Sig Brokerage, LP Biotechnology

Sig Brokerage, LP

Stock	Option Type	Value	Options Held	Last Trade
REGN Regeneron Pharmaceuticals, Inc.	CALL	$8.88 Billion	14K	Q4 2024 New holding
NVO Novo Nordisk A S	PUT	$7.99 Billion	115K	Q4 2024 New holding
VRTX Vertex Pharmaceuticals Inc	CALL	$4.85 Billion	10K	Q1 2025 Reduced 42.21%
VRTX Vertex Pharmaceuticals Inc	PUT	$3.64 Billion	7.5K	Q1 2025 Reduced 42.21%
MDGL Madrigal Pharmaceuticals, Inc.	CALL	$1.82 Billion	5.5K	N/A
NVO Novo Nordisk A S	CALL	$861 Million	12.4K	Q4 2024 New holding
SRRK Scholar Rock Holding Corp	PUT	$762 Million	23.7K	Q1 2025 Added 15.99%
RVMD Revolution Medicines, Inc.	PUT	$598 Million	16.9K	Q1 2025 New holding
SRPT Sarepta Therapeutics, Inc.	CALL	$549 Million	8.6K	N/A
ALNY Alnylam Pharmaceuticals, Inc.	PUT	$540 Million	2K	N/A
ALNY Alnylam Pharmaceuticals, Inc.	CALL	$540 Million	2K	N/A
BGNE Bei Gene, Ltd.	CALL	$408 Million	1.5K	N/A
BGNE Bei Gene, Ltd.	PUT	$408 Million	1.5K	N/A
BBIO Bridge Bio Pharma, Inc.	PUT	$346 Million	10K	N/A
RYTM Rhythm Pharmaceuticals, Inc.	CALL	$265 Million	5K	N/A
SNDX Syndax Pharmaceuticals Inc	PUT	$246 Million	20K	N/A
PTGX Protagonist Therapeutics, Inc	PUT	$242 Million	5K	N/A
MRNA Moderna, Inc.	CALL	$227 Million	8K	N/A
CAPR Capricor Therapeutics, Inc.	CALL	$222 Million	23.4K	N/A
ARDX Ardelyx, Inc.	PUT	$191 Million	38.8K	Q1 2025 New holding
CAPR Capricor Therapeutics, Inc.	PUT	$190 Million	20K	N/A
AVXL Anavex Life Sciences Corp.	CALL	$85.8 Million	10K	N/A
CMPX Compass Therapeutics, Inc.	CALL	$76 Million	40K	N/A

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