Manufacturers Life Insurance Company, The Biotechnology

Manufacturers Life Insurance Company, The

$108 Billion
Q3 2024

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
REGN Regeneron Pharmaceuticals, Inc.	$79.1B	$355 Million 0.33% of portfolio	338,044	Q3 2024 Reduced 0.74%
VRTX Vertex Pharmaceuticals Inc	$116B	$289 Million 0.27% of portfolio	622,225	Q3 2024 Reduced 1.79%
MRNA Moderna, Inc.	$16.1B	$205 Million 0.19% of portfolio	3,073,934	Q3 2024 Added 6.18%
ALNY Alnylam Pharmaceuticals, Inc.	$30.1B	$52.6 Million 0.05% of portfolio	191,382	Q3 2024 Reduced 41.84%
BBIO Bridge Bio Pharma, Inc.	$3.47B	$39 Million 0.04% of portfolio	1,532,224	Q3 2024 Reduced 0.18%
JAZZ Jazz Pharmaceuticals PLC	$7.94B	$38.8 Million 0.04% of portfolio	347,752	Q3 2024 Reduced 0.86%
UTHR United Therapeutics Corp	$17B	$34.9 Million 0.03% of portfolio	97,469	Q3 2024 Reduced 1.33%
ARGX Argenx Se	$33.5B	$33.4 Million 0.03% of portfolio	61,586	Q3 2024 Added 11.1%
INSM Insmed Inc	$9.91B	$21 Million 0.02% of portfolio	288,073	Q3 2024 Added 1.79%
PCVX Vaxcyte, Inc.	$5.25B	$17.9 Million 0.02% of portfolio	157,024	Q3 2024 Added 19.18%
TECH Bio Techne Corp	$2.8B	$15.9 Million 0.01% of portfolio	199,340	Q3 2024 Reduced 11.03%
HALO Halozyme Therapeutics, Inc.	$6.83B	$14.9 Million 0.01% of portfolio	260,355	Q3 2024 Reduced 1.84%
BPMC Blueprint Medicines Corp	$5.62B	$13.9 Million 0.01% of portfolio	149,996	Q3 2024 Reduced 11.12%
RARE Ultragenyx Pharmaceutical Inc.	$3.31B	$13.2 Million 0.01% of portfolio	238,055	Q3 2024 Reduced 3.68%
BGNE Bei Gene, Ltd.	$19.8B	$12.9 Million 0.01% of portfolio	57,384	Q3 2024 Added 14.17%
IONS Ionis Pharmaceuticals Inc	$4.83B	$12.4 Million 0.01% of portfolio	308,947	Q3 2024 Added 12.41%
NVO Novo Nordisk A S	$237B	$12.1 Million 0.01% of portfolio	101,261	Q3 2024 Reduced 23.21%
RNA Avidity Biosciences, Inc.	$2.25B	$11.8 Million 0.01% of portfolio	257,456	Q3 2024 Reduced 5.61%
CYTK Cytokinetics Inc	$4.62B	$11.3 Million 0.01% of portfolio	214,832	Q3 2024 Added 23.63%
BMRN Biomarin Pharmaceutical Inc	$11.9B	$11.2 Million 0.01% of portfolio	159,917	Q3 2024 Reduced 11.46%
INCY Incyte Corp	$16B	$10.9 Million 0.01% of portfolio	165,537	Q3 2024 Added 33.29%
ASND Ascendis Pharma A/S	$7.24B	$10.6 Million 0.01% of portfolio	71,307	Q3 2024 Added 49.45%
RVMD Revolution Medicines, Inc.	$4.98B	$9.64 Million 0.01% of portfolio	212,841	Q3 2024 Added 0.22%
SRPT Sarepta Therapeutics, Inc.	$10B	$9.34 Million 0.01% of portfolio	74,778	Q3 2024 Reduced 16.47%
SWTX Spring Works Therapeutics, Inc.	$2.43B	$9.15 Million 0.01% of portfolio	285,555	Q3 2024 Added 131.37%
