Wellington Management Group LLP Biotechnology

Wellington Management Group LLP

$545 Billion
Q3 2025

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
VRTX Vertex Pharmaceuticals Inc	$111B	$1.87 Billion 0.34% of portfolio	4,772,042	Q3 2025 Reduced 0.86%
ALNY Alnylam Pharmaceuticals, Inc.	$55.3B	$833 Million 0.15% of portfolio	1,826,321	Q3 2025 Reduced 12.02%
UTHR United Therapeutics Corp	$21.2B	$586 Million 0.11% of portfolio	1,398,781	Q3 2025 Reduced 3.06%
ARGX Argenx Se	$50.2B	$538 Million 0.1% of portfolio	729,986	Q3 2025 Added 80.1%
RVMD Revolution Medicines, Inc.	$5.94B	$458 Million 0.08% of portfolio	9,813,436	Q3 2025 Reduced 4.35%
RNA Avidity Biosciences, Inc.	$3.69B	$439 Million 0.08% of portfolio	10,065,187	Q3 2025 Added 8.82%
IONS Ionis Pharmaceuticals Inc	$10.2B	$431 Million 0.08% of portfolio	6,588,811	Q3 2025 Added 3.83%
CYTK Cytokinetics Inc	$6.25B	$407 Million 0.07% of portfolio	7,408,561	Q3 2025 Reduced 5.35%
ASND Ascendis Pharma A/S	$11.4B	$358 Million 0.07% of portfolio	1,798,931	Q3 2025 Added 95.94%

CRNX Crinetics Pharmaceuticals, Inc.	$2.34B	$349 Million 0.06% of portfolio	8,381,991	Q3 2025 Added 44.34%
PTCT Ptc Therapeutics, Inc.	$5.39B	$302 Million 0.06% of portfolio	4,918,619	Q3 2025 Added 4.78%
KYMR Kymera Therapeutics, Inc.	$3.55B	$294 Million 0.05% of portfolio	5,195,691	Q3 2025 Reduced 3.28%
TECH Bio Techne Corp	$2.33B	$285 Million 0.05% of portfolio	5,115,133	Q3 2025 Added 349.84%
FOLD Amicus Therapeutics, Inc.	$2.66B	$226 Million 0.04% of portfolio	28,628,829	Q3 2025 Reduced 1.7%
APLS Apellis Pharmaceuticals, Inc.	$2.23B	$210 Million 0.04% of portfolio	9,290,960	Q3 2025 Added 3.5%
AKRO Akero Therapeutics, Inc.	$2.52B	$202 Million 0.04% of portfolio	4,251,861	Q3 2025 Added 24.69%
NUVL Nuvalent, Inc.	$4.15B	$199 Million 0.04% of portfolio	2,300,865	Q3 2025 Added 45.96%
MDGL Madrigal Pharmaceuticals, Inc.	$9.05B	$186 Million 0.03% of portfolio	404,455	Q3 2025 Added 5,381.16%

