 0.0% of portfolio	69,252	Q1 2025 Reduced 1.13%
DSGN Design Therapeutics, Inc.	$237M	$50,000 0.0% of portfolio	12,957	Q1 2025 Reduced 0.86%
PBYI Puma Biotechnology, Inc.	$159M	$48,000 0.0% of portfolio	16,506	Q1 2025 New
QSI Quantum Si Inc	$215M	$46,000 0.0% of portfolio	38,518	Q1 2025 Added 10.53%
NKTR Nektar Therapeutics	$4.59B	$44,000 0.0% of portfolio	64,853	Q1 2025 Reduced 0.34%
AUTL Autolus Therapeutics PLC	$237M	$42,000 0.0% of portfolio	27,130	Q1 2025 Reduced 4.25%
ADCT Adc Therapeutics Sa	$237M	$41,000 0.0% of portfolio	29,695	Q1 2025 Added 3.87%
EDIT Editas Medicine, Inc.	$231M	$39,000 0.0% of portfolio	33,734	Q1 2025 Added 2.02%
NKTX Nkarta, Inc.	$101M	$38,000 0.0% of portfolio	21,151	Q1 2025 Added 4.52%
ZNTL Zentalis Pharmaceuticals, Inc.	$81.5M	$36,000 0.0% of portfolio	22,874	Q1 2025 Reduced 82.16%
CCCC C4 Therapeutics, Inc.	$109M	$35,000 0.0% of portfolio	22,021	Q1 2025 Added 2.08%
KOD Kodiak Sciences Inc.	$290M	$34,000 0.0% of portfolio	12,424	Q1 2025 Reduced 86.3%
LRMR Larimar Therapeutics, Inc.	$149M	$34,000 0.0% of portfolio	16,216	Q1 2025 Added 3.27%
PROK Prokidney Corp Ord Shs Cl A(Cy	$188M	$34,000 0.0% of portfolio	38,798	Q1 2025 Added 2.21%
CHRS Coherus Bio Sciences, Inc.	$71.5M	$30,000 0.0% of portfolio	37,848	Q1 2025 Reduced 0.15%
MGNX Macrogenics Inc	$94.6M	$30,000 0.0% of portfolio	23,914	Q1 2025 Reduced 80.24%
FATE Fate Therapeutics Inc	$120M	$29,000 0.0% of portfolio	37,096	Q1 2025 Reduced 3.4%
CRBU Caribou Biosciences, Inc.	$144M	$28,000 0.0% of portfolio	31,076	Q1 2025 Reduced 7.54%
PLRX Pliant Therapeutics, Inc.	$76.4M	$28,000 0.0% of portfolio	21,223	Q1 2025 Reduced 71.64%
SCPH Sc Pharmaceuticals Inc.	$147M	$28,000 0.0% of portfolio	11,004	Q1 2025 New
VTYX Ventyx Biosciences, Inc.	$171M	$27,000 0.0% of portfolio	23,753	Q1 2025 Added 1.1%
TNGX Tango Therapeutics, Inc.	$588M	$26,000 0.0% of portfolio	19,438	Q1 2025 Added 0.74%
BMEA Biomea Fusion, Inc.	$53.3M	$22,000 0.0% of portfolio	10,743	Q1 2025 Added 2.25%
SAVA Cassava Sciences Inc	$103M	$20,000 0.0% of portfolio	13,998	Q1 2025 Reduced 6.32%
STRO Sutro Biopharma, Inc.	$44.9M	$20,000 0.0% of portfolio	30,993	Q1 2025 Added 0.36%
BDTX Black Diamond Therapeutics, Inc.	$118M	$15,000 0.0% of portfolio	10,062	Q1 2025 New
ATOS Atossa Therapeutics, Inc.	$109M	$12,000 0.0% of portfolio	19,020	Q1 2025 Reduced 58.95%

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