ACLX Arcellx, Inc.	$3.96B	$7.08 Million 0.01% of portfolio	84,839	Q3 2024 Added 15.69%
CRNX Crinetics Pharmaceuticals, Inc.	$3.01B	$6.85 Million 0.01% of portfolio	134,087	Q3 2024 Added 2.31%
SMMT Summit Therapeutics Inc.	$3.81B	$6.47 Million 0.01% of portfolio	295,629	Q3 2024 Added 43.47%
AGIO Agios Pharmaceuticals, Inc.	$3.05B	$6.37 Million 0.01% of portfolio	143,431	Q3 2024 Added 4.05%
ACAD Acadia Pharmaceuticals Inc	$2.65B	$6.36 Million 0.01% of portfolio	413,269	Q3 2024 Reduced 10.56%
MDGL Madrigal Pharmaceuticals, Inc.	$5.94B	$6.36 Million 0.01% of portfolio	29,957	Q3 2024 Reduced 16.04%
EXEL Exelixis, Inc.	$11.5B	$6.25 Million 0.01% of portfolio	241,037	Q3 2024 Reduced 5.04%
KYMR Kymera Therapeutics, Inc.	$2.46B	$6.07 Million 0.01% of portfolio	128,267	Q3 2024 Reduced 1.39%
DNLI Denali Therapeutics Inc.	$3.31B	$6.02 Million 0.01% of portfolio	206,819	Q3 2024 Added 20.05%
MLTX Moon Lake Immunotherapeutics	$2.01B	$5.96 Million 0.01% of portfolio	118,126	Q3 2024 Added 3.41%
KRYS Krystal Biotech, Inc.	$4.89B	$5.68 Million 0.01% of portfolio	31,225	Q3 2024 Reduced 23.87%
PTGX Protagonist Therapeutics, Inc	$2.28B	$5.2 Million 0.0% of portfolio	115,765	Q3 2024 Added 1.19%
NUVL Nuvalent, Inc.	$4.08B	$4.68 Million 0.0% of portfolio	45,705	Q3 2024 Added 100.5%
VERA Vera Therapeutics, Inc.	$1.31B	$4.5 Million 0.0% of portfolio	101,861	Q3 2024 Reduced 0.17%
RPRX Royalty Pharma PLC	$11.6B	$4.3 Million 0.0% of portfolio	152,027	Q3 2024 Reduced 45.68%
CNTA Centessa Pharmaceuticals PLC	$1.61B	$4.24 Million 0.0% of portfolio	264,969	Q3 2024 Added 88.06%
ROIV Roivant Sciences Ltd.	$8.83B	$4.12 Million 0.0% of portfolio	356,600	Q3 2024 Added 10.76%
DYN Dyne Therapeutics, Inc.	$1.54B	$3.82 Million 0.0% of portfolio	106,215	Q3 2024 Reduced 15.87%
LBPH Longboard Pharmaceuticals, Inc.	$812M	$3.78 Million 0.0% of portfolio	113,411	Q3 2024 Reduced 3.68%
LEGN Legend Biotech Corp	$6.85B	$3.75 Million 0.0% of portfolio	76,998	Q3 2024 Reduced 10.89%
CLDX Celldex Therapeutics, Inc.	$1.26B	$3.59 Million 0.0% of portfolio	105,777	Q3 2024 Reduced 18.5%
BEAM Beam Therapeutics Inc.	$1.76B	$3.57 Million 0.0% of portfolio	145,851	Q3 2024 Added 6.39%
IMCR Immunocore Holdings PLC	$1.42B	$3.34 Million 0.0% of portfolio	107,391	Q3 2024 Reduced 11.8%
GERN Geron Corp	$1.54B	$3.16 Million 0.0% of portfolio	695,535	Q3 2024 Reduced 24.06%
IDYA Ideaya Biosciences, Inc.	$1.29B	$3.12 Million 0.0% of portfolio	98,387	Q3 2024 Reduced 6.1%

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