Jim Simons Biotechnology

Renaissance Technologies LLC

$70.6 Billion
Q3 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade
UTHR United Therapeutics Corp	$21.2B	$911 Million 1.29% of portfolio	2,173,392	Q3 2025 Added 2.56%
EXEL Exelixis, Inc.	$13.4B	$638 Million 0.9% of portfolio	15,459,266	Q3 2025 Reduced 2.28%
CORT Corcept Therapeutics Inc	$8.09B	$506 Million 0.72% of portfolio	6,089,347	Q3 2025 Reduced 2.83%
INCY Incyte Corp	$23.2B	$384 Million 0.54% of portfolio	4,528,132	Q3 2025 Added 16.65%
VRTX Vertex Pharmaceuticals Inc	$111B	$288 Million 0.41% of portfolio	735,888	Q3 2025 Reduced 26.77%
NVO Novo Nordisk A S	$109B	$160 Million 0.23% of portfolio	2,881,996	Q3 2025 Reduced 41.62%
REGN Regeneron Pharmaceuticals, Inc.	$74.3B	$155 Million 0.22% of portfolio	275,162	Q3 2025 Added 510.63%
JAZZ Jazz Pharmaceuticals PLC	$8.84B	$122 Million 0.17% of portfolio	924,874	Q3 2025 Added 2.72%
BMRN Biomarin Pharmaceutical Inc	$10.2B	$103 Million 0.15% of portfolio	1,893,571	Q3 2025 Added 4.8%
GMAB Genmab A/S	$19.9B	$86.5 Million 0.12% of portfolio	2,821,543	Q3 2025 Added 1.98%
INVA Innoviva, Inc.	$1.55B	$83.7 Million 0.12% of portfolio	4,586,932	Q3 2025 Reduced 3.65%
HALO Halozyme Therapeutics, Inc.	$9.75B	$73.4 Million 0.1% of portfolio	1,000,209	Q3 2025 Added 195.39%
CPRX Catalyst Pharmaceuticals, Inc.	$2.38B	$69.8 Million 0.1% of portfolio	3,544,830	Q3 2025 Added 9.02%
VRNA Verona Pharma PLC	$6.52B	$65.7 Million 0.09% of portfolio	615,900	Q3 2025 Added 317.84%
PTCT Ptc Therapeutics, Inc.	$5.39B	$56.9 Million 0.08% of portfolio	927,300	Q3 2025 Reduced 3.74%
MDGL Madrigal Pharmaceuticals, Inc.	$9.05B	$55.4 Million 0.08% of portfolio	120,682	Q3 2025 Added 1,013.71%
RYTM Rhythm Pharmaceuticals, Inc.	$5.54B	$55.2 Million 0.08% of portfolio	546,593	Q3 2025 Added 73.58%
SRPT Sarepta Therapeutics, Inc.	$1.65B	$51.1 Million 0.07% of portfolio	2,650,178	Q3 2025 Added 324.38%
INSM Insmed Inc	$26.2B	$50.8 Million 0.07% of portfolio	352,887	Q3 2025 Added 14.32%
TVTX Travere Therapeutics, Inc.	$2.21B	$41.9 Million 0.06% of portfolio	1,752,114	Q3 2025 Reduced 29.78%
ADMA Adma Biologics, Inc.	$3.06B	$40.6 Million 0.06% of portfolio	2,770,442	Q3 2025 Reduced 11.94%
MIRM Mirum Pharmaceuticals, Inc.	$2.63B	$37.6 Million 0.05% of portfolio	513,448	Q3 2025 Added 29.54%
IONS Ionis Pharmaceuticals Inc	$10.2B	$31.8 Million 0.05% of portfolio	486,714	Q3 2025 Added 79.79%
HRMY Harmony Biosciences Holdings, Inc.	$2.01B	$31.3 Million 0.04% of portfolio	1,137,071	Q3 2025 Added 22.34%
ACAD Acadia Pharmaceuticals Inc	$3.89B	$30.9 Million 0.04% of portfolio	1,449,533	Q3 2025 Reduced 6.34%
LEGN Legend Biotech Corp	$5.07B	$27.5 Million 0.04% of portfolio	843,200	Q3 2025 Added 28.48%
AXSM Axsome Therapeutics, Inc.	$5.99B	$18.2 Million 0.03% of portfolio	150,000	Q3 2025 Added 8.15%