PCVX Vaxcyte, Inc.	$2.87B	$181 Million 0.03% of portfolio	5,032,771	Q3 2025 Added 1.57%
IMCR Immunocore Holdings PLC	$1.58B	$174 Million 0.03% of portfolio	4,780,889	Q3 2025 Added 13.46%
SRRK Scholar Rock Holding Corp	$1.95B	$170 Million 0.03% of portfolio	4,545,887	Q3 2025 Added 124.5%
AXSM Axsome Therapeutics, Inc.	$5.99B	$162 Million 0.03% of portfolio	1,334,560	Q3 2025 Added 84.07%
CLDX Celldex Therapeutics, Inc.	$1.2B	$150 Million 0.03% of portfolio	5,800,003	Q3 2025 Added 10.85%
XENE Xenon Pharmaceuticals Inc.	$2.54B	$145 Million 0.03% of portfolio	3,609,857	Q3 2025 Added 65.99%
PTGX Protagonist Therapeutics, Inc	$4.15B	$127 Million 0.02% of portfolio	1,908,446	Q3 2025 Added 83.9%
VCYT Veracyte, Inc.	$2.82B	$116 Million 0.02% of portfolio	3,373,224	Q3 2025 Reduced 2.89%
INSM Insmed Inc	$26.2B	$103 Million 0.02% of portfolio	718,043	Q3 2025 Reduced 38.08%
AGIO Agios Pharmaceuticals, Inc.	$2.39B	$99.2 Million 0.02% of portfolio	2,471,416	Q3 2025 Added 485.46%
RARE Ultragenyx Pharmaceutical Inc.	$2.32B	$58.5 Million 0.01% of portfolio	1,945,129	Q3 2025 Added 3.92%
ZLAB Zai Lab LTD	$2.13B	$58.2 Million 0.01% of portfolio	1,718,455	Q3 2025 Added 24.8%
MIRM Mirum Pharmaceuticals, Inc.	$2.63B	$58 Million 0.01% of portfolio	790,689	Q3 2025 Added 566.85%
BBIO Bridge Bio Pharma, Inc.	$9.84B	$52.9 Million 0.01% of portfolio	1,019,194	Q3 2025 Added 1,698.5%
PHVS Pharvaris N.V.	$795M	$43.3 Million 0.01% of portfolio	1,734,743	Q3 2025 New
MRUS Merus N.V.	$4.4B	$43.2 Million 0.01% of portfolio	459,087	Q3 2025 Reduced 87.68%
TRVI Trevi Therapeutics, Inc.	$661M	$29.1 Million 0.01% of portfolio	3,253,888	Q3 2025 Added 1,791.99%
TVTX Travere Therapeutics, Inc.	$2.21B	$28.7 Million 0.01% of portfolio	1,201,469	Q3 2025 Added 3,331.89%
VRDN Viridian Therapeutics, Inc.\De	$1.15B	$24.1 Million 0.0% of portfolio	1,122,532	Q3 2025 Added 314.92%
ACLX Arcellx, Inc.	$3.94B	$19.1 Million 0.0% of portfolio	232,199	Q3 2025 Reduced 3.82%
MNKD Mannkind Corp	$1.3B	$18.6 Million 0.0% of portfolio	3,467,721	Q3 2025 Added 316.2%
STOK Stoke Therapeutics, Inc.	$1.05B	$17.3 Million 0.0% of portfolio	737,753	Q3 2025 Added 438.25%
RCUS Arcus Biosciences, Inc.	$1.45B	$17.2 Million 0.0% of portfolio	1,266,289	Q3 2025 Added 35.28%
JANX Janux Therapeutics, Inc.	$1.22B	$17.1 Million 0.0% of portfolio	701,604	Q3 2025 Added 42.5%
JAZZ Jazz Pharmaceuticals PLC	$8.84B	$17 Million 0.0% of portfolio	129,199	Q3 2025 Added 8.22%
IMTX Immatics N.V.	$778M	$12.9 Million 0.0% of portfolio	1,512,241	Q3 2025 Reduced 71.57%
SVRA Savara Inc	$495M	$9.31 Million 0.0% of portfolio	2,644,000	Q3 2025 Reduced 21.08%
VCEL Vericel Corp	$1.88B	$9.07 Million 0.0% of portfolio	288,156	Q3 2025 Reduced 13.25%
ADPT Adaptive Biotechnologies Corp	$2.01B	$7.5 Million 0.0% of portfolio	501,084	Q3 2025 New
COGT Cogent Biosciences, Inc.	$2.21B	$5.84 Million 0.0% of portfolio	406,899	Q3 2025 Added 36.84%
TRDA Entrada Therapeutics, Inc.	$266M	$5.54 Million 0.0% of portfolio	954,419	Q3 2025 Reduced 10.02%
LQDA Liquidia Corp	$1.84B	$5.5 Million 0.0% of portfolio	239,580	Q3 2025 Added 17.45%

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