VNDA Vanda Pharmaceuticals Inc.	$246M	$17.3 Million 0.02% of portfolio	3,476,925	Q3 2025 Added 0.85%
ABCL Ab Cellera Biologics Inc.	$1.05B	$16.9 Million 0.02% of portfolio	3,360,729	Q3 2025 Added 1.61%
BBIO Bridge Bio Pharma, Inc.	$9.84B	$16.7 Million 0.02% of portfolio	322,246	Q3 2025 Added 31.02%
APLS Apellis Pharmaceuticals, Inc.	$2.23B	$16.4 Million 0.02% of portfolio	722,895	Q3 2025 Added 6,478.95%
BCRX Biocryst Pharmaceuticals Inc	$1.32B	$16.2 Million 0.02% of portfolio	2,140,534	Q3 2025 Reduced 15.28%
AUPH Aurinia Pharmaceuticals Inc.	$2.18B	$16 Million 0.02% of portfolio	1,449,600	Q3 2025 Added 25.2%
CYTK Cytokinetics Inc	$6.25B	$15.9 Million 0.02% of portfolio	289,967	Q3 2025 Added 2,752.04%
FOLD Amicus Therapeutics, Inc.	$2.66B	$15.3 Million 0.02% of portfolio	1,943,171	Q3 2025 Reduced 3.5%
MDXG Mimedx Group, Inc.	$838M	$14 Million 0.02% of portfolio	2,008,227	Q3 2025 Reduced 4.72%
SNDX Syndax Pharmaceuticals Inc	$940M	$13.2 Million 0.02% of portfolio	860,500	Q3 2025 Added 2.72%
XERS Xeris Biopharma Holdings, Inc.	$986M	$13.1 Million 0.02% of portfolio	1,622,840	Q3 2025 Reduced 21.04%
MRVI Maravai Lifesciences Holdings, Inc.	$479M	$12.4 Million 0.02% of portfolio	4,318,089	Q3 2025 Added 3.15%
GLPG Galapagos Nv	$2.06B	$12.3 Million 0.02% of portfolio	356,200	Q3 2025 Reduced 23.35%
RVMD Revolution Medicines, Inc.	$5.94B	$11.8 Million 0.02% of portfolio	253,104	Q3 2025 Added 3.94%
NTLA Intellia Therapeutics, Inc.	$661M	$11.2 Million 0.02% of portfolio	651,000	Q3 2025 Reduced 3.83%
LQDA Liquidia Corp	$1.84B	$11.1 Million 0.02% of portfolio	484,753	Q3 2025 New
PBYI Puma Biotechnology, Inc.	$226M	$11 Million 0.02% of portfolio	2,151,213	Q3 2025 Added 14.75%
AKBA Akebia Therapeutics, Inc.	$313M	$10.7 Million 0.02% of portfolio	3,952,727	Q3 2025 Reduced 5.76%
NVAX Novavax Inc	$545M	$10.4 Million 0.01% of portfolio	1,196,750	Q3 2025 Added 79.25%
CELC Celcuity Inc.	$1.38B	$9.57 Million 0.01% of portfolio	194,800	Q3 2025 Added 1,387.02%
ARDX Ardelyx, Inc.	$908M	$9.33 Million 0.01% of portfolio	1,690,093	Q3 2025 Added 29.89%
CTMX Cytom X Therapeutics, Inc.	$255M	$8.12 Million 0.01% of portfolio	2,545,260	Q3 2025 Added 36.68%
AUTL Autolus Therapeutics PLC	$126M	$8.01 Million 0.01% of portfolio	4,881,372	Q3 2025 Added 178.74%

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Jim Simons

Jim Simons is the founder and chairman of Renaissance Technologies, a successful investment firm that uses quantitative approaches to investing. Simons is known for his expertise in mathematical modeling and has a reputation for being a skilled and successful investor. He has generated strong returns for his clients over the long term.